Jagatheesan R.,St. Joseph's College |
Joseph Santhana Raj K.,St. Joseph's College |
Lawrence S.,Mills College |
Christopher C.,St Xaviers College Email
RSC Advances | Year: 2016
A greener and expeditious method for the side chain bromination of acetophenone using in situ generated bromonium ions from NH4Br and a catalytic amount of H2SO4 as a supporting electrolyte in a H2O:CH3CN medium at ambient temperature has been developed in an undivided cell equipped with a Pt/Pt electrode. This method results in a good yield (80%) of α-bromo acetophenone with high selectivity when only 2F of electricity was passed. Optimization studies such as variation of the current density, charge passed, solvent, solvent/water ratio, acid, acid strength, bromide salt, bromide salt concentration, etc., are carried out and reported. © The Royal Society of Chemistry 2016.