City of Westminster, United Kingdom
City of Westminster, United Kingdom

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Kluk J.,Dermatology St Thomas Hospital | Moonim M.,St Thomas Hospital | Duran A.,Queen Elizabeth Hospital | Costa Rosa J.,Instituto Portugues Of Oncologia Of Lisbon | And 5 more authors.
British Journal of Dermatology | Year: 2015

The development of high-grade lymphoma in patients with chronic lymphocytic leukaemia is known as Richter syndrome (RS) and is associated with a grave prognosis, with a mean survival of 8 months despite treatment. Cutaneous RS has been described in a handful of cases and may be associated with a better outcome than the more common extracutaneous variants. We review the literature with particular emphasis on pathogenesis, treatment and survival of RS. We postulate that the absence of B symptoms and a normal lactate dehydrogenase level, presumably reflecting localized or limited disease, and a lower tumour burden, may explain the apparently better survival in some patients with cutaneous RS than with extracutaneous variants. © 2014 British Association of Dermatologists.

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