Time filter

Source Type

Annapurna V.,St Theresas College For Women | Jyothi G.,St Theresas College For Women | Rohini Kumari T.,St Theresas College For Women | Sailaja B.B.V.,Andhra University
E-Journal of Chemistry | Year: 2010

Simple, accurate and reproducible visible spectrophotometric method for the assay of drugs such as pyrilamine and fluvoxamine as maleates was established based on the formation of charge-transfer complex and redox reaction between the corresponding drug and substituted p-benzoquinone (chloranilic acid). The optical characteristics such as Beer's law limits, molar absorptivity and Sandell's sensitivity are reported. Regression analysis using the method of least squares was made to evaluate the slope (b), intercept (a) and correlation coefficient (r) and standard error of estimation (Se) for each drug.


Annapurna V.,St Theresas College For Women | Jyothi G.,St Theresas College For Women | Nagalakshmi V.,St Theresas College For Women | Sailaja B.B.V.,Andhra University
Journal of the Indian Chemical Society | Year: 2010

Simple, accurate and reproducible UV-Visible spectrophotometric methods were established for the assay of fluvoxamine maleate (FXA) based on the oxidative coupling and condensation reactions. Oxidative coupling of the FXA with Brucine-IO4- in Method A, oxidative coupling of FXA with 2,6-dichloroquinone-4-chlorimide (DCQC) in Method B and condensation of FXA with p-dimethylaminocinnamaldehyde (PDAC) in Method C have been developed. The optical characteristics such as Beer's law limits, molar absorptivity and Sandell's sensitivity for the Methods (A-C) are given. Regression analysis using the method of least squares was made to evaluate the slope (b), intercept (a) and correlation coefficient (r) and standard error of estimation (Sc) for each system. Determination of FXA in bulk form and in pharmaceutical formulations were also incorporated. The methods have been applied for the determination of FXA in bulk form and in pharmaceutical formulations.


Rani V.U.,Andhra University | Jyothi G.,St Theresas College For Women | Rao G.N.,Andhra University | Sailaja B.B.V.,Andhra University
Acta Chimica Slovenica | Year: 2010

Protonation and complexation equilibria of embelin were investigated in 86% v/v dimethyl sulphoxide - water mixture electrometrically at an ionic strength of 0.17 mol dm-3 and at a temperature of 303K. The best fit chemical models were arrived at based on statistical grounds employing crystallographic R factor, χ2, skewness and kurtosis. The existence of binary complex species with Co(II), Ni(II), Cu(II) and Zn(II) were established from modeling studies using the computer program MINIQUAD75. Distribution diagrams of various species of the complex in relation to pH are presented.


Annapurna V.,St Theresas College For Women | Jyothi G.,St Theresas College For Women | Subbayamma A.V.,St Theresas College For Women | Sailaja B.B.V.,Andhra University
E-Journal of Chemistry | Year: 2010

Simple, accurate and reproducible UV spectrophotometric methods were established for the assay of buclizine (BUCZ) based on the formation of precipitation, charge transfer complex and inner complex formation. Method A involves the precipitation, charge transfer complex formation of BUCZ with tannic acid/ p-N-methyl aminophenol sulphate (PMAP)-Cr(VI), the complex formation with cobalt thiocyanate (CTC) in method B and inner complex formation of BUCZ with sodium nitroprusside hydroxylamine hydrochloride and sodium carbonate in method C were proposed. The optical characteristics such as Beers law limits, molar absorptivity and Sandell's sensitivity for the methods (AC) are given. Regression analysis using the method of least squares was made to evaluate the slope(b), intercept(a) and correlation coefficient (r) and standard error of estimation (Se) for each system Determination of BUCZ in bulk form and in pharmaceutical formulations were also incorporated.


Annapurna V.,St Theresas College For Women | Jyothi G.,St Theresas College For Women | Nagalakshmi V.,St Theresas College For Women | Sailaja B.B.V.,Andhra University
E-Journal of Chemistry | Year: 2010

Simple, accurate and reproducible UV spectrophotometric methods were established for the assay of pyrilamine maleate (PYRA) based on the formation of oxidative coupling and precipitation, charge transfer complexation products. Method A includes the oxidative coupling reaction of PYRA with 3-methyl-2- benzathiazolinone hydrazone (MBTH) in presence of Ce(IV). The formation of oxidative coupling product with 4-amino phenazone (4-AP) in presence of K3Fe(CN)6 is incorporated in method B. Precipitation/charge transfer complex formation of the PYRA with tannic acid (TA)/Metol-Cr(VI) in method C were proposed. The optical characteristics such as Beers law limits, molar absorptivity and Sandell's sensitivity for the methods (A-C) are given. Regression analysis using the method of least squares was made to evaluate the slope (b), intercept (a) and correlation coefficient (r) and standard error of estimation (Se) for each system. Determination of pyrilamine in bulk form and in pharmaceutical formulations were also incorporated.


Annapurna V.,St Theresas College For Women | Jyothi G.,St Theresas College For Women | Nagalakshmi V.,St Theresas College For Women | Sailaja B.B.V.,Andhra University
E-Journal of Chemistry | Year: 2010

Simple, accurate and reproducible UV-Visible spectrophotometric methods were established for the assay of FXA based on the oxidative coupling and condensation reactions. Condensation and coupling of the FXA with ninhydrin-ascorbic acid is proposed in method A. Method B includes complexation of FXA with cobalt thiocyanate. The ligating property of FXA with sodium nitro prusside is incorporated in method C. The optical characteristics such as Beers law limits, molar absorptivity and Sandell's sensitivity for the methods (A-C) are given. Regression analysis using the method of least squares was made to evaluate the slope(b), intercept(a) and correlation coefficient (r) and standard error of estimation (Se) for each system. Determination of FXA in bulk form and in pharmaceutical formulations were also incorporated.


Subbayamma A.V.,St Theresas College For Women | Rambabu C.,Acharya Nagarjuna University
Oriental Journal of Chemistry | Year: 2010

A simple and sensitive spectrophotometric method by exploiting the importance of the oxidation reaction of Sodium metaperiodate for the assay of nebivolol has been described. This method is based on the oxidation of nebivolol with excess of periodate and estimating the aldehyde formed with MBTH. MBTH is used to determine aromatic, aliphatic and alicyclic amines. MBTH (3-methyl-2-benzothlazolinone- hydrozone) has become an analytical tool of considerable versatility. Recoveries are almost quantitative.


Subbayamma A.V.,St Theresas College For Women | Rambabu C.,Acharya Nagarjuna University
Oriental Journal of Chemistry | Year: 2010

A Simple and sensitive method is presented for determining Trandolapril and Aripiprazole. The drugs were extracted from formulations with chloroform In an alkaline medium and reacted with citric acid - acetic anhydride reagent to produce a red-violet color having absorption maximum at 590nm. Beer's law is obeyed between 2-12 μig/ml for Trandolapril and Aripiprazole. The results obtained are statistically validated.

Loading St Theresas College For Women collaborators
Loading St Theresas College For Women collaborators