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Tsimplaki E.,St. Savvas Regional Anticancer Oncology Hospital of Athens | Argyri E.,St. Savvas Regional Anticancer Oncology Hospital of Athens | Xesfyngi D.,St. Savvas Regional Anticancer Oncology Hospital of Athens | Daskalopoulou D.,St. Savvas Regional Anticancer Oncology Hospital of Athens | And 2 more authors.
Anticancer Research | Year: 2014

Background/Aim: Human papillomavirus (HPV) infection has been considered a potential risk factor for the development of oral tongue squamous cell carcinoma (SCC). The purpose of the present study was to investigate HPV infection and high-risk HPV E6/E7 mRNA expression in SCC of the oral tongue in 53 Greek patients. Materials and Methods: Fifty-three biopsies were collected from patients with SCC of the oral tongue and tested for HPV DNA and E6/E7 mRNA expression. Results: The overall prevalence of HPV DNA was 11.3% (6/53), while high-risk HPV DNA was found in 7.5% (4/53) of SCC of the oral tongue. E6/E7 mRNA expression was observed in 9.4% (5/53) samples examined. HPV 16 was the commonest genotype identified by both DNA and RNA assays. A total of 28.3% (15/53) of the patients were non-smokers and non-drinkers. HPV infection was strongly associated with abstinence from tobacco and alcohol (p=0.013). Conclusion: The presence of high-risk HPV E6/E7 mRNA expression suggests that HPV may be implicated in the pathogenesis of SCC of the oral tongue. © 2014, International Institute of Anticancer Research. All rights reserved. Source


Apostolaki A.,St. Savvas Regional Anticancer Oncology Hospital of Athens | Arnogiannaki N.,St. Savvas Regional Anticancer Oncology Hospital of Athens | Papassideri I.,National and Kapodistrian University of Athens | Chatonidis I.,St. Savvas Regional Anticancer Oncology Hospital of Athens | And 3 more authors.
Anticancer Research | Year: 2010

Background: BAG-1 isomorphs are regulating proteins with antiapoptotic action in endometrium. ERa and PRA isomorphs seem to have an important role in endometrial cancer. Patients and Methods: We investigated the expression of BAG-1, ERa and PRA isomorphs in endometrioid adenocarcinoma and we correlated them with clinicopathological findings of the tumor. Fresh endometrial tissues were obtained from 33 patients with endometrial carcinoma and 191 paraffin-embedded tissues were analyzed by real-time PCR and immunochemistry for BAG-1, ER and PR. Results: BAG-1 protein is expressed in both nucleus and cytoplasm. Grade 3 tumors were considered to have the highest intensity. Only 4 out of 79 samples showed intense expression of ERa, while 37 samples out of 72 samples strongly expressed PRA. Conclusion: BAG-1 nuclear isomorph appeared more frequently in grade 2 tumors than in grade 1 and 3 tumors, and the cytoplasmatic isomorph was expressed more strongly than the nuclear one. Source

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