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Topkova O.V.,St Petersburg State Chemico Pharmaceutical Academy | Yakovleva E.P.,St Petersburg State Chemico Pharmaceutical Academy | Kolodyaznaya V.A.,St Petersburg State Chemico Pharmaceutical Academy
Antibiotiki i Khimioterapiya | Year: 2010

Changes in the fermentative activity of Streptomyces imbricatus under the conditions of stimulated biosynthesis of imbricin with addition of a crude endoregulator to the medium were studied. The activity of the two main enzymes of the glycolysis, i. e. phos-phofructokinase and fructose-1,6-diphosphate aldolase (aldolase) was determined and the functioning of the pentozophosphate pathway was estimated by the activity of glucose-6-phosphate dehydrogenase and NADP-specific glutamate dehydrogenase. Under the conditions of the endoregulation the increase of the imbricin production was observed when the level of the glucose catabolism either by the glycolytic pathway or by the pentozophosphate pathway was comparatively high, thus providing the antibiotic biosynthesis with the required precursors and reducing equivalents. Source


Kuvaeva E.V.,St Petersburg State Chemico Pharmaceutical Academy | Fedorova E.V.,St Petersburg State Chemico Pharmaceutical Academy | Zaitsev V.V.,St Petersburg State Chemico Pharmaceutical Academy | Yakovlev I.P.,St Petersburg State Chemico Pharmaceutical Academy | And 2 more authors.
Russian Journal of Organic Chemistry | Year: 2012

Aroylamidines can be obtained as salts in a reaction of the corresponding arylcarbonitriles with anhydrous ethanol in the presence of dry HCl followed by treating intermediate imidoesters with alcoholic solution of ammonia. N-Arylbenzamidines are obtained by reacting benzonitrile with arylamines in the presence of AlCl 3. The structure of arylamines and the reaction conditions signifi cantly affect the yield of the target product, and sometimes the very possibility of its preparation. © Pleiades Publishing, Ltd., 2012. Source

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