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Khavinson V.K.,RAS Pavlov Institute of Physiology | Kuznik B.I.,Chita State Medical Academy | Ryzhak G.A.,St Petersburg Institute Of Bioregulation And Gerontology
Advances in Gerontology | Year: 2013

This review summarizes the results of long-term research of authors who studied the mechanisms of aging and the effectiveness of peptide bioregulators in preventing age-related diseases in laboratory animals. The data on evaluating the peptide effects produced using the advanced techniques in research institutes in Russia and abroad are presented. The most attention is focused on the ability of peptide bioregulators to increase the life span and inhibit the carcinogenesis in animals. © 2013 Pleiades Publishing, Ltd.

Anisimov V.N.,Nn Petrov Research Institute Of Oncology | Khavinson V.Kh.,St Petersburg Institute Of Bioregulation And Gerontology
Biogerontology | Year: 2010

The review comprises the results of author's long-term investigation in the mechanisms of aging and a role of peptide bioregulators in prevention of age-related pathology. A number of small peptides have been isolated from different organs and tissues and their analogues (di-, tri-,tetrapeptides) were synthesized from the amino acids. It was shown that long-term treatment with some peptide preparations increased mean life span by 20-40%, slow down the age-related changes in thebiomarkers of aging and suppressed development of spontaneous and induced by chemical or radiation carcinogens tumorigenesis in rodents. Possible mechanisms of the biological effects of small peptides arediscussed in the paper. The results of clinical applications of peptide preparation during the period of 6-12 years are presented as well.

Arkhipova N.S.,Russian Academy of Medical Sciences | Ariev A.L.,North State Medical University | Popova E.K.,Ammosov Medical Institute of Yakutsk State University | Grigorieva L.V.,Russian Academy of Medical Sciences | Kozina L.S.,St Petersburg Institute Of Bioregulation And Gerontology
Advances in Gerontology | Year: 2013

A comparative analysis was performed for frequency distribution of I/D polymorphism of angiotensin-converting enzyme (ACE) gene and D442G polymorphism of cholesterol ester transfer protein (CETP) gene in elderly and senile patients and long-lived patients with CHD with regard to ethnicity, age, and gender. The frequency of ACE*I/*I genotype reduces with age; the tendency towards increased proportion of ACE*D/*D genotype was observed. During the comparative analysis of ACE*D/*D and ACE*D/*I genotypes, gender differences were found in frequency of homozygous ACE*D/*D genotype. The carriers of ACE*D/D genotype were identified significantly more often among men than among women. Among all patients and especially among Yakuts, left ventricular hypertrophy confirmed by Sokolov-Lyon index for ECG was observed significantly more often in carriers of ACE*I/*I genotype. During the study of D442G polymorphism of CETP gene, the carriers of CETP*D/*G genotype were identified significantly more often among Yakuts than among nonindigenous individuals. During the comparison of frequencies of I/D polymorphism of the ACE gene, significant differences were observed with respect to body mass index (BMI) and blood lipids. In comparison of CETP*D/*D and CETP*D/*G genotypes, no significant association with CHD risk factor was found. © 2013 Pleiades Publishing, Ltd.

Sidorenko A.V.,European Center for Social Welfare Policy and Research | Mikhailova O.N.,St Petersburg Institute Of Bioregulation And Gerontology
Advances in Gerontology | Year: 2014

This review article is devoted to the issues of international cooperation on aging. It aims to describe the basic areas of cooperation and introducing its major players. Within the limited length of a journal article, it is hardly possible to offer an exhaustive presentation of all available information; thus, the article strives to provide a general orientation within the selected themes. The authors are hopeful that the presented materials will be of interest to policy-oriented researchers, policy makers, and professionals working in the field of aging and related areas such as social security, health and social services, etc., as well as to the activists of nongovernmental organizations. © 2014, Pleiades Publishing, Ltd.

Kozina L.S.,St Petersburg Institute Of Bioregulation And Gerontology
Advances in Gerontology | Year: 2014

This article provides basic information on the establishment and operation of the Dissertation Council on Gerontology and Geriatrics of the St. Petersburg Institute of Bioregulation and Gerontology, which has played an invaluable role in the training of highly qualified personnel in this field of science, which has rapidly developed in Russia in recent decades. In the period from June 2001 to December 2013, 41 doctoral dissertations were defended (32 in medicine and 9 in biology). In the same period, 186 candidate’s dissertations (152 in medicine and 34 in biological sciences) were defended. The defenders were from different regions of Russia and foreign countries. The defense-representative trend data acquired over the period of activity of the Dissertation Council suggests that the number of defended doctoral dissertations was relatively small in 2002–2008 and then significantly increased in 2009–2013. The number of candidate’s dissertations defended during this period also increased significantly. Many dissertations considered by the Dissertation Council were dedicated to basic research in gerontology and geriatrics. The priority topics of many dissertations performed in both St. Petersburg and other Russian cities are the age-related pathology mechanisms, geroprotective effects of regulatory peptides, and the efficiency of their use in clinical practice. © 2014, Pleiades Publishing, Ltd.

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