St Petersburg Institute Of Bioregulation And Gerontology

Saint Petersburg, Russia

St Petersburg Institute Of Bioregulation And Gerontology

Saint Petersburg, Russia
SEARCH FILTERS
Time filter
Source Type

Korenevsky A.,Do Ott Institute Of Obstetrics | Milyutina Y.,Do Ott Institute Of Obstetrics | Kozina L.,St Petersburg Institute Of Bioregulation And Gerontology | Kerkeshko G.,Do Ott Institute Of Obstetrics | Arutjunyan A.,Do Ott Institute Of Obstetrics
Current Aging Science | Year: 2017

Industrial xenobitics, as well as endogenous damaging factors, such as L-homocysteine, are a well-known source of reactive oxygen species that disrupt biological processes. Among many others, luteinizing hormone releasing hormone synthesis and secretion mediated by a variety of neurotransmitters, which are under control of the hypothalamus and pineal gland, may be put in peril by reactive oxygen species. Their formation can be one of the reasons for the reproductive function shutdown in ageing as the generic response to the damaging factors independent of their nature. We review recent findings demonstrating the role of reactive oxygen species in disrupting the circadian signal originated in the main pacemaker of the organism, the suprachiasmatic nuclei of the hypothalamus, on its way to the hypothalamic areas responsible for the luteinizing hormone preovulatory surge. © 2017 Bentham Science Publishers.


PubMed | Toxicology Institute, Saint Petersburg State Institute of Psychology and Social Work, Academy of Public Administration, St Petersburg Institute Of Bioregulation And Gerontology and 3 more.
Type: Journal Article | Journal: Stomatologiia | Year: 2016

The aim of the study was to evaluate the effect of combined use of Cytoflavin and cognitive therapy on the dynamics of psychosomatic status and effectiveness of the treatment of generalized periodontitis in elderly patients. The results of treatment of 103 patients aged 60 and older were analyzed. All patients received standard therapy for 10-14 days depending on the severity of the process. In addition, the patients of the main group (51 patients) received Cytoflavin: 2 tabs. 2 times a day with an interval between doses of 8-10 hours for 25 days, and cognitive therapy aimed at training alternative realistic way of life perception. Treatment results were monitored by PMA, Russell periodontal index (PI), Green-Vermillion hygienic index. Psychosomatic dynamics was assessed by means of Spielberger anxiety scale and SUN methods of before and after a month of treatment. The inclusion in the treatment regimen of Cytoflavin and cognitive therapy had a positive impact: reduction of PMA by 61.8%, PI by 45.3% and Green-Vermillion index by 39.8%. The psychosomatic tests proved anxiety level decrease by 28.7% in terms of reactive anxiety and 31.5% in terms of personal anxiety, emotional status (21.2%), activity (21.7%) and mood (21.8%) improvement.


Anisimov V.N.,Nn Petrov Research Institute Of Oncology | Khavinson V.Kh.,St Petersburg Institute Of Bioregulation And Gerontology
Biogerontology | Year: 2010

The review comprises the results of author's long-term investigation in the mechanisms of aging and a role of peptide bioregulators in prevention of age-related pathology. A number of small peptides have been isolated from different organs and tissues and their analogues (di-, tri-,tetrapeptides) were synthesized from the amino acids. It was shown that long-term treatment with some peptide preparations increased mean life span by 20-40%, slow down the age-related changes in thebiomarkers of aging and suppressed development of spontaneous and induced by chemical or radiation carcinogens tumorigenesis in rodents. Possible mechanisms of the biological effects of small peptides arediscussed in the paper. The results of clinical applications of peptide preparation during the period of 6-12 years are presented as well.


Khavinson V.K.,RAS Pavlov Institute of Physiology | Kuznik B.I.,Chita State Medical Academy | Ryzhak G.A.,St Petersburg Institute Of Bioregulation And Gerontology
Advances in Gerontology | Year: 2013

This review summarizes the results of long-term research of authors who studied the mechanisms of aging and the effectiveness of peptide bioregulators in preventing age-related diseases in laboratory animals. The data on evaluating the peptide effects produced using the advanced techniques in research institutes in Russia and abroad are presented. The most attention is focused on the ability of peptide bioregulators to increase the life span and inhibit the carcinogenesis in animals. © 2013 Pleiades Publishing, Ltd.


Kozina L.S.,St Petersburg Institute Of Bioregulation And Gerontology | Borzova I.V.,St Petersburg Institute Of Bioregulation And Gerontology | Arutiunov V.A.,St Petersburg Institute Of Bioregulation And Gerontology | Ryzhak G.A.,St Petersburg Institute Of Bioregulation And Gerontology
Advances in Gerontology | Year: 2013

The review covers the literature that prove that the formation of ROS in aging overbalances the antioxidant defence system potential of the skin structure (horny layer, epidermis, and dermis). It has been shown that ROSs are involved in the pathogenesis of inflammatory processes and allergic responses in the skin. The role of ROS and antioxidant systems in the cell-mediated responses associated with the MAP kinase activity in the skin is discussed. Special attention is focused on exposure to ultraviolet radiation, which accounts for its genotoxic, immunosuppressive, and carcinogenic effects on skin. © 2013 Pleiades Publishing, Ltd.


Kozina L.S.,St Petersburg Institute Of Bioregulation And Gerontology
Advances in Gerontology | Year: 2014

This article provides basic information on the establishment and operation of the Dissertation Council on Gerontology and Geriatrics of the St. Petersburg Institute of Bioregulation and Gerontology, which has played an invaluable role in the training of highly qualified personnel in this field of science, which has rapidly developed in Russia in recent decades. In the period from June 2001 to December 2013, 41 doctoral dissertations were defended (32 in medicine and 9 in biology). In the same period, 186 candidate’s dissertations (152 in medicine and 34 in biological sciences) were defended. The defenders were from different regions of Russia and foreign countries. The defense-representative trend data acquired over the period of activity of the Dissertation Council suggests that the number of defended doctoral dissertations was relatively small in 2002–2008 and then significantly increased in 2009–2013. The number of candidate’s dissertations defended during this period also increased significantly. Many dissertations considered by the Dissertation Council were dedicated to basic research in gerontology and geriatrics. The priority topics of many dissertations performed in both St. Petersburg and other Russian cities are the age-related pathology mechanisms, geroprotective effects of regulatory peptides, and the efficiency of their use in clinical practice. © 2014, Pleiades Publishing, Ltd.


Sidorenko A.V.,European Center for Social Welfare Policy and Research | Mikhailova O.N.,St Petersburg Institute Of Bioregulation And Gerontology
Advances in Gerontology | Year: 2014

This review article is devoted to the issues of international cooperation on aging. It aims to describe the basic areas of cooperation and introducing its major players. Within the limited length of a journal article, it is hardly possible to offer an exhaustive presentation of all available information; thus, the article strives to provide a general orientation within the selected themes. The authors are hopeful that the presented materials will be of interest to policy-oriented researchers, policy makers, and professionals working in the field of aging and related areas such as social security, health and social services, etc., as well as to the activists of nongovernmental organizations. © 2014, Pleiades Publishing, Ltd.


Khavinson V.K.,RAS Pavlov Institute of Physiology | Solov'ev A.Y.,St Petersburg Institute Of Bioregulation And Gerontology | Zhilinskii D.V.,St Petersburg Institute Of Bioregulation And Gerontology | Shataeva L.K.,St Petersburg Institute Of Bioregulation And Gerontology | Vanyushin B.F.,Moscow State University
Advances in Gerontology | Year: 2012

Endogenous peptides in the cyto- and nucleoplasm are formed upon the specific proteasomal degradation of nuclear proteins. These peptides are formed by short blocks of amino-acid residues with charged side groups and therefore a high local concentration of electrostatic charge of either sign is characteristic of them. These peptides are capable of complementary binding to certain short nucleotide sequences in DNA strands. This binding can cause a significant weakening of the interstrand bonds in the double helix of DNA and therefore stimulate the splitting of strands, which is necessary for gene transcription and replication. Aging is always accompanied by a decrease in the degree of genome methylation. The age-related decrease of the degree of methylation of nucleotide repeat sequences in the genome promotes the site-specific binding of short peptides to DNA, which hinders the hydrolysis of non-methylated DNA fragments by endonucleases. The available experimental data on the peculiarities of binding to methylated DNA are indicative of the involvement of short peptides in the epigenetic regulation of aging processes. © Pleiades Publishing, Ltd., 2012.


Khavinson V.Kh.,RAS Pavlov Institute of Physiology | Tarnovskaya S.I.,St Petersburg Institute Of Bioregulation And Gerontology | Linkova N.S.,St Petersburg Institute Of Bioregulation And Gerontology | Pronyaeva V.E.,St Petersburg Institute Of Bioregulation And Gerontology | And 2 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2013

Analysis of the main parameters of molecular mechanics (number of hydrogen bonds, hydrophobic and electrostatic interactions, DNA-peptide complex minimization energy) provided the data to validate the previously proposed qualitative models of peptide-DNA interactions and to evaluate their quantitative characteristics. Based on these estimations, a three-dimensional model of Lys-Glu and Ala-Glu-Asp-Gly peptide interactions with DNA sites (GCAG and ATTTC) located in the promoter zones of genes encoding CD5, IL-2, MMP2, and Tram1 signal molecules. © 2013 Springer Science+Business Media New York.


PubMed | St Petersburg Institute Of Bioregulation And Gerontology, Chita State Medical Academy and RAS Pavlov Institute of Physiology
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

Irisin produced by muscles during exercise and promoting fat burning also exhibits geroprotective effect and induces telomere elongation in normal somatic cells. Special attention is paid to studies of the role of peptides Lys-Glu, Glu-Asp-Arg, and Ala-Glu-Asp-Gly in epigenetic regulation of irisin content. The data suggest that the immunomodulatory peptide Lys-Glu and neuroprotective peptide Glu-Asp-Arg modulate the life span by modulating irisin gene expression.

Loading St Petersburg Institute Of Bioregulation And Gerontology collaborators
Loading St Petersburg Institute Of Bioregulation And Gerontology collaborators