St Petersburg Chemical Pharmaceutical Academy

Saint Petersburg, Russia

St Petersburg Chemical Pharmaceutical Academy

Saint Petersburg, Russia
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Terninko I.I.,St Petersburg Chemical Pharmaceutical Academy | Nemyatykh O.D.,St Petersburg Chemical Pharmaceutical Academy | Sakipova Z.B.,Kazakh National Medical University | Kuldyrkaeva E.V.,St Petersburg Chemical Pharmaceutical Academy | Onishschenko U.E.,St Petersburg Chemical Pharmaceutical Academy
Pharmaceutical Chemistry Journal | Year: 2017

The composition of phenolic constituents from common mallow leaves was studied by HPLC. Total flavonoids and hydroxycinnamic acids were determined quantitatively as 2.97 ± 0.08% and 2.84 ± 0.03%, respectively. Luteolin (96.12 mg/100 g) and chlorogenic acid (51.04 mg/100 g) dominated the extracted phenolic compounds. Pharmacological tests (acute exudative inflammation model, wound-tensiometry on linear incised wound model, Nesterov test) were conducted. It was established that a gel with mallow extract applied to animals with inflammatory pathologies decreased statistically significantly as compared with a control the inflammation index and exudation rate. The complex of phenolic compounds may have been responsible for this. Reparative, capillary-protective, and hydrating effects of the plant extract were also found. The obtained results provided experimental justification for treating inflammatory pathologies with mallow leaves and using this plant to treat dermatological diseases. The prerequisites for developing dosage forms from common mallow extract and introducing it into official medicine have been created. © 2017, Springer Science+Business Media New York.


Flisyuk E.V.,St Petersburg Chemical Pharmaceutical Academy
Pharmaceutical Chemistry Journal | Year: 2010

The application of coatings to tablets is considiered as a complex process with a number of side effects. We present here the results of theoretical and experimental studies of the application of film coatings to tablets in fluidized bed and drum coater devices. Identification of the optimum conditions for applying the correct quantity of coating to tablets should take account of all effects accompanying this process. © 2010 Springer Science+Business Media, Inc.


Kuchuk V.I.,St Petersburg Chemical Pharmaceutical Academy | Shirokova I.Y.,St Petersburg Chemical Pharmaceutical Academy | Golikova E.V.,Saint Petersburg State University
Glass Physics and Chemistry | Year: 2012

The results of a study of physicochemical properties (density, viscosity, refractive index, contraction, and surface tension) of water-alcohol (water-ethanol, water-propanol, and water-isopropanol) and alcohol-alcohol (propanol-butanol) mixtures are presented. The ratios of water and alcohol corresponding to the maxima of the viscosity and contraction of the mixtures are determined. A nonlinear character of dependences of the density and refractive index for water-alcohol mixtures versus their composition is demonstrated. © Pleiades Publishing, Ltd., 2012.


Golikova E.V.,Russian Academy of Sciences | Kuchuk V.I.,St Petersburg Chemical Pharmaceutical Academy | Grigor'Ev V.S.,Russian Academy of Sciences | Sharypin V.V.,Russian Academy of Sciences
Glass Physics and Chemistry | Year: 2011

The aggregate stability of natural diamond sols in LiCl aqueous solutions in the acidic region of pH values has been investigated using flow ultramicroscopy. The range of variations in parameters of structural forces for natural diamond in these solutions has been determined. The possibility of applying the Smoluchowski theory and the Muller theory of reversible coagulation to the description of the kinetics of coagulation and the equilibrium aggregate state of polydisperse diamond sols has been discussed. © 2011 Pleiades Publishing, Ltd.


Moshinskii A.I.,St Petersburg Chemical Pharmaceutical Academy
Journal of Engineering Physics and Thermophysics | Year: 2015

Based on the traditional model with direct flow and counterflow of heat transfer agents in a stationary regime, the operation of a heat exchanger of the tube-in-tube type is analyzed. Account is taken of the natural limitations for the model that are connected with the possibility of practical realization of the similarity numbers involved in the equations of the model, as well as with the conditions (assumptions) invoked in the derivation of the model. A comparison of the efficiency of heat transfer in the noted regimes of heat transfer agent motions is made. For the purposes of this comparison, it is proposed to use an averaged value of the function that represents the ratio of efficiencies with heat transfer agent direct flow and counterflow over the region of possible values of similarity numbers. The necessary calculations and illustrations are presented. © 2015, Springer Science+Business Media New York.


Moshinskii A.I.,St Petersburg Chemical Pharmaceutical Academy
Journal of Engineering Physics and Thermophysics | Year: 2012

A formula dependent on two parameters has been proposed for the approximation of typical phase-equilibrium functions. This formula can be used for analysis of a number of mass-transfer processes, in particular, distillation, rectification, adsorption, etc. Using the dependence proposed, a mathematical model of periodic distillation of a binary mixture in the presence of a dephlegmator has been analyzed; in the dephlegmator, partial condensation of the separated mixture occurs in a nonstationary mode under certain supplementary conditions. Analytical expressions describing this process and convenient for calculations have been obtained. © 2012 Springer Science+Business Media, Inc.

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