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Ravindernath A.,Osmania University | Reddy M.S.,St Peters Institute Of Pharmaceutical Science Vidyanagar
Medicinal Chemistry Research

A series of benzo[d]imidazolyl chromeno[2,3-d]pyrimidnones were described. The key intermediate 2-cyano-N-(2-mercapto-1H-benzo[d]imidazol-5-yl)acetamide (3) is obtained by reacting 5-amino-2-mercaptobenzimidazole (1) with ethyl cyanoacetate (2). Compound 3 on reaction with substituted salicylaldehydes afforded 2-imino-N-(2-mercapto-1H-benzo[d]imidazol-5-yl)-2H-chromene-3- carboxamides (5) in good yields. Compounds 5 on condensation with formalin furnished the title compounds viz., 3-(2-mercapto-1H-benzo[d]imidazol-5-yl)-2H- chromeno[2,3-d]pyrimidin-4(3H)-ones (7). All the synthesized compounds were screened for their anti-microbial and anti-oxidant activities. © 2013 Springer Science+Business Media New York. Source

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