St Peters Institute Of Pharmaceutical Science

Warangal, South Korea

St Peters Institute Of Pharmaceutical Science

Warangal, South Korea
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Reddy Poonuru R.S.,St Peters Institute Of Pharmaceutical Science
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: The present study involves formulation and evaluation of gastro retentive drug delivery systems of lamotrigine Methods: Gastro retentive drug delivery systems were prepared by developing buoyancy by usage of effervescent and non effervescent strategies utilising gas generating materials and low density porous materials respectively. The finished tablets were subjected to floating studies, dissolution studies, release kinetic studies and stability studies. Results: The optimized tablets of lamotrigine, F4 showed floating lag time of 30 seconds and total floating time more than 12 hours with in vitro percentage release of 89.43% at the end of 12hours. The kinetic studies showed that the release was by zero order and is best fit to Peppas model showing the release by non- Fickian diffusion implying that both diffusion and erosion controlled the drug release. The n value greater than 0.89 indicates super case II transport mechanism which refers to the erosion of the polymeric chain. The optimized formulation when subjected to stability studies showed no significant differences in drug content and release profile. Conclusion: This design of the study will be helpful for the spatial and temporal control over the release from the dosage form making the bioavailability to improvise with better patient compliance.


Rondi S.,St Peters Institute Of Pharmaceutical Science | Peddolla R.,St Peters Institute Of Pharmaceutical Science
Journal of Advanced Pharmaceutical Technology and Research | Year: 2014

Diabetes is associated with complications like neuropathy, nephropathy, cardiomyopathy, and retinopathy due to increased oxidative stress and serum lipids. In the present study, rosuvastatin, a HMG-CoA inhibitor, was investigated for its protective effect in neuropathy, nephropathy, and cardiomyopathy based on the lipid-lowering property along with its pleiotropic effects such as improved blood flow to the organ and antioxidant defense. Type 2 diabetes was induced in Wistar rats by single i.p. administration of streptozotocin (50 mg/kg). These diabetic rats were treated with daily doses of rosuvastatin (10 mg/kg) alone, metformin (120 mg/kg) and glimepiride (1 mg/kg) and rosuvastatin in combination with metformin (120 mg/kg) and glimepiride (1 mg/kg) for a period of 6 weeks. The biochemical parameters involved in neuropathy, renopathy, and cardiopathy were estimated. Treatment resulted in significant (P < 0.05) decrease in thiobarbituric acid reactive substances (TBARS) and increase in levels of glutathione peroxidise and catalase in brain and kidney homogenates. Significant (P < 0.05) increase in high-density lipoproteins and decrease in creatinine kinase, triglycerides, total serum cholesterol represents the cardioprotective action, whereas significant (P < 0.05) increase in the latency in the hotplate model shows the neuroprotective activity, and significant (P < 0.05) decrease in blood urea nitrogen, creatinine levels and increase in serum total protein levels suggested the renoprotective actions. The unique properties of rosuvastatin such as antioxidant defense and lipid-lowering nature might have resulted in cardio, neuro, and renoprotective activity in type 2 diabetic rats treated with metformin and glimepiride.


Bobbala S.K.R.,St Peters Institute Of Pharmaceutical Science
Journal of Liposome Research | Year: 2012

Proliposomes loaded with isradipine were prepared successfully to enhance the oral bioavailability of isradipine. In this study, proliposomes were prepared by film deposition by the carrier method with varying ratios of hydrogenated soy phosphatidyl choline (HSPC) and cholesterol using spray-dried mannitol (Pearlitol SD 200) as the carrier. The formulation containing an equimolar ratio of HSPC and cholesterol showed smaller vesicle size, high surface charge, and entrapment efficiency. The formation of liposomes and surface morphology of optimized proliposome formulation was studied by optical and scanning electron microscopy, respectively. Fourier transform infrared, differential scanning calorimetry, and powder X-ray diffractometry studies were performed to assess the solid-state characteristics of the formulation. Ex vivo permeation enhancement assessed from flux, permeability coefficient, and enhancement ratio were significantly higher for proliposomes, compared to control. The pharmacokinetic parameters were evaluated in male albino Wistar rats, and a significant improvement in bioavailability (2.4-fold) was observed from the optimized proliposome formulation, compared to control (oral suspension). The stability study revealed that the formulations are stable when stored at 4°C. © 2012 Informa Healthcare USA, Inc.


Talla V.,National Institute of Pharmaceutical Education and Research | Veerareddy P.R.,St Peters Institute of Pharmaceutical science
Journal of Young Pharmacists | Year: 2011

The aim of the study is to examine the oxidative stress in patients on fluoroquinolones (ciprofloxacin, levofloxacin, gatifloxacin) therapy for complicated urinary tract infections and to correlate with plasma concentrations at different time intervals. Superoxide dismutase (SOD), glutathione, plasma antioxidant status and lipid peroxides were evaluated in 52 patients on different dosage regimens up to 5 days. There is significant and gradual elevation of lipid peroxide levels in patients on ciprofloxacin (3.6 0.34 nmol/ml to 6.2 0.94 nmol/ml) and levofloxacin (3.5 0.84 nmol/ml to 5.1 0.28 nmol/ml) dosage regimen but not with gatifloxacin (3.5 0.84 nmol/ml to 3.74 0.17 nmol.ml). There was substantial depletion in both SOD and glutathione levels particularly with ciprofloxacin. On the 5 th day of treatment, plasma antioxidant status decreased by 77.6% %, 50.5%, 7.56% for ciprofloxacin, levofloxacin and gatifloxacin respectively. In conclusion ciprofloxacin and levofloxacin induce more reactive oxygen species that lead to cell damage than gatifloxacin irrespective of their concentrations in patient population.


Kumar G.P.,St Peters Institute Of Pharmaceutical Science | Rao P.R.,St Peters Institute Of Pharmaceutical Science
Asian Journal of Pharmaceutical Sciences | Year: 2012

Topical route of delivery is the most popular with use of ointments, creams, lotions, gels and transdermal patches. It is preferred over oral dosage forms to avoid gastric irritation, multiple dosage regimes and drug wastage by first pass effect thus increasing the bioavailability. Development of successful transdermal drug delivery systems has been limited in scope due to the significant penetration barrier provided by the top most layer of skin, the stratum corneum. To overcome this barrier, numerous active and passive penetration enhancement methods have been assessed. Although active methods including iontophoresis, electroporation, and microneedles have shown some efficiency, but more work is needed to establish their safety and cost effectiveness. Promising passive methods include the use of vesicular systems amongst the colloidal systems which provide design flexibility and possibility of application over a larger area of skin compared to active methods. Many vesicular systems like liposomes, niosomes, ethosomes and transferosomes are introduced for therapeutically effective transdermal drug delivery. And also special type of vesicles introduced as deformable vesicles which are novel type of liquid state vesicles that could pass readily across the skin. This review addresses the scope, mechanism of penetration and interaction of ultra deformable niosomes with the skin.


Marasani A.,St Peters Institute Of Pharmaceutical Science
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: Besides the great efficacy of isoniazid (INH) and rifampicin (RMP) combination, in the treatment and chemoprophylaxis of tuberculosis, hepatotoxicity is the most common serious complication. The aim of present study is to evaluate the Hepatoprotective activity of Bauhinia variegata against a rat model of INH-RMP induced hepatotoxicity. Methods: Wistar albino rats of either sex (200-250 g) were treated with alcoholic extract of Bauhinia variegata (BV) (200 and 400 mg/kg; p.o) for 15 days. Hepatotoxicity was induced by oral administration of INH (50 mg/kg, p.o.), RMP (100 mg/kg p.o.) body weight /day each. Silymarin (50 mg/kg) used as reference drug. Hepatic marker enzymes, Serum glutamate oxaloacetate transaminase (SGOT), Serum glutamate pyruvate transaminase (SGPT), Alkaline phosphatase (ALP); Gamma glutamyl transferase (GGT), Lactate dehydrogenase (LDH), lipid peroxidation (LPO) in liver and cholesterol (CHO), triglycerides (TGL), Albumin (ALB), Bilirubin and total protein(TOP) in serum was estimated in experimental rats after 15 days. Results: Levels of marker enzymes (SGOT, SGPT, ALP, GGT, and LDH), ALB, TOP, CHO, and TGL were assessed in serum. The effect of BV on LPO was assayed in liver homogenates to evaluate antioxidant activity. BV and Silymarin elicited a significant hepatoprotective activity by lowering the levels of serum marker enzymes and lipid peroxidation. Conclusion: Histopathological examination revealed preservation of liver integrity of the protected groups compared to combination-treated rats alone. The present findings suggest that the hepatoprotective effect of BV in INH-RMP induced oxidative damage may be related to its antioxidant and free radical scavenging activity.


Vemula S.K.,St Peters Institute Of Pharmaceutical Science | Veerareddy P.R.,St Peters Institute Of Pharmaceutical Science
Latin American Journal of Pharmacy | Year: 2011

The purpose of development oral fast disintegrating drug delivery is not only to give fast relief but also to overcome difficulty in swallowing tablets and capsules, resulting in non-compliance and ineffective therapy. The aim of present study is to formulate fast disintegrating of flurbiprofen by using superdisintegrants. Flurbiprofen fast disintegrating tablets were prepared by using direct compression method and were characterized for both pre-compression parameters and post-compression parameters to comply with pharmacopoeial limits. From the in vitro drug release studies the optimized formulation showed almost complete drug release (above 99%) within 15 min. DSC and FTIR studies were carried out to understand the drug-polymer compatibility and revealed that there was no possible interaction between them. Thus developed fast disintegrating tablets may be suitable to give rapid drug delivery and rapid onset of action.


Anisetti R.,Osmania University | Reddy M.S.,St Peters Institute Of Pharmaceutical Science
Journal of Sulfur Chemistry | Year: 2012

An efficient synthesis of novel spiro(imidazo[4′,5′:4,5′] benzo[1,2-e][1,4]thiazepine)-9,3′-indolines has been accomplished from 5-amino-2-mercapto benzimidazole, istains and mercapto acetic acid. Compounds 6 were characterized by IR, 1HNMR, 13C NMR and mass spectral data. The title compounds 6a-6e were evaluated for their antimicrobial, anti-inflammatory and antioxidant activity. Compounds 6a-6e exhibited significant antimicrobial activity, and as potent anti-inflammatory and antioxidant activities as that shown by standard drugs. © 2012 Taylor & Francis.


Veerareddy P.R.,Chaitanya Institute of Pharmaceutical Education and Research | Bobbala S.K.R.,St Peters Institute Of Pharmaceutical Science
Drug Development and Industrial Pharmacy | Year: 2013

The objective of the present research was to develop a proniosomal formulation of isradipine and to evaluate the influence of proniosomal systems on the oral bioavailability of the drug in albino Wistar rats. Proniosomes were prepared by film deposition on carrier's method using various molar ratios of nonionic surfactants such as span20, span40, span60, and span80 with cholesterol as membrane stabilizing agent and dicetylphosphate as a charge inducer. The formation of niosomes and surface morphology of proniosome formulations were studied by optical and scanning electron microscopy (SEM), respectively. The prepared proniosomes have shown higher dissolution of isradipine compared with pure drug powder. Fourier transform infrared spectroscopy, differential scanning calorimetry, and powder X-ray diffractometry studies were performed to understand the solid state properties of the drug. Ex vivo permeation enhancement assessed from flux, permeability coefficient, and enhancement ratio were significantly higher for proniosomes compared with control. The pharmacokinetic parameters were evaluated in male albino Wistar rats and a significant enhancement in the bioavailability (2.3-fold) was observed from optimized proniosome formulation compared with control (oral suspension). The stability study reveals that the proniosome formulations are stable when stored at 4°C. © 2013 Informa Healthcare USA, Inc.


Kallakunta V.R.,St Peters Institute Of Pharmaceutical Science | Bandari S.,St Peters Institute Of Pharmaceutical Science | Jukanti R.,St Peters Institute Of Pharmaceutical Science | Veerareddy P.R.,St Peters Institute Of Pharmaceutical Science
Powder Technology | Year: 2012

The current investigation was aimed to improve the solubility of poorly soluble lercanidipine hydrochloride as self emulsifying powder (SEP). Liquid SEDDS of LCH was formulated with Capmul MCM L8 as oil, Tween (R) 80 as surfactant and PEG 400 as co surfactant after screening various vehicles. The prepared formulations were evaluated for self emulsifying ability and phase diagram was constructed to optimize the system. These systems were further characterized for globule size, effect of pH and robustness to dilution, cloud point, thermodynamic stability, surface morphology and drug release. The system was robust to different pH media and dilution volumes. The optimized system possessed a mean globule size of 169. ±. 06. nm and cloud point of 76. °C. The self emulsifying powder was prepared by adsorbing the liquid SEDDS on to neusilin as carrier. The SEP formulated was free flowing with similar emulsification characteristics as that of liquid SEDDS. The X-ray diffraction, Differential Scanning Calorimetric studies of SEP revealed transformation of crystalline structure of LCH because of its molecularly dissolved state in the liquid SEDDS. This was further confirmed by scanning electron microscopy. High dissolution efficiency value of SEP compared with pure drug indicated the increase in dissolution characteristics of LCH in SEP. © 2012 Elsevier B.V.

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