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Papacocea T.,St. Pantelimon Emergency Hospital | Papacocea R.,Carol Davila University of Medicine and Pharmacy | Badarau A.,Carol Davila University of Medicine and Pharmacy | Ion A.D.,Carol Davila University of Medicine and Pharmacy | And 3 more authors.
Therapeutics, Pharmacology and Clinical Toxicology | Year: 2011

The brain has a particular predisposition to oxidative stress which makes it vulnerable to free radicals. They trigger lipid peroxidation of the cellular membranes, oxidation of proteins and DNA leading to changes in chromosome structure, genetic mutation, and/or modulation of cell growth. It was shown that oxygen-derived free radicals play an important role in brain tumor development due to DNA strand braking, appearance of point mutations and aberrant DNA cross-linking. Consequently, a genomic instability is created which contributes to carcinogenesis. In the next steps of carcinogenesis, oxygen free radicals may initiate signal transduction pathways and activate fundamental transcription factors such as NF-kB, Nrf2 or HIF-1. In this context, the contribution of oxidative stress in brain tumors genesis and the role of antioxidants were analysed. © 2011. Source


Mohan D.,University of Oradea | Moisa H.A.,University of Bucharest | Nica D.A.,St. Pantelimon Emergency Hospital | Ciurea A.V.,University of Bucharest | Ciurea A.V.,Sanador Medical Center Hospital
World Neurosurgery | Year: 2016

The development of neurosurgery as an independent specialty took place with great difficulty in Romania. In this respect, the most revered personalities are those of Professor Alexandru Moruzzi (1900-1957) (in Iasi) and Professor Dimitrie Bagdasar (1893-1946) (in Bucharest), who are the fathers of modern neurosurgery in Romania. Professor Bagdasar was schooled in Professor Harvey Cushing's clinic in Boston and is credited with creating the first completely independent neurosurgical unit in Romania. His legacy was carried on with honor by Professor Constantin Arseni (1912-1994), who, in 1975, tasked Dr. Lenke Horvath (1917-1991) with creating the first autonomous pediatric neurosurgery unit in Bucharest. This article is a small tribute to the founder of pediatric neurosurgery in Romania and one of the female pioneer neurosurgeons, who, by personal example of dedication and hard work, radically changed medical thinking and neurosurgery in Romania. © 2016 Elsevier Inc. All rights reserved. Source


Papacocea T.,St. Pantelimon Emergency Hospital | Papacocea R.,Carol Davila University of Medicine and Pharmacy | Badarau A.,Carol Davila University of Medicine and Pharmacy | Ion A.D.,Carol Davila University of Medicine and Pharmacy | And 4 more authors.
Therapeutics, Pharmacology and Clinical Toxicology | Year: 2011

Intracerebral hemorrhage (ICH) represents the most lethal form of stroke and has deleterious conequences. Primary injuries are generated by the blood collection itself and consist in local tissue destruction. They are prolonged and amplified by a combination of secondary injuries involving the toxic effects of blood, oxidative stress, recruitment of activated microglia/macrophages and neutrophils and excitotoxicity. Brain tissue is particulary vulnerable oxidative attack due to its rich content in polyunsaturated fatty acids which favors lipid peroxidation. Different from other tissues, brain presents only reduced amounts of antioxidant enzymes-catalase (CAT), glutation peroxidase (GPX) and superoxid dismutase (SOD) and their activity decreases with age. It also contains elevated amounts of non-heme iron. The study of neuroprotection in ICH use as targets pathological processes like oxidative stress, inflammation, cerebral edema. In this context, the role for oxidative stress in and potential antioxidant therapies were analysed. © 2011. Source


Visan R.,St. Pantelimon Emergency Hospital | Groseanu Fl.,St. Pantelimon Emergency Hospital | Prundeanu A.,St. Pantelimon Emergency Hospital | Cristea St.,St. Pantelimon Emergency Hospital
Archives of the Balkan Medical Union | Year: 2013

Charcot's neuroarthropathy represents a progressive disease affecting the whole musculosqueletal system, the diagnosis and the treatment of which are still hard to establish. It is manifested through the moderate inflammation of the joints, accompanied or not of their distorsion. Its natural evolution is towards instability and progressive and invalidating deformities, often complicated by ulcers and infections. The priority treatment is orthopaedicimmobilization in casting device after having reduced the deformities with the pressure-relieving sustaining areas. The surgical treatment is indicated only in case of failure of the conservative one. There are preferred the percutaneous operations with less complications. The scope of the treatment is to obtain a stable uninfected foot, in order to normally put on the shoes or with adequate plantar shoe horns. Source

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