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Rochester, NY, United States

St. John Fisher College is a private liberal arts college located in Pittsford, New York, United States, an eastern suburb of Rochester. Fisher is ranked by U.S. News & World Report among the Doctoral Research Universities , which reflects the college's growth in the area of doctoral program offerings. It is named after St. John Fisher, the former Bishop of Rochester, in England. Wikipedia.

Hunter R.,St. John Fisher College
Computers and Composition | Year: 2011

The collaborative affordances of the wiki, in conjunction with local literacy practices, have important implications for the development of contemporary online notions of authorship. Using discourse analytic methods focused on the talk pages of several World of Warcraft Wiki (WoWWiki) articles, this essay seeks to identify particular patterns of language use in the interactions between members of this online voluntary writing group in order to identify how contributors think about authorship in a clearly collaborative writing space. Candace Spigelman's (1998) theoretical construct of " habits of mind" and James Paul Gee (1989) theory of discourse are used to describe more or less effective ways of collaborating on writing in this context. The findings suggest the direction of this writing is toward much more collaborative and communal notions of authorship-ones in which the meaning of " collaborative" and " authorship" are being redefined. Successful collaborative writing on WoWWiki is a result of writers sharing common " habits of mind," and collaboration can be disrupted by those who hold more author-centric perspectives of textual ownership. © 2010 Elsevier Inc.

Venci J.V.,University of Rochester | Gandhi M.A.,St. John Fisher College
Annals of Pharmacotherapy | Year: 2013

Objective: To describe the clinical evidence supporting the safety, efficacy, and clinical utility of oral dimethyl fumarate for the treatment of multiple sclerosis (MS). Data Sources: A comprehensive PubMed search was conducted in July 2013 using the search terms dimethyl fumarate and Tecfidera. Reference lists of abstracted publications were reviewed to identify relevant works that were not retrieved via the electronic search. Additional information was obtained from the FDA Web site, manufacturer prescribing information, and Clinicaltrials.gov. Study Selection and Data Abstraction: Clinical trials and review articles that included the use of dimethyl fumarate in the treatment of MS and were available in English were abstracted for review. Data Synthesis: The safety and efficacy of dimethyl fumarate for the treatment of relapsing remitting MS was confirmed in 2 phase III trials, DEFINE and CONFIRM. Relative to placebo, twice-daily dimethyl fumarate was found to reduce the proportion of patients with relapses at 2 years by 34% to 49% and the annualized relapse rate by 44% to 53%. Although the incidence of serious adverse effects did not differ from that of placebo, intolerable flushing and gastrointestinal adverse effects prompted discontinuation in 3% and 4% of patients, respectively. Conclusions: In March 2013, dimethyl fumarate was approved as a third oral option for patients with relapsing forms of MS. Although no head-to-head trials have been conducted, a comparison of data from phase III trials suggests that the efficacy of dimethyl fumarate is comparable to that of existing oral agents and may offer a preferable safety profile. © The Author(s) 2013.

Woytowish M.R.,St. John Fisher College | Maynor L.M.,West Virginia University
Annals of Pharmacotherapy | Year: 2013

OBJECTIVE: To evaluate and review the literature surrounding serotonin toxicity in patients receiving linezolid and determine the clinical relevance of this reaction. DATA SOURCES: Literature was accessed via MEDLINE/PubMed and Google Scholar (both through February 2013) using the search terms linezolid, serotonin syndrome, serotonin toxicity, and adverse reaction. STUDY SELECTION AND DATA EXTRACTION: Relevant case reports, retrospective studies, surveys, and review articles were included. Bibliographies of all relevant articles were reviewed for additional sources. DATA SYNTHESIS: Linezolid exhibits mild, nonselective inhibition of monoamine oxidase and has been associated with serotonin toxicity when used in combination with other serotonergic agents. Based on published reports, the incidence of linezolid-associated serotonin toxicity is between 0.54% and 18.2%. Our review identified 32 documented cases, including 3 fatalities. Most cases occurred in patients concurrently receiving selective serotonin reuptake inhibitors. Receipt of multiple agents with serotonergic activity seems to increase the risk of serotonin toxicity. Both onset and resolution of symptoms varied from hours to days. CONCLUSIONS: Current Food and Drug Administration recommendations to avoid the use of linezolid in patients receiving select serotonergic agents highlight the need to carefully balance the risk/benefit ratio in this situation. Although linezolid has been available for 12 years, reports of serotonin toxicity with this agent are uncommon. While clinicians should be aware of this potentially severe interaction and closely monitor patients who are receiving linezolid in combination with serotonergic agents, our findings show that linezolid is not contraindicated in this situation. © 1967-2013 Harvey Whitney Books Co. All rights reserved.

Kraft B.M.,St. John Fisher College | Brennessel W.W.,University of Rochester
Organometallics | Year: 2014

A series of neutral organosilicon compounds, R3Si(OPO) (R = Me (1), Et (2), Ph (3)), cis-R2Si(OPO)2 (R = Me (4), Et (5), iPr (6), tBu (7), Ph (9)), (CH2) 3Si(OPO)2 (8), and cis-R2Si(OPO)Cl (R = Me (10), Et (11)) (OPO = 1-oxo-2-pyridinone) have been prepared and fully characterized. X-ray crystallographic analyses show 1 to be tetracoordinate, 3, 7, and 10 to be pentacoordinate, and 4-6, 8, and 9 to be hexacoordinate. In the hexacoordinate structures, a mixture of diastereomers is observed in the form of C/N site disorder in each OPO ligand. Variable-temperature 13C and 29Si NMR studies indicate reversible Si←OC bond dissociation occurring in all pentacoordinate and hexacoordinate complexes to a varying degree with greater tendency toward dissociation in hydrogen-bonding donor solvents. Significant weakening of the dative Si←OC bond in 3 is observed in the cocrystallized adduct solvate 3·Ph3SiOH· 1/2C5H12, providing structural evidence for the decrease in coordination number of the OPO ligand by hydrogen-bonding donors. In the hexacoordinate complexes, increasing steric bulk of ancillary ligands also was found to promote dissociation. 1H and 13C VT-NMR studies of 4, 6, 8, and 9 indicate stereoisomerization equilibria concurrent with Si←OC bond dissociation proposed to occur through trigonal-bipyramidal intermediates. © 2013 American Chemical Society.

Background: This intervention study examined the prevalence of bullying in an urban/suburban middle school and the impact of the Olweus Bullying Prevention Program (OBPP). Methods: A quasi-experimental design consisting of a time-lagged contrast between age-equivalent groups was utilized. Baseline data collected for 158 students prior to implementation of the OBPP were compared to 112 students who received the OBPP intervention for 1 year. Multiple perspectives on bullying were collected using the Revised-Olweus Bully/Victim Questionnaire. Similarly, a teacher questionnaire collected data for 17 teachers on prevalence of bullying and capacity to intervene pre- and post- OBPP intervention. Descriptive and inferential statistics were generated to analyze findings. Results: Statistically significant findings were found for 7th grade female students who received 1 year of the OBPP on reports of prevalence of bullying (p = .022) and exclusion by peers (p = .009). In contrast, variability in statistical findings was obtained for 8th grade females and no statistical findings were found for males. Following 1 year of the OBPP, teachers reported statistically significant improvements in their capacity to identify bullying (p = .016), talk to students who bully (p = .024), and talk with students who are bullied (p = .051). Other substantial percentile changes were also noted. Conclusion: Findings suggest a significant positive impact of the OBPP on 7th grade females and teachers. Other grade and gender findings were inconsistent with previous literature. Recommendations for further research are provided along with implications for school health prevention programming. © 2011, American School Health Association.

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