Gillingham D.,St. Johanns Ring 19 |
Shahid R.,COMSATS Institute of Information Technology
Current Opinion in Chemical Biology | Year: 2015
To study DNAs and RNAs it is often necessary to chemically modify them. Nature's strategy for nucleic acid modification is to use selective catalysts, and chemists have begun to emulate this conceptual approach. In this review we present a summary of catalytic approaches toward the construction of modified RNAs and DNAs and outline our opinions on where new research is needed. © 2015 Elsevier Ltd.