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Flohe S.,Heinrich Heine University Düsseldorf | Betsch M.,Heinrich Heine University Düsseldorf | Russe K.,Sankt Josef Orthopaedic and Rheumatology Center Wuppertal | Wild M.,Heinrich Heine University Düsseldorf | And 2 more authors.
European Journal of Trauma and Emergency Surgery | Year: 2011

Purpose: The treatment of full-thickness cartilage defects of the knee is a common problem in orthopaedic surgery. Autologous chondrocyte transplantation (ACT) is one of the few reliable treatment options of cartilage defects with good long-term outcomes. The improvement of ACT led to the matrix-based ACT (MACT). The purpose of the study was to compare two different commercially available MACT systems. Methods: Eleven patients with a cartilage defect of the knee were treated with the MACI® system and another nine patients with the CaRes® implant. The patients were prospectively followed and re-examined after one year. Results: One year after surgery all but one patient have significantly improved in their clinical outcome. Both types of MACT revealed similar results in terms of increase in level of activity, pain relief and knee function. Conclusion: The study showed that MACT is a good therapeutic option for full-size defects of the femoral condyle. The MACI® implant seems to be easier to handle which is reflected by smaller incisions and a shorter operation time. © 2010 Urban & Vogel.


PubMed | St Johannes Hospital Varel, Heinrich Heine University Düsseldorf and Sankt Josef Orthopaedic and Rheumatology Center Wuppertal
Type: Journal Article | Journal: European journal of trauma and emergency surgery : official publication of the European Trauma Society | Year: 2016

The treatment of full-thickness cartilage defects of the knee is a common problem in orthopaedic surgery. Autologous chondrocyte transplantation (ACT) is one of the few reliable treatment options of cartilage defects with good long-term outcomes. The improvement of ACT led to the matrix-based ACT (MACT). The purpose of the study was to compare two different commercially available MACT systems.Eleven patients with a cartilage defect of the knee were treated with the MACI() system and another nine patients with the CaRes() implant. The patients were prospectively followed and re-examined after one year.One year after surgery all but one patient have significantly improved in their clinical outcome. Both types of MACT revealed similar results in terms of increase in level of activity, pain relief and knee function.The study showed that MACT is a good therapeutic option for full-size defects of the femoral condyle. The MACI() implant seems to be easier to handle which is reflected by smaller incisions and a shorter operation time.

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