St. Elizabeth College of Health and Social Work

www.vssvalzbety.sk
Bratislava, Slovakia
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Slezakova Z.,St. Elizabeth College of Health and Social Work | Zavodna V.,St. Elizabeth College of Health and Social Work | Vcelarikova A.,St. Elizabeth College of Health and Social Work
Activitas Nervosa Superior Rediviva | Year: 2013

OBJECTIVE: The number of Parkinson's disease patients is instantly growing in Slovakia. As it is progressing disease which extends to the area of human needs it increases the demands on nursing care with the aim to ensure the quality of life of patients who suffer the Parkinson's disease. DESIGN: In the diploma thesis a standard questionnaire Jenkinson Parkinson disease questionnaire PDQ-39 was used. It consists of 39 questions, aimed at research of areas of everyday needs for clinical practice. Researched sample consists of 120 patients suffering the Parkinson's disease. For statistical evaluation mathematical methods and excel were used. RESULTS: In this research we analysed and interpreted results of PDQ-39 questionnaire for individual physical, psychical and social domains. Monitoring quality of life assessment was carried out by using sub-topics such as Mobility, Daily Activities, Disease Symptoms, Emotions, Social Support, Cognitive Functions, Communication and Physical Discomfort. Significant differences were found in the circumstances that identify Physical Needs. Overall, we note the difficulties for 53.17% of respondents with Mobility, especially with Mobility Over Longer Distances and When In Public. We also have found significant differences in the psychological needs, especially in the categories of Disease Symptoms, Emotions, Cognitive Functions and Communication as they effect quality of life in managing daily activities. The outcome of the questionnaire is that patients perceive quality of life in a very negative way mostly in the area of mobility and in the emotional area. CONCLUSIONS: In the research of how does Parkinson's disease restrict the quality of life in areas such as mobility, daily activities, disease symptoms, emotional and cognitive functions most of the patients feel lower quality of life. When analysing the area of social support, communication and physical discomfort we can assume that the disease has only seldom negative impact on quality of life. In the psychical area we can confirm that symptoms of depression and anxiety cause restrictions in everyday activities. Knowing the problems of patients with Parkinson's Disease affects the identification of nursing interventions in meeting the biological, psychological and social needs and improving the quality of life. © 2013 Activitas Nervosa Superior Rediviva ISSN 1337-933X.


Obtulovicova K.,Klinika ORL A Chirurgie Hlavy A Krku | Sicak M.,Klinika ORL A Chirurgie Hlavy A Krku | Obtulovic M.,Klinika Otorinolaryngologie A Chirurgie Hlavy A Krku | Kalis A.,St. Elizabeth College of Health and Social Work
Otorinolaryngologie a Foniatrie | Year: 2017

Objectives: Recurrent salivary pleomorphic adenoma is oncogenic continuance of primary tumor. Despite intraoperative capsule rupture, tumor cell spillage and histopathologic type, presumably the internal cell biology plays a role in the recurrence. Revision parotidectomy has high rate of facial nerve morbidity and does not exclude becoming recurrence. The aim of study was to evaluate the results of revisional surgery and to emphasize an importance of primary surgery. Materials and Methods: Eighteen patients who underwent 26 reoperations for recurrent parotid pleomorphic adenoma since 1989 to June 2016 were evaluated. The age of particular patients at the time of primary surgery ranged from 13 to 75 (mean 35) years. The female- to-male ratio made 7:2. In retrospective study we evaluated time interval between primary surgery and recurrence and surgical results including consecutive recurrence and facial nerve palsy. Results: In a group of 18 patients, the second recurrence was present in 7 cases, third in 4 cases and fourth in 1 case. The time interval between the primary and consecutive first, second, third and fourth recurrence was 1-24 (mean 8.0±7.1), 5-15 (8.3±3.1), 10-25 (11.5±2.1) and 27 years, respectively. Temporary facial nerve palsy was present in 11 cases (61%). Permanent facial nerve palsy (VI.degree of Brackmann-House classification) was present in one case (5.5%). The risk of second and consecutive recurrence was 39%. Conclusion: Recurrent pleomorphic adenoma is challenging problem. High risk of facial nerve injury in scar tissue is reduced in experienced hands using facial nerve monitoring. The risk of recurrence still exists even after long period after revisional surgery.


Hruby R.,St. Elizabeth College of Health and Social Work | Maas L.M.,Neuroendocrinology Letters | Fedor-Freybergh P.G.,St. Elizabeth College of Health and Social Work
Activitas Nervosa Superior Rediviva | Year: 2013

The article introduces an integrative psychoneurodevelopmental model of complex human brain and mind development based on the latest findings in prenatal and perinatal medicine in terms of integrative neuroscience. The human brain development is extraordinarily complex set of events and could be influenced by a lot of factors. It is supported by new insights into the early neuro-ontogenic processes with the help of structural 3D magnetic resonance imaging or diffusion tensor imaging of fetal human brain. Various factors and targets for neural development including birth weight variability, fetal and early-life programming, fetal neurobehavioral states and fetal behavioral responses to various stimuli and others are discussed. Molecular biology reveals increasing sets of genes families as well as transcription and neurotropic factors together with critical epigenetic mechanisms to be deeply employed in the crucial neurodevelopmental events. Another field of critical importance is psychoimmuno-neuroendocrinology. Various effects of glucocorticoids as well as other hormones, prenatal stress and fetal HPA axis modulation are thought to be of special importance for brain development. The early postnatal period is characterized by the next intense shaping of complex competences, induced mainly by the very unique mother - newborn's interactions and bonding. All these mechanisms serve to shape individual human mind with complex abilities and neurobehavioral strategies. Continuous research elucidating these special competences of human fetus and newborn/child supports integrative neuroscientific approach to involve various scientific disciplines for the next progress in human brain and mind research, and opens new scientific challenges and philosophic attitudes. New findings and approaches in this field could establish new methods in science, in primary prevention and treatment strategies, and markedly contribute to the development of modern integrative and personalized medicine. © 2013 Act Nerv Super Rediviva.


Didic R.,St. Elizabeth College of Health and Social Work | Cmorej P.C.,St. Elizabeth College of Health and Social Work
Klinicka Farmakologie a Farmacie | Year: 2014

After patent expiry of original drug, generic drugs can enter to market. Manufacturer of original drugs create subsidiary company, which produce generic drugs or push drugs form group of prescription drug to group of over the counter medicine. Invention of new solid form of drugs is one of ability to protraction spend life of patent. For example cocrystals offer better solid form of drugs, with better pharmacokinetic and physical property and better of drugs efficacy per consequens. Invention of new forms of drugs as cocrystals can affect considerably state of pharmaceutical manufacturers on market and affect considerably conflict in patent policy. Invention of new solid form of active farmaceutical ingredients can be new form of protection of mental property. © 2014, SOLEN s.r.o. All rights reserved.


Furdova A.,Comenius University | Strmen P.,Comenius University | Waczulikova I.,Comenius University | Chorvath M.,St. Elizabeth College of Health and Social Work | And 2 more authors.
European Journal of Ophthalmology | Year: 2012

Purpose. LINAC-based stereotactic radiosurgery (SRS) of posterior uveal melanoma is a conservative method to treat uveal melanoma. Methods. This was a retrospective clinic-based study of patients with posterior uveal melanoma in stage T2/T3 who underwent 1-day session SRS at LINAC accelerator or SRS plus combined methods from 2001 to 2008. Results. Thirty-nine patients with posterior uveal melanoma were treated with SRS (age 25-80 years, median 54 years). Median tumor volume at baseline was 0.6 cm3 (range 0.2-1.3 cm3). The therapeutic dose (TD) was 35.0 Gy, median of maximal dose applied was 49.0 Gy (range 37.0-60.0 Gy). Patient data were analyzed in groups: group 1, single SRS irradiation; group 2, SRS with subsequent endoresection or cyclectomy or additional transpupillary thermotherapy (TTT) or brachytherapy by Ru106 plaques; group 3a, enucleation after single SRS; group 3b, enucleation after SRS and endoresection/cyclectomy or TTT or brachytherapy Ru106. In patients with visual acuity of 20/40 or better, the median rate of best-corrected visual acuity (BCVA) decline was higher than that of the total and significantly higher than the rate of decline in the complementary group of patients with BCVA less than 20/40 (p=0.0077; Mann-Whitney U test). Conclusions. One-step LINAC-based SRS with a single dose 35.0 Gy is a method to treat middle-stage posterior uveal melanoma and to preserve the eye globe or as the first step of combined methods: irradiation before endoresection or cyclectomy. © 2011 Wichtig Editore.


Tesarova D.,St. Elizabeth College of Health and Social Work
Casopis Lekaru Ceskych | Year: 2013

The article deals with the selected parts of the writings of M. Tullius Cicero De natura deorum and Cato Maior De senectute dealing with medicine. It is an attempt to illustrate medical knowledge of educated people in ancient Rome. In its true sense, the above given writings have not a scientific character. However, the errors that the writings contain belong to the time when Marcus Tullius Cicero had lived. Cicero's knowledge in anatomy is given as an example. © 2008-2013 MeDitorial.


Hruby R.,St. Elizabeth College of Health and Social Work | Fedor-Freybergh P.G.,St. Elizabeth College of Health and Social Work
Neuroendocrinology Letters | Year: 2013

The article introduces an integrative psychoneurodevelopmental model of complex human brain and mind development based on the latest findings in prenatal and perinatal medicine in terms of integrative neuroscience. The human brain development is extraordinarily complex set of events and could be influenced by a lot of factors. It is supported by new insights into the early neuro-ontogenic processes with the help of structural 3D magnetic resonance imaging or diffusion tensor imaging of fetal human brain. Various factors and targets for neural development including birth weight variability, fetal and early-life programming, fetal neurobehavioral states and fetal behavioral responses to various stimuli and others are discussed. Molecular biology reveals increasing sets of genes families as well as transcription and neurotropic factors together with critical epigenetic mechanisms to be deeply employed in the crucial neurodevelopmental events. Another field of critical importance is psychoimmuno-neuroendocrinology. Various effects of glucocorticoids as well as other hormones, prenatal stress and fetal HPA axis modulation are thought to be of special importance for brain development. The early postnatal period is characterized by the next intense shaping of complex competences, induced mainly by the very unique mother - newborn's interactions and bonding. All these mechanisms serve to shape individual human mind with complex abilities and neurobehavioral strategies. Continuous research elucidating these special competences of human fetus and newborn/child supports integrative neuroscientific approach to involve various scientific disciplines for the next progress in human brain and mind research, and opens new scientific challenges and philosophic attitudes. New findings and approaches in this field could establish new methods in science, in primary prevention and treatment strategies, and markedly contribute to the development of modern integrative and personalized medicine. ©2013 Neuroendocrinology Letters.


Podoba J.,St. Elizabeth College of Health and Social Work
Bratislava Medical Journal | Year: 2010

Background: Despite very good prognosis patients with previously treated well-differentiated thyroid cancer (DTC) require lifelong monitoring for recurrent disease. Apart from neck ultrasonography (USG) two diagnostic tests play a central role in follow-up of these patients: radioiodine whole body scanning and serum thyroglobulin (Tg) measurement. The diagnostic value of both tests is most accurate during thyroid stimulating hormone (TSH) stimulation. Temporary discontinuation of thyroid hormone therapy was previously the sole effective approach for TSH-stimulated testing. However, hormone withdrawal was associated with the morbidity of severe hypothyroidism. The introduction of recombinant human TSH (rhTSH)-stimulated testing offers an alternative way. Recent clinical trials have shown that measurement of the rhTSH-stimulated serum Tg concentration (rhTSH-Tg) alone is the most sensitive way to detect residual or recurrent thyroid cancer. Objectives: The aim of the study was to investigate rhTSH-Tg in patients considered to be cured with already finished radioiodine treatment 1-3 years ago (routine follow-up) and in patients more years after radioiodine therapy with a new indefinite (mild) suspicion for DTC recurrence and to report the first experience with this diagnostic procedure in Slovakia. Patients and methods: RhTSH-Tg was examined in 84 patients (72 women and 12 men) clinically free of disease, 1-3 years after finishing radioiodine therapy. Second group consisted of 4 patients (2 women and 2 men) 5, 9, 12 and 38 years after 131I treatment with a mild suspicion of DTC recurrence. Results: RhTSH testing was well tolerated. No adverse events were detected. In the first group clinically free of disease undetectable rhTSH-Tg (<0.2 ng/ml) was found in 77 patients (91.7 %), Tg above diagnostic cutoff (>2 ng/ml) in 4 patients (4.8 %) and Tg in the range 0.6-2 ng/ml in 3 cases (3.6 %). In all patients of second group previous indefinite suspicion of DTC recurrence was confirmed by the rhTSH-Tg rise (2.9-7.3 ng/ml). Conclusion: In accordance with the literature rhTSH-Tg concentration in combination with neck USG has the highests sensitivity and negative predictive value in detecting residual or recurrent DTC (Tab. 1, Fig. 1, Ref. 14). Full Text (Free, PDF) www.bmj.sk.


Tesarova D.,St. Elizabeth College of Health and Social Work
Casopis Lekaru Ceskych | Year: 2015

Pharmacological literature in the Late Antique period followed the Roman tradition and widely used Scribonius Largus and excerpts from the writings of Pliny the Elder. Literature was created both in the western part of the Roman Empire and in North Africa in Carthage. Manuals have been written about medicinal plants (Herbarius of Pseudo-Apuleius, De herba vettonica of Pseudo-Musa), for drugs obtained from the animal kingdom (Liber medicinae of Sextus Placitus) or documents containing both (De medicina of Cassius Felix, De medicamentis of Marcellus Empiricus). The contribution of this literature is the mediation of ancient knowledge into the Middle Ages.


Podoba J.,St. Elizabeth College of Health and Social Work
Bratislavské lekárske listy | Year: 2010

BACKGROUND: Despite very good prognosis patients with previously treated well-differentiated thyroid cancer (DTC) require lifelong monitoring for recurrent disease. Apart from neck ultrasonography (USG) two diagnostic tests play a central role in follow-up of these patients: radioiodine whole body scanning and serum thyroglobulin (Tg) measurement. The diagnostic value of both tests is most accurate during thyroid stimulating hormone (TSH) stimulation. Temporary discontinuation of thyroid hormone therapy was previously the sole effective approach for TSH-stimulated testing. However, hormone withdrawal was associated with the morbidity of severe hypothyroidism. The introduction of recombinant human TSH (rhTSH)-stimulated testing offers an alternative way. Recent clinical trials have shown that measurement of the rhTSH-stimulated serum Tg concentration (rhTSH-Tg) alone is the most sensitive way to detect residual or recurrent thyroid cancer. OBJECTIVES: The aim of the study was to investigate rhTSH-Tg in patients considered to be cured with already finished radioiodine treatment 1-3 years ago (routine follow-up) and in patients more years after radioiodine therapy with a new indefinite (mild) suspicion for DTC recurrence and to report the first experience with this diagnostic procedure in Slovakia. PATIENTS AND METHODS: RhTSH-Tg was examined in 84 patients (72 women and 12 men) clinically free of disease, 1-3 years after finishing radioiodine therapy. Second group consisted of 4 patients (2 women and 2 men) 5, 9, 12 and 38 years after 1311 treatment with a mild suspicion of DTC recurrence. RESULTS: RhTSH testing was well tolerated. No adverse events were detected. In the first group clinically free of disease undetectable rhTSH-Tg (< 0.2 ng/ml) was found in 77 patients (91.7%), Tg above diagnostic cutoff (> 2 ng/ml) in 4 patients (4.8%) and Tg in the range 0.6-2 ng/ml in 3 cases (3.6%). In all patients of second group previous indefinite suspicion of DTC recurrence was confirmed by the rhTSH-Tg rise (2.9-7.3 ng/ml). CONCLUSION: In accordance with the literature rhTSH-Tg concentration in combination with neck USG has the highests sensitivity and negative predictive value in detecting residual or recurrent DTC (Tab. 1, Fig. 1, Ref. 14). Full Text (Free, PDF) www.bmj.sk.

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