Elisabeth-Sophien-Koog, Germany
Elisabeth-Sophien-Koog, Germany

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Rezai M.,Heinrich Heine University Düsseldorf | Rezai M.,European Academy of Senology EAoS | Kramer S.,European Academy of Senology EAoS | Kramer S.,Universitatsklinikum Cologne | And 2 more authors.
Klinikarzt | Year: 2015

In a case cohort study of more than 1000 oncoplastic patients, we validated the system of simple techniques - adapted to the location of the tumor and the tumor-breast-ratio. More than 60 of all patients with breast conserving therapy (BCT) have been operated with the glandular rotation technique and more than 30 patients with (dermo-) glandular rotation mastopexy, tumor-adapted reduction- mammoplasty and lateral advancement flap (Rezai) with a high level of patient satisfaction. Only in rare circumstances, volume replacement techniques (thoraco-epigastric flap, latissimus-dorsi-flap) were necessary 4 5 8.


Rosenkranz K.,Ruhr University Bochum | Kumbruch S.,Ruhr University Bochum | Tenbusch M.,Ruhr University Bochum | Marcus K.,Ruhr University Bochum | And 3 more authors.
Cell and Tissue Research | Year: 2012

Transplantation of human umbilical cord blood (hucb) cells in a model of hypoxic-ischemic brain injury led to the amelioration of lesion-impaired neurological and motor functions. However, the mechanisms by which transplanted cells mediate functional recovery after brain injury are largely unknown. In this study, the effects of hucb cell transplantation were investigated in this experimental paradigm at the cellular and molecular level. As the pathological cascade in hypoxic-ischemic brain injury includes inflammation, reduced blood flow, and neuronal cell death, we analyzed the effects of peripherally administered hucb cells on these detrimental processes, investigating the expression of characteristic marker proteins. Application of hucb cells after perinatal hypoxic-ischemic brain injury correlated with an increased expression of the proteins Tie-2 and occludin, which are associated with angiogenesis. Lesion-induced apoptosis, determined by expression of cleaved caspase-3, decreased, whereas the number of vital neurons, identified by counting of NeuN-positive cells, increased. In addition, we observed an increase in the expression of neurotrophic and pro-angiogenic growth factors, namely BDNF and VEGF, in the lesioned brain upon hucb cell transplantation. The release of neurotrophic factors mediated by transplanted hucb cells might cause a lower number of neurons to undergo apoptosis and result in a higher number of living neurons. In parallel, the increase of VEGF might cause growth of blood vessels. Thus, hucb transplantation might contribute to functional recovery after brain injury mediated by systemic or local effects. © Springer-Verlag 2012.

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