St Aloysius Autonomous College

Jabalpur, India

St Aloysius Autonomous College

Jabalpur, India
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Stephen D.S.,St Aloysius Autonomous College | Stephen D.S.,Indian Institute of Technology Bombay | Abraham A.,St Aloysius Autonomous College
Nutritional Neuroscience | Year: 2017

Objectives: To study the effect of specially formulated high-fat simple carbohydrate diet (HFSC) on the serotonin metabolic pathway in male C57BL/6J mice. Methods: Previous studies from our laboratory have shown that specially formulated HFSC induces metabolic syndrome in C57BL/6J mice. In the present investigation, 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid were analyzed in two brain regions (hypothalamus, corpus striatum), urine and plasma of HFSC-fed mice on a monthly basis up to 5 months using high-performance liquid chromatography fitted with electrochemical detector. The data were analyzed using Graph pad Prism v7.3 by two-way ANOVA and post hoc Tukey’s test (to assess the effect of time on the serotonergic metabolic pathway). Results: HFSC feed was observed to lower the hypothalamic serotonergic tone as compared to the age-matched control-fed C57BL/6J mice. Although the hypothalamic serotonergic tone was unaltered over time due to consumption of diet per se, hypothalamic 5-HTP levels were observed to be lower on consumption of HFSC feed over duration of 5 months as compared to 1st month of consumption of HFSC feed. The striatal 5-HTP levels were lowered in the HFSC-fed mice after 4 months of feeding as compared to the age-matched control-fed mice. The striatal 5-HTP levels were also lower in both control and HFSC-fed mice due to consumption of the respective diet over a duration of 5 months. Increased plasma 5-HTP levels were observed due to consumption of HFSC feed over duration of 5 months in the HFSC-fed group. However, higher breakdown of serotonin was observed in both the plasma and urine of HFSC-fed C57BL/6J mice as per the turnover studies. Discussion: The central and peripheral serotonergic pathway is affected differentially by both the type of diet consumed and the duration for which the diet is consumed. The hypothalamic, striatal and plasma serotonergic pathway were altered both by the type of feed consumed and the duration of feeding. The urine serotonergic pathway was affected by mainly the duration for which a particular diet was consumed. These findings may have implications in the feeding behavior, cognitive decline and depression associated with metabolic syndrome patients. © 2017 Informa UK Limited, trading as Taylor & Francis Group


Chaitanya P.,St Aloysius Autonomous College | Mishra R.,Rani Durgavati University | Ahirwal P.K.,Rani Durgavati University | Shukla A.,National Institute of Technology Tiruchirappalli | And 4 more authors.
Integrated Ferroelectrics | Year: 2015

The electrical behavior of strontium titanate borosilicate glass ceramics (SrO.TiO2- 2SiO2.B2O3) with additives K2O, La2O3, CoO and Nb2O5 was studied by using Impedance Spectroscopy as a function of temperature and composition. An equivalent circuit model having three parallel RC's connected in series with a capacitor C4 could represent the data well. By comparing the complex modulus plots with simulated ones and looking at the values of the time constants these RC's were attributed to represent crystalline, glassy and glass-crystal interface regions of the glass- ceramic whereas C4 represented the glass-ceramic sample and contact electrode interface. When the glass ceramic sample contained only SrTiO3 crystalline phase and the remaining glassy matrix, the interface capacitance showed an Arrhenius type of nature with an activation energy (0.11 ± 0.04) eV and when the glass- ceramic sample contained number of crystalline phases no clear cut trend appeared. These findings are useful in selecting suitable electrodes for applications as well as in deciding upon experimental techniques for measurement of dielectric constants of materials. Copyright © Taylor & Francis Group, LLC.


Mamta G.,St Aloysius Autonomous College | Bansal Y.K.,Rd University | Sandhu S.S.,Rd University
Recent Patents on Biotechnology | Year: 2013

Flavonoids are substances which are widely distributed in the plant kingdom. They occur in considerable quantities in common food products, spices and beverages. Interest of researchers has been greatly enhanced towards therapeutic potential of flavonoids in last some years. This review summarizes important patents pertaining to recent biotechnological techniques applied for the production, analysis of biosynthetic pathways, effects and applications of different flavonoids. For systematic studies investigations which have been published in the form of patents, are classified in different sectors like biosynthesis, medical application, antimicrobial activity, alteration of flower color, industrial application, cosmetics, food and plant tissue culture. A number of activities have been observed in each sector with vast area of research on flavonoids. © 2013 Bentham Science Publishers.


Gokhale M.,St Aloysius Autonomous College | Bansal Y.K.,RD University
Indian Journal of Biotechnology | Year: 2015

Random amplified polymorphic DNA (RAPD) markers were used to verify the clonal fidelity in in vitro regenerated plants of Oroxylum indicum (L.) Vent. (Bignoniaceae). Deviation from normal/natural leaf shape and branching pattern was detected in indirectly (from callus) regenerated plants. Percentage of phenotypical variation was observed and calculated upto five subculture passages. RAPD profiles of directly (from axillary bud) and indirectly regenerated plants were compared with mother plant. To screen the genetic variation 20 arbitrary decamers were used to study of randomly selected nature grown plant as well as direct and indirect regenarants. Genetic variation among nature grown and direct regenerants was 10%, whereas 24.59% polymorphism frequency was estimated for indirect plantlets. These results indicate that the regeneration of plants through axillary bud culture is a low-risk method for generating genetic variability, whereas material regenerated through callus has genetic variation, resulting in the formation of somaclones. Cytological studies of cells of callus, root tip of directly and indirectly regenerated plants showed the incidence of polyploidy.


PubMed | St Aloysius Autonomous College
Type: Journal Article | Journal: Recent patents on biotechnology | Year: 2013

Flavonoids are substances which are widely distributed in the plant kingdom. They occur in considerable quantities in common food products, spices and beverages. Interest of researchers has been greatly enhanced towards therapeutic potential of flavonoids in last some years. This review summarizes important patents pertaining to recent biotechnological techniques applied for the production, analysis of biosynthetic pathways, effects and applications of different flavonoids. For systematic studies investigations which have been published in the form of patents, are classified in different sectors like biosynthesis, medical application, antimicrobial activity, alteration of flower color, industrial application, cosmetics, food and plant tissue culture. A number of activities have been observed in each sector with vast area of research on flavonoids.

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