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Karunakar P.,PES Institute of Technology | Krishnamurthy V.,PES Institute of Technology | Girija C.R.,SSMRV Degree College | Krishna V.,Kuvempu University
International Journal of Pharma and Bio Sciences | Year: 2013

The structure of 2,3-Bis-(1-furan-2-yl-ethylidene)-succinic acid (Furan succinic acid (FSA)) has been established by X-ray crystallography to understand the structureactivity relationship, which is of paramount importance in the pharmaceutical studies of the compound. Compound showed carbonyl-φ and C-H..O interactions along with O-H..O interactions in the assembly of the supramolecular architecture. Crystal structure analysis of FSA possessing anti-inflammatory activity was extrapolated to docking study to elucidate the action against enzyme cyclooxygenases. Using AutoDock suite, FSA was docked at the binding sites of COX-1 and COX-2 enzymes and a strong affinity of -6.55kcal/mol, Ki = 15.93 μM and -6.96kcal/mol, Ki = 7.91μM, respectively was observed with formation of hydrogen bonds and hydrophobic interactions. These results suggest that FSA can be a promising lead for the development of COX family inhibitors.


Pandurangachar M.,SSMRV Degree College | Kumara Swamy B.E.,Kuvempu University | Chandrashekar B.N.,Kuvempu University | Gilbert O.,Kuvempu University | And 2 more authors.
International Journal of Electrochemical Science | Year: 2010

A carbon paste electrode (CPE) modified by 1- butyl 4-methylpyridinium tetrafluoro borate (BMPTB) was used for the detection of K3Fe(CN)6 and dopamine. Cyclic voltammetric technique demonstrated highly improved response of K3Fe(CN)6 and dopamine at BMPTB/CPE compared to bare CPE with different shape of cyclic voltammorams. The effect of BMPTB concentration on the electrode quality also reveals that BMPTB formed on a CPE surface with a high density of negative charged end directed outside the electrode. The detection limit for modified electrode for K3Fe(CN)6 is 1×10-4 M and dopamine 1 ×10-5 M. © 2010 by ESG.


Chandrashekar B.N.,Kuvempu University | Kumara Swamy B.E.,Kuvempu University | Pandurangachar M.,SSMRV Degree College | Shankar S.S.,Kuvempu University | And 3 more authors.
International Journal of Electrochemical Science | Year: 2010

Polyethylene glycol (PEG) modified carbon paste electrode (CPE) was fabricated for the detection of dopamine and potassium ferricyanide. It showed an excellent sensitivity towards the oxidation of dopamine (DA) in 0.1M phosphate buffer (PBS) at 6.6 pH and potassium ferricyanide in 1 M KCl solution. Effect of scan rate, concentration and pH were studied by the cyclic voltammetric technique. The concentration effect of modifier in the carbon paste electrode also reveals that the change in the electrode interface which would leads to the surface modification of the electrode, enhanced the interaction between the electrode and the cationic charged dopamine. The detection limit of dopamine is 1×10-5 M and the potassium ferricyanide is 1×10-4 M was observed for the PEG/CPE. © 2010 by ESG.


Chandrashekar B.N.,Kuvempu University | Kumara Swamy B.E.,Kuvempu University | Pandurangachar M.,SSMRV Degree College | Sathisha T.V.,Kuvempu University | Sherigara B.S.,Kuvempu University
Colloids and Surfaces B: Biointerfaces | Year: 2011

l-arginine was electropolymerised on a carbon paste electrode (CPE) to form the biopolymer by free radical formation in the electro oxidation process of the amino and carboxylic group containing compound by cyclic voltammetric technique. The modified electrode shows an excellent electrocatalytic activity towards the oxidation of both dopamine (DA) and ascorbic acid (AA). It was demonstrated that the deposited biopolymer has positive charges over the bare carbon electrode surface, which leads to the formation of electrical double layer made the fast electron transfer process could leads to the diffusion of dopamine, ascorbic acid and uric acid on their charge gradient by cyclic voltammetric technique. The response of the sensor was tested towards the different dopamine concentration. The catalytic peak current obtained was linearly related to DA concentrations in the ranges of 5×10 -5 to 1×10 -4ML -1 with correlation co-efficient of 0.9924 which reveals the adsorption controlled process. The detection limit for dopamine was 5×10 -7ML -1. The interference studies showed that the modified electrode exhibits excellent selectivity in the presence of large excess of ascorbic acid (AA) and response is fast stable, reliable, resistant to biofouling and can be applied for the real sample analysis in medical, pharmaceutical and biotechnological sectors. The adsorption-controlled process and kinetic parameters of the poly(l-arginine) were determined using electrochemical approaches. © 2011 Elsevier B.V.


Nagaraja R.,Kuvempu University | Girija C.R.,Ssmrv Degree College | Nagabhushana B.M.,M.S. Ramaiah Institute of Technology | Donappa N.,Mla College For Women | Manjunatha Sastry K.,Mla College For Women
Asian Journal of Chemistry | Year: 2011

We report here the synthesis of ZnO nanoparticles by solution-combustion method employing a mixture of zinc nitrate and sugar (O/F = 1) as reactants. Powder X-ray diffraction, scanning electron microscopy and ultra violet-visible absorption spectra were employed to characterize the product. The studies showed that the ZnO nanoparticles could be used to catalytically degrade organic dyes present in waste water of textile dye effluent under UV light irradiation. More than 95 % decolourization of textile dye effluent occurs with ZnO as catalyst with in 8 min at basic medium under solar light. It was also found that chemical oxygen demand takes place at a faster rate under solar light as compared to that under UV light. The results further suggest that, ZnO nanoparticles are better catalyst than the calcined ZnO under solar and UV light irradiation.


Nagaraja R.,Kuvempu University | Nagappa B.,Karnataka Pollution Control Board | Girija C.R.,Ssmrv Degree College | Nagabhushana B.M.,M.S. Ramaiah Institute of Technology | And 2 more authors.
Asian Journal of Chemistry | Year: 2011

Nanocrystalline LaMnO3+δ has been synthesized by low temperature initiated, self propagating solution combustion process. It is an inexpensive synthesis and readily yields nanocrystalline product. It was characterized by powder XRD, FT-IR and SEM. The surface area of product is ca. 24 m2/g. The SEM micrographs show that the product is voluminous, fluffy and porous. It is found that 60 mg of LaMnO3+δ powder could remove 85 % of chemical oxygen demand from 100 mL of industrial effluent at pH 10.


Chandrashekar B.N.,Kuvempu University | Kumara Swamy B.E.,Kuvempu University | Pandurangachar M.,SSMRV Degree College | Sathisha T.V.,Kuvempu University | Sherigara B.S.,Kuvempu University
Analytical and Bioanalytical Electrochemistry | Year: 2011

4-aminophenol is the main impurity present in preparations of paracetamol. Using the cyclic voltammetry, the electrode behaviour of 4-aminophenol has been studied in 0.1 M phosphate buffer solutions at carbon paste electrode and surfactant modified carbon paste electrode. The optimal potential window of wide range from -0.4 V to 0.7 V was selected. The electron transfer kinetics of the CTAB/CPE in the detection of analyte was determined by the scan rate effect and concentration variation studies. The scan rate effect showed the electrode process is adsorption controlled. The oxidation peak currents represented a linear dependence on 4-aminophenol concentration from 1 mM to 4 mM with correlation coefficient r2=0.9942. The effect of cationic surfactant shows good high sensitivity and stability for the redox process of the 4-amino phenol. The detection limit was found to be 1×10-7 M. © 2011 by CEE.


Chandra U.,Kuvempu University | Kumara Swamy B.E.,Kuvempu University | Gilbert O.,Kuvempu University | Pandurangachar M.,SSMRV Degree College | And 3 more authors.
Chinese Chemical Letters | Year: 2010

The electropolymerized film of amaranth was prepared on the surface of graphite pencil electrode (GPE) using cyclic voltammetric technique. This poly(amaranth) film coated electrode exhibited an excellent electrocatalytic activity towards the detection of dopamine (DA) in the presence of uric acid (UA) in 0.2 mol/L phosphate buffer solution at pH 7.0. The effect of interference study was carried out using differential pulse voltammetric technique. The poly(amaranth) modified GPE was applied for the detection of DA in dopamine injection with satisfactory results. © 2010 B.E. Kumara Swamy.


Nagaraja R.,Kuvempu University | Kottam N.,M.S. Ramaiah Institute of Technology | Girija C.R.,Ssmrv Degree College | Nagabhushana B.M.,M.S. Ramaiah Institute of Technology
Powder Technology | Year: 2012

Nano-sized ZnO powder with crystallite size in the range 12 to 50. nm were prepared by solution combustion route. The product was characterized by powder X-ray diffraction (PXRD), scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR). Photocatalytic degradation of rhodamine B (RB) dye was carried out with ZnO nanopowder. The effect of parameters such as the crystallite size, amount of catalyst, concentration of the dye, pH and irradiation on photocatalytic degradation of RB is studied. The results reveal that the maximum decolorization (more than 95%) of dye occurred with ZnO catalyst in 8. min of stirring at basic pH under solar light irradiation. It was also found that chemical oxygen demand (COD) reduction takes place at a faster rate under solar light as compared to that of UV light. The results suggest that, the ZnO solar photocatalytic irradiation is better than the calcined ZnO/solar and UV light irradiation. © 2011.


Pandurangachar M.,SSMRV Degree College | Kumara Swamy B.E.,Kuvempu University | Chandrashekar B.N.,Kuvempu University | Gilbert O.,Kuvempu University | Sherigara B.S.,Kuvempu University
Journal of Molecular Liquids | Year: 2011

Negatively charged 1-butyl-4-methyl-pyridiniumtetrafluroborate (BMPTB) ionic liquid was electrochemically deposited on the surface of carbon paste electrode (CPE) by cyclic voltammetric (CV) technique in 0.1 M nitric acid. It exhibited an electrocatalytic activity towards the oxidation of DA, AA, and UA in 0.1 M phosphate buffer solution (pH 6.6). The effect of concentration, scan rate, and pH was studied for dopamine. The BMPTB/CPE showed an excellent electrocatalytic activity for selective detection of DA in the presence of AA and UA by using CV and differential pulse voltammetry (DPV) respectively. Detection limit of dopamine was found to be 1 × 10- 8 M. The present technique provides a novel method for the simultaneous determination of DA, AA and UA in their mixture sample. © 2010 Elsevier B.V.

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