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Bangalore, India

Karunakar P.,PES Institute of Technology | Krishnamurthy V.,PES Institute of Technology | Girija C.R.,SSMRV Degree College | Krishna V.,Kuvempu University
International Journal of Pharma and Bio Sciences | Year: 2013

The structure of 2,3-Bis-(1-furan-2-yl-ethylidene)-succinic acid (Furan succinic acid (FSA)) has been established by X-ray crystallography to understand the structureactivity relationship, which is of paramount importance in the pharmaceutical studies of the compound. Compound showed carbonyl-φ and C-H..O interactions along with O-H..O interactions in the assembly of the supramolecular architecture. Crystal structure analysis of FSA possessing anti-inflammatory activity was extrapolated to docking study to elucidate the action against enzyme cyclooxygenases. Using AutoDock suite, FSA was docked at the binding sites of COX-1 and COX-2 enzymes and a strong affinity of -6.55kcal/mol, Ki = 15.93 μM and -6.96kcal/mol, Ki = 7.91μM, respectively was observed with formation of hydrogen bonds and hydrophobic interactions. These results suggest that FSA can be a promising lead for the development of COX family inhibitors.

Nagaraja R.,Kuvempu University | Kottam N.,M.S. Ramaiah Institute of Technology | Girija C.R.,SSMRV Degree College | Nagabhushana B.M.,M.S. Ramaiah Institute of Technology
Powder Technology | Year: 2012

Nano-sized ZnO powder with crystallite size in the range 12 to 50. nm were prepared by solution combustion route. The product was characterized by powder X-ray diffraction (PXRD), scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR). Photocatalytic degradation of rhodamine B (RB) dye was carried out with ZnO nanopowder. The effect of parameters such as the crystallite size, amount of catalyst, concentration of the dye, pH and irradiation on photocatalytic degradation of RB is studied. The results reveal that the maximum decolorization (more than 95%) of dye occurred with ZnO catalyst in 8. min of stirring at basic pH under solar light irradiation. It was also found that chemical oxygen demand (COD) reduction takes place at a faster rate under solar light as compared to that of UV light. The results suggest that, the ZnO solar photocatalytic irradiation is better than the calcined ZnO/solar and UV light irradiation. © 2011.

Nagaraja R.,Kuvempu University | Girija C.R.,SSMRV Degree College | Nagabhushana B.M.,M.S. Ramaiah Institute of Technology | Donappa N.,Mla College For Women | Manjunatha Sastry K.,Mla College For Women
Asian Journal of Chemistry | Year: 2011

We report here the synthesis of ZnO nanoparticles by solution-combustion method employing a mixture of zinc nitrate and sugar (O/F = 1) as reactants. Powder X-ray diffraction, scanning electron microscopy and ultra violet-visible absorption spectra were employed to characterize the product. The studies showed that the ZnO nanoparticles could be used to catalytically degrade organic dyes present in waste water of textile dye effluent under UV light irradiation. More than 95 % decolourization of textile dye effluent occurs with ZnO as catalyst with in 8 min at basic medium under solar light. It was also found that chemical oxygen demand takes place at a faster rate under solar light as compared to that under UV light. The results further suggest that, ZnO nanoparticles are better catalyst than the calcined ZnO under solar and UV light irradiation.

Nagaraja R.,Kuvempu University | Nagappa B.,Karnataka Pollution Control Board | Girija C.R.,SSMRV Degree College | Nagabhushana B.M.,M.S. Ramaiah Institute of Technology | And 2 more authors.
Asian Journal of Chemistry | Year: 2011

Nanocrystalline LaMnO3+δ has been synthesized by low temperature initiated, self propagating solution combustion process. It is an inexpensive synthesis and readily yields nanocrystalline product. It was characterized by powder XRD, FT-IR and SEM. The surface area of product is ca. 24 m2/g. The SEM micrographs show that the product is voluminous, fluffy and porous. It is found that 60 mg of LaMnO3+δ powder could remove 85 % of chemical oxygen demand from 100 mL of industrial effluent at pH 10.

Chandrashekar B.N.,Kuvempu University | Kumara Swamy B.E.,Kuvempu University | Pandurangachar M.,SSMRV Degree College | Sathisha T.V.,Kuvempu University | Sherigara B.S.,Kuvempu University
Colloids and Surfaces B: Biointerfaces | Year: 2011

l-arginine was electropolymerised on a carbon paste electrode (CPE) to form the biopolymer by free radical formation in the electro oxidation process of the amino and carboxylic group containing compound by cyclic voltammetric technique. The modified electrode shows an excellent electrocatalytic activity towards the oxidation of both dopamine (DA) and ascorbic acid (AA). It was demonstrated that the deposited biopolymer has positive charges over the bare carbon electrode surface, which leads to the formation of electrical double layer made the fast electron transfer process could leads to the diffusion of dopamine, ascorbic acid and uric acid on their charge gradient by cyclic voltammetric technique. The response of the sensor was tested towards the different dopamine concentration. The catalytic peak current obtained was linearly related to DA concentrations in the ranges of 5×10 -5 to 1×10 -4ML -1 with correlation co-efficient of 0.9924 which reveals the adsorption controlled process. The detection limit for dopamine was 5×10 -7ML -1. The interference studies showed that the modified electrode exhibits excellent selectivity in the presence of large excess of ascorbic acid (AA) and response is fast stable, reliable, resistant to biofouling and can be applied for the real sample analysis in medical, pharmaceutical and biotechnological sectors. The adsorption-controlled process and kinetic parameters of the poly(l-arginine) were determined using electrochemical approaches. © 2011 Elsevier B.V.

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