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Prasad R.K.,CSIR - Central Electrochemical Research Institute | Singh V.S.,CSIR - Central Electrochemical Research Institute | Krishnamacharyulu S.K.G.,Srtm University | Banerjee P.,CSIR - Central Electrochemical Research Institute
Environmental Monitoring and Assessment | Year: 2011

Geographic information system (GIS) has become one of the leading tools in the field of hydrogeological science that helps in assessing, monitoring, and conserving groundwater resources. Groundwater is a finite resource, which is being overexploited due to increase in demand over the years leading to decrease in its potentiality. In the present study, DRASTIC model has been used to prepare groundwater vulnerable zone in hard rock aquifer of granitic terrain. The main objective is to determine susceptible zone for groundwater pollution by integrating hydrogeological layers in GIS environment. The layers such as depth of aquifer, recharge, aquifer yield, soil type, topography, vadose zone, and transmissivity are incorporated in the DRASTIC model. The final output of the map shows that around 60% of the area falls under low to no risk of pollution zone. The high risk of pollution zones are mostly present towards the margin of southeastern periphery. The lower part of the basin as well as small area on northern side falls under moderate risk of pollution zone. For the assessment of groundwater pollution zone, 24 groundwater samples have been collected from different vulnerable zones. The chemical analysis of sample shows that the southeastern margin of basin has relatively high concentration of nitrate as compared to other parts of the basin. It is present in high pollution zone as well as moderate pollution zone. The present model can be used for assessment and management of groundwater. © 2010 Springer Science+Business Media B.V. Source


Kalyankar T.M.,Srtm University | Kakde R.B.,Rashtrasant Tukadoji Maharaj Nagpur University
Research Journal of Pharmacy and Technology | Year: 2011

A simple, rapid, precise and accurate reversed phase high performance liquid chromatographic method has been developed for the simultaneous determination of Artesunate in combination with Mefloquine. This method uses a Hypersil ODS C 18 (250mm×4.6mm×5μ particle Size) analytical column, a mobile phase of Methanol, Acetonitrile and 0.1% Acetic acid in the ratio 70:10:20 (v/v), and pH 4.5 adjusted with orthophosphoric acid. The instrumental settings are a flow rate of 1 ml/min and PDA detector wavelength at 210-360 nm. The retention times for Artesunate and Mefloquine are 6.57 min and 2.19min, respectively. The method is validated and shown to be linear. The linearity range for Artesunate and Mefloquine are 250-1500 and 500-3000 μg/ml respectively. The Percentage recovery for Artesunate and Mefloquine are 99.60-99.35 and 99.49-99.78 respectively. The correlation coefficients of Artesuante and Mefloquine are 0.999, and 0.999, respectively. The relative standard deviation for six replicates is always less than 2%. The Statistical analysis proves that the method is suitable for analysis of Artesunate and Mefloquine as a bulk drug and in pharmaceutical formulation without any interference from the excipients © RJPT All right reserved. Source


Keche A.P.,Maharashtra Udaygiri Mahavidayla | Hatnapure G.D.,Maharashtra Udaygiri Mahavidayla | Tale R.H.,Srtm University | Rodge A.H.,Srtm University | And 2 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2012

A series of novel 1-acetyl-3-(3,4-dimethoxypheny)-5-(4-(3-(arylureido/ arylthioureido/arylsulfonamido) phenyl)-4,5-dihydropyrazole derivatives of biological interest have been prepared by sequential cyclization of 1-(4-nitrophenyl)-3-(3,4-dimethoxyphenyl)-pro-2-ene-1 with hydrazine hydrate, reduction followed by reaction of resulting amine with different arylisocyanates or arylisothiocyanates or arylsulfonyl chlorides. All the synthesized compounds (1-32) have been screened for their pro-inflammatory cytokines (TNF-α and IL-6) and antimicrobial activity (antibacterial and antifungal). Biological evaluation study showed, the compounds 4, 5, 9, 11, 14 and 16 found to have promising anti-inflammatory activity (up to 61-85% TNF-α and 76-93% IL-6 inhibitory activity) at concentration of 10 μM with reference to standard dexamethasone (76% TNF-α and 86% IL-6 inhibitory activity at 1 μM). Compounds 24, 26, 27, 28 and 29 exhibited promising antimicrobial activity at MIC values ranging from 70 to 10 μg/mL against all the selected pathogenic bacteria and fungi. © 2012 Elsevier Ltd. All rights reserved. Source


Gacche R.N.,Srtm University | Kaid A.M.S.,Srtm University
Hepatitis Monthly | Year: 2012

Background: Objectives: The study was undertaken to study the epidemiology and prevalence of viral hepatitis (HBV) and (HCV) in Ibb city, Yemen. Patients and Methods: 554 pre-designed questionnaires and sera samples were collected in July 2010. Sera were tested for HBsAg and HCV antibodies by ELISA quantitative technique. Each individual's data were collected in a pre-designed questionnaire. Results: The prevalence of HBV in Ibb city was 1.81 %, whereas, the prevalence of HCV was 1.99 %. Conclusions: This study revealed low level risk of hepatitis B virus and hepatitis C virus infections. Inadequate information on the prevalence and risk determinants of viral hepatitis among the different population groups in Yemen are responsible about morbidity and mortality of HBV and HCV in Ibb city, Yemen. © 2012 Kowsar Corp. Source


Haleem Khan A.A.,Srtm University | Mohan Karuppayil S.,Srtm University
Aerobiologia | Year: 2011

Indoor environments play important roles in human health. The health hazards posed by polluted indoor environments include allergy, infections and toxicity. The term 'sick building syndrome' (SBS) describes causes of building occupants experiencing adverse health effects that appear to be linked to the time spent in a building. Questionnaire-based data were collected from the people who live or work in air-conditioned (A/C) rooms. Responses of the occupants were analyzed to understand the practices contributing to biotic pollution of indoor air-conditioned environments. Our survey revealed some interesting facts about the users of A/C rooms and their practices that may be contributing to the indoor air quality. The allergy complaints and use of anti-allergy medicines were noted commonly among the occupants of government (Govt.) organizations and computer training centers where cleaning of room and A/C filters were not done periodically. Cleaning practices may reduce the complaints. © 2010 Springer Science+Business Media B.V. Source

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