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Morshi, India

Benzanide group containing nitrogen and sulphur heteroacycles have added their own identity and importance in pharmaceutical, medicinal, agricultural and drug sciences.Thiocarbamido heteroacyclic compounds showed noticeable and remarkable applications in industrial, pharmaceutical, medicinal and drug chemistry. Considering all these facts into consideration it was thought interesting to synthesize 2-(3,4,5-trimethoxyphenyl)thiocarbamide/ substitutedthiocarbamids by interacting 2-(3,4,5-trimethoxyphenyl)ethamine with various thiourea in isopropanol medium The justification and identification of the structure of these newly synthesized compounds had been established on the basis of chemical characterization, elemental analysis and through spectral data The antimicrobial activities of this compounds were screened against E. coli, S. typhi, S. abony, P. aeruginosa, B. subtilis, A. niger, and C. albicons pathogens which are not studied up till now.

Deshmukh A.Y.,S.S.S.K.R. Innani Mahavidyalaya | Rathod D.B.,S.S.S.K.R. Innani Mahavidyalaya | Tayade D.T.,S.S.S.K.R. Innani Mahavidyalaya | Tayade D.T.,Srrl Science College | And 4 more authors.
Asian Journal of Chemistry | Year: 2010

2-Amino-4-hydroxy-s-triazine was synthesized by the interaction of cyanoguanidine with formic acid. On further reaction with various isothiocyanate in acetone-ethanol medium to produce 1-(4-hydroxy)-s-triazino-3-substituted thiocarbamide (III). The products synthesized in these reactions were characterized on the basis of conventional elemental analysis, chemical characteristics and through IR and NMR spectral analysis.

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