Gupta A.,SRMSIMS |
Ahmad Ansari N.,SRMSIMS |
International Journal of Pharmaceutical Sciences Review and Research | Year: 2013
To compare efficacy and safety of a dipeptidyl peptidase-4 inhibitor (sitagliptin) against a commonly used sulphonyl urea (Glimepiride) in patients of newly diagnosed type 2 diabetes mellitus. In a 24 weeks, randomized parallel group interventional trial, 167 patients of newly diagnosed Type-2 Diabetes Mellitus who were on diet control alone but diabetes not controlled as per blood glucose level assessment, were randomized to either sitagliptin 50-200mg or Glimepiride 1-4 mg per day. Dose of drugs was adjusted after 4 weeks, if glycemic control was not reached. At 24 weeks both groups (sitagliptin and Glimepiride) produced significant (P<0.001) reduction in glycosylated haemoglobin A1c (HbA1c) 0.55% and 1.22% respectively, with 17% patients in sitagliptin group and 24% patients in Glimepiride group achieving target HbA1c. Reduction was also significant (P<0.001) in both groups in fasting blood glucose (13.3% and 14.9% respectively) and 2 hour post-prandial blood glucose (16.0% and 16.4% respectively). Sitagliptin group showed net decrease in body weight by 0.121 kg whereas Glimepiride group showed net increase in body weight by 0.324 kg. Incidence of hypoglycemia was 3% in sitagliptin group and 11% in Glimepiride group. In this study in addition to achieving almost similar reductions in HbA1c, fasting blood glucose and 2 hour post-prandial blood glucose, treatment with sitagliptin resulted in less weight gain, and a significantly lower risk of hypoglycemic events compared with Glimepiride.
PubMed | Dr DY Patil Medical College and SRMSIMS
Type: Journal Article | Journal: Annals of medical and health sciences research | Year: 2015
Urinary tract infection (UTI) is the most common infection experienced by humans after respiratory and gastro-intestinal infections, and also the most common cause of nosocomial infections for patients admitted to hospitals indeed UTIs are the most frequent bacterial infection in women.The aim was to determine the prevalence of UTI and to identify factors associated with an increased risk of UTI among nursing students.The cross-sectional study involved 177 unmarried nursing students aged 18-30 years studying in the SRMSIMS, Nursing College Bareilly. A structured questionnaire was used, and study subjects were asked regarding the symptoms of UTI in the previous 3 months. Chi-square test and Univariate Logistic Regression was used to analyze the data.The overall prevalence of UTI was found to be 19.8% (35/177). Rural background, inadequate water intake, and unsatisfactory toilet habits were found to be strong predictors of UTI.There is an urgent need to sensitize the nursing students regarding the growing need of the issue so that they themselves become aware in addition to raising the awareness of other high-risk groups.
Iqbal Z.,SRMSIMS |
Sharma S.C.,JNMCH |
Sami H.,SRMSIMS |
Indian Journal of Otology | Year: 2016
Myiasis is a disease caused by fly larvae and aural myiasis is a rare clinic condition often occurring in children or mentally retarded people. We report the case of an unusual presentation of a unilateral aural myiasis in a 3-year-old female child patient belonging to a slum with unilateral chronic otitis media caused by Musca domestica (housefly) larvae. Eight larvae were removed from the external auditory canal while five more larvae were located in the middle ear cavity and were removed through perforation of the tympanic membrane. Management of ear myiasis is based on removal of the maggots and cleansing of the ear with ethanol, chloroform, or physiological saline. Physiological saline is preferred in patients who have tympanic membrane perforation. Myiasis is related to personal hygiene. Therefore, to decrease the incidence of these infestations, care, and hygiene standards should be carried out for those at risk through information, education, and communication. © 2016 Indian Journal of Otology | Published by Wolters Kluwer - Medknow.
Kumar S.,SRMSIMS |
Pathak A.K.,IGIMS |
Saikia D.,AIIMS |
Journal of Clinical and Diagnostic Research | Year: 2015
Introduction: Metformin is a preferred drug for starting treatment in type 2 diabetes mellitus. But, eventually most of the patients need additional drug to control blood sugar level. The choice of drug depends upon several factors including patient specific criteria, economical factors and treatment satisfaction. Aim: The aim of the present study is to investigate the effects of adding sitagliptin or glimepiride on efficacy, safety and treatment satisfaction in patients with type 2 diabetes mellitus. Materials and Methods: It was a retrospective observational study on 50 patients each in sitagliptin and glimepiride group, who are receiving treatment for at least 12 weeks and are stable on respective treatment regimen. Glycated haemoglobin (HBA1c) was the primary measure of efficacy. Safety was assessed by checking weight gain/loss, hypoglycaemia episodes and other laboratory investigations. Patient satisfaction was assessed by Diabetes Treatment Satisfaction Questionnaire. Results: The HbA1c level after 12-24 weeks of treatment was not found to be significant compared to each other or from baseline. Compared to baseline fasting plasma glucose & postprandial plasma glucose were lower in glimepiride group. Sitagliptin was associated with less episodes of hypoglycaemia. Weight gain was associated with glimepiride but it was non-significant (p=0.08). Overall treatment satisfaction score were better for sitagliptin but were not statistically significant. Conclusion: The efficacy of sitagliptin was comparable. Sitagliptin had superior adverse effect profile with less chances of hypoglycaemia and weight gain. Questionnaire scores were higher for sitagliptin indicating better treatment satisfaction compared to glimepiride. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.
Vyas S.,HIMS |
Sharma P.,Hospital and Research Center |
Srivastava K.,Hospital and Research Center |
Nautiyal V.,HIMS |
Journal of Clinical and Diagnostic Research | Year: 2015
Introduction: UTI is a well known entity amongst young girls, and the majority of girls have recurrent infections within one year. Anything that disturbs the usual vaginal environment would result in conditions favouring the production of unwanted microorganisms leading to infections of this very sensitive area. Studies have shown that, there is an evident relation of UTI's among students and practices of personal hygiene. Aim: To determine association between the behavioural risk factors and UTI among nursing girls. Materials and Methods: The present study was undertaken amongst unmarried nursing students of a Medical College Hospital. A predesigned pretested questionnaire was used to know the personal hygiene of students and to find out its association with UTI in the last three months. Chi-square test was used to analyse the data. Results: A significant association was observed between perineal hygiene and UTI. The major risk factors of UTI identified were incorrect perineal washing technique, use of synthetic/silk innerwears, not sundrying the innerwears, improper menstrual hygiene. Conclusion: There are still major gaps in the knowledge regarding causation of UTI among the nursing students. This calls for an urgent need for educational talks periodically addressing these gaps. © 2015 Journal of Clinical and Diagnostic Research. All right reserved.
Vyas S.,Himalayan Institute of Medical science |
Kandpal S.D.,Himalayan Institute of Medical science |
Semwal J.,Himalayan Institute of Medical science |
Chauhan S.,SRMSIMS |
Nautiyal V.,Institute of Medical science
International Journal of Preventive Medicine | Year: 2014
Background: Weaning plays a major role in determining the nutritional status of a child. Poor weaning practices during infancy and early childhood, resulting in malnutrition, contribute to impairment of cognitive and social development, poor school performance and reduced productivity in later life. The objective of this study is to know weaning practices of mothers of difficult terrain. Methods: Cross-sectional study was conducted in all villages under Rural Health Training Center, the field practice area of Department of Community Medicine. A total of 500 mothers with children within 3 years of age were included in the study. Pre-tested pre-designed semi-structured questionnaire was used to collect information on weaning practices. Results: Majority of children (51.57%) were weaned at >6 months and were observed to be more under nourished (79.34%) as compared with those between 4 months and 6 months (61.50%). Majority of boys were weaned earlier than girls irrespective of the age of the weaning. Malnutrition was found in majority of those children who were weaned inadequately in terms of both frequency and amount. Conclusions: The present study revealed suboptimal weaning practices among the mothers of hilly region. Thus, appropriate educational strategies should be directed particularly on counteracting various myths related to infant feeding Moreover, promotion of appropriate feeding should target not only on maternal caregivers, but also on other family members, particularly husbands and grandmothers, taking into account the social and cultural situation of the area.
PubMed | SRMSIMS, Institute of Medical science and Himalayan Institute of Medical science
Type: Journal Article | Journal: International journal of preventive medicine | Year: 2014
Weaning plays a major role in determining the nutritional status of a child. Poor weaning practices during infancy and early childhood, resulting in malnutrition, contribute to impairment of cognitive and social development, poor school performance and reduced productivity in later life. The objective of this study is to know weaning practices of mothers of difficult terrain.Cross-sectional study was conducted in all villages under Rural Health Training Center, the field practice area of Department of Community Medicine. A total of 500 mothers with children within 3 years of age were included in the study. Pre-tested pre-designed semi-structured questionnaire was used to collect information on weaning practices.Majority of children (51.57%) were weaned at >6 months and were observed to be more under nourished (79.34%) as compared with those between 4 months and 6 months (61.50%). Majority of boys were weaned earlier than girls irrespective of the age of the weaning. Malnutrition was found in majority of those children who were weaned inadequately in terms of both frequency and amount.The present study revealed suboptimal weaning practices among the mothers of hilly region. Thus, appropriate educational strategies should be directed particularly on counteracting various myths related to infant feeding Moreover, promotion of appropriate feeding should target not only on maternal caregivers, but also on other family members, particularly husbands and grandmothers, taking into account the social and cultural situation of the area.
Sharma N.,Jln Medical College |
Baliarsingh S.,S.R.M.S.I.M.S |
Kaushik G.G.,Jln Medical College
Clinical Laboratory | Year: 2012
Background: To find out the incidence of hyperprolactinemia in infertile women and to find its correlation with hypothyroidism. Methods: One hundred infertile women attending the out patient Department of Obstetrics and Gynaecology formed the subject matter of the study. Hormone levels of prolactin and thyroid stimulating hormone (TSH) were studied in all the subjects. The exclusion criterion was male factor infertility. Amongst the female factors leading to exclusion from the study were tubal factor, congenital abnormality of the urogenital tract, and any organic lesions. Results: Of the one hundred infertile women, sixty (60%) had primary infertility and forty women (40%) had secondary infertility. Galactorrhea was present in 15% of the women. The incidence of hyperprolactinemia i.e. serum prolactin level >15 ng/mL was 46%. Out of forty six, thirty women had primary infertility and sixteen women had secondary infertility. The mean serum prolactin level in hyperprolactinemic women was 79.40 ±56.59 ng/mL (range: 25.0-230.0 ng/mL). The mean serum prolactin level was not significantly different in the primary and secondary infertile group. The incidence of hypothyroidism in hyperprolactinemia was 28.26%. The mean serum TSH level in hypothyroid women with hyperprolactinemia was 32.06 ±23.00 (range: 7.92-78.00 μIU/mL). The TSH level was not significantly different in primary and secondary infertile women. Conclusions: A high incidence of hyperprolactinemia was found in infertile women and a positive correlation was found between hyperprolactinemia and hypothyroidism.
Rastogi M.K.,SRMSIMS |
Gupta A.,SRMSIMS |
Soodan P.S.,SRMSIMS |
Mishra N.,SRMSIMS |
Journal of Clinical and Diagnostic Research | Year: 2015
Introduction: Awareness about skin beauty or cosmetic elegance has received worldwide attention in the present day youth oriented society. Along with careful detailed history and thorough examination patch test is considered cornerstone in diagnosis of allergic contact dermatitis. Materials and Methods: Fifty patients suspected clinical diagnosis of contact facial dermatitis due to attended the Department of Dermatology, were included in a hospital based study. The patch test was applied on the upper back of using 32 allergens present in Indian cosmetic series and 20 known allergens in Indian standard battery series procured from Systopic Pharmaceutical Ltd, after applying the patch test, the patient was asked to come after 48h and 72h for reading the results of the patch test. Results: Out of 50 patients there were 32 (64%) females (housewives 36%) patients and 18 (36%) male (farmers 12%). Itching was the most common presenting symptom in 39 patients (78%) least was hypopigmentation and pain in 2%. Forehead was the most common site of involvement in 25 patients (50%) least were cheeks in 15 patients (30%). Erythema was the commonest morphological presentation seen in 36 patients (72%). Hair dye was suspected in maximum number of patients that is 13 (26%). Most common antigen showing patch test positivity was paraphenylenediamine in nine patients (18%). There are significantly more chances of developing positive test reaction with Indian standard series compared to cosmetic series. (p=.0053 using Fischer Exact test).Conclusion: In India there is no legislation regarding labeling ingredients on cosmetics as in the western countries, so labelling of the contents of cosmetic products should be the main challenge in cosmetic dermatitis is to identify. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.
PubMed | SRMSIMS
Type: Journal Article | Journal: Indian dermatology online journal | Year: 2012
Varicella zoster virus causes both chicken pox and herpes zoster. The phenomenon of herpes zoster occurring concurrently in two non-contiguous dermatomes involving different halves of the body is termed herpes zoster duplex bilateralis (HZDB). Few cases, reported in the literature, were seen in either an immunosuppressed host or in the older age group. Here we present a case of HZDB in an immunocompetent host, probably the first in India.