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Agrawal S.C.,Muzaffarnagar Medical College | Agrawal S.C.,Formerly at SRMS Institute of Medical science | Kumari A.,SRMS Institute of Medical science
Indian Journal of Community Health

Background: Despite the ongoing National Immunization Program, the immunization coverage in our country remains unsatisfactory, particularly in U.P.; moreover, a wide disparity is seen in the immunization coverage of children at different ages. Objectives: The present study was conducted to know the immunization status of children, up to the age of 6 years, and particularly to evaluate the same with regard to the age of the child. Methods: The present study was carried out as a cross sectional study, between September, 2012 and May, 2013 at the pediatric OPD of SRMS Institute of Medical Sciences, Bareilly. A total of 1000 children, aged up to 6 years were included. Immunization status with regard to the doses of BCG, OPV, DPT, DT and measles vaccine given at different time was assessed by interviewing parents and checking immunization cards. An endeavor was also made to know the various factors responsible for incomplete or no immunization through interviewing parents. Results: Over all, number of children with complete, partial and no immunization were 41.4%, 44.8% and 13.8% respectively. An inverse correlation exists between the age of the child and the vaccine acceptability - lesser the age, better is the coverage. Besides, a selective pattern is seen, the OPV-1 being the most preferred and DT booster (5-6 years) as the least preferred vaccine. Conclusions: There is need for improving the immunization coverage, particularly for the older children for reducing the burden of vaccine preventable diseases. Source

Deepak D.,VCSG Government Medical science and Research Institute | Sinha A.N.,VCSG Government Medical science and Research Institute | Gusain V.S.,VCSG Government Medical science and Research Institute | Goel A.,SRMS Institute of Medical science
Journal of Clinical and Diagnostic Research

Objective: Meditation has long been known to affect human physiology through autonomic nervous system. This study was designed to assess sympathetic autonomic functional status of meditators of various age groups. Material and Methods: Three clinical tests, Isometric handgrip test,Cold pressor test and Valsalva Meneuver were studied in 25 meditators of age ranging from 25 to 75 years. The results were compared with those observed in 25 non-meditators of matching age and socio economic status. Observation and Results: The basal cardiac parameters viz heart rate and blood pressure were uniformly lower in meditators than non meditators in all age groups, more so in senior meditators. On performing isometric handgrip test, non-meditators developed significant increase in blood pressure and heart rate during gripping than that seen in meditators. In cold pressor test, as compared to non-meditators, mediators showed blunted increase in blood pressure along with returning of blood pressure to basal level earlier, which indicated presence of controlled sympathetic drive in meditators. In Valsalva maneuver the overshoot of BP was lower in meditators than in non meditators. Conclusion: It can be concluded that the regular practice of meditation initially blunted the sympathetic drive and later on developed control over sympathetic function of meditators. Source

Mitra R.,Banaras Hindu University | Bhan S.,NEHU | Nath G.,Banaras Hindu University | Kumar N.,Banaras Hindu University | Ali Z.,SRMS Institute of Medical science
The Scientific World Journal

To aid the clinical diagnosis of typhoid fever in India, where most hospitals and primary health centres have no facilities for culture, we report on the development of a novel and rapid immunodiagnostic kit for the direct detection of Salmonella Typhi-specific IgG antibodies against S. Typhi flagellar H antigen. The disease often does not show a specific clinical picture, and can be confused with other febrile illness such as malaria, dengue fever and Staphylococcus aureus. To overcome the problem of cross reactivity specific epitope of the flagellar H antigen was immobilised on the testing kit strip eliminating chances of cross reactivity and false positive results thereby increasing the specificity of the test. Since the immunodiagnostic kit, uses the flagellar H antigen from bacteria present in our country, the antibodies present in the serum of patients of our country will have maximum binding affinity, enhancing the sensitivity of our test kit. The immunodiagnostic kit on analysis gave a positive result with clinically diagnosed typhoid positive patient serum and negative results were obtained with the sera of clinically diagnosed malaria, abscess of Staphylococcus aureus and Visceral leishmaniasis (Kala-azar) patients. Copyright © 2013 Rahul Mitra et al. Source

Bedi H.S.,Christian Medical College and Hospital | Bedi N.K.,Christian Medical College and Hospital | Singh P.,Vrk Womens Medical College | Nanda H.S.,SRMS Institute of Medical science
Indian Journal of Thoracic and Cardiovascular Surgery

There are some lacunae in the standard preoperative informed consent process being followed at present. We have formulated guidelines for an audio-visual recording of the consent process for safeguarding the interests of both the doctor and the patient. © 2015, Indian Association of Cardiovascular-Thoracic Surgeons. Source

Kumari A.,SRMS Institute of Medical science | Agrawal S.C.,SRMS Institute of Medical science
Pakistan Paediatric Journal

Chronic or progressive ataxia in children may be caused by a number of conditions, including brain tumors, malformations and hereditary disorders.We report here a case of a 5 year old boy who presented with ataxia and developmental delay and on investigation was found to be a case of Joubert syndrome. MRI of the brain shows the characteristic molar tooth sign. Although, Joubert syndrome is not a common condition, yet it has clinical features which are very commonly found; that is why a high index of suspicion is needed, as such children are frequently misdiagnosed. Source

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