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Chennai, India

Ravi G.,SRMC
Journal of Chemical and Pharmaceutical Sciences | Year: 2013

The aim of the present study is to formulate and evaluate Venlafaxine SR capsules. venlafaxine is a novel anti-depressant used widely for treatment of depression and generalised anxiety disorder, but it is having disadvantage of less biological half life of about 5 hrs due to extensive hepatic first pass metabolism. So in order to maintain the therapeutic concentration of venlafaxine for a prolonged period of time the SR capsules has been formulated. The present research work was directed towards the development of a sustained release dosage form of venlafaxine in the form of capsules to be taken once daily. In the present study polymers such as Ethyl cellulose (10, 20, 50 cps), Hydroxypropylmethylcellulosephthalate, were used as coating polymers which helps in providing sustained release. The dissolution studies of the dosage form was performed and analysed by UV- Spectrophotometer. Different evaluation parameters such as drug- excipient compatibility studies were done by X-ray diffraction, Differential Scanning Calorimetry and in-vitro drug release was performed. Different polymers are optimized on the basis of release pattern. The marketed formulation was evaluated for the in-vitro release studies and the optimized formulation is compared with the marketed product which is in the form of extended release pellets. Source

Mann A.,PGIMS | Makkar V.,Dayanand Medical College and Hospital DMCH | Mann S.,PGIMS | Dhamija P.,AIIMS | Soundarajan P.,SRMC
Indian Journal of Nephrology | Year: 2016

Fetuin-A levels, its correlation with vascular calcification and other biochemical markers of chronic kidney disease-mineral and bone disorder (CKD-MBD) has not been studied in Indian end-stage renal disease population. Forty patients on dialysis for more than 3 months were studied. Biochemical parameters of CKD-MBD, highly sensitive-C reactive protein (hs-CRP), lipid profile and fetuin-A levels were estimated. Multi-slice computed tomography (MSCT) at the level of L1-L4 was done, and calcification score calculated using AJ 130 smart score. Levels of fetuin-A were correlated with calcification score and biochemical markers of CKD-MBD. Mean fetuin-A levels were 0.33 ± 0.098 g/l. Positive correlation of abdominal aortic calcification scores was found with age (P < 0.01) and duration of dialysis (P = 0.018). No correlation was detected between MSCT score, calcium phosphate product, intact parathyroid hormone, vitamin D, triglycerides and fetuin-A, and there was no correlation between fetuin-A levels, age, dialysis duration and calcium phosphate product but a significant correlations with vitamin D3 (P = 0.034), serum albumin (P = 0.002) was detected. Inverse correlation with hs-CRP was obtained. Patients with ischemic heart disease had numerically lower levels of fetuin-A (P = 0.427) and numerically higher MSCT score (P = 0.135). Patients with low hs-CRP (<10) had numerically higher fetuin-A levels (P = 0.090) and significantly low MSCT scores (P = 0.020). Calcium deposition seen on MSCT increases with age and duration of dialysis but is not related to fetuin-A levels. Inconclusive relationship exists with other parameters of CKD-MBD. Large controlled studies are needed to establish the role of fetuin-A in vascular calcification in Indian population. Source

Rengaraj R.,SRMC | Mariappan S.,SRMC | Sekar U.,SRMC | Kamalanadhan A.,CLTRI
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: Vancomyc in remains the drug of choice for resistant gram positive infections caused by Enterococcus spp and Methicillin resistant Staphylococcus aureus (MRSA). Increased use of vancomycin has led to frank resistance and increase in MIC (MIC creep). Vancomycin intermediate Staphylococcus aureus (VISA), Vancomycin resistant Staphylococcus aureus (VRSA) & Vancomycin resistant Enterococci (VRE) are important emerging nosocomial pathogens resulting in treatment failures. Aim: This study was undertaken to detect vancomycin resistance among clinical isolates of Staphylococcus aureus and Enterococcus faecalis by phenotypic and genotypic methods. Materials and Methods: The study was conducted in a 1850 bedded university teaching hospital from November 2013 to April 2014. Non-repetitive, consecutive clinically significant Staphylococcus aureus (109) and Enterococcus faecalis (124) were included in this study. They were identified up to species level by conventional and automated methods. Susceptibility to various antibiotics was tested by disc diffusion method. MIC of vancomycin was determined by agar dilution method. Inducible resistance to clindamycin was detected by the D test. Methicillin resistance in Staphylococcus aureus (MRSA) was screened using cefoxitin disc. All isolates were subjected to polymerase chain reaction (PCR) to detect van A and van B genes. Results: Out of 109 Staphylococcus aureus isolates, 54 were MRSA. By MIC there was no resistance observed to vancomycin.MIC50 was 1μg/ml. None of the isolates harboured van A and van B. Among Enterococcus faecalis, sixteen isolates (12.9%) and four isolates (3.2%) exhibited resistance to vancomycin and teicoplanin by disc diffusion respectively. All isolates were susceptible to linezolid. Van A was detected in 2, van B in 7 and one had both van A and van B. Conclusion: PCR remains the gold standard for diagnosis of vancomycin resistance. There was no resistance observed to vancomycin among Staphylococci though the MIC creep detected is a cause for concern. Eight percent of Enterococci were vancomycin resistant. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved. Source

Joshua Daniel M.,Salem College | Prakash H.M.,Salem College | Dhivya K.,Salem College | Aswin Kumar S.,Salem College | And 3 more authors.
Journal of Clinical and Diagnostic Research | Year: 2014

Objective: There is limited literature in the Indian subcontinent on the attitude of the medical personnel regarding blood donation. The purpose of the present study was to identify and assess the barriers that prevent people from becoming blood donors and also to devise recruitment strategies to increase the blood collection. Materials and Methods: This study was conducted in a tertiary care centre with attached medical college in Tamilnadu amongst Seven hundred and fifty medical personnel. A self administered questionnaire was used for data collection from each individual. Results: Amongst the 750 medical personnel under study, 470 were never donors and 280 were lapsed donors. The foremost reason for not donating blood among lapsed donors and non donors was never being asked again. Conclusion: Donors often donate blood once and rarely return to make a second or subsequent donation. Further education, motivation and dissemination of information would help in recruitment and retention of non-remunerated blood donors. Source

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