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News Article | June 16, 2017

Helsinn Investment Fund leads the financial round in GreenBone Lugano, Switzerland, June 16, 2017: Helsinn Investment Fund S.A., a fund focused on early-stage investments in areas of high unmet patient need, today announces that it has made a Euro 2M investment in GreenBone, a privately-held developer of bone regeneration technology. GreenBone, which is based in Faenza, Italy, provides innovative, easy to use bio-inspired solutions designed to help cure severe bone diseases. This is one of a series of early-stage investments made by Helsinn Investment Fund, which is incorporated in Luxembourg and is fully owned by Helsinn Group. The investment by Helsinn Investment Fund, part of a wider fundraising, will be mainly used to complete by 2019 clinical development conducted in load bearing long bones defects, receive CE Mark and other general corporate purposes. In addition, GreenBone intends to conduct the pre-clinical development for further applications in other skeleton diseases. GreenBone has already completed successfully a pre-clinical study at the Assaf-Harofeh Hospital (Israel) in cooperation with the Rizzoli Orthopedic Institute in Bologna. GreenBone Ortho srl (Faenza, Italy) has developed a patented, innovative, wood-derived, bone regenerative implant for extensive bone damage in non-loaded and load-bearing skeletal segments such as long bone non-union fractures, spinal damage, trauma and cancer induced bone loss. Due to its structure and chemical composition, GreenBone has the ideal biomimetic, resorbable and regenerative properties for bone grafting. GreenBone is expected to provide patients new functional bone, increasing their quality of life dramatically, while reducing healthcare and social costs that are typically high for such patients. The idea was conceived and developed by a research group at ISTEC-CNR in Faenza (Institute of Science and Technology for Ceramics - National Research Council) led by Dr. Anna Tampieri. A first patent has already been granted in USA, EU, China and other countries, with an international PCT patent application pending. The patent portfolio has been subject of a worldwide exclusive license agreement between GreenBone Ortho srl and CNR. The company is led by a world class team that has advanced multiple products including orthopaedic ones from bench-to-market. GreenBone closed a EURO 3 million seed round of investment in 2015 from ZernikeMeta Ventures, Italian Angels for Growth (IAG) and some private Italian and foreign investors. Helsinn Investment Fund was set up to draw on over 40 years' expertise in research and development and commercialization of therapeutic candidates in cancer care, pain and inflammation and gastroenterology. The Fund aims to help companies working across a range of areas in healthcare to develop early-stage technologies into commercial solutions that will impact health-related quality of life of patients. Riccardo Braglia, Helsinn Group Vice Chairman and CEO, commented: "GreenBone is a great example of a dynamic, technology-driven innovation which we at Helsinn Investment Fund believe can revolutionise the treatment of bone conditions brought about by impacts such as trauma and tumors. Since its creation in 2014, GreenBone has come a long way very quickly and we look forward to working with the management to further advance this life changing technology through to commercialisation." Lorenzo Pradella, Co-founder and CEO of GreenBone, said: "Securing an investment partner like Helsinn Investment Fund is of great value to GreenBone. Helsinn Investment Fund brings financial resources, but also experience and commercial know-how to help bringing a product to market in a timely and cost effective manner. We look forward to working with them and to progressing our product through clinical trials and ultimately bringing it to patients." The Helsinn Investment Fund is focused on early-stage investments in areas of high unmet patient need. Backed by the Helsinn Group, and guided by Helsinn's core values of quality, integrity and respect, Helsinn Investment Fund aims to help companies with innovative technologies to transform new ideas into commercial solutions with the potential to impact health-related quality of life of patients. Drawing on Helsinn's over 40 years of investment into research and development and commercial expertise, the investment fund selects companies with technologies in a range of areas including cancer therapeutics and diagnostics, cancer supportive care, metabolic and gastrointestinal disorders, and dermatology conditions. For more information, visit Helsinn is a privately owned pharmaceutical group with an extensive portfolio of marketed cancer care products and a robust drug development pipeline. Since 1976, Helsinn has been improving the everyday lives of patients, guided by core family values of respect, integrity and quality. The Group works across pharmaceuticals, biotechnology, medical devices and nutritional supplements and has expertise in research, development, manufacture and the commercialization of therapeutic and supportive care products for cancer, pain and inflammation and gastroenterology. In 2016, Helsinn created the Helsinn Investment Fund to support early-stage investment opportunities in areas of unmet patient need. The company is headquartered in Lugano, Switzerland, with operating subsidiaries in Switzerland, Ireland and the U.S., a representative office in China as well as a product presence in approximately 190 countries globally. For further information please visit: GreenBone is a start-up based in Faenza (Italy) founded in 2014. The company wants to become a worldwide leader for bone regeneration by providing innovative and easy to use bio-inspired solutions that will help cure severe diseases. In particular, it develops a revolutionary technology in the orthopedic-traumatological field for the production of bone implants derived from natural structures such as wood, with outstanding regenerative properties. GreenBone scaffolds are particularly suited to address the large bone loss caused by trauma, tumors and other nasty skeleton damages having high incidence and often leading to significant disablements. GreenBone presented at TEDxBinnenhof 2016, being selected among the 10 very best 'Ideas from Europe' (March 31, The Hague NL). For more information, please visit

Ibi A.,SRL ISTEC | Miyata S.,SRL ISTEC | Taneda T.,SRL ISTEC | Yoshizumi M.,SRL ISTEC | And 9 more authors.
Physics Procedia | Year: 2013

We have been developing long REBa2Cu3O 7-δ coated conductors with high performance by the combination of the IBAD and the PLD methods. To realize the low production cost for REBa2Cu3O7-δ coated conductors, growth conditions were optimized for long tape fabrication in the in-plume PLD method . As a result, the Ic performance was confirmed with a high production rate under the high oxygen gas pressure and high laser energy density of > 800 mTorr and > 3 J/cm2, respectively. We successfully fabricated a 35 m long GdBa2Cu3O7-δ coated conductor with high Ic value of 619 A/cm-w by the production rate of 30 m/h. © 2013 The Authors.

Shiohara K.,Kyushu University | Higashikawa K.,Kyushu University | Kawaguchi T.,Kyushu University | Inoue M.,Kyushu University | And 3 more authors.
Physica C: Superconductivity and its Applications | Year: 2011

We have carried out 2-dimensional (2D) measurement of local critical current in a Trifluoroacetates-Metal Organic Deposition (TFA-MOD) processed YBCO coated conductor using scanning Hall-probe microscopy. Recently, remarkable R&D accomplishments on the fabrication processes of coated conductors have been conducted extensively and reported. The TFA-MOD process has been expected as an attractive process to produce coated conductors with high performance at a low production cost due to a simple process using non-vacuum equipments. On the other hand, enhancement of critical currents and homogenization of the critical current distribution in the coated conductors are definitely very important for practical applications. According to our measurements, we can detect positions and spatial distribution of defects in the conductor. This kind of information will be very helpful for the improvement of the TFA-MOD process and for the design of the conductor intended for practical electric power device applications. © 2011 Elsevier B.V. All rights reserved.

Shiohara K.,Kyushu University | Higashikawa K.,Kyushu University | Inoue M.,Kyushu University | Kiss T.,Kyushu University | And 4 more authors.
Physica C: Superconductivity and its Applications | Year: 2013

We have investigated electric field criterion of in-plane critical current density in a coated conductor characterized by scanning Hall-probe microscopy (SHPM). From remanent field distribution and its relaxation measurements, we could obtain critical current distribution and induced electric field simultaneously by considering the Biot-Savart law and the Faraday's law, respectively. These results lead us to evaluate a distribution of local critical current density and the corresponding criterion of electric field. As a result, it was found that the electric field criterion for the SHPM analysis was several orders lower than that used in the conventional 4-probe resistive method. However, the data point obtained by the SHPM shows good agreement with E-J curve analytically extended from the measurements by the 4-probe method. This means that we could characterize in-plane distribution of critical current density in a coated conductor at an electric field criterion quantitatively by this method in a nondestructive manner. These findings will be very important information since the uniformity of local critical current density in a coated conductor at extremely low electric fields is a key issue (1) especially for DC applications, (2) for quality control of coated conductors, and (3) for the standardization of the characterization of critical current among different methods.

Adachi S.,SRL ISTEC | Tsukamoto A.,SRL ISTEC | Moon Y.,SRL ISTEC | Oshikubo Y.,SRL ISTEC | Tanabe K.,SRL ISTEC
2015 15th International Superconductive Electronics Conference, ISEC 2015 | Year: 2015

We have fabricated high-Tc SQUIDs consisting of ramp-edge-type Josephson junctions and oxide multilayer structures. Preparation of a superconducting layer with c-axis orientation on ramp-surfaces is one of key issues. We report transmission electron microscope (TEM) study of the La0.1Er0.95Ba1.95Cu3Oy(L1ErBCO) layer prepared by a pulsed laser deposition (PLD) method on ramp-surfaces made of SrSnO3(SSO) and SmBa2Cu3Oy(SmBCO). Inclusion of grains with aaxis orientation was seen in L1ErBCO on SSO. After observation of various samples, we found a tendency that the number of aoriented grains was reduced by depositing L1ErBCO on shallower ramps. On the other hand, successful growth of the layer with c-axis orientation was observed in the L1ErBCO layer on the SmBCO ramp, suggesting that the SmBCO promoted the c-axis growth of L1ErBCO. Electron diffraction indicated that in-plane orientation was also achieved for the L1ErBCO grains on SmBCO. © 2015 IEEE.

Tsukamoto A.,SRL ISTEC | Hato T.,SRL ISTEC | Adachi S.,SRL ISTEC | Motoori M.,Japan Oil, Gas and Metals National Corporation | And 2 more authors.
2015 15th International Superconductive Electronics Conference, ISEC 2015 | Year: 2015

We have developed a magnetic prospecting system with HTS SQUID gradiometers for exploration of metal resources. The SQUID gradiometer consists of a flux transformer chip made of a YBCO thin film and a SQUID gradiometer chip which is stacked on the transformer chip. The SQUID gradiometer chip was fabricated by using an HTS multilayer and ramp-edge junction technology at ISTEC. Their effective volume and the balance estimated by using a Helmholtz coil were approximately 3 x 10-9 m3 and 1/500, resulting in the gradiometric field noise of 7 pT/m/Hz1/2 at 10 Hz. Two assembled SQUID gradiometers which measure dBz/dx and dBz/dy field gradients were cooled with liquid nitrogen in a cryostat of the magnetic prospecting system. The cryostat was suspended from the frame of the system and its attitude was self-controlled by gravity. The magnetic prospecting system with the HTS SQUID gradiometers, flux-gate sensors, a GPS module, and a gyro sensor was also tested in a field near an old mine. © 2015 IEEE.

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