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News Article | December 7, 2016
Site: phys.org

A graduate of the University of California at Berkeley, Son founded Softbank in 1981 after selling a pocket translator he invented while still in college to Sharp Corp. for $1 million. Softbank became Japan's largest distributor of computer software and leading publisher of computer-related magazines and books, going public in 1994. The Tokyo-based company is now one of Japan's biggest telecoms providers, with more than 63,590 employees, a solar power business, humanoid robots for home use, ride-booking services and financial technology. It recently set up a $25 billion private fund for technology investments, along with Saudi Arabia and other investors, that Son says could grow to $100 billion. But Softbank has had its ups and downs over the years, occasionally having to retrench and sell off investments. Here are some highlights: ARM HOLDINGS: In July, Softbank bought Britain's ARM Holdings for 24.3 billion pounds ($32 billion), in a deal the British government hailed as a vote of confidence despite its decision to leave the European Union. ARM is known as an innovator in smartphone technologies and the "internet of things." ''Now is the time. This is the Cambrian explosion," Son recently told investors in a presentation. SPRINT CORP.: Son's 2013 purchase of a 70 percent stake in Sprint Nextel for $20 billion was the biggest foreign acquisition in the history of Japan Inc. The U.S. wireless carrier is slowly turning itself around, though it reported a loss of $142 million in its fiscal second quarter. Son hopes to expand Softbank's U.S. footprint by acquiring T-Mobile. On Tuesday, he praised Trump as a "deregulator," suggesting he is hoping the new administration might ease hurdles to such a deal. Son has said he believes the mobile Internet is the most important, backbone technology for the 21st century, but the U.S. lags in terms of speed. He could be looking to focus investments in that area. ALIBABA: Son says he parted "unwillingly" with some of his investment in the Chinese e-commerce giant to help pay for the ARM acquisition. "But I still believe in Alibaba's future; it is still in the process of growth and it has a big future," he said in an earnings presentation last month. SUPERCELL: Earlier this year, Softbank sold its stake in Finnish game developer Supercell to Chinese technology firm Tencent in a deal that values the company at about $10.2 billion. INDIA: Son has pledged to invest $10 billion in India over 10 years, though Softbank has had to write off losses from ride hailing technology company Ola Cabs and e-commerce company Snapdeal. EARLIER DEALS: In 1995, back when Softbank was still a software distributor and publisher of computer and hi-tech magazines, it bought Comdex and other computer-related show businesses from The Interface Group. Eventually it sold off the trade shows. Over the years, Son has also invested in satellite TV and other media ventures, in banking and in Japan's Nasdaq. An investment in U.S. computer memory board maker Kingston Technology Corp., in 1996, is considered one of Son's missteps. Explore further: SoftBank eyes $100 bn for new tech fund with Saudis


PubMed | Shizuoka Cancer Center Research Institute, Japan SRL Inc. and Shizuoka Cancer Center Hospital and Research Institute
Type: Journal Article | Journal: Anticancer research | Year: 2016

The identification of additional therapeutic targets by clinical molecular profiling is necessary to expand the range of molecular-targeted cancer therapeutics. This study aimed to identify novel functional tumor-specific single nucleotide variants (SNVs) in the kinase domain of receptor tyrosine kinases (RTKs), from whole-exome sequencing (WES) data.SNVs were selected from WES data of multiple cancer types using both cancer-related databases and the index reflecting molecular evolution. Immunoblotting and luciferase assay were performed to assess the function of selected SNVs.Among the seven selected SNVs, two, namely neurotrophic receptor tyrosine kinase 1 (NTRK1) V710A and fms related tyrosine kinase 3 (FLT3) K868N, detected in kinase subdomain IX, were investigated. These SNVs inhibited the autophosphorylation of the respective RTKs, thereby reducing the activity of extracellular signal-regulated kinases.RTK subdomain IX is a promising target for the molecular design of kinase inhibitors.


News Article | March 17, 2016
Site: phys.org

Glance, and a video-game character talks back. Or use a death stare to shoot down virtual spaceships. Watch a movie of a forest or a room and be able to look around wherever you want. "It allows you to go inside the world that's behind the display," said Yuka Kojima, Fove's co-founder and a rare female chief executive in male-dominated Japan Inc. Fove, which comes from "fovea," the part of the eye with the sharpest vision, from "field of view," and the word's similarity with "love," has devised a way to use tiny infrared sensors inside headset goggles to monitor the movements of a wearer's pupils. It's a small company, founded in 2014, with offices in Tokyo, San Francisco and Los Angeles, and employing just 17 people. But Fove is getting attention from the fledgling VR industry, as "virtual reality" is known, and winning backing from innovative financiers. It has raised about $500,000 through Kickstarter. Virtual reality could revolutionize entertainment, like movies, games and live-streaming of sports. It has myriad potential business applications, such as giving apartment hunters a virtual look at real estate options and car buyers tours of virtual showrooms. It could also prove useful for training of pilots and surgeons, and has already been adopted by the military. The make-believe experience could aid in so-called "empathy training" for police and other service providers. Pornography is another potentially lucrative application. A recent report by New York-based Superdata, which analyzes data on games, said smaller companies could become "first-movers," as established players keep a cautious wait-and-see attitude. Rahat Ahmed, co-founder and chief of strategy at New York-based Trinity VR, an investor in technology and emerging markets, says the big plus of VR is "intuitive interaction." Augmented reality enables users to see three-dimensional objects in the real world, while VR delivers a 360-degree fictional universe. "Every major company has to have a VR-AR strategy," Ahmed said recently at the CLSA Japan Forum in Tokyo, referring by AP to "augmented reality," which enables users to see three-dimensional objects in the real world, while VR delivers a 360-degree fictional universe. "It allows connecting—going fishing with your father who is far away." New technology usually has its share of detractors, and there are worries that VR could have harmful effects if users become too immersed in their fantasy environments and estranged from reality. But Fove developers say VR can play a positive role. In one poignant demonstration, a bed-ridden grandmother wears a Fove headset to "attend" her grandson's wedding, sending a human-shaped robot controlled by her eyes in her place. The woman gestures happily, reaching out from her bed as if the newlyweds are standing before her. Eye-tracking can enable disabled people to use their eyes to control devices, says Kojima's co-founder at Fove, Australian Lochlainn Wilson. He developed Fove's breakthrough technology for eye-tracking. With the help of Fove and a Japanese university, for example, a young man with spinal muscular atrophy, an illness that has weakened his arms and fingers, used eye movements to play a piano. "We want to do things with VR that people haven't thought about, or have thought to be impossible," said Wilson, who met Kojima while she was studying English for four months in Australia. "And we have got other secret projects in the future." Fove has potential rivals, such as electronics and entertainment company Sony Corp. and Facebook's Oculus, which later this month will begin shipping the consumer version of its Rift virtual-reality headset for $600, plus $1,500 for an "Oculus-ready" PC. Oculus says it is working on eye-tracking for its headsets, and other players like Eyefluence Inc., based in Milpitas, California, have also developed the technology. Microsoft Corp. will soon have a developer version of its augmented reality device, HoloLens, for $3,000. Fove's headset for game and other content developers will become available sometime later this year for about $500—though for the headset to work well, you need in addition a good PC costing $1,000 or more. The company plans to make 1,200 such headset kits, but Kojima says Fove could boost production to as many as a million headsets if she clinches a deal to supply them to Internet cafes. Fove also is offering to license the technology to other companies. Fove's eye-tracking technique is convincing: In one recent demonstration, a headset wearer watched a computer-graphic figure holding a machine gun slowly approach, evoking a sense of menace. Looking at the space behind the figure, the background came into more vivid focus and the figure in front dimmed bit, enhancing the illusion of perspective. Kojima, who is also a filmmaker, became interested in story-telling from when she was studying at Tokyo's prestigious Ochanomizu University. Later, while working as a game producer at Sony Computer Entertainment, she began to wonder why games allowed only "yes" or "no" choices, when stories usually called for more subtlety. Fove, she believes, can fix that by making the interaction more intuitive. "It should feel more like the way we are facing each other now, laughing, making eye contact, a nonverbal form of communication," said Kojima. "Nuances should be part of storytelling. It should be natural."


News Article | February 15, 2017
Site: phys.org

The company projected a 712.5 billion yen ($6.3 billion) loss for its nuclear business related to the acquisition of CB&I Stone & Webster by its U.S. nuclear unit Westinghouse. The company also said it will not take on new projects to construct nuclear plants. President Satoshi Tsunakawa said the company also was looking for potential partners to acquire a stake in Westinghouse. He bowed deeply at a news conference to apologize for "troubling investors and stakeholders." Earlier Tuesday, Toshiba delayed reporting its official financial results by a month, citing auditing problems. That sent Toshiba stock tumbling 8 percent in Tokyo trading. After the market closed, it released unaudited numbers, warning they may change "by a wide margin." The company said Shigenori Shiga, the chairman, will step down from the board, effective Wednesday, but stay on as a Toshiba executive. Toshiba said its net worth was in the negative, at minus 191 billion yen ($1.7 billion) by the end of last year. The company hopes to fix that by the end of March by selling its flash-memory business and other assets. In a stunning acknowledgement, Tsunakawa told reporters the company viewed its move into the nuclear sector by acquiring Westinghouse in 2006 as a misstep that led to its present woes. Westinghouse's purchase in 2015 of CB&I Stone & Webster, a nuclear construction and services business, was aimed at winning more business in decontamination, decommissioning and plant projects. But it just amplified that problem. Auditors questioned Toshiba's latest reporting on the acquisition of CB&I Stone & Webster after a whistleblower, an employee at Westinghouse, wrote a letter to the Westinghouse president. The company said it will reorganize its nuclear business to be directly under Tsunakawa for stricter monitoring. It will also focus on reactor maintenance, the nuclear fuel business and decommissioning of the Fukushima nuclear plant in Japan, where reactors went into multiple meltdowns after the March 2011 earthquake and tsunami. Efficiency moves expected at CB&I Stone & Webster never played out, resulting in a huge overvaluation of the company's worth that led to the huge losses. Toshiba denied it had purposely covered up the problems. In its preliminary results, Toshiba said it anticipates a group net loss of 500 billion yen ($4.4 billion) for April-December of last year, including the 712.5 billion yen hit from its nuclear business. The company is forecasting a group net loss of 390 billion yen ($3.43 billion) for the full year through March 31, instead of the 145 billion yen profit it had anticipated earlier. Toshiba, founded in 1875, employs about 190,000 people and used to be one of the most respected brands of Japan Inc. It still has a sprawling business spanning household appliances, railways, hydrogen energy and elevator systems. The company has been grappling in recent years with a scandal over company officials' doctoring of accounting books to meet unrealistic profit targets. "It is so unfortunate that this has happened," said Ryoji Sato, a company director, when asked by a reporter about the company's promises to come clean. "We must keep trying to do better." In this Jan. 30, 2017, photo, a man walks past an advertisement of Toshiba Corp.'s products in Tokyo. Japanese electronics and energy giant Toshiba delayed reporting its financial results by a month Tuesday, Feb. 14, 2017, citing problems with its auditing. Toshiba stock tumbled 8 percent in Tokyo trading after its earnings weren't announced as scheduled. The company said the earnings won't be out until March 14. Auditors had questioned Toshiba's reporting on the acquisition of CB&I Stone & Webster by its U.S. nuclear unit Westinghouse, the company said in a statement. (AP Photo/Koji Sasahara) Toshiba Corp. President Satoshi Tsunakawa arrives for a press conference at the company's headquarters in Tokyo, Tuesday, Feb. 14, 2017. Japanese electronics and energy giant Toshiba said Tuesday that its chairman is resigning to take responsibility for problems that will result in a 713 billion yen ($6.3 billion) loss in its nuclear business. Toshiba warned, however, that unaudited financial results it announced may change "by a wide margin." It earlier delayed reporting its official financial results by a month, citing auditing problems related to the losses in its nuclear business. That sent Toshiba stock tumbling 8 percent in Tokyo trading. (AP Photo/Shizuo Kambayashi) Toshiba Corp. President Satoshi Tsunakawa listens to a reporter's question during a press conference at the company's headquarters in Tokyo, Tuesday, Feb. 14, 2017. Japanese electronics and energy giant Toshiba said Tuesday that its chairman is resigning to take responsibility for problems that will result in a 713 billion yen ($6.3 billion) loss in its nuclear business. Toshiba warned, however, that unaudited financial results it announced may change "by a wide margin." It earlier delayed reporting its official financial results by a month, citing auditing problems related to the losses in its nuclear business. That sent Toshiba stock tumbling 8 percent in Tokyo trading. (AP Photo/Shizuo Kambayashi) Toshiba Corp. President Satoshi Tsunakawa speaks during a press conference at the company's headquarters in Tokyo, Tuesday, Feb. 14, 2017. Japanese electronics and energy giant Toshiba said Tuesday that its chairman is resigning to take responsibility for problems that will result in a 713 billion yen ($6.3 billion) loss in its nuclear business. Toshiba warned, however, that unaudited financial results it announced may change "by a wide margin." It earlier delayed reporting its official financial results by a month, citing auditing problems related to the losses in its nuclear business. That sent Toshiba stock tumbling 8 percent in Tokyo trading. (AP Photo/Shizuo Kambayashi) Explore further: Toshiba warns of huge losses in US nuclear power unit


News Article | December 8, 2016
Site: www.businesswire.com

NEW YORK--(BUSINESS WIRE)--Liquidnet, the global institutional trading network, has been named one of the Best Places to Work in New York City by Crain’s New York Business and the Best Companies Group. The annual survey and recognition program identifies and recognizes New York City’s best employers. “We always put employees first at Liquidnet, that’s how we attract and retain the best talent. Ultimately our customers win and we continue to grow because we have awesome people who love working here,” said Seth Merrin, CEO and Founder of Liquidnet. “This culture, one fueled by passion, a drive to succeed, and fun, has allowed us to expand across the globe without losing the startup feel we’ve held close to our core.” Companies from all five boroughs participated in a two-part survey process that evaluated nominees’ workplace policies, practices, philosophies, and an employee survey to assess personal experiences. “A key element of the Liquidnet culture has always been about building an environment that encourages each employee to be his or her best self,” said Jerilyn Medrea, Head of Global Talent Engagement at Liquidnet. “So it is especially fulfilling to be recognized as one of the best places to work in New York City.” A full list of the 100 organizations named as Best Places to Work in New York City is available on Crain’s New York Business’ website, crainsnewyork.com. For more about life at Liquidnet, please visit: www.liquidnet.com/careers Liquidnet is the global institutional trading network where more than 800 of the world’s top asset managers and other like-minded investors come to execute their large trades with maximum anonymity and minimum market impact. As the global leader in large block trading, Liquidnet provides access to unique trading opportunities in 44 markets across five continents. Liquidnet approaches every market with the same bold vision to provide a better, more efficient way to trade on a massive scale. It is this focus on size, combined with the strength of its network, disruptive technology, and commitment to transparency, that is revolutionizing the way equities and corporate bonds are traded. For more information, visit www.liquidnet.com and follow us on Twitter @Liquidnet. © 2016 Liquidnet Holdings, Inc. and its subsidiaries. Liquidnet, Inc. is a member of FINRA/SIPC. Liquidnet Europe Limited is authorized and regulated by the Financial Conduct Authority in the UK, is licensed by the Financial Services Board in South Africa, and is a member of the London Stock Exchange and a remote member of the Warsaw Stock Exchange and SIX Swiss Exchange. Liquidnet Canada Inc. is a member of IIROC and a member of the Canadian Investor Protection Fund. Liquidnet Asia Limited is regulated by the Hong Kong Securities and Futures Commission as a licensed dealer and a provider of automated trading services pursuant to the Securities and Futures Ordinance and is regulated by the Monetary Authority of Singapore as a Recognized Market Operator. Liquidnet Japan Inc. is regulated by the Financial Services Agency of Japan and is a member of JSDA/JIPF. Liquidnet Australia Pty Ltd. is registered with the Australian Securities and Investment Commission as an Australian Financial Services Licensee, AFSL number 312525, and is registered with the New Zealand Financial Markets Authority as a Financial Service Provider, FSP number FSP3781.


News Article | February 27, 2017
Site: globenewswire.com

NEW YORK, Feb. 27, 2017 (GLOBE NEWSWIRE) -- WisdomTree Investments, Inc. (NASDAQ:WETF), an exchange-traded fund ("ETF") and exchange-traded product ("ETP") sponsor and asset manager, today announced that WisdomTree Japan Inc., a wholly-owned subsidiary (“WisdomTree Japan”), entered into an agreement with Monex Securities (“Monex”), a leading Japanese online securities firm, whereby Monex will provide WisdomTree’s ETFs through Japan’s first commission-free program, Overseas ETFs with Zero Commissions on Transactions (”Zero ETF”’). Zero ETF is a long-term investment program offered to individual investors in Japan for the first time that not only provides commission-free transactions but also offers ETF holders a range of potential long-term benefits from Monex and WisdomTree. Kurt MacAlpine, WisdomTree Head of Global Distribution, said, “We are excited about the potential of this new collaboration we have established with Monex and believe it will enhance the investing experience for individuals in Japan. WisdomTree takes pride on being an industry innovator, extending beyond the development of our differentiated products. It also includes our strategy behind working with platforms to deliver these products to various markets." Junichi Kamitsubo, WisdomTree Japan Head of Sales, said, “WisdomTree and Monex will work together to provide information and services to individual investors on a continuous basis not only at the time of purchase, but also over the long term. As part of this service, we will regularly send investors model portfolios, hold investment seminars online and provide research reports that are limited to Zero ETF holders only.” Jesper Koll, Head of WisdomTree Japan, said, “WisdomTree has developed distinctive ETFs investing in a wide range of asset classes covering various countries in the world.  We are a pioneer of Smart Beta ETFs and have available for sale in Japan a suite of Smart Beta ETFs with ten-year track records.  Other innovative products offered in Japan include interest rate hedged high yield fixed income ETFs – including the industry’s only negative duration high yield ETF – and long/short U.S. equity ETFs. We believe that with commission-free transactions and after-purchase support, many individual investors can benefit from and use U.S. ETFs to diversify their long-term investments.” The following WisdomTree ETFs are available for sale in Japan and are included in the Zero ETF long-term investment program: About WisdomTree WisdomTree Investments, Inc., through its subsidiaries in the U.S., Europe, Japan and Canada (collectively, “WisdomTree”), is an exchange-traded fund (“ETF”) and exchange-traded product (“ETP”) sponsor and asset manager headquartered in New York.  WisdomTree offers products covering equities, fixed income, currencies, commodities and alternative strategies.  WisdomTree currently has approximately $43.3 billion in assets under management globally. WisdomTree® is the marketing name for WisdomTree Investments, Inc. and its subsidiaries worldwide.


News Article | November 30, 2016
Site: www.marketwired.com

Business partnership to expand tourism and e-commerce options for Chinese tourists visiting Japan BEIJING, CHINA--(Marketwired - Nov 30, 2016) -  Baidu Japan (HQ: Minato, Tokyo; henceforth, "Baidu") ( : BIDU) has announced that it is partnering with Yahoo! JAPAN to expand tourism and e-commerce options for Chinese tourists, and to bolster sales opportunities for Japanese businesses by increasing advertising channels for Chinese consumers. In the partnership, Yahoo! JAPAN will act as the general sales agent in Japan for all China-focused advertising and ad network advertising managed by Baidu. The business partnership will leverage the strengths of both companies to create marketing solutions aimed at Chinese consumers. With Yahoo! JAPAN's expertise in internet advertising, Baidu will be able to expand its advertising sales channels to a national scale in Japan, and will create new opportunities for Japanese businesses to connect with enterprises and consumers in China. Baidu will also provide solutions for Chinese tourists visting Japan, incuding in the area of cross-border e-commerce which reached a total transaction volume of USD $26 billion (3 trillion JPY) during the 2016 Singles' Day shopping holiday. "We at Baidu are very happy to join hands with Yahoo! JAPAN for outbound advertising and marketing solutions aimed at Chinese users," said Mr. Ya-Qin Zhang, President of Baidu. "Together, we will continue to improve Baidu's offerings to help companies in Japan reach Chinese tourists, e-commerce shoppers and businesses. We see this as a very positive step to contribute to the further development of business between China and Japan," he said. "Yahoo! JAPAN sincerely welcomes the collaboration with Baidu Japan Inc. The need to market to China is likely to increase as we head toward 2020, the Olympic year. We firmly believe that this partnership with Baidu Japan, one of the largest IT companies in China, will allow us to provide even better solutions and services to companies and municipalities all over Japan," said Miki Nakajima, Vice President, Head of Search Advertising, Marketing Solutions Company at Yahoo! JAPAN. "By bringing together the know-how and achievements of both companies, we hope to further accelerate the growth of marketing directed toward China," she said. According to the Japan National Tourism Organization, the total number of Chinese visitors to Japan from January 2016 to September 2016 reached five million, surpassing last year's record. The total number of Chinese visitors this year is expected to exceed six million. Search data from Baidu.com indicates that Chinese tourists are visiting not only big cities in Japan but also rural towns, which points to significant untapped business and tourism potential. Given the popularity of Japanese products among Chinese consumers, as well as the upcoming 2020 Tokyo Olympics, cross-border e-commerce is expected to increase in the coming years. Baidu Japan is a Japan-based subsidiary of Baidu, Inc. Since its establishment in December 2006, Baidu Japan has provided internet advertising products including listing advertising and ad-network advertising for Chinese-speaking users, in order to support the marketing activities of Japanese enterprises in China as well as inbound tourism and cross-border e-commerce. Baidu Japan also offers the Japanese-language keyboard input and emoticon app "Simeji", which boasts over 24 million downloads. In May 2015, Baidu acquired the native advertising company popIn Inc., which features an online media recommendation engine as well as internet and smartphone advertising tools. Baidu, Inc. is the leading Chinese language Internet search provider. As a technology-based media company, Baidu aims to provide the best and most equitable way for people to find what they're looking for. In addition to serving individual Internet search users, Baidu provides an effective platform for businesses to reach potential customers. Baidu's ADSs trade on the NASDAQ Global Select Market under the symbol "BIDU". Currently, ten ADSs represent one Class A ordinary share. Yahoo Japan Corporation was founded in 1996 and operates Yahoo! JAPAN, a leading internet brand and one of the most trafficked internet destinations in Japan. Yahoo! JAPAN provides more than 100 services including search, news and e-commerce via PC and smart devices and offers a full range of tools and marketing solutions for businesses to connect with internet users in Japan.

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