Srinivas Institute of Medical science and Research Center

Mangalore, India

Srinivas Institute of Medical science and Research Center

Mangalore, India

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Mohan K.H.,Srinivas Institute of Medical science and Research Center | Manjunath H.,Srinivas Institute of Medical science and Research Center
Indian Journal of Dermatology | Year: 2013

Schwannomas are benign tumors derived from Schwann cells. They are comparatively rare on scalp and easily mistaken for tumors of hair. Trichilemmal cysts are common over scalp and present as dermal or subcutaneous growths over scalp. We present a solitary schwannoma of scalp clinically mimicking trichilemmal cyst. The tumor was surgically excised and the same was confirmed by histopathology.


Kudur M.H.,Srinivas Institute of Medical science and Research Center
Indian Journal of Dermatology | Year: 2013

Cutaneous piloleiomyoma is a rare benign tumor of skin originating from skeletal muscle of arrector pili attached to hair follicle. It can be single or multiple, solitary piloleiomyoma are common over genitalia. Multiple cutaneous piloleiomyomas are rare and they can cause pain on exposure to cold or with emotional disturbance. The prognosis of cutaneous piloleiomyomas after surgical excision is good. Here, we present a rare case of generalized multiple cutaneous piloleiomyoma in a young male. © Indian Journal of Dermatology 2013.


Kudur M.H.,Srinivas Institute of Medical science and Research Center | Hulmani M.,Srinivas Institute of Medical science and Research Center
Indian Journal of Dermatology | Year: 2013

Angiokeratoma of Fordyce occurring over vulva is rare. Angiokeratoma of Fordyce commonly occurs in males over scrotum or penile shaft and presents as multiple verrucous reddish papules. They are usually asymptomatic and noticed accidentally. In the present article, we present and review the literature of giant angiokeratoma of Fordyce in middle-aged women due to its rarity. © Indian Journal of Dermatology 2013.


Kudur M.H.,Srinivas Institute of Medical science and Research Center | Hulmani M.,Srinivas Institute of Medical science and Research Center
Indian Journal of Dermatology | Year: 2013

Plexiform neurofibroma is common over the branches of trigeminal and cervical nerves over the face. Plexiform neurofibroma over palm is rare and affects the individuals with fine motor functions of hand. Here, we report a case of isolated plexiform neurofibroma over the palm with review of literature. © Indian Journal of Dermatology 2013.


Kudur M.H.,Srinivas Institute of Medical science and Research Center | Hulmani M.,Srinivas Institute of Medical science and Research Center
Indian Journal of Dermatology | Year: 2013

Rebamipide is an amino acid analog of 2 (1H)-quinolinone. It is being introduced and used since 1980 for the treatment of peptic ulcer. Its therapeutic use in recurrent aphthous ulcer was not known. It acts by the decrease in oxygen radicals, increase in blood flow and production of protective prostaglandins in ulcer mucosa, which accelerates the process of healing. In this article, we focus on the pharmacodynamics, pharmacokinetics, side-effects and other therapeutic uses of Rebamipide. It will be a new and effective drug in the dermatologists' drug armamentarium for the treatment of aphthous ulcers and related diseases.


Menezes R.G.,Srinivas Institute of Medical science and Research Center
The Medico-legal journal | Year: 2012

It was a sad and emotional moment for the citizens of Mangalore, India when the "Dubai to Mangalore" Air India Express Boeing 737-800 flight IX-812 crashed at the Mangalore International Airport on 22 May 2010, killing 158 people on board. Identification of the victims was difficult as most of the bodies were charred beyond easy recognition. The practical problems faced by the legal authorities in identifying the charred victims in a populous and developing country like India are discussed in this paper.


Vijaya M.,Srinivas Institute of Medical Science and Research Center | Malathi M.,Father Muller Medical College | Shivashankara A.R.,Father Muller Medical College
Asian Pacific Journal of Cancer Prevention | Year: 2012

Background: This study was conducted to determine levels of lipid peroxidation and antioxidant vitamin status in patients with oral cavity and oropharyngeal cancer. Methods: The study group consisted of a total number of 80 subjects between the age 40-68 years, 40 with clinically and histopathologically proved cases of oral cavity and oropharyngeal cancer and 40 normal healthy, age and sex matched volunteers as controls. Levels of lipid peroxidation products as malondialdehyde (MDA) and antioxidant vitamins as vitamin A and vitamin C were estimated and compared between the two groups. Results: There was a statistical significant difference in the mean MDA, plasma vitamin A and vitamin C in the oral and oropharyngeal cancer patients compared with the healthy controls (p<0.0001). Conclusions: Lipid peroxidation (MDA) is higher and plasma antioxidant vitamins like vitamin A and vitamin C were lower in oral cavity and oropharyngeal cancer patients than healthy controls.


Hegde S.V.,Srinivas Institute of Medical Science and Research Center | Adhikari P.,Manipal University India | Nandini M.,Manipal University India | D'Souza V.,Manipal University India
Complementary Therapies in Clinical Practice | Year: 2013

This study sought to examine whether consumption of two low-calorie fruit/day for 3-months can effectively improve oxidative stress, anthropometry, blood pressure and glycaemic control in type 2 diabetes mellitus. Study involved 123 patients who were assigned to receive either standard care or with additional dietary therapy. Dietary intervention resulted in significant reduction in malondialdehyde, plasma glucose, glycated haemoglobin and improvement in antioxidants like vitamin C and reduced glutathione when compared to controls. Mean plasma levels of vitamin C increased by 64% (p < 0.001). There were no differences in waist circumference, waist-to-hip ratio, blood pressure, vitamin E and superoxide dismutase in the intervention group at follow-up. Diet rich in fruits can improve some antioxidants which are likely to reduce oxidative stress in type 2 diabetes. Regular consumption of fruits can lower the glycaemic status in these patients. The study supports the usefulness of plasma vitamin C as a biomarker for fruit intake. © 2012 Elsevier Ltd.


Hegde S.V.,Srinivas Institute of Medical Science and Research Center | Adhikari P.,Manipal University India | Kotian S.,Manipal University India | Pinto V.J.,Manipal University India | And 2 more authors.
Diabetes Care | Year: 2011

OBJECTIVE - To assess the effect of yoga on anthropometry, blood pressure, glycemic control, and oxidative stress in type 2 diabetic patients on standard care in comparison with standard care alone. RESEARCH DESIGN AND METHODS - The study involved 123 patients stratified according to groups with microvascular complications, macrovascular complications, and peripheral neuropathy and without complications and assigned to receive either standard care or standard care along with additional yoga for 3 months. RESULTS - In comparison with standard care alone, yoga resulted in significant reduction in BMI, glycemic control, and malondialdehyde and increase in glutathione and vitamin C. There were no differences in waist circumference, waist-to-hip ratio, blood pressure, vitamin E, or superoxide dismutase in the yoga group at follow-up. CONCLUSIONS - Yoga can be used as an effective therapy in reducing oxidative stress in type 2 diabetes. Yoga in addition to standard care helps reduce BMI and improve glycemic control in type 2 diabetic patients. © 2011 by the American Diabetes Association.


Vernekar P.V.,Srinivas Institute of Medical Science and Research Center | Ananda Vaidya K.,Srinivas Institute of Medical Science and Research Center
Journal of Clinical and Diagnostic Research | Year: 2013

Introduction: Increased mean platelet volume is a known risk factor for various acute vascular complications, which is commonly associated with patients with diabetes mellitus. This study was aimed to investigate the association of Mean Platelet Volume (MPV) with Type 2 Diabetes Mellitus (DM) and to know the difference of MPV in patients on oral hypoglycaemic drugs and insulin therapy. Material and Methods: A total of 150 patients were selected and allocated to three Groups of 50 each, referred to as DM Group on insulin therapy, DM Group on oral hypoglycaemic therapy and non-DM Group (Negative control Group). Investigations like fasting blood glucose, HB A1c and MPV were performed. Difference between the means of age, MPV were calculated by analysis of variance (ANOVA) by using Tukey's Honestly Significant Difference (HSD) test. p-value and Confidence intervals were also calculated (p<0.05). Result: The outcome of study has shown that values of MPV are increased in patients with Type 2 DM, and are significantly higher in those patients on oral hypoglycaemic therapy than patients on insulin therapy. Conclusion: MPV is a simple and cost-effective tool which can be explored for predicting the possibility of acute vascular events in patients suffering from diabetes mellitus. Values of MPV are increased in patients with uncontrolled Type 2 DM, and are significantly higher in diabetic patients treated with oral hypoglycaemic therapy than in those patients on insulin therapy. Early initiation of insulin treatment in confirmed cases of Type 2 diabetics not only helps in controlling blood glucose level but also helps in keeping MPV low and thereby preventing possibility of impending acute vascular events.

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