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Sashidharan N.,Srinivas Institute of Medical science | Shenoy S.,Manipal University India | Kishore M.K.K.,Manipal University India | Thanusubramanian H.,Manipal University India
Journal of Clinical and Diagnostic Research | Year: 2015

Background: Multiple myeloma accounts for 1% of all neoplastic disorders and 10% of all haematological malignancies. Drugs like thalidomide, lenalidomide and bortezomib have emerged as active drugs in the treatment of multiple myeloma.There are few studies which have compared thalidomide-dexamethasone (thal/dex) and lenalidomide-dexamethasone (len/dex) in the treatment of multiple myeloma in Indian scenario Aim: To compare the efficacy and the adverse events observed with thalidomide-dexamethasone and lenalidomide-dexamethasone in the treatment of newly diagnosed cases of multiple myeloma. Settings and Design: Observational Study conducted in tertiary care centre. Materials and Methods: The case record files of patients from the year January 2006 to July 2011 with diagnosis of multiple myeloma were studied. Statistical Analysis: Primarily Descriptive. Results: There was no significant difference between thal/dex and len/dex treatment groups with respect to efficacy and safety in our study. Conclusion: Studies with larger sample size and a longer follow up to compare efficacy and safety of thal/dex and len/dex in treatment of multiple myeloma are required to be carried out to provide significant results. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.


Manjrekar P.A.,Center for Basic science | Hegde A.,Center for Basic science | Shrilaxmi,Srinivas Institute of Medical science | D'souza F.,Clinical Embryology | And 4 more authors.
Journal of Clinical and Diagnostic Research | Year: 2012

Introduction: A positive family history of diabetes increases the chances of developing the disease manifold. The earliest diagnostic marker for diabetes is elevated plasma glucose levels. Glycosylated haemoglobin (HbA1c) gives information on the long term control of diabetes, while the estimation of fructosamine (FA) depicts the short term glycaemic control. The specificity of the estimation of fructosamine and its comparison with the established markers in a group with high risk for the disease was the purport. Methods: 23 non-diabetic first degree relatives of type 2 diabetics (Group 2) were compared with 20 healthy controls (Group 1) and 23 type 2 diabetic people (Group 3). Fasting plasma glucose (FPG), glycosylated haemoglobin (HbA1c), serum fructosamine and total proteins (TP) were estimated in fasting blood samples. The saliva was analyzed for fasting salivary glucose (SG), salivary fructosamine and total proteins. The body mass index (BMI), waist circumference (WC) and the blood pressure were recorded and compared. Results: Group 3 had significantly higher mean FPG (150.26mg/dl), HbA1c (8.23 %) and salivary FA (202.05 mg/dl) values. Group 2 was associated with elevated serum FA levels (533.62 mg/dl), increased serum FA/ total protein (TP) ratio and a larger WC. On correlation analysis, FPG correlated significantly and positively with HbA1c in all three groups and with WC and BMI (0.613 and 0.400 respectively) in Group 2 only. Conclusion: Serum FA foretells the development of diabetes in high risk populations, but it has less sensitivity in depicting chronic hyperglycaemia. Serum FA and WC could be useful predictors of the development of diabetes in 'high risk' individuals.


Prabhu R.,Kasturba Medical College | Natarajan A.,Kasturba Medical College | Shenoy R.,Kasturba Medical College | Vaidya K.,Srinivas Institute of Medical science
BMJ Case Reports | Year: 2013

A 50-year-old man presented with a 5-month history of swelling over the right side of neck. The swelling was associated with dull aching pain radiating to the forearm without associated weakness of upper extremity or sensory loss. There was no history of trauma. On examination a fixed mass approximately 8×6 cm in size, smooth, firm in consistency, with ill-defined margins was present in the right posterior triangle. MRI scan of the neck revealed well-defined, lobulated, heterogeneously enhancing altered signal intensity mass at the root of neck. Debulking of the tumour was performed in view of its close proximity to the brachial plexus. Histopathology revealed aggressive fibromatosis (AF). AF is a benign fibrous neoplasm arising from fascia, periosteum and musculoaponeurotic structures of the body. AF in the head and neck region tends to be locally aggressive with a nature to invade bone and soft tissue structures. Copyright © 2013 BMJ Publishing Group. All rights reserved.


Sadhu S.,Kasturba Medical College | Prabhu R.,Kasturba Medical College | Natarajan A.,Kasturba Medical College | Vaidya K.,Srinivas Institute of Medical science
BMJ Case Reports | Year: 2013

A 43-year-old man known case of retropositive illness presented with abdomen pain of 15 days and loose stools for 10 days. Loose stools were foul smelling and blood stained. The patient was a known case of type 2 diabetes and retroviral illness on highly active antiretroviral therapy (HAART). General physical examination was normal. On examination an irregular mass was palpable in the right iliac fossa and right flank. The mass was hard in nature; irregular with restricted mobility. There was no palpable liver or spleen. CT of the abdomen and pelvis revealed a well-defined heterogeneously enhancing hypodense mass lesion measuring 16×11.7×12 cm involving the ileocaecal region and extending medially and inferiorly to sigmoid colon and rectum. A colonoscopy showed a proliferative highly vascular mass 15 cm from anal verge at the rectosigmoid junction. Histopathology revealed sheets of neoplastic lymphoid cells in rectal wall suggestive of non-Hodgkins lymphoma. Copyright 2013 BMJ Publishing Group. All rights reserved.


Prabhu R.,Kasturba Medical College | Natarajan A.,Kasturba Medical College | Shenoy R.,Kasturba Medical College | Vaidya K.,Srinivas Institute of Medical science
BMJ Case Reports | Year: 2013

A 65-year-old man presented with a swelling in the right groin of 6 months duration. The swelling was associated with dull aching pain and the patient reported of increase in size of the swelling during lifting of heavy weights. The swelling was 6×5 cm, hard in consistency, mobile and there was no impulse of cough. Ultrasonography showed a solid mass measuring 5.3×1.5×5.2 cm arising from the spermatic cord. High-inguinal orchiectomy was performed. Histopathology revealed rhabdomyosarcoma (RMS) of the spermatic cord. Patient was advised adjuvant chemotherapy but he refused. Spermatic cord RMS is a rare tumour derived from the undifferentiated mesoderm. It is most often observed in children and adolescents. It rarely appears after the second decade of life. It usually manifests as a painless, firm to hard mass in the inguinal canal or scrotum. Radical high-inguinal orchiectomy is the treatment of choice. © Copyright 2013 BMJ Publishing Group.

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