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Bhat B.M.,Kasturba Medical College | Raghuveer C.V.,Srinivas Institute of Medical science | D'Souza V.,Kasturba Medical College | Manjrekar P.A.,Kasturba Medical College
Journal of Clinical and Diagnostic Research | Year: 2012

Objectives: The present study was conducted to evaluate the effect of a standardized hydroalcoholic root extract of Salacia oblonga (SOE) on the Random Blood Glucose (RBG) levels, serum insulin, glycated haemoglobin (HbA1c) and the serum lipid profile in long standing, experimentally induced Diabetes Mellitus (DM) with glibenclamide (Glb) as the standard. Materials and Methods: Streptozotocin (STZ) induced, dia-betic, Wistar rats of either sex were treated with two oral doses of SOE, 100 and 50mg/kg body wt /day, for a period of 16 weeks. The RBG was estimated at day-1 and at the end of the 16 weeks by using a glucometer. The fasting serum insulin was determined by an ELISA technique. The plasma HbA1c was evaluated by a Turbidimetric Inhibition Immunoassay (TINIA) and the lipid profile was estimated enzymatically. Results and Analysis: A 45% decrease in the RBG was seen after the treatment with the higher dose of SOE, whereas a 44% decrease was observed with the lower dose as compared to the diabetic control. Serum insulin was significantly increased (P<0.05) in all the treated groups as compared to the diabetic control. Plasma HbA1c was significantly decreased (P<0.05). The serum Triacyl Glycerol (TG) levels were significantly decreased (P<0.05) in the treated rats as compared to the diabetic control. A significant increase in HDL-cholesterol (P<0.05) in the diabetic rats as a result of the 100mg/kg SOE treatment was a remarkable finding. Conclusion: SOE improves the glycaemic parameters in diabetic rats after a prolonged treatment. The serum TG levels were normalized on treatment. A higher dose of the extract could not alter the parameters significantly, except for HDL-C.


Sashidharan N.,Srinivas Institute of Medical science | Shenoy S.,Manipal University India | Kishore M.K.K.,Manipal University India | Thanusubramanian H.,Manipal University India
Journal of Clinical and Diagnostic Research | Year: 2015

Background: Multiple myeloma accounts for 1% of all neoplastic disorders and 10% of all haematological malignancies. Drugs like thalidomide, lenalidomide and bortezomib have emerged as active drugs in the treatment of multiple myeloma.There are few studies which have compared thalidomide-dexamethasone (thal/dex) and lenalidomide-dexamethasone (len/dex) in the treatment of multiple myeloma in Indian scenario Aim: To compare the efficacy and the adverse events observed with thalidomide-dexamethasone and lenalidomide-dexamethasone in the treatment of newly diagnosed cases of multiple myeloma. Settings and Design: Observational Study conducted in tertiary care centre. Materials and Methods: The case record files of patients from the year January 2006 to July 2011 with diagnosis of multiple myeloma were studied. Statistical Analysis: Primarily Descriptive. Results: There was no significant difference between thal/dex and len/dex treatment groups with respect to efficacy and safety in our study. Conclusion: Studies with larger sample size and a longer follow up to compare efficacy and safety of thal/dex and len/dex in treatment of multiple myeloma are required to be carried out to provide significant results. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.


Prabhu R.,Kasturba Medical College | Natarajan A.,Kasturba Medical College | Shenoy R.,Kasturba Medical College | Vaidya K.,Srinivas Institute of Medical science
BMJ Case Reports | Year: 2013

A 50-year-old man presented with a 5-month history of swelling over the right side of neck. The swelling was associated with dull aching pain radiating to the forearm without associated weakness of upper extremity or sensory loss. There was no history of trauma. On examination a fixed mass approximately 8×6 cm in size, smooth, firm in consistency, with ill-defined margins was present in the right posterior triangle. MRI scan of the neck revealed well-defined, lobulated, heterogeneously enhancing altered signal intensity mass at the root of neck. Debulking of the tumour was performed in view of its close proximity to the brachial plexus. Histopathology revealed aggressive fibromatosis (AF). AF is a benign fibrous neoplasm arising from fascia, periosteum and musculoaponeurotic structures of the body. AF in the head and neck region tends to be locally aggressive with a nature to invade bone and soft tissue structures. Copyright © 2013 BMJ Publishing Group. All rights reserved.


Sadhu S.,Kasturba Medical College | Prabhu R.,Kasturba Medical College | Natarajan A.,Kasturba Medical College | Vaidya K.,Srinivas Institute of Medical science
BMJ Case Reports | Year: 2013

A 43-year-old man known case of retropositive illness presented with abdomen pain of 15 days and loose stools for 10 days. Loose stools were foul smelling and blood stained. The patient was a known case of type 2 diabetes and retroviral illness on highly active antiretroviral therapy (HAART). General physical examination was normal. On examination an irregular mass was palpable in the right iliac fossa and right flank. The mass was hard in nature; irregular with restricted mobility. There was no palpable liver or spleen. CT of the abdomen and pelvis revealed a well-defined heterogeneously enhancing hypodense mass lesion measuring 16×11.7×12 cm involving the ileocaecal region and extending medially and inferiorly to sigmoid colon and rectum. A colonoscopy showed a proliferative highly vascular mass 15 cm from anal verge at the rectosigmoid junction. Histopathology revealed sheets of neoplastic lymphoid cells in rectal wall suggestive of non-Hodgkins lymphoma. Copyright 2013 BMJ Publishing Group. All rights reserved.


Nagesh K.R.,Father Muller Medical College | Menezes R.G.,Srinivas Institute of Medical science | Rastogi P.,Manipal University India | Naik N.R.,Regional Forensic Science Laboratory | And 3 more authors.
Journal of Forensic and Legal Medicine | Year: 2011

Colchicum autumnale is commonly known as autumn crocus, and as 'gowri gedde' in the southern region of Karnataka State in South India. It contains an alkaloid called colchicine, which blocks the cell division by inhibiting mitosis. We present a sporadic case of suicidal plant poisoning wherein a 24-year-old man consumed 'gowri gedde' to end his life. Initially he presented with severe vomiting, diarrhoea and epigastric pain. He died on the third day of ingestion due to multiorgan failure. Chemical analysis of blood and viscera obtained postmortem confirmed the presence of colchicine. Colchicine poisoning is potentially life threatening because of its high toxicity and unavailability of specific antidotal treatment. It classically presents with gastroenterocolitis, and may result in multiorgan failure in fatal cases. © 2011 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.


Prabhu R.,Kasturba Medical College | Natarajan A.,Kasturba Medical College | Shenoy R.,Kasturba Medical College | Vaidya K.,Srinivas Institute of Medical science
BMJ Case Reports | Year: 2013

A 65-year-old man presented with a swelling in the right groin of 6 months duration. The swelling was associated with dull aching pain and the patient reported of increase in size of the swelling during lifting of heavy weights. The swelling was 6×5 cm, hard in consistency, mobile and there was no impulse of cough. Ultrasonography showed a solid mass measuring 5.3×1.5×5.2 cm arising from the spermatic cord. High-inguinal orchiectomy was performed. Histopathology revealed rhabdomyosarcoma (RMS) of the spermatic cord. Patient was advised adjuvant chemotherapy but he refused. Spermatic cord RMS is a rare tumour derived from the undifferentiated mesoderm. It is most often observed in children and adolescents. It rarely appears after the second decade of life. It usually manifests as a painless, firm to hard mass in the inguinal canal or scrotum. Radical high-inguinal orchiectomy is the treatment of choice. © Copyright 2013 BMJ Publishing Group.


Ingle S.P.,Srinivas Institute of Medical science | Ramona I.,Srinivas Institute of Medical science | Sukesh,Srinivas Institute of Medical science
Journal of Clinical and Diagnostic Research | Year: 2013

Background: The objective of this study was to evaluate the serum PSA levels in patients presenting with enlarged prostate and to evaluate the efficiency of serum PSA to diagnose and differentiate benign and malignant enlargements. Methods: The authors evaluated the patients coming in surgical OPD with enlarged prostate and were advised to undergo serum PSA testing. Results: The efficiency of serum PSA to differentiate Benign and malignant lesions was 97.18% and 83.33% respectively.


PubMed | Manipal University India, Srinivas Institute of Medical science and District Civil Hospital
Type: Journal Article | Journal: Indian journal of pharmacology | Year: 2017

The present study was undertaken to evaluate anxiolytic effect of Eight groups of rats with six in each group were used. Group I served as control. Group II received diazepam (1 mg/kg). Groups III, IV, and V received CS in doses of 3.3, 16.5, and 33 mg/kg, respectively. Three pharmacologically validated experimental models - elevated plus maze (EPM), light and dark box (LDB), and open field tests (OFT) - were employed. Each animal was tested initially in the EPM and then in the LDB, followed by the OFT in a single setting. In EMP, number of entries into, time spent in, and number of rears in each arm in a 5-min period were noted. In LDB, number of entries and time spent in bright arena, number of rears, and duration of immobility were noted. In OFT, number of peripheral and central squares crossed, time spent, and number of rears in central squares were observed for a 5-min period. One-way ANOVA followed by In EPM and LDB, CS at 3.3, 16.5, and 33 mg/kg (acute and chronic models) increased the number of entries and time spent and rearing in the open arms and bright arena, respectively, compared to control. In the OFT, CS at 16.5 and 33 mg/kg significantly increased the number of squares crossed, time spent, and the number of rears in the central squares compared to control. Anxiolytic effect was dose dependent in EPM and LDB and CS at 33 mg/kg showed better anxiolytic activity compared to diazepam (1 mg/kg) in all models. Flumazenil (0.5 mg/kg) and bicuculline (1 mg/kg) completely inhibited while picrotoxin (1 mg/kg) partially inhibited the anxiolytic effect of CS. Diazepam and CS at 33 mg/kg reduced the locomotor activity in rats.CS has dose-dependent anxiolytic activity which is comparable to diazepam. Anxiolytic action of CS is likely mediated through GABA


PubMed | Kasturba Medical College, Srinivas Institute of Medical science, KVG Medical College and Aj Institute Of Medical Science
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2015

To measure the anthropometric data of school children and to compare with the CDC and Agarwal centile Growth charts. The prevalence of thinness, stunting, overweight and obesity were estimated. Children were also screened for hypertension, refractory errors, dental problems, skin disease and other abnormalities.Study was conducted in November in a central school in Surathkal, Dakshina Kannada, Karnataka, India. All children from nursery up to 10(th) standard were screened.Weight and Height were measured using standard equipment and plotted on CDC and Agarwal Charts. BMI was calculated and plotted on both charts. Blood Pressure (BP) was taken using mercury sphygmomanometer by a trained nurse. Vision was tested using Snellens chart by refractionist. Dental evaluation was done by dentist.Chi-square test and Students unpaired t test were used for statistical analysis. A statistical package SPSS version 17.0 were used. p<0.05 was considered as significant.Total 755 children were screened. Among these 392 (51.9%) were females and 363 (48.1%) were males. Eighty five (11.3%) children had short stature and 283 (37.5%) had under nutrition when plotted on CDC chart. Values were lower when plotted on Agarwal charts. Thinness was more prevalent than obesity and overweight. Majority were normotensive though hypertension was noted in 6(0.8%) children and prehypertension in 14(1.9%).112 children (16.3%) had undetected refractory error. Common skin disease noted was T.Versicolor in 27 children. Common dental problem noted was Caries teeth (22.9%).Weight and height were below the CDC centile charts. Under nutrition was more prevalent than overweight and obesity. Majority were normotensive. High prevalence of undetected refractory error and caries teeth were noted. Prevalence of skin disease was low.


Lasrado S.,Father Muller Medical College | Prabhu P.,Kasturba Medical College | Kakria A.,Kasturba Medical College | Kanchan T.,Manipal University India | And 6 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2012

Regional cancer epidemiology is an important basis for determining the priorities for cancer control in different countries worldwide. There is no reliable information about the pattern of head and neck cancer in western Nepal and hence an attempt was here made to evaluate the situation based on hospital data, which provide the only source in the western region of Nepal. A clinicopathological analysis of head and neck cancers treated between 2003 and 2006 in Manipal Teaching Hospital affiliated to Manipal College of Medical Sciences, Pokhara, Western Development Region, Nepal was performed. A total of 105 head and neck cancer cases were identified with a male to female ratio of 1.8:1. The median ages of male and female patients were 62 and 64 years, respectively. Ninety-seven (92.4%) of the cancer patients were suffering from carcinoma, three (2.9%) had blastoma, three (2.9%) had sarcoma, and two (1.9%) had lymphoma. The majority (61.9%) of carcinoma cases were squamous cell carcinoma followed by anaplastic carcinoma (7.2%). Of the carcinoma cases, the most common site of primary lesion was larynx (19.6%), followed by the thyroid (14.4%), the tongue and hypopharynx with 10.3% cases each. Comparative analysis among males and females did not reveal any sex difference in type of head and neck cancers. The head and neck cancer pattern revealed by the present study provides valuable leads to cancer epidemiology in western Nepal and useful information for health planning and cancer control, and future e research in western Nepal.

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