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Challa N.R.,Srini Pharmaceuticals Ltd. | Challa N.R.,Osmania University | Ghantac M.R.,Macleods Pharmaceuticals Ltd andheri East Mumbai | Padic P.R.,Macleods Pharmaceuticals Ltd andheri East Mumbai
Letters in Organic Chemistry | Year: 2011

During the course of our investigation in the field of thienopyridine based antithrombotic agents, we have identified and synthesized 4'-(6,7-dihydro-4H- thieno[3,2-c]pyridin-5-ylmethyl)-biphenyl-2-carboxylic acid derivatives 5a-i, a thienopyridine derivative with good in vivo activity against thrombus formation. These findings prompted us to prepare new 4'-(6,7-dihydro-4H-thieno[3,2-c] pyridin-5-ylmethyl)-bipheny1-2-carboxylic acid derivatives bearing different acid derivatives 5a-i in the hope of increasing activity and better understanding the influence of esters and amides on the thrombus formation. © 2011 Bentham Science Publishers Ltd. Source

Muralidhar A.,Sri Krishnadevaraya University | Babu K.S.,Sri Krishnadevaraya University | sankar T.R.,Srini Pharmaceuticals Ltd. | Reddanna P.,University of Hyderabad | Latha J.,Sri Krishnadevaraya University
International Journal of Phytomedicine | Year: 2011

The study aims to evaluate the wound healing properties of bioactive fractions from the extract of Butea monosperma (Lam) stem bark. In this study the stem bark powder was extracted with ethanol, further the ethanolic extract was fractionated with different solvents (petroleum ether, benzene, chloroform and acetone) in increasing order of polarity. Thus prepared extracts were subjected to preliminary phytochemical analysis. The wound healing activity of the ethanolic extract and the fractions isolated from the stem bark of Butea monosperma were evaluated in excision, incision and dead space wound healing models using Albino wistar rats. The wound healing activity was assessed by the breaking strength in case of incision wounds, epithelialization and wound contraction in case of excision wound and granulation tissue dry weight, breaking strength and hydroxyproline content in case of dead space wound. The ethanolic extract and the acetone fraction showed the significant wound healing activity on all three wound models. The phytochemical investigations revealed the presence of alkaloids, tannins, flavonoids, phenolic compounds and steroids. The increased rate of wound contraction and hydroxyproline content in the ethanolic extract and the acetone fraction treated animals provides a scientific base to the ethno medicinal use of Butea monosperma, which is largely attributable to the additive or synergistic effect of their constituents. Source

Challa N.R.,Srini Pharmaceuticals Ltd. | Challa N.R.,Osmania University | Mamidisetty B.,Srini Pharmaceuticals Ltd. | Ghanta M.R.,Macleods Pharmaceuticals Ltd. andheri East | Padi P.R.,Macleods Pharmaceuticals Ltd. andheri East
Journal of Saudi Chemical Society | Year: 2014

One pot synthesis and characterization of new 5-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridines (. 3a-k) using amides (. 2a-k) were reported. The prepared 5-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine (. 3a) is a bioisostere of 4'-(6,7-dihydro-4H-thieno [3,2-c]pyridin-5-ylmethyl)-biphenyl-2-carboxylic acid (. 1), having good in vivo antithrombotic activity compared with Clopidogrel. The new tetrazole derivatives (. 3a-k) were screened for their in vitro activity as platelet aggregation inhibitors. © 2011 . Source

Rao S.N.,Srini Pharmaceuticals Ltd. | Babu K.S.,Krishna University
Organic Communications | Year: 2011

Development of a new improved and efficient process suitable for the large-scale production of Irbesartan has been described. The key steps are tetrazole formation from secondary amide for the preparation of the key intermediate 1-Benzyl-5-(4'-bromomethyl-biphenyl-2-yl)-1H-tetrazole (9), N-alkylation and debenzylation. © 2011 Reproduction is free for scientific studies. Source

Somaiah S.,Srini Pharmaceuticals Ltd. | Sashikanth S.,Srini Pharmaceuticals Ltd. | Raju V.,Srini Pharmaceuticals Ltd. | Reddy K.V.,Osmania University
Tetrahedron Asymmetry | Year: 2011

An asymmetric conjugate addition reaction between a chiral α,β-unsaturated amido ester and ethyl-N-methylmalonamide has been used as a key step in the synthesis of (3S,4R)-(-)-trans-4-(4′- fluorophenyl)-3-hydroxymethyl-N-methylpiperidine, a key intermediate for (-)-paroxetine. © 2011 Elsevier Ltd. All rights reserved. Source

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