Srinagar, India
Srinagar, India
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Raturi R.,Central University of Costa Rica | Sati S.C.,Srinagar | Singh H.,Central University of Costa Rica | Sati M.D.,Srinagar | And 2 more authors.
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

Chemical examination of methanolic extract of Prunus persica steam bark, led to isolation of Acetophenone 6-hydroxy 4-methoxy 2-O-p-D-glucopyranoside (1), Crysophenol 8-O-p-D-glactopyranoside (2), along with p-Sitosterol and Querceitin. The structure of compounds 1 & 2 were elucidated with the help of chemical and spectral studies. The methanolic extract of plant was also evaluated for anti inflammatory activity against the wistar species of rats.

Kovil R.,Kovil Diabetes Center | Chawla M.,BSES Municipal General Hospital | Rajput R.,PGIMS | Singh A.K.,GD Hospital and Diabetes Institute | And 14 more authors.
Journal of Association of Physicians of India | Year: 2017

Introduction: Insulin is the oldest of the currently available treatment options in Type 2 diabetes mellitus (T2DM) and is considered as the most effective glucose lowering agent. Despite this, decision on starting insulin therapy is often delayed in India as well as worldwide due to various barriers at both patient and physician levels. Appropriate insulin dosing and titration is also critical to the successful achievement of tight glycaemic control. Objective: To provide simple and easily implementable guidelines to primary care physicians on appropriate insulin dosing and titration of various insulin regimens for both initiation and intensification. Methodology: Each insulin regimen (once daily [OD] basal, OD, twice daily and thrice daily premixed, basal-plus and basal-bolus) was presented and evaluated for dosing and titration based on established guidelines, data from approved pack inserts, and published scientific literature. These evaluations were then factored into the national context based on the expert committee representatives patient-physician experience in their clinical practice and common therapeutic practices followed in India. Results: Recommendations for dosing and titration of basal, basal-plus, premixed and basal-bolus insulins were developed. The key recommendations are that insulin doses can be adjusted once or twice weekly; adjustment can be based on lowest/mean of three recent self-monitoring of plasma glucose pre-meal/fasting plasma glucose (FPG) values. The titration should be based on FPG or pre-meal value of 80-130 mg/dL and the dose should be reduced by 10-20% for patients reporting hypoglycaemia(<70mg/dL). Conclusion:The consensus based recommendations mentioned in this paper will be a useful reference tool for health care practitioners, to initiate, optimise and intensify insulin therapy and to successfully achieve optimal glucose control. © 2017, Journal of Association of Physicians of India. All rights reserved.

Hussain A.,Srinagar | Aziz S.A.,Medical Oncology | Bhatt G.M.,Srinagar | Lone A.R.,Srinagar | And 3 more authors.
Journal of Obstetrics and Gynecology of India | Year: 2015

Aims: Gestational trophoblastic neoplasia (GTN) comprise a spectrum of interrelated conditions originating from the placenta. With sensitive assays for human chorionic gonadotropin (β-hCG) and current approaches to chemotherapy, most women with GTN can be cured with preservation of reproductive potential. The purpose of this analysis was to address the outcome of GTN in patients from a tertiary care center of India. Materials and Methods: We undertook a retrospective and prospective review of GTN cases treated at our center over a period of 7 years from 2008 to 2014. Patients of GTN were assigned to low-risk or high-risk categories as per the FIGO scoring system. The low-risk group was treated with combination of actinomycin-D and methotrexate and the high-risk group received the Etoposide, Methotrexate, Actinomycin-D/ Cyclophosphamide, Vincristine (EMA/CO) regimen. Salvage therapy was Etoposide, Paclitaxel /Paclitaxel, Cisplatin (EP/TP). Treatment was continued for three cycles after normalization of β-hCG level, after which the patients were followed up regularly. Results: In total, 41 GTN patients were treated at our institution during the above period; 17 were in the low-risk and 24 were in the high-risk category. The lung was the most common site of metastasis. All low-risk patients achieved complete remission. Among high-risk patients, one patient died while receiving first cycle chemotherapy, one patient relapsed, and 22 patients achieved complete remission. The single relapsed patient also achieved remission with second-line chemotherapy. Conclusion: Risk-stratified treatment of GTN was associated with acceptable toxicity and resulted in outcome that was comparable with international standards. The use of two-drug combination in low-risk patients is a better option especially in developing countries. © 2015 Federation of Obstetric & Gynecological Societies of India

Khan M.A.,Srinagar
Lakes and Reservoirs: Research and Management | Year: 2015

Hokersar wetland (altitude of 1584 masl), a shallow (0.5 m) floodplain waterfowl habitat in Kashmir, India, gained international importance in 2005 with its declaration as a Ramsar site. Although isolated in the western Himalayan mountains, it is being impacted by a silt-laden river (Doodhganga). Human activities, not the least of which is affected by the closeness of the wetland to suburban areas, have gradually altered its trophic state. Its alkaline- and calcium-rich waters contain many planktonic diatoms, green algae and cyanobacteria. Nitrate-nitrogen and total phosphorus concentrations are high (370-4750 and 101-968 μg L-1, respectively). A pronounced seasonal cycle in phytoplankton production (g C m-2 day-1) was evident in a minimum value of 0.38 (Jan-Feb, 2002) and a maximum value of 4.02 (July, 2002), closely paralleling the seasonal cycles of temperature and light. The photosynthetic efficiency of the wetland was highest (1.97%) during the summer. The annual phytoplankton production of this wetland ecosystem was 210 × 102 KJ m-2, suggestive of a meso-eutrophic status. © 2015 Wiley Publishing Asia Pty Ltd.

Wani I.A.,Srinagar | Bhat M.Y.,Srinagar | Banday F.A.,Srinagar | Khan I.A.,Srinagar | And 3 more authors.
Plant Archives | Year: 2012

Studies were carried out to find out association between different characters and magnitude of association of different characters in thirty three genotypes of pomegranate (Punica granatum L.). Data revealed that plant height, plant spread, number of fruit per tree, yield per tree and yield efficiency exhibited highly significant positive correlation. Among fruit characters, fruit length, fruit diameter, fruit weight, fruit volume, total aril weight, number of arils per fruit, rind thickness and rind weight recorded maximum positive correlation at phenotypic level. This study revealed that number of fruits per tree, yield per tree, fruit size; fruit weight and anthocyanin content form selection criteria for yield improvement in pomegranate. Therefore, direct emphasis need to be laid on the traits showing positive direct effects while selection for the number of fruits and fruit weight in pomegranate.

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