Srimad Andavan Arts and Science College

Tiruchirappalli, India

Srimad Andavan Arts and Science College

Tiruchirappalli, India

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Nithya V.,Srimad Andavan Arts and Science College | Baskar A.,Dhanalakshmi Srinivasan College for Women
Research Journal of Phytochemistry | Year: 2011

Lawsonia ulbalArav., is a reputed medicinal plant used in the treatment of various skin diseases in the Indian system of medicine. The objective of the study presented in this article was to evaluate the wound-healing potential of the ethanolic extract. The study was done on Wistar albino rats using excision, and dead space wounds models. The extract of Lawsonia ulba Linn., treated wounds were found to epithelize faster and the rate of wound contraction was significantly increased as compared to control wounds (p<0.01). Wet and dry granulation tissue weights and granulation tissue tensil strength in a dead space wound model also increased at statistically Significant differences at p<0.001 when compared to control. From the results, it may be concluded that, the ethanolic extract of Lawsonia ulba Linn, had greater wound healing activity than the nitrofurazone ointment. © 2011 Academic Journals Inc.


Prabhu R.N.,Srimad Andavan Arts and Science College | Ramesh R.,Bharathidasan University
Tetrahedron Letters | Year: 2016

A simple route for the synthesis of a new square-planar nickel(II) complex bearing 2-((3-methylthiophen-2-yl)methylene)-N-phenylhydrazinecarbothioamide ligand has been described. The composition of the complex has been established by elemental analysis, FT-IR, NMR, and single crystal X-ray crystallographic technique. The complex acts as an active homogeneous catalyst for the Sonogashira reaction of phenylacetylene with electron deficient (activating) and electron rich (deactivating) aryl halides (iodides and bromides) under optimized conditions. © 2016 Elsevier Ltd


Karnan M.,Srimad Andavan Arts and Science College | Balachandran V.,Aa Government Arts College | Murugan M.,Aa Government Arts College
Journal of Molecular Structure | Year: 2013

In this article the FT-IR and FT-Raman spectra of 5-chloro-4-nitro-o- toludine (CNOT) have been recorded and analyzed. The optimized geometry of the other halogen substitution (Br, F) has been computed with the help of density functional theory (DFT). The detailed interpretations of vibrational spectra of 5-chloro-4-nitro-o-toludine are furnished her, in terms of potential energy distribution analysis. Natural bond orbital analysis, HOMO-LUMO and molecular electrostatic potential surface on 5-chloro-4-nitro-o-toludine, 5-bromo-4-nitro-o-toludine and 5-fluoro-4-nitro-o-toludine were carried out for various intramolecular interactions that are responsible for the stabilization of the molecule. The thermodynamic functions were analyzed. The Mulliken charges, the values of electric dipole moment of the molecule were computed using DFT calculations obtained from Gaussian 09 software. We conclude that the observed and the calculated frequencies are found to be in good agreement. © 2013 Elsevier B.V. All rights reserved.


Agnel Arul John N.,Srimad Andavan Arts and Science College | Shobana G.,Srimad Andavan Arts and Science College
Journal of Applied Pharmaceutical Science | Year: 2012

Inflammation is a reaction of a living vascularised tissue to an injury. Conventional or synthetic drugs used in the treatment of inflammatory diseases are inadequate, it sometimes have serious side effects. So, number of herbal medicines is recommended for the treatment of inflammation that has no side effects. The present study is aimed to evaluate the anti inflammatory activity of Talinum fruticosum L on formalin induced paw edema in rats as for controlling inflammatory disorders. The objectives of the present study are to carry out phytochemical screening of selected plant drug, to prepare an aqueous extract from Talinum fruticosum L and to screen the in vivo anti inflammatory effect of Talinum fruticosum L. For phytochemical screening, the secondary metabolites like alkaloid, flavonoid, tannin, saponin, quinine were tested using qualitative spot tests. For anti inflammatory activity, wistar albino rats were used and divided into 6 groups and treated accordingly:Normal control, formalin induced group (0.1ml/kg bw), formalin+ Talinum fruticosum L (100mg/kg bw), formalin+ Talinum fruticosum L (200mg/kg bw), formalin+ Talinum fruticosum L (300mg/kg bw), and plant treated (300mg/kg bw).After the experimental period of 15 days, the blood and tissue samples were collected and biochemical parameter and histpathological studies were carried out. The phytochemical screening suggests the standardization, identity, purity and of presence of phytochemicals like saponins, tannins, flavonoids, terpenoids and cardiac glycosides. Oral administration of formalin to the experimental animals produced reduction in the levels of SOD, GSH, GPX , GR, serum protein and total RBC and Hb. The animals pretreated with Talinum fruticosum L extract at dose levels of 100,200,300mg/kg bw were significantly increased the levels of the above parameters. A significant increase in the length of the paw thickness, in the level of serum enzymes (SGOT, SGPT, ALP, CK) and Lipid peroxide (LPO), in the level of hydroxy proline, hexosamine and leucocytes was noted in the rats induced with formalin, while these levels were normalized by pretreatment with Talinum fruticosum L extract. The histopathological studies of edematous sections of formalin induced rat paw showed loss of cartilage, osteoblast hyperplasia. Talinum fruticosum L treated formalin induced rats showed moderate reduction in the cartilage and osteoblast. From the present observation, it is evidenced that Talinum fruticosum L would be an effective drug for the treatment of inflammatory reactions.


Karnan M.,Srimad Andavan Arts and Science College | Balachandran V.,Aa Government Arts College | Murugan M.,Aa Government Arts College
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2012

The optimized molecular structure and corresponding vibrational assignments of 3-hydroxy-6-methyl-2-nitropyridine have been investigated using density functional theory (DFT) B3LYP method with 6-311++G(d,p), 6-311++G(2d,2p) and 6-311++G(3d,3p) basis sets. Investigation of the relative orientation of the hydroxyl group with respect to the nitro group has shown that two conformers (O-cis) and (O-trans) exist. The vibrational analysis of the stable conformer of the title compound is performed by means of infrared absorption and Raman spectroscopy in combination with theoretical simulations. The molecular stability and bond strength were investigated by applying the natural bond orbital (NBO) analysis. Information about the size, shape, charge density distribution and site of chemical reactivity of the molecule has been obtained by mapping electron density isosurface with electrostatic potential (ESP). The isotropic chemical shift computed by 1H and 13C nuclear magnetic resonance (NMR) chemical shifts of the HMNP calculated using the gauge invariant atomic orbital (GIAO) method also shows good agreement with experimental observations. © 2012 Elsevier B.V. All rights reserved.


Sundaram M.,SASTRA University | Patra S.,University of Alabama at Birmingham | Maniarasu G.,Srimad Andavan Arts and Science College
Journal of Chinese Integrative Medicine | Year: 2012

OBJECTIVE: To evaluate antitumor activity of Gracilaria edulis in Swiss albino mice with Ehrlich ascites carcinoma (EAC). METHODS: Tumors were induced in mice by intraperitoneal injection of EAC cells. Ethanol extract of Gracilaria edulis (EEGE) was administered to the experimental animals in different doses after 24 h of tumor inoculation. The antitumor effect of the EEGE was evaluated by assessing in vitro cytotoxicity, survival time, biochemical parameters and hepatic enzyme levels. RESULTS: EEGE increased the life span of EAC-bearing mice compared with that of the model control mice (P<0.05 or P<0.01). EEGE treatment also converted the changes of biochemical parameters and hepatic enzyme levels in the EAC-bearing mice (P<0.05 or P<0.01). EEGE induced inhibition of tumor formation in EAC-bearing mice compared with that of the model control group (P<0.05 or P<0.01). CONCLUSION: The present study scientifically proved the antitumor activity of marine algae G. edulis and the effect can be correlated with doses.


Athesh K.,Srimad Andavan Arts and Science College | Divakar M.,Srimad Andavan Arts and Science College | Brindha P.,SASTRA University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014

Objective: This study was undertaken to evaluate the anti-obesity potential of the aqueous tuber extract of Cyperus rotundus L. (ATECR) in high fat cafeteria diet (HFCD) fed obese rats. Methods: Wistar strain of albino rats were divided into six groups comprising of six rats each. Group I served as normal control fed with normal pellet chow, group II served as disease control fed with high fat cafeteria diet, group III, IV and V animals, received ATECR at a dose level of 100, 200 and 300mg/kg bw along with HFCD for 40 days, while, group VI served as standard drug control, which received Orlistat at a dosage of 50mg/kg bw along with HFCD. Results: Administration of HFCD for 40 successive days to experimental rats significantly increased the body weight, organ and fat pad weights, serum total cholesterol, LDL cholesterol, VLDL cholesterol, triglycerides and glucose levels; and decreased HDL cholesterol as compared to normal control. While treatment with ATECR showed a significant reduction in the body weight gain, organ weight of the liver, kidney, spleen, weight of fat pads and the levels of serum triglycerides, total cholesterol, LDL cholesterol, VLDL cholesterol, glucose and increase in HDL cholesterol in a dose dependent manner. Further, the levels of liver markers such as aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP), which were found to be elevated in the serum of obese rats, also resumed to normal on treatment with different concentrations of ATECR. Moreover, the consumption of ATECR reduced oxidative stress by enhancing the levels of glutathione (GSH), glutathione peroxidase (GPx), super oxide dismutase (SOD) and catalase in the hepatic tissue of rats with HFCD induced obesity. Conclusion: These results demonstrate clearly that repeated oral administration of tubers of Cyperus rotundus L. aqueous extract can evoke a potent anti-obesity activity.


Akilavalli N.,Srimad Andavan Arts and Science College | Radhika J.,Srimad Andavan Arts and Science College | Brindha P.,SASTRA University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2011

Background: Recently man has started depending on natural resources even for his healthcare. Problems with drug resistant microorganisms, side effects of the modern medicine and the increasing number of emerging diseases for which no cure is available in modern medicine has renewed the interest in plants as a significant source of therapeutics. Primary Study Objective: Liver is a versatile organ that regulates the internal environment of the body and hence becomes prone to toxicity. Despite the tremendous strides in modern medicine there is still a need for a drug that stimulates liver function. Hence the present study focuses on the study of the hepatoprotective potentials of Ocimum sanctum Linn. in lead induced toxicity. Methods and Design: Aqueous extract of O. sanctum was prepared as per protocol. Wistar strains of Albino rats were used as the experimental models. Animals were grouped into six comprising of six rats each. Hepatotoxicity was induced using lead. The selected plant drug was administered to the animals orally for a period of 21 days. The Hepatic serum markers AST, ALT, ALP, GGT, Serum Protein, Serum Bilirubin and Tissue Glycogen were analyzed. The antioxidant status of the animals was also assessed in the animals by measuring the activity of GSH and SOD. The extent of lipid per oxidation (LPO) was also measured. Results: The results obtained depicted the protective nature of the selected drug source. The induction of liver injury with lead resulted in significant raise in the serum marker enzyme level along with an increase in the serum bilirubin content. The inactivation of the liver was evident from the lowered levels of serum protein and tissue glycogen levels. The antioxidant status was very low thus causing an accumulation in lipid peroxides in the hepatic tissues. All the parameters studied were restored to near normal when treated with the aqueous extract of O. sanctum. Values, p<0.05 were considered statistically significant. Conclusion: The present study clearly depicts the hepatoprotective nature of O.sanctum in lead induced toxicity. The protective activity may be attributed to the antioxidant activity of the plant.


Balakumar S.,SASTRA University | Rajan S.,Srimad Andavan Arts and Science College | Thirunalasundari T.,Bharathidasan University | Jeeva S.,Center for Biodiversity and Biotechnology
Asian Pacific Journal of Tropical Biomedicine | Year: 2011

Objective: To evaluate the in vitro antifungal activity of Aegle marmelos leaf extracts and fractions on the clinical isolates of dermatophytic fungi like Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis, Microsporum gypseum and Epidermophyton floccosum. Methods: The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of various extracts and fractions of the leaves of Aegle marmelos were measured using method of National Committee for Clinical Laboratory Standards (NCCLS). Results: Aegle marmelos leaf extracts and fractions were found to have fungicidal activity against various clinical isolates of dermatophytic fungi. The MIC and MFC was found to be high in water and ethyl alcohol extracts and methanol fractions (200μg/mL) against dermatophytic fungi studied. Conclusions: Aegle marmelos leaf extracts significantly inhibites the growth of all dermatophytic fungi studied. If this activity is confirmed by in vivo studies and if the compound is isolated and identified, it could be a remedy for dermatophytosis. © 2011 Asian Pacific Tropical Biomedical Magazine.


Rajan S.,Srimad Andavan Arts and Science College | Thirunalasundari T.,Bharathidasan University | Jeeva S.,Center for Biodiversity and Biotechnology
Asian Pacific Journal of Tropical Medicine | Year: 2011

Objective: To evaluate the phytochemical and anti-bacterial efficacy of the seed kernel extract of Mangifera indica (M. indica) against the enteropathogen, Shigella dysenteriae (S. dysenteriae), isolated from the diarrhoeal stool specimens. Methods: The preliminary phytochemical screening was performed by the standard methods as described by Harborne. Cold extraction method was employed to extract the bioactive compounds from mango seed kernel. Disc diffusion method was adopted to screen antibacterial activity. Minimum inhibitory concentration (MIC) was evaluated by agar dilution method. The crude extracts were partially purified by thin layer chromatography (TLC) and the fractions were analyzed by high performance thin layer chromatography (HPTLC) to identify the bioactive compounds. Results: Phytochemical scrutiny of M. indica indicated the presence of phytochemical constituents such as alkaloids, gums, flavanoids, phenols, saponins, steroids, tannins and xanthoproteins. Antibacterial activity was observed in two crude extracts and various fractions viz. hexane, benzene, chloroform, methanol and water. MIC of methanol fraction was found to be (95±11.8) μg/mL. MIC of other fractions ranged from 130-380 μg/mL. Conclusions: The present study confirmed that each crude extracts and fractions of M. indica have significant antimicrobial activity against the isolated pathogen S. dysenteriae. The antibacterial activity may be due to the phytochemical constituents of the mango seed kernel. The phytochemical tannin could be the reason for its antibacterial activity. © 2011.

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