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Karnan M.,Srimad Andavan Arts and Science College | Balachandran V.,Aa Government Arts College | Murugan M.,Aa Government Arts College
Journal of Molecular Structure | Year: 2013

In this article the FT-IR and FT-Raman spectra of 5-chloro-4-nitro-o- toludine (CNOT) have been recorded and analyzed. The optimized geometry of the other halogen substitution (Br, F) has been computed with the help of density functional theory (DFT). The detailed interpretations of vibrational spectra of 5-chloro-4-nitro-o-toludine are furnished her, in terms of potential energy distribution analysis. Natural bond orbital analysis, HOMO-LUMO and molecular electrostatic potential surface on 5-chloro-4-nitro-o-toludine, 5-bromo-4-nitro-o-toludine and 5-fluoro-4-nitro-o-toludine were carried out for various intramolecular interactions that are responsible for the stabilization of the molecule. The thermodynamic functions were analyzed. The Mulliken charges, the values of electric dipole moment of the molecule were computed using DFT calculations obtained from Gaussian 09 software. We conclude that the observed and the calculated frequencies are found to be in good agreement. © 2013 Elsevier B.V. All rights reserved. Source

Sundaram M.,SASTRA University | Patra S.,University of Alabama at Birmingham | Maniarasu G.,Srimad Andavan Arts and Science College
Journal of Chinese Integrative Medicine | Year: 2012

OBJECTIVE: To evaluate antitumor activity of Gracilaria edulis in Swiss albino mice with Ehrlich ascites carcinoma (EAC). METHODS: Tumors were induced in mice by intraperitoneal injection of EAC cells. Ethanol extract of Gracilaria edulis (EEGE) was administered to the experimental animals in different doses after 24 h of tumor inoculation. The antitumor effect of the EEGE was evaluated by assessing in vitro cytotoxicity, survival time, biochemical parameters and hepatic enzyme levels. RESULTS: EEGE increased the life span of EAC-bearing mice compared with that of the model control mice (P<0.05 or P<0.01). EEGE treatment also converted the changes of biochemical parameters and hepatic enzyme levels in the EAC-bearing mice (P<0.05 or P<0.01). EEGE induced inhibition of tumor formation in EAC-bearing mice compared with that of the model control group (P<0.05 or P<0.01). CONCLUSION: The present study scientifically proved the antitumor activity of marine algae G. edulis and the effect can be correlated with doses. Source

Nithya V.,Srimad Andavan Arts and Science College | Baskar A.,Dhanalakshmi Srinivasan College for Women
Research Journal of Phytochemistry | Year: 2011

Lawsonia ulbalArav., is a reputed medicinal plant used in the treatment of various skin diseases in the Indian system of medicine. The objective of the study presented in this article was to evaluate the wound-healing potential of the ethanolic extract. The study was done on Wistar albino rats using excision, and dead space wounds models. The extract of Lawsonia ulba Linn., treated wounds were found to epithelize faster and the rate of wound contraction was significantly increased as compared to control wounds (p<0.01). Wet and dry granulation tissue weights and granulation tissue tensil strength in a dead space wound model also increased at statistically Significant differences at p<0.001 when compared to control. From the results, it may be concluded that, the ethanolic extract of Lawsonia ulba Linn, had greater wound healing activity than the nitrofurazone ointment. © 2011 Academic Journals Inc. Source

Karnan M.,Srimad Andavan Arts and Science College | Balachandran V.,Aa Government Arts College | Murugan M.,Aa Government Arts College
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2012

The optimized molecular structure and corresponding vibrational assignments of 3-hydroxy-6-methyl-2-nitropyridine have been investigated using density functional theory (DFT) B3LYP method with 6-311++G(d,p), 6-311++G(2d,2p) and 6-311++G(3d,3p) basis sets. Investigation of the relative orientation of the hydroxyl group with respect to the nitro group has shown that two conformers (O-cis) and (O-trans) exist. The vibrational analysis of the stable conformer of the title compound is performed by means of infrared absorption and Raman spectroscopy in combination with theoretical simulations. The molecular stability and bond strength were investigated by applying the natural bond orbital (NBO) analysis. Information about the size, shape, charge density distribution and site of chemical reactivity of the molecule has been obtained by mapping electron density isosurface with electrostatic potential (ESP). The isotropic chemical shift computed by 1H and 13C nuclear magnetic resonance (NMR) chemical shifts of the HMNP calculated using the gauge invariant atomic orbital (GIAO) method also shows good agreement with experimental observations. © 2012 Elsevier B.V. All rights reserved. Source

Balakumar S.,SASTRA University | Rajan S.,Srimad Andavan Arts and Science College | Thirunalasundari T.,Bharathidasan University | Jeeva S.,Center for Biodiversity and Biotechnology
Asian Pacific Journal of Tropical Biomedicine | Year: 2011

Objective: To evaluate the in vitro antifungal activity of Aegle marmelos leaf extracts and fractions on the clinical isolates of dermatophytic fungi like Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis, Microsporum gypseum and Epidermophyton floccosum. Methods: The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of various extracts and fractions of the leaves of Aegle marmelos were measured using method of National Committee for Clinical Laboratory Standards (NCCLS). Results: Aegle marmelos leaf extracts and fractions were found to have fungicidal activity against various clinical isolates of dermatophytic fungi. The MIC and MFC was found to be high in water and ethyl alcohol extracts and methanol fractions (200μg/mL) against dermatophytic fungi studied. Conclusions: Aegle marmelos leaf extracts significantly inhibites the growth of all dermatophytic fungi studied. If this activity is confirmed by in vivo studies and if the compound is isolated and identified, it could be a remedy for dermatophytosis. © 2011 Asian Pacific Tropical Biomedical Magazine. Source

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