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Khusroo M.J.,Jamia Hamdard University | Ahmad P.,Jamia Hamdard University | Rahman R.U.,Sri Siddhartha Medical College and Research Center | Alam M.J.,Jamia Hamdard University | And 3 more authors.
Molecular and Cellular Biochemistry | Year: 2013

The hepatoprotective activity of flavonoid rhamnocitrin 4'-β-d-galactopyranoside (RGP) obtained from leaves of Astragalus hamosus L. against N-diethylnitrosamine (DENA)-induced hepatic cancer in Wistar albino rats was evaluated. Hepatic cancer in rats was induced by single-dose intraperitoneal administration of DENA (200 mg/kg). Induction of hepatic cancer was confirmed after 7 days of DENA administration by measurement of elevated level of serum α-feto protein (AFP). Administration of DENA in a single dose lofted the levels of serum biochemical parameters like alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, total protein and AFP. Antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and lipid per oxidation (LPO) were annealed significantly by administration of RGP in a dose-dependant manner. The histopathological examination of rat liver section was found to reinforce the biochemical observations significantly. It was observed that a substantial and dose-dependent reversal of DENA-diminished activity of antioxidant enzymes like SOD, CAT, GPx, GST and the reduced DENA-elevated level of LPO with a marked change. Any elevation in the levels of serum markers along with suppression of free radical formation by scavenging the hydroxyl radicals is significantly prevented by RGP. It also modulates the levels of LPO and perceptibly increases the endogenous antioxidant enzymes level in DENA-induced hepatocellular carcinogenesis. The findings suggest that RGP prevents hepatocellular carcinoma by suppressing the marked increase in the levels of serum marker enzymes, and suppresses the free radical by scavenging hydroxyl radicals. © 2013 Springer Science+Business Media New York.


Parvathidevi G.K.,Sri Siddhartha Medical College and Research Center | Panduranga C.,Sri Siddhartha Medical College and Research Center | Munishwar G.B.,Sri Siddhartha Medical College and Research Center
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2011

The "ancient" variant of schwannomas is a rare subtype of a benign encapsulated neoplasm of nerve sheath. A review of current literature has revealed several reported sites but not in the hypopharynx. Here we report such a hypopharyngeal tumour arising in a 32 year old man, paying particular attention to the potential diagnostic difficulties. © 2011 Association of Otolaryngologists of India.


Bhargavi S.K.,Sri Siddhartha Medical College and Research Center | Maruthi Prasad B.V.,Bangalore Medical College and Research Institute | Vishwanath H.L.,Bangalore Medical College and Research Institute
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism in which glucose is underused, producing hyperglycemia. An epidemic of Type 2 DM is underway and has become one of the world's most important public health problems. Adiponectin, a protein hormone, is produced by the adipose tissue. It has pronounced effects on the metabolism of both carbohydrates and lipids in liver and muscle. It is considered to have anti-inflammatory and anti-atherogenic effects. Levels are low in presence of insulin resistance and show important relationships with development of type 2 Diabetes Mellitus and its complications. Hence serum adiponectin levels were measured as a risk factor for DM. A case control study was done to estimate serum adiponectin levels in 30 type 2 DM patients and compare with age and sex matched controls and to assess adiponectin levels as an early predictor of onset of type 2 DM. Patients with renal, liver and thyroid disorders were excluded. Serum adiponectin was measured by competitive ELISA method. The mean serum adiponectin levels in cases is 5.91±1.47μg/mL and p value <0.001. The mean serum adiponectin levels in controls is 11.40±1.88μg/mL and p value <0.001. The mean serum adiponectin levels in diabetics without complications is 6.67 ±1.01μg/mL and that of diabetics with complications is 4.14±0.66μg/mL and p value of <0.001**. Diabetic patients have lower levels of adiponectin compared to healthy controls. Results of this study also show that diabetic patients with complications have lower adiponectin levels compared to that of diabetics without complications. Thus adiponectin may represent a link between insulin resistance and endothelial dysfunction making it an attractive candidate marker for further studies in type 2 DM.


Arathi C.A.,Sri Siddhartha Medical College and Research Center | Prabhudeva N.,Sri Siddhartha Medical College and Research Center | Arundhathi S.,Sri Siddhartha Medical College and Research Center
International Journal of Pharma and Bio Sciences | Year: 2014

Background: Population based surveys have renewed the debate and have referred to the high prevalence of anemia among elderly people as a "public health crisis". Anemia of any degree is recognized as a significant independent contributor to morbidity, mortality, and frailty in elderly patients. Efforts to understand anemia in elderly has become a major target of research interest About one third of them have anemia secondary to nutritional defieciency, one third due to chronic inflammation or chronic renal disease, and one third have unexplained anemia. Aim: To study the morphlogical types and etiologies of anemias in elderly Material and methods: 100 patients (either sex, >60yrs) were selected, clinical data and various laboratory investigations, complete hemogram, reticulocyte count, blood urea nitrogen, creatinine and serum ferritin were done for all and special investigations like bone marrow study, endoscopy, ultrasound examinations etc were done wherever required. Based on history, clinical evaluation and the laboratory investigations, the anemias were morphologically and aetiologically classified. Results: Majority of the patients had hemoglobin levels in the range of 9.8 to 11.4gm%. Anemia was morphologically typed based on the peripheral smear findings and complete blood counts, into normocytic(42%), microcytic(28%), macrocytic(19%), and pancytopenia(11%). Majority of the cases, had anemia of chronic diseases(36%) followed by anemia of unknown etiology(24%). 17% included both hematological and non-hematological malignant cases. Conclusion: Until further data are available, anemia in the elderly should be evaluated and remediable causes treated, but the anemia itself should not be treated unless the patient is severely symptomatic or in danger of needing a transfusion.

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