Baliga M.S.,Father Muller Hospital Road |
Haniadka R.,Father Muller Hospital Road |
Pereira M.M.,Father Muller Hospital Road |
D'Souza J.J.,Father Muller Hospital Road |
And 2 more authors.
Critical Reviews in Food Science and Nutrition | Year: 2011
The rhizomes of Zingiber officinale Roscoe (Zingiberaceae), commonly known as ginger, is one of the most widely used spice and condiment. It is also an integral part of many traditional medicines and has been extensively used in Chinese, Ayurvedic, Tibb-Unani, Srilankan, Arabic, and African traditional medicines, since antiquity, for many unrelated human ailments including common colds, fever, sore throats, vomiting, motion sickness, gastrointestinal complications, indigestion, constipation, arthritis, rheumatism, sprains, muscular aches, pains, cramps, hypertension, dementia, fever, infectious diseases, and helminthiasis. The putative active compounds are nonvolatile pungent principles, namely gingerols, shogaols, paradols, and zingerone. These compounds are some of the extensively studied phytochemicals and account for the antioxidant, anti-inflammatory, antiemetic, and gastroprotective activities. A number of preclinical investigations with a wide variety of assay systems and carcinogens have shown that ginger and its compounds possess chemopreventive and antineoplastic effects. A number of mechanisms have been observed to be involved in the chemopreventive effects of ginger. The cancer preventive activities of ginger are supposed to be mainly due to free radical scavenging, antioxidant pathways, alteration of gene expressions, and induction of apoptosis, all of which contribute towards decrease in tumor initiation, promotion, and progression. This review provides concise information from preclinical studies with both cell culture models and relevant animal studies by focusing on the mechanisms responsible for the chemopreventive action. The conclusion describes directions for future research to establish its activity and utility as a human cancer preventive and therapeutic drug. The above-mentioned mechanisms of ginger seem to be promising for cancer prevention; however, further clinical studies are warranted to assess the efficacy and safety of ginger. © Taylor and Francis Group, LLC.
Gangadhar S.B.,Sri Siddhartha Medical College |
Gopal T.M.,Maidstone General Hospital |
Sathyabhama,Maidstone General Hospital |
Paramesh K.S.,Kingston Hospital
Indian Journal of Anaesthesia | Year: 2012
The number of day-care surgeries is increasing every day. The boundaries of day-care surgeries are being redefined on a continual basis. Multi-dimensional benefits to the patient, hospital and national economy are the driving forces behind the changing scenario on the horizon of day surgery. The literature search included Google, medlinx, pubmed and medline. We have attempted to look at the controversies in patient selection with comorbidities, preoperative assessment and an acceptable ASA grade of patients. An attempt is also made to look at suitable surgical procedures, a pathway of introducing procedures, which are still complex and specialist procedures in challenging environment. The techniques of general anaesthesia, central neuraxial blocks, regional nerve blocks with indwelling catheters and monitoring techniques are deliberated upon. Finally the most important post-operative issues of discharge criteria, including recovery after spinal anaesthetic, oral fluid intake, voiding and travel after day surgery, are considered.
Belagavi A.C.,Ms Ramaiah Medical College And Hospitals |
Shalini M.,Sri Siddhartha medical College
Journal of Association of Physicians of India | Year: 2011
Objectives: to assess the utility of C-reactive protein (CrP) levels and adenosine deaminase (ADA) activity in the cerebrospinal fluid (CsF) as rapid screening tests to differentiate various types of meningitis in adults and to establish a cut off level for ADA. Methods: CsF samples were obtained from 50 patients who presented to the emergency room and out-patient of sri siddhartha medical Hospital, tumkur during the period between August 2006 and september 2008. Diagnosis of meningitis was based on the clinical presentation and CsF analysis. Results: Out of a total of 50 patients who were enrolled in the study, 24 were diagnosed as tubercular meningitis (tbm) based on the clinical features and CsF analysis. the mean Adenosine deaminase (ADA) activity was 14.14±7.44 U/l in the tbm group. the sensitivity and specificity was 73.9% and 92.6% respectively when a cut-off value of ADA of 10U/l was used, with an accuracy of 84%. CsF-C reactive protein (CrP) was significantly higher in pyogenic meningitis compared to non-pyogenic meningitis. the sensitivity and specificity of the test was 83.3% and 100% respectively with an accuracy of 98%. Conclusions: 2 rapid screening tests- CrP and ADA activity in the CsF can help in the differential diagnosis of pyogenic from non-pyogenic meningitis and tubercular from viral meningitis respectively. CrP being elevated in pyogenic meningitis and ADA activity noted to be higher in tbm. the levels of ADA and CrP were found to be low in viral meningitis. © JAPI.
Ragunatha S.,Sri Siddhartha Medical College |
Ramesh M.,Sri Siddhartha Medical College |
Anupama P.,Sri Siddhartha Medical College |
Kapoor M.,Sri Siddhartha Medical College |
Bhat M.,Sri Siddhartha Medical College
Pediatric Dermatology | Year: 2015
Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder of keratinization caused by homozygous mutations in the gene encoding lysosomal protease cathepsin C (CTSC). It is clinically characterized by transgredient palmoplantar keratoderma (PPK) and periodontitis. A 15-year-old boy presenting with PPK from the age of 6 months and late-onset periodontitis that began at the age of 12 years is described. Mutation analysis revealed a homozygous nonsense mutation (p.Y304X) in exon 7 of the CTSC gene. Late-onset periodontitis in a patient with Papillon-Lefèvre syndrome is a rare phenotypic variation. © 2015 Wiley Periodicals, Inc.
Chandru K.,Sri Siddhartha Medical College
Indian Journal of Forensic Medicine and Toxicology | Year: 2010
Back ground and objective: With wide spread use of electricity at home and work place the amount of electrical related injuries are on the rise. The present study attempts to know distribution pattern of electrical injuries and Histo Pathological changes in skin with electrical contact mark and in internal organs. Methods: Study was conducted on deaths due to electrocution brought to Victoria hospital mortuary during the period of two years. Specimen of skin with contact mark and internal organs like heart, kidney was sent for Histo Pathological examination. Data will be collected from police inquest and photographic evidence from scene of occurrence. Result: Total number of 61 cases was studied in two-year period. High voltage electrocution constituted 54% of cases. Low voltage electrocution constituted 46%. High voltage electrocution mainly presented as flash burns, while low voltage electrocution presented with contact mark. Typical Histo Pathological changes were seen in skin and heart specimen sent for examination. Histo Pathological changes in kidney were nonspecific. Conclusion: Electric contact mark is diagnostic criteria for electrocution. Histo Pathological changes were used as supportive evidence in determining cause of death. Main reasons for electrocution deaths were found to be human negligence, faulty electrical equipments and connections and lack of protective measures.
Mallikarjuna Swamy C.M.,stitute of Medical science and Research Center |
Arathi C.A.,Sri Siddhartha Medical College |
Kodandaswamy C.R.,Sri Siddhartha Medical College
Journal of Cytology | Year: 2011
Background: The evaluation and management of various hepatic lesions is a common clinical problem and their appropriate clinical management depends on accurate diagnoses. Aims: To study the cytomorphological features of distinctive non-neoplastic and neoplastic lesions of the liver and to evaluate the sensitivity, specificity and diagnostic accuracy of ultrasonography (USG)-guided fine needle aspiration cytology (FNAC) in the diagnosis of liver diseases. Materials and Methods: Seventy - two patients with evidence of liver diseases underwent USG-guided, percutaneous FNAC. Cytomorphological diagnoses were correlated with clinical, biochemical and radiological findings, histopathological diagnoses and follow-up information. Results: The age of the patients ranged from eight months to 90 years with 48 males (66.67%) and 24 females (33.33%). Of the 72 cases, the cytological diagnosis was rendered in 71 patients and smears were inadequate for interpretation in one case. Neoplastic lesions (68.06%) were more common than non-neoplastic lesions (30.56%). The majority of the neoplastic lesions were hepatocellular carcinomas (36.12%) followed by metastatic adenocarcinomas (19.45%). Among non-neoplastic lesions, cirrhosis was the commonest lesion (8.34%). The overall diagnostic accuracy of FNAC was 97.82% with a sensitivity and specificity of 96.87 and 100% respectively. Conclusion: USG-guided FNAC of the liver is a safe, simple, cost-effective and accurate method for cytological diagnosis of hepatic diffuse, focal/nodular and cystic lesions with good sensitivity and specificity.
Arundhathi S.,Sri Siddhartha Medical College |
Ragunatha S.,Sri Siddhartha Medical College |
Mahadeva K.C.,Ms Ramaiah Medical College
Journal of Clinical and Diagnostic Research | Year: 2013
Background: Accurate diagnosis of vesiculobullous lesions of skin requires evaluation of clinical, histopathologic and immunofluorescence findings. Methods: A cross-sectional study of 68 patients to evaluate the clinical, histopathological and direct immunofluorescence (DIF) features in the diagnosis of cutaneous vesiculobullous disorders. The patients with vesiculobullous lesions were subjected to clinical examination regarding socio-demographic and clinical data. Two biopsy specimens were taken, one from intact vesicle for histopathological study and another from perilesional normal looking skin or oral mucosa for DIF. Results: Vesiculobullous lesions constituted 22.08% of total number of skin biopsies. The most common clinical diagnosis was pemphigus vulgaris (PV) in 36 cases, followed by bullous pemphigoid (BP) in 8 cases, pemphigus foliaceous (PF) in 6 cases, and dermatitis herpetiformis (DH) in 4 cases. Characteristic histopathological features were present in 26 cases of PV, 9 cases of BP and 4 cases of PF, and 17.7% showed non- specific changes. DIF was positive in 24 cases of PV, 9 cases of BP and 3 cases of PF, and negative in 34.92% of cases. Conclusion: Clinical, histopathological and DIF features together or in combination help in the final diagnosis of vesiculobullous disorders. Individually, none of these methods are diagnostic in each and every case.
Haniadka R.,Father Muller Medical College |
Popouri S.,Sri Siddhartha Medical College |
Palatty P.L.,Father Muller Medical College |
Arora R.,Office of the Controller Research and Development Life science and International Collaboration |
Baliga M.S.,Father Muller Medical College
Integrative Cancer Therapies | Year: 2012
Chemotherapy- and radiotherapy-induced nausea and vomiting are the most common, intractable and unpleasant side effects in patients undergoing treatment for cancer. 5-Hydroxytryptamine-3 (5-HT3) receptor antagonists plus dexamethasone have significantly improved the control of acute nausea and vomiting, but delayed nausea and vomiting remains a significant clinical problem. Combined neurokinin-1 receptor antagonists with 5-HT3 antagonists and steroids are observed to be better in the control of both acute and delayed emesis. However, the use of these antiemetics is observed to possess inherent side effects. The medicinal plants such as Scutellaria baicalensis, Korean red ginseng, American ginseng berry, Ganoderma lucidum, Zingiber officinale, grape seed extract, and the oil of Mentha spicata are reported to be effective in the treatment of nausea and vomiting mostly in preclinical studies. Of these, ginger has also been evaluated for its efficacy in humans and the results have been contradictory. The current review for the first time summarizes the results related to these properties. An attempt is also made to address the lacunae in these published studies and to emphasize aspects that need further investigations for these plants to be of use in clinics in the future. © The Author(s) 2012.
Geethanjali H.T.,Sri Siddhartha Medical College |
Lakshmi Prabha R.,Sri Siddhartha Medical College
Medico-Legal Update | Year: 2012
The skeletal remains presented to forensic anthropologists are often fragmentary. The objective of this study is to assess the feasibility of estimation of the length of femur from the measurements of its distal fragments. Then the stature could be estimated either by using multiplication factors or with the application of regression equations.1 A sample of 100 femora (50 male and 50 female) were obtained from Anatomy Department. Regression equations for the estimation of maximum femoral length have been calculated. The applicability of these equations to a forensic sample is addressed.
Ajith S.,Sri Siddhartha Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015
Eye is a mirror that reflects pathological changes occurring in many organs of the body. Chronic renal failure is irreversible and progressive process that result in End stage renal disease [ESRD] where patient depend on renal replacement for survival1. In this study we are looking for diabetic retinopathy in patients with ESRD of diabetic origin. To record the stage of retinopathy in end stage renal disease patients of diabetic origin and record the progress of retinopathy at the end of 6 months and 12 months in these patients. The study was done in Sri Siddartha Medical College, Tumkur from May 2014 to May 2015. This is a prospective non randomized study of 50 patients who were diagnosed end stage renal disease of diabetic etiology with or without hypertension. Majority of patients were in age group of 55-60 years accounting 60%, men 32% and women 28%. All patients were known to be diabetic for more than 5 years. Patients who were diabetic for about 11-15 years were the majority. All patients of NIDDM with ESRD had retinopathy.