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Mani P.M.,Sree Narayana Institute of Medical science | Kumar N.,Sri Siddartha Medical College | Manjunath G.N.,Sri Siddartha Medical College | Swamy R.M.,Sri Siddartha Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Osteoarthritis is a joint inflammation that results from cartilage degeneration in which nonsteroidal antiinflammatory drugs (NSAIDs) are the commonly used analgesics. This study intended to compare the selective NSAID (celecoxib) and non specific NSAID (diclofenac) in terms of Visual Analog Scale (VAS) scoring. This was a 7 days follow up study. Fifty male patients attending the out patient department of orthopedics with diagnosed osteoarthritis of knee joint were chosen. Patients treated with celecoxib were cosidered as group 1 and patients treated with diclofenac as group 2. VAS scoring was obtained before the treatment (day 1) and after the treatment (day 3, 5 and 7). Responses were analyzed using Paired Wilcoxon signed rank test and the rates of adverse events were compared between the two treatment groups using the Fisher's exact test. The patients were aged between 40 to 60 years. The age difference was not statistically significant (p-value = 0.59). The VAS scores between the groups before the treatment were not statistically significant. After the treatment, comparison for the corresponding days (i.e. day 3, 5 and day 7) showed that the difference in VAS scores were statistically significant only on day 5 and 7 (p<0.001). The comparison of the GI adverse events showed the difference was statistically significant (p<0.01). Also, the cost incurred on PIP was more with the patients treated with diclofenac. Celecoxib was associated with a lower VAS pain score and less upper gastrointestinal symptoms when compared to diclofenac in osteoarthritis of the knee joint.


Mani P.M.,Sree Narayana Institute of Medical science | Swamy R.M.,Sri Siddartha Medical College | Manjunath G.N.,Sri Siddartha Medical College | Venkatesh G.,Sri Siddartha Medical College | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

Dental students have a major role in dental health promotion not only through their skills but also as a role model for the general population. Therefore, this study intended to evaluate the attitude of undergraduate dental students towards their self oral care. This study also intended to find out the difference in attitude between the genders and between the students in the preclinical and clinical year. This is a questionnaire based study conducted in four colleges in Bangalore. The study was conducted using a modified version of HU-DBI questionnaire. The participants gave their responses according to five point Likert scale. High scores denoted the strength of positivity of the attitude. The data was analyzed using SPSS. Student t-test was used to find the significance level. Questionnaire was distributed to 430 students, out of which 421 students answered, that included consisted of 191 females (45.4%) and 230 males (54.6%). Among 421 participants, 199 participants (47.2%) belong to preclinical year of study and 222 (52.7%) from clinical year of study. Mean per question was higher in clinical year students when compared to preclinical year students, indicating the improvement in the attitude with the progress in the academic years. There was no significant difference in attitude between the genders towards the oral care. The current study shows that dental students show better attitude towards their dental care and they may form a better role model for the general population and patients.


Kumar G.V.,Sri Siddartha Medical College | Georgeen A.J.,Sri Siddartha Medical College | Viswanatha Kumar H.M.,Sri Siddartha Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

In India, as many as 1.72million children die annually in the the neonatal period. The main reason for this is Low Birth Weight (LBW) which important factor affecting maternal and child health. Therefore this was conducted to assess the morbidity and mortality patterns of LBW neonates in a tertiary care hospital. Low birth weight neonates (n- 100) who admitted in NICU were selected for the study. Complete clinical examination and investigations were done and complications were observed and studied. Of the 100 babies, 19 died due to respiratory failure, Septicemia and other factors. Aspiration and HIE were found to be other significant causes of mortality. NEC was not a significant cause of mortality. Low birth weight babies of mother of booked case, female babies and birth weight = 1500gms had better outcome in our study. It is important to monitor low birth weights babies and predisposing factors to decrease the neonatal morbidity and mortality.


Swamy R.M.,Sri Siddartha Medical College | Kumar N.,Sri Siddartha Medical College | Srinivasa K.,Sri Siddartha Medical College | Manjunath G.N.,Sri Siddartha Medical College | And 2 more authors.
Biomedical Research | Year: 2012

Diabetes mellitus (DM) and Thyroid dysfunction, the two endocrine disorders have found to influence each other. The effects of which are poorly understood. Therefore, the present study was undertaken to understand the association trend of thyroid dysfunction with diabetic process and to assess the hyperglycemic effect by correlating fasting serum glucose (FSG) and thyroid profile parameters. 58 type 2 DM patients were studied for their thyroid profile along with their fasting glucose levels. Analysis was performed by comparing the values with age and gender matched controls using student 't' test. Analysis showed that in type 2 diabetes mellitus patients, 7 (12.06%) patients had hypothyroidism and 18 (31.03%) subjects had subclinical hypothyroidism out of 58 subjects. Serum T3 and T4 hormone concentrations were low and Thyroid Stimulating Hormone (TSH) concentrations were high in Type 2 DM when compared to controls. But significant difference was found with T4 and TSH only (p value: <0.001). FSG did not show significant correlations with thyroid profile parameters. Type 2 Diabetes Mellitus patients are at risk for hypothyroidism and hence have to be followed up with serum TSH levels.


Ajith S.,Sri Siddartha Medical College | Basavaraju K.,Sri Siddartha Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The electrocardiogram (ECG) is the graphical recording of the electrical activity of the heart recorded from the body surface by electrodes positioned to reflect activity from variety of spatial perspectives. QT interval is of potential use in cardiovascular risk profiling. Acute and chronic smoking alters QT interval duration. In this study we are studying the association between QTc interval in smokers. Study was conducted in male individuals above 18 years age group selected from the general population. Smokers were selected as per World Health Organisation (WHO) 10th revision of International Statistical Classification of Diseases and related health problems (ICD-10) criteria of harmful use, Subjects were grouped into control and smokers. Each group consists of 50 subjects. QTC interval is determined using modified Bazett's formula. QTC interval values (in seconds) were 0.40 ± 0.06, 0.45 ± 0.04, among controls and smokers respectively. There was prolongation of QTc Interval in smokers compared to controls which was statistically significant. Cigarette smoking was associated with prolongation of the QTc interval. It may be due to autonomic dysfunction, and may be implicated with an increased cardiovascular risk in this population.


Tejaswini K.S.,Mysore Medical College and Research Institute | Shilpa M.,Sri Siddartha Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Meditation has profound effects on psychology and physiology. However less is known about the effect of Autosuggestion on physiological parameters. So the objective of this study is to assess the effect of meditation alone and the added effects of autosuggestion to meditation and to compare the effects of the two on respiratory parameters. The respiratory parameters like RR, TV, FVC, FEV1 and FEV1% were recorded by computerised Spirometer in 60 medical students of age group 16 to 20years, who were divided into two equal teams to be trained on meditation and meditation with autosuggestion. Results showed significant decrease (p < 0.001) in RR in both the groups after the training session. There was a significant increase in TV, FVC, FEV1 and FEV1% in both groups, but no significant differential increase between the groups, though meditation with autosuggestion had greater increase of all above compared to only meditation group. From the above results it was concluded that meditation can bring significant improvement in respiratory performance and wellbeing. Inculcation of autosuggestion in the practice provides an added benefit.


Swamy R.M.,Sri Siddartha Medical College | Mani P.M.,Sree Narayana Institute of Medical science | Manjunath G.N.,Sri Siddartha Medical College | Kumar N.,Sri Siddartha Medical College | Byrav P.,Sri Siddartha Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

In recent times plant derived substances has received attention and their use as medicines are being tried. Aegle Marmelos, one of the medicinal plants with traditional values against various diseases. Therefore, this study intended to investigate its bark extracts for its anti coagulant activity as it contains more coumarin than in any other part of the plant. The bark of Aegle Marmelos was dried, powdered and used for preparation of extracts. Two types of extracts were prepared, decoction and alcohol extract. Extracts were fed to male albino rats of 100gm to 200gm body weight which were grouped into 6 groups with 6 animals in each group. Group 1 was a "control" group, Group 2 "standard" and Group 3, 4, 5 & 6 were test rats. Tests were conducted after 1 hour of administering the drug. No animal was reused. The coagulation tests, namely bleeding time, whole blood clotting time, one stage Prothrombin time (PT) and Prothrombin index (PI) were conducted. Mice fed with either decoction or alcohol extract did not show any effect on bleeding time and clotting time. Both decoction and alcohol extract decreased the prothrombin index significantly (<0.05). The decrease was highly significant at larger dosages (200, 500 and 500mg/100gm body weight). Aegle marmelos extracts decreases the prothrombin index without affecting the bleeding or clotting time.


Ajith S.,Sri Siddartha Medical College | Sandhya R.,Sri Siddartha Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Refractive errors are the most common causes of childhood blindness in India. Refractive errors in childhood affects performance in school and has a negative influence on the development and maturity, thus affecting their performance. Early detection and correction of refractive errors with spectacles is best remedy to control prevalence of refractive errors. total of 1604 children were examined to study the prevalance of eye disorders. Visual acuity was tested by using Snellen's visual acuity chart. Fundus examination by direct ophthalmoscope. The prevalence of hypermetropia(44.6%) was high followed by astigmatism(33.1%) and myopia(22.3%). Study of clinical profile of visual impairment helps in early detection and treatment of refractive errors. Proper education of school teachers in detecting eye related disorders could be helpful in early detection and treatment of the child.

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