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Kannangai R.,Christian Medical College | David S.,Christian Medical College | Sundaresan V.C.,Christian Medical College | Sachithanandham J.,Christian Medical College | And 5 more authors.
Molecular Diagnosis and Therapy | Year: 2015

Introduction: Morbidity and mortality among HIV-1-infected individuals has been dramatically reduced by the implementation of combinational antiretroviral therapy (ART). However, the efficiency of these therapies is compromised due to HIV-1 transmitted drug resistance mutations (TDRMs). Methods: We collected a total of 127 samples from ART-naïve HIV-infected individuals and sequenced the pol gene and analysed for drug resistance mutations using the Calibrated Population Resistance (CPR) tool in the Stanford database. Results: All the 127 clinical samples (100 %) were identified as HIV-1 subtype C. Based on the CPR tool, three strains (2.4 %) had TDRMs, and these were K101E, Y181C and G190A. Our findings correlated well with the WHO surveys conducted in Asia, including India, which consistently reported <5 % TDRM among the specific populations assessed. Conclusion: In countries like India, regular monitoring of TDRMs will provide better information for clinical practice improvement and policy making. © 2015, Springer International Publishing Switzerland.


PubMed | Sri Sakthi Amma Institute of Biomedical Research Institute and Christian Medical College
Type: Journal Article | Journal: Molecular diagnosis & therapy | Year: 2015

Morbidity and mortality among HIV-1-infected individuals has been dramatically reduced by the implementation of combinational antiretroviral therapy (ART). However, the efficiency of these therapies is compromised due to HIV-1 transmitted drug resistance mutations (TDRMs).We collected a total of 127 samples from ART-nave HIV-infected individuals and sequenced the pol gene and analysed for drug resistance mutations using the Calibrated Population Resistance (CPR) tool in the Stanford database.All the 127 clinical samples (100%) were identified as HIV-1 subtype C. Based on the CPR tool, three strains (2.4%) had TDRMs, and these were K101E, Y181C and G190A. Our findings correlated well with the WHO surveys conducted in Asia, including India, which consistently reported<5% TDRM among the specific populations assessed.In countries like India, regular monitoring of TDRMs will provide better information for clinical practice improvement and policy making.

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