Sri Sai Aditya Institute of Pharmaceutical science and Research

Sri Mādhopur, India

Sri Sai Aditya Institute of Pharmaceutical science and Research

Sri Mādhopur, India
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Killi G.D.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Maddinapudi R.K.,Matrix | Dinakaran S.K.,Aditya Institute of Pharmaceutical science and Research | Harani A.,Andhra University
Brazilian Journal of Pharmaceutical Sciences | Year: 2014

A simple gradient Ultra Performance liquid chromatographic method (UPLC) was developed for determination of lopinavir and ritonavir from its related impurities and assay for the first time. This method involves the use of a C18 (Acquity UPLC BEH C18, 50 × 2.1 mm, 1.7 µm) column thermostated at 30 oC using triethylamine (pH 2.2): 0.1% H3PO4 in acetonitrile and methanol (85:15) as mobile phase in gradient elution mode. A Photo Diode Array (PDA) detector set at 215 nm was used for detection with flow rate 0.4 mL/min. This method was validated over the range of limit of quantitation (LOQ) to 50 to 150% of impurity specification limit and of working concentration for assay. The developed method was validated for linearity, range, precision, accuracy and specificity. This method was successfully applied for content determination of lopinavir and ritonavir in pharmaceutical formulations. This method can be conveniently used in quality control laboratory for routine analysis for assay and related substances as well as for evaluation of stability samples of bulk drugs and pharmaceutical formulations. © 2014, Faculdade de Ciencias Farmaceuticas (Biblioteca). All rights reserved.


Das S.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Ganapaty S.,Andhra University
Indian Journal of Pharmaceutical Sciences | Year: 2015

Phytochemical evaluation of the chloroform extract of roots of Polygonum viscosum has yielded six compounds, stigmasterol, 7,4-dimethylquercetin, kaempferol, quercetin, myricetin and scutellarein. Among the six compounds isolated and characterized by chemical and spectral (UV, NMR and Mass) analysis in the present phytochemical evaluation, stigmasterol was not reported earlier from P. viscosum. The compounds, 7,4-dimethylquercetin, quercetin and scutellarein were reported from P. hydropiper. Kaempferol from P. amphibium, P. aviculare, P. convolvulus, P. hydropiper, P. lapathifolium and P. persicaria and myricetin from P. aviculare and P. lapathifolium were also reported earlier. This appers to be the first report of the occurrence of all the six compounds from P. viscosum.


Das S.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Bhavani M.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Naresh P.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Ramana M.V.,Sri Sai Aditya Institute of Pharmaceutical science and Research
Indian Journal of Pharmaceutical Sciences | Year: 2015

A cross-sectional study of 250 cases of type 2 diabetes management was conducted in a governmental tertiary care hospital of urban south India to determine the comparative prevalence of type 2 diabetes and its comorbidity with cardiovascular diseases in diabetic population, core drug use indicators and drug utilization pattern in the management of diabetics entirely and with cardiovascular diseases. Highest prevalent age group for type 2 diabetes/cardiovascular diseases (greater incidence in female than male) was 51-60 years. The 62.8% prevalence of cardiovascular diseases in the diabetic population ascertained in the study could provide an evidence-based rationale for the World Health Organization guidelines for the management of hypertension in type 2 diabetics. Incidence of polypharmacy (6.06, the mean number of total drug products prescribed); 59.26% of encounters prescribed antibiotics; 17.6 and 18.5 min of average consultation and dispensing time, respectively; 100% of drugs actually dispensed and adequately labeled; 81.26% of patients having knowledge of correct dosage and average drug cost of Indian Rupees 145.54 per prescription were the core drug use indicators found mainly. Moreover, drugs prescribed from the Essential Drug List were more than 90% and thereby indicated the drug use in this set-up quite rational. Around 71.09% of cardiovascular agents prescribed by generic name revealed the cost effective medical care. Among the agents in type 2 diabetes management, Actrapid® (35.43%) was the highest. Among the cardiovascular agents prescribed, lasix (19.37%) was the highest. Cardiovascular agents prescribed orally by 76.48% signified the good prescription habit indicating the improved patients' adherence to the treatment. The present study emphasizes the need of early detection of hypertension as a preliminary diagnostic parameter of cardiovascular diseases in diabetics and appropriate management through concomitant therapy of cardiovascular drugs to minimize the risks of death. © 2015 Indian Journal of Pharmaceutical Sciences.


Ahalya B.,Sri Sai Aditya Institute of Pharmaceutical science And Research | Shankar K.R.,Sri Sai Aditya Institute of Pharmaceutical science And Research | Kiranmayi G.V.N.,Sri Sai Aditya Institute of Pharmaceutical science And Research
International Journal of Pharmaceutical Sciences Review and Research | Year: 2014

Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for diabetes mellitus. The aim of present study was to demonstrate the hypoglycemic and anti-diabetic activity of the Ethanolic extract of Annona muricata stem bark in alloxan induced diabetic animals with a view to explore its use for the treatment of diabetes mellitus in humans. The Ethanolic extract of Annona muricata (Annonaceae) stem was investigated for its anti-hyperglycemic and anti-hyperlipidemic effects in male albino rats. Diabetes was induced in the albino rats by administration of a single dose of alloxan monohydrate (150 mg/kg, bwt, i.p) and the Ethanolic bark extract of A. muricata was administered daily at single doses of 150 and 300 mg/kg, p. o to diabetesinduced rats for a period of 14 days. The effect of Ethanolic extract of A. muricata bark on blood glucose level was measured in the diabetic rats. Serum lipid profiles [total cholesterol, triglycerides, phospholipids (low density, very low density and high density lipoprotein)] were also determined. The activities were also compared to the activity produced by a standard anti diabetic agent, Glibenclamide (500 μg/kg). The present investigation established pharmacological evidence to support the folklore claim that Ethanolic extract of Annona muricata stem bark is an anti-diabetic agent.


Narayana Reddy T.N.V.S.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Divya Teja Banda S.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Diwaker Srinivas G.,Sri Sai Aditya Institute of Pharmaceutical science and Research
International Journal of Pharmaceutical Sciences Review and Research | Year: 2013

Fast Dissolving Tablets (FDT) are most accepted and exploited for the drug delivery for the patients who are having difficulty with swallowing i.e., mainly paediatrics' and Geriatric's. Amlodipine besilate (ADB) is an anti-hypertensive and it is also used in many Coronary artery diseases, Whereas Atorvastatin Calcium (ASC) is an anti-hyperlipidaemia that prevents of Atheroma. In the present study a combination of ADB, ASC is formulated into a fast dissolving tablet using three super disintegrates such as Croscarmellose Sodium (CCS), Cross povidone (CP), Sodium Starch Glycolate (SSG) at various concentrations. The tablets were evaluated for weight variations, Hardness, Friability, Wetting time, disintegration time (DT) and Dissolution study. Prepared tablets are subject to FT-IR Study for Characterization and compatibility study. No Chemical interaction between drug and excipients were indicated in the FT IR. Disintegration and dissolution profiles decreases with addition of super disintegrating agents like Croscarmellose Sodium (CCS), Cross povidone (CP), Sodium Starch Glycolate (SSG). For CCS, CP increase in concentration up to 5% show increase in super disintegrant activity, but beyond that concentration they fail to delivery same as Sodium Starch Glycolate (SSG). Among all the formulation F9one with SSG in 8% Concentration found to be best in release profile. The tablets prepared by using direct compression method were found best. Drug Contents were estimated by using RP-HPLC method and assay of sample was compared with standard drugs (Amlodipine and Atorvastatin) were well resolved and the retention times were around at 3.437 and 6.067 respectively. From the result obtained, it was concluded that Super disintegrates CCS, CP have showed a super Disintegrant action better in lower concentration but they failed to show the same at concentrations greater than 5% w/w but Formulation with SSG has showed constant decrease in dissolution profile with increase in concentration.


Parvathi M.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Ravishankar K.,Sri Sai Aditya Institute of Pharmaceutical science and Research
Journal of Natural Remedies | Year: 2013

Clitoria ternatea (CT), a perennial herbaceous plant commonly known as 'butterfly pea', has been used for centuries as a traditional Ayurvedic medicine. The aim of present study was to investigate the anti depressant (by Tail suspension test and Forced swimming test), motor coordination (by Rota-rod method) and locomotor (with an actophotometer) activities of ethanolic root extract of Clitoria ternatea Linn. in experimental animals. The study revealed that the extracts (150 and 300 mg/kg, p.o.) were able to reduce the immobility time of rats in a dose-dependent manner when subjected to both Tail suspension and Forced swim tests, and the results were similar to that of standard drug imipramine (15 mg/kg, p.o.). Clitoria ternatea ethanolic root extract (300 mg/kg) showed mild reducti on in locomotor and motor coordinati on activity. The results indicated that ethanolic root extract of Clitoria ternatea has significant anti depressant activity (150 mg/kg (p<0.01) and 300 mg/kg (p<0.001)) when compared with standard imipramine (p<0.001) with a mild sedative effect (300 mg/kg only). The results of the sedative effect are not statistically significant, and the sedative effect may be due to higher dose. Therefore, Clitoria ternatea may be served as a potential resource for natural psychotherapeutic agent against depression and mood disorders.


Ravi Shankar K.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Das S.,Sri Sai Aditya Institute of Pharmaceutical science and Research
Indian Drugs | Year: 2011

The study was carried out to evaluate the in vitro anthelmintic activity of Dregea volubilis (L. f.) Benth. ex Hook. f. [Synonym: Wattakaka volubilis (L. f.) Stapf., Marsdenia volubilis (L. f.) Cooke and Schollia volubilis (L. f.) Jacq. ex Steud.] (Family: Asclepiadaceae) leaf from its ethanol (continuous hot percolation by ethanol in soxlet apparatus) and aqueous (cold maceration in distilled water for 72 h) extract using Indian earthworm Pheretima posthuma (Annelida). Different concentrations (10, 20 and 40 mg/mL) of each extract were tested in the bioassay using albendazole as reference standard to determine the time of paralysis and death of the worms. Both the extracts were found not only to paralyze (vermifuge) but also to kill the earthworms (vermicidal).


Das S.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Ganapaty S.,Andhra University
Asian Pacific Journal of Tropical Disease | Year: 2014

Objective: To study the anthelmintic activity of phytochemically charaterized chloroform extracts of Millettia auriculata leaves and stems. Methods: Chloroform extracts of leaves and stems were prepared. Phytochemical characterisation involved preliminary screening, optimisation of solvent system in thin layer chromatography (TLC) and UV absorption measurement of each bright yellow (in view of a common physical property of flavonoids) TLC fraction for each extract. Anthelmintic activity of each extract was carried out for different concentrations (10, 20 and 40 mg/mL) using Pheretima posthuma. Results: Phytochemical characterisation of the extracts revealed the presence of steroids/triterpenes, phenolics/flavonoids and carbohydrates with optimum TLC-separation in chloroform-hexane, 19:1. All the investigated extracts possessed significant anthelmintic activity (P<0.001) at a minimal dose of 10 mg/mL when compared with the corresponding concentration of reference drug albendazole. Leaf extract was found to have more efficacy and potency than that of stem and albendazole. Conclusions: The results of this study indicated that Millettia auriculata can be used as anthelmintic drug. It would be also interesting to find out any novel or existing chemical entities showing anthelmintic activity with mechanism of action. © 2014 Asian Pacific Tropical Medicine Press.


Vaidehi B.N.B.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Gnana Deepika K.,Sri Sai Aditya Institute of Pharmaceutical science and Research
International Journal of Pharma and Bio Sciences | Year: 2012

A set of 2-substituted benzimidazoles were successfully synthesized. Benzimidazoles were prepared by condensation of ortho-phenylenediamine with substituted acids in presence of ring closing agents like Polyphosphoric acid/ HCl. The synthesized compounds were characterized by IR spectroscopy and Elemental analysis. All the synthesized compounds were screened for anthelmenthic activity by using Albendazole as standard.


Ravishankar K.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Vishnu Priya P.S.V.,Sri Sai Aditya Institute of Pharmaceutical science and Research
International Journal of Pharma and Bio Sciences | Year: 2012

The present study was undertaken to investigate the diuretic effect of ethanolic seed extracts of Macrotyloma uniflorum and Cucumis melo in Albino rats. Ethanolic extracts of the seeds were administered to experimental rats orally at doses of 200mg/kg and 400mg/kg each p.o. Furosemide (5mg/kg) was used as a standard. The diuretic effects of the extracts were evaluated by measuring the Urine volume, Sodium, Potassium, Chloride and Bicarbonate contents. A significant Diuretic effect was observed from the experimental animals treated with extracts of Macrotyloma uniflorum and Cucumis melo individually compared to the control. Further, extract of Cucumis melo (400mg/kg) showed more diuretic effect than standard. This might be the first formal report on diuretic effects of both extracts individually. The results, to some extent explains the use of Macrotyloma uniflorum and Cucumis melo as a cure for renal diseases in Indian traditional medical practice. 1.

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