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Das S.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Ganapaty S.,Andhra University
Asian Pacific Journal of Tropical Disease | Year: 2014

Objective: To study the anthelmintic activity of phytochemically charaterized chloroform extracts of Millettia auriculata leaves and stems. Methods: Chloroform extracts of leaves and stems were prepared. Phytochemical characterisation involved preliminary screening, optimisation of solvent system in thin layer chromatography (TLC) and UV absorption measurement of each bright yellow (in view of a common physical property of flavonoids) TLC fraction for each extract. Anthelmintic activity of each extract was carried out for different concentrations (10, 20 and 40 mg/mL) using Pheretima posthuma. Results: Phytochemical characterisation of the extracts revealed the presence of steroids/triterpenes, phenolics/flavonoids and carbohydrates with optimum TLC-separation in chloroform-hexane, 19:1. All the investigated extracts possessed significant anthelmintic activity (P<0.001) at a minimal dose of 10 mg/mL when compared with the corresponding concentration of reference drug albendazole. Leaf extract was found to have more efficacy and potency than that of stem and albendazole. Conclusions: The results of this study indicated that Millettia auriculata can be used as anthelmintic drug. It would be also interesting to find out any novel or existing chemical entities showing anthelmintic activity with mechanism of action. © 2014 Asian Pacific Tropical Medicine Press. Source


Peer Basha D.,TherDose Pharma Pvt. Ltd. | Ravi Shankar K.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Kiranmayi G.V.N.,Sri Sai Aditya Institute of Pharmaceutical science and Research
International Journal of Pharma and Bio Sciences | Year: 2012

A rapid and sensitive RP-HPLC method with UV detection at 205 nm for routine analysis of Monothioglycerol in bulk and pharmaceutical formulations was developed. Chromatography was performed with mobile phase containing a mixture of acetonitrile and 0.01Mphosphate buffer in the ratio of 5:95, v/v with flow rate 1.0 ml/min. The calibration graph of Monothioglycerol was found to be linear over the range of 0.5 to1.5 mg/ml with correlation coefficient of 0.99. Sensitivity, accuracy, range, precision, robustness, ruggedness, stability, specificity, limit of detection, limit of quantification and system suitability parameters were validated for the developed method. The developed method was successfully applied to estimate the amount of Monothioglycerol in injection formulations. Source


Vaidehi B.N.B.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Gnana Deepika K.,Sri Sai Aditya Institute of Pharmaceutical science and Research
International Journal of Pharma and Bio Sciences | Year: 2012

A set of 2-substituted benzimidazoles were successfully synthesized. Benzimidazoles were prepared by condensation of ortho-phenylenediamine with substituted acids in presence of ring closing agents like Polyphosphoric acid/ HCl. The synthesized compounds were characterized by IR spectroscopy and Elemental analysis. All the synthesized compounds were screened for anthelmenthic activity by using Albendazole as standard. Source


Ravishankar K.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Vishnu Priya P.S.V.,Sri Sai Aditya Institute of Pharmaceutical science and Research
International Journal of Pharma and Bio Sciences | Year: 2012

The present study was undertaken to investigate the diuretic effect of ethanolic seed extracts of Macrotyloma uniflorum and Cucumis melo in Albino rats. Ethanolic extracts of the seeds were administered to experimental rats orally at doses of 200mg/kg and 400mg/kg each p.o. Furosemide (5mg/kg) was used as a standard. The diuretic effects of the extracts were evaluated by measuring the Urine volume, Sodium, Potassium, Chloride and Bicarbonate contents. A significant Diuretic effect was observed from the experimental animals treated with extracts of Macrotyloma uniflorum and Cucumis melo individually compared to the control. Further, extract of Cucumis melo (400mg/kg) showed more diuretic effect than standard. This might be the first formal report on diuretic effects of both extracts individually. The results, to some extent explains the use of Macrotyloma uniflorum and Cucumis melo as a cure for renal diseases in Indian traditional medical practice. 1. Source


Ravishankar K.,Sri Sai Aditya Institute of Pharmaceutical science and Research | Sandhya Ch.,Sri Sai Aditya Institute of Pharmaceutical science and Research
Biosciences Biotechnology Research Asia | Year: 2012

The world today is focusing more upon the herbal medication for curing various ailments. The trend of validating the plants with traditional medicinal usage is increasing. The present investigation deals with the phytochemical screening and evaluation of in vitro antioxidant properties of Mimosa catechu ethanolic bark extract. The In vitro antioxidant activity was evaluated using DPPH and Reducing power assay methods and the results are compared with Gallic acid as reference standard . Phytochemical screening of Ethanolic bark extract of Mimosa catechu showed the presence of various constituents like flavonoids, phytosterols, tannins and showed appreciable and concentration dependent in vitro antioxidant activity. Source

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