Sri Padmavati Mahila Visvavidyalayam is a women's university in Tirupati, Andhra Pradesh, India. It was established as a state university by the Andhra Pradesh legislature in 1983, named after the goddess Sri Padmavati, the consort of Lord Venkateswara. The university has approximately 3,000 students. Wikipedia.
Soumya V.,Sri Padmavati University |
Muzib Y.I.,Sri Padmavati University
Indian Journal of Pharmacology | Year: 2016
Objective: To evaluate the potential effect of bamboo seed oil in decreasing the major metabolic symptoms associated with letrozole-induced polycystic ovarian disease using female rat model. Materials and Methods: A new method of microwave-assisted extraction was developed. Female rats were grouped into four with six animals each. All rats were daily administered with letrozole (1 mg/kg b.wt.) for 21 days except control, and during this period, changes in estrous cycle were observed. After letrozole treatment, Group 2 was considered negative control, Groups 3 and 4 were treated orally with bamboo oil, 0.5 ml/kg b.wt. and 1 ml/kg b.wt., respectively, for 3 weeks (five consecutive estrus cycles). Various parameters such as estrus cycle, blood sugar level, lipid profile, and weights of reproductive system were determined. The characteristics of cystic ovaries were evaluated by histopathological studies. Results: The isolated bamboo oil restored estrus cyclicity showed hypoglycemic and hypolipidemic effects. 1 ml/kg b.wt. of bamboo oil showed a marked glucose reduction from 254.04 ± 2.08 to 92.6 ± 1.63, and levels of total cholesterol, very low-density lipoprotein, triglyceride were reduced from 186.45 ± 2.28, 30.07 ± 2.36, 100.36 ± 2.35 to 152.14 ± 2.63, 25.94 ± 1.66, 93.32 ± 1.09, respectively. Histopathological results showed the presence of ovulation and recovery from cystic ovaries. Conclusion: A novel and promising drug was isolated in the treatment and maintenance of various metabolic symptoms associated with polycystic ovary disease. © 2016 Indian Journal of Pharmacology Published by Wolters Kluwer - Medknow.
Rani K.U.,Sri Padmavati University
Procedia Computer Science | Year: 2016
Clustering of data simplifies the task of data analysis and results in better disease diagnosis. Well-existing K-Means clustering hard computes clusters. Due to which the data may be centered to a specific cluster having less concentration on the effect of the coupling of clusters. Soft Computing methods are widely used in medical field as it contains fuzzy natured data. A Soft Computing approach of clustering called Fuzzy C-Means (FCM) deals with coupling. FCM clustering soft computes the clusters to determine the clusters based on the probability of having memberships in each of the clusters. The probability function used, determines the extent of coupling among the clusters. In order to achieve the computational efficiency and binding of features genetic evaluation is introduced. Genetic-based features are identified having more cohesion based on the fitness function values and then the coupling of the clusters is done using K-Means clustering in one trial and FCM in another trial. Analysis of coupling and cohesion is performed on Wisconsin Breast Cancer Dataset. Nature of clusters formations are observed with respect to coupling and cohesion. © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
Koganti B.,Sri Padmavati University |
Prasad K.V.S.R.G.,Sri Padmavati University
Indian Journal of Natural Products and Resources | Year: 2010
Urolithiasis in its different forms is a frequently encountered urological disorder. For many years it has been at the forefront of urology. In the present study ethanolic extract of whole plant of Phyla nodiflora (Linn.) Greene was studied for its antiurolithiatic activity against most common type of renal stones i.e. calcium oxalate type. Calcium oxalate urolithiasis was induced by administration of Gentamycin and calculi producing diet (5% ammonium oxalate in standard rat pellet feed). The extract was also assessed for effect on in vivo antioxidant parameters like lipid peroxidation, reduced glutathione, catalase in hyperoxaluric kidney and in vitro scavenging of nitric oxide and 2-diphenyl-2-picryl hydrazyl free radicals. Ethanolic extract of P. nodiflora exhibited significant effect in preventing calcium oxalate stone formation and also in dissolving the pre-formed calcium oxalate stones in the kidney along with significant effect on both in vitro and in vivo antioxidant parameters. The present study clearly demonstrates the antiurolithiatic activity of P. nodiflora supporting the traditional claim.
Pounambal M.,Vellore Institute of Technology |
Krishna P.V.,Sri Padmavati University
International Journal of Communication Systems | Year: 2016
In wireless mesh networks, the availability of spectrum should be utilized efficiently because the exchanging of traffic rate of multimedia applications is increasing day to day. The traffic of multimedia content may degrade the network performance in terms of high packet loss and throughput degradation because of asynchronous behavior between the sender and the receiver. The proposed Efficient Channel Reservation and Assignment (EchRA) results in successful originating and handing off of multimedia call transmissions using the four dimensional Markov chain process. The EChRA algorithm, proposed in this paper, achieves the maximum throughput performance considering the parameters of blocking probability, dropping probability, and synchronized dwell time between the source and destination. The quality of service is guaranteed by sharing the available slots and by using efficient queuing model to service the incoming and handoff calls, and henceforth, the successful completion of handoff calls rate is increased. Copyright © 2015 John Wiley & Sons, Ltd.
Asha S.,Sri Padmavati University |
Vidyavathi M.,Sri Padmavati University
Applied Biochemistry and Biotechnology | Year: 2010
Drug metabolism studies are essential and necessary during the evaluation of drugs. This review discusses the in vitro human liver models to estimate the drug metabolic fates in vivo. Different approaches are provided and emphasis is placed on the potential of human liver microsomes for drug metabolism and inhibition studies. The methodology for these studies using human liver microsomes, applications of human liver microsomes, and the drugs studied by human liver microsomes are listed. Human liver microsomes represent a critical experimental model for the evaluation of drug metabolites with a high probability of clinical success. © 2009 Humana Press.
Design, synthesis and evaluation of dialkyl 4-(benzo[d][1,3]dioxol-6-yl)-1, 4-dihydro-2,6-dimethyl-1-substituted pyridine-3,5-dicarboxylates as potential anticonvulsants and their molecular properties prediction
Prasanthi G.,Sri Padmavati University |
Prasad K.V.S.R.G.,Sri Padmavati University |
Bharathi K.,Sri Padmavati University
European Journal of Medicinal Chemistry | Year: 2013
The present study is on the development of dialkyl 4-(benzo[d][1,3]dioxol- 6-yl)-1,4-dihydro-2,6-dimethyl-1-substituted pyridine-3,5-dicarboxylate derivatives as isosteric analogues of isradipine and nifedipine, by the replacement of benzofurazanyl and 2-nitrophenyl groups respectively with benzo [d][1,3]dioxo-6-yl group, as potential anticonvulsants. Fivfteen new derivatives (8a - 8o) were synthesized and tested for anticonvulsant activity using maximal electroshock and subcutaneous pentylenetetrazole induced seizure methods. Compound 8f possessing free NH group in 1,4-dihydropyridine ring, diethyl ester functionality at the positions 3 and 5 showed significant anticonvulsant and antioxidant activities. This was also supported by molecular properties prediction data. Selected compounds were evaluated for antinociceptive activity in capsaicin induced nociception assay at 10 mg/kg body weight, but displayed no significant activity at the tested dose. © 2013 Elsevier Masson SAS. All rights reserved.
Akondi K.B.,Sri Padmavati University |
Lakshmi V.V.,Sri Padmavati University
OMICS A Journal of Integrative Biology | Year: 2013
Microorganisms constitute two out of the three domains of life on earth. They exhibit vast biodiversity and metabolic versatility. This enables the microorganisms to inhabit and thrive in even the most extreme environmental conditions, making them all pervading. The magnitude of biodiversity observed among microorganisms substantially supersedes that exhibited by the eukaryotes. These characteristics make the microbial world a very lucrative and inexhaustible resource for prospecting novel bioactive molecules. Despite their vast potential, over 99% of the microbial world still remains to be explored. The primary reason for this is that the culture-dependent methods used in the laboratories are grossly insufficient, as they support the growth of under 1% of the microorganisms found in nature. This limitation necessitated the development of techniques to circumvent culture dependency and gain access to the outstanding majority of the microorganisms. The development of culture-independent techniques has essentially reshaped the study of microbial diversity and community dynamics. Application of genomic and metagenomic approaches is contributing substantially towards characterization of the real microbial diversity. The amenability of these techniques to high throughput has opened the doors to explore the vast number of "uncultivable" microbial forms in substantially lesser time. The present article provides an update on the recent technological advances and emerging trends in exploring microbial community. © Copyright 2013, Mary Ann Liebert, Inc. 2013.
Yaidikar L.,Sri Padmavati University |
Thakur S.,Sri Padmavati University
Molecular and Cellular Biochemistry | Year: 2015
Punicalagin (PG) is a hydrolysable tannin compound found in Punica granatum L. The purpose of the present work is to explore the neuroprotective mechanism of PG against ischemia–reperfusion (I/R) injury in rat model of middle cerebral artery occlusion (MCAO). Rats were randomly divided into sham, MCAO, and PG-treated groups. PG (15 and 30 mg/kg), the vehicle was administered orally for 7 days prior to MCAO. Rats were anesthetised with ketamine (100 mg/kg/im), xylazine (10 mg/kg/im) and subjected to 2 h occlusion and 22 h reperfusion. The effects of PG on behavioral deficit and infarct volume, the levels of glutamate and calcium as well as the levels of inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) were evaluated. Moreover, the expressions of caspase-3, Bcl-2, and Bax were detected by Western blotting. As compared with MCAO group, PG-treated rats showed dose-dependent reduction in infarct volume and substantial improvement in behavioral deficit. The levels of glutamate, calcium, TNF-α, IL-1β, and IL-6 were restored significantly. The Western blotting results revealed that the expression of Bcl-2 was up-regulated and that of caspase-3, Bax were down-regulated when exposed to PG. From our results, it can be concluded that PG showed an ameliorative effect against cerebral I/R injury in rats through its anti-inflammatory, antioxidant actions besides it inhibits excitotoxicity. It also suppresses apoptosis through regulating, Bcl-2, caspase-3, and Bax protein expressions, perhaps another mechanism by which PG employs its neuroprotective action. © 2015, Springer Science+Business Media New York.
Anitha T,Sri Padmavati University |
Usha R,Sri Padmavati University
International Journal of Pharma and Bio Sciences | Year: 2012
Salinity stress is a major adverse factor that limits agricultural productivity and this is one of the major abiotic stresses faced by plants. Salinity affects plant growth, physiological activities and developmental processes. Soya bean is one of the proteinaceous commercial crops in India, where salt stress is the limiting factor. In the present work,six cultivars of beans (ADB-22, DSB-20, JS-93.05, JS-93.37, JS-335, and LSB-18) were tested under differing NaCl concentrations to assess their performance in salt conditions. The aim was to select salt tolerant bean cultivars. In order to investigate the effect of salt stress on plant height, fresh and dry weight, chlorophyll levels, total protein content, SOD, Catalase, Lipid peroxidase (LPX), Glutathione reductase (GR) and Ascorbate peroxidase (APX) of Soya plants of all the six cultivars subjected to salinity levels at varying concentrations of NaCl (control, 50, 100, 150, 200mM) and collected after 10days of NaCl treatment. The obtained results showed that higher levels of NaCl concentrations, reduced plant height, fresh weight, dry weight, chlorophyll levels and total protein content. Under stress conditions a decline in SOD and Catalase activity were observed in all six cultivars but the percentage of decrease was more significant in DSB-20. Meanwhile there was an increase in APX, LPX and GR activities in all the cultivars of soyabean. Among all the cultivars studied under salt conditions, changes were drastic and more in ADB-22, where as changes were less significant in JS-93.37 and DSB-20. Thus this paves a way to state that ADB-22 may be a salt susceptible variety while JS-93.37 and DSB-20may be salt tolerant varieties. The present findings indicate that salinity (NaCl) triggered an antioxidant response in Glycine max L.
Yaidikar L.,Sri Padmavati University |
Byna B.,Sri Padmavati University |
Thakur S.R.,Sri Padmavati University
Journal of Stroke and Cerebrovascular Diseases | Year: 2014
Background: Punicalagin (PG) is a hydrolyzable polyphenol in Punica granatum. It has been previously reported that it has a protective effect against hypoxia-induced ischemia brain injury. It is a potent antioxidant. The present study is aimed to evaluate the antioxidant potential of PG against focal cerebral ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion (MCAO). Methods: Rats were randomly divided into sham, MCAO, PG-treated groups. PG (15 and 30 mg/kg) vehicle was administered orally for 7 days before MCAO. Rats were anesthetized with ketamine (100 mg/kg), xylazine (10 mg/kg), and subjected to 2 hours occlusion, and 22 hours reperfusion.Neurologic deficit, brainwater content (BWC), histopathology changes, and oxidative stress markers were evaluated after 22 hours of reperfusion. In comparison with MCAO model group, treatment with PG significantly reduced the neurologic deficit scores and BWC. Results: PGattenuated neuronal damage occurred by downregulating the levels of malondialdehyde, sodium-potassiumadenosine triphosphatase activity, nitric oxide, protein carbonyl content, and mitochondria-generated reactive oxygen species and upregulating the superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, glutathione reductase activities. Conclusions: Taken together, these results suggested that supplementation of PG treatment effectively ameliorates the cerebral ischemia/reperfusion induced oxidative damage by virtue of its antioxidant potential.