Tirupati, India

Sri Padmavati University

Tirupati, India

Sri Padmavati Mahila Visvavidyalayam is a women's university in Tirupati, Andhra Pradesh, India. It was established as a state university by the Andhra Pradesh legislature in 1983, named after the goddess Sri Padmavati, the consort of Lord Venkateswara. The university has approximately 3,000 students. Wikipedia.

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Hemalatha K.,Sri Padmavati University | Usha Rani K.,Sri Padmavati University
Proceedings - 7th IEEE International Advanced Computing Conference, IACC 2017 | Year: 2017

Neural Networks are one of the widely used Soft Computing Techniques. Neural Networks are adaptive and learn from past examples. Neural Networks are used successfully in extensive range of applications related to different areas particularly in Medical Domain. Neural Networks mimic human brain to solve problems concern to non-linear and complex data such as clinical samples. Cervical Cancer is a silent cancer which does not disclose any pain and symptoms. But it becomes dangerous silently with in a long period of 10-15 years. Hence early diagnosis is an essential action to prevent it in early stages. In this study most commonly used Neural Networks such as Multi Layer Perceptron (MLP), Probabilistic Neural Network (PNN), Radial Basic Function (RBF) and Linear Vector Quantization (LVQ) networks are used. Dimensionally reduced Cervical Pap smear Dataset using Fuzzy Edge Detection method is considered for classification. The Four Neural Networks are compared and the best suitable network to classify the dataset is evaluated. © 2017 IEEE.

Suneel A.S.,Sri Padmavati University | Prasanthi K.,Sri Padmavati University
International Conference on Signal Processing, Communication, Power and Embedded System, SCOPES 2016 - Proceedings | Year: 2017

Spectrum sensing is a imperative dilemma in cognitive radio networks. Cooperation among the many secondary users is utilized to strengthen the performance of spectrum sensing. On this paper outcome the sensing of Spectrum via Cognitive Radio (CR) or Adaptive Radio or smart Radio to exploit unoccupied frequencies for a more suitable spectral utilization. The present work objectives at transmitting the indicators in multiple-input-multiple-output (MIMO) mode using decode-and-forward (DF) half of-duplex two-hop relay channels with an immediate source vacation spot hyperlink. Cooperative communications were proposed to exploit spatial diversity beneficial properties inherent in multi-consumer wireless methods with out the need of a couple of antennas at each and every node. Within the present situation, supply and relay nodes are equipped with multiple antennas and the destination node is deployed with a single antenna. © 2016 IEEE.

Background Arjunolic acid (AA), a pentacyclic triterpenoidal saponin of Terminalia arjuna is well recognized for its antioxidant properties. We proposed to evaluate its antioxidant potential against focal cerebral ischemia reperfusion (I/R) injury in rats subjected to middle cerebral artery occlusion (MCAO). Methods In the present study, rats were randomly divided into a sham, MCAO, AA (10 and 20 mg/kg) treated groups. Rats received their respective treatment orally by gavage for 7 days prior to MCAO. Rats were anaesthetized with ketamine (100 mg/kg), xylazine (10 mg/kg) and subjected to 2 h occlusion and 22 h reperfusion. Neurological deficit, brain water content and oxidative stress markers were measured after 22 h of reperfusion. Results Rats pretreated with AA showed significantly reduced neurological deficit score, infarct size. AA prevented neuronal damage induced by I/R by regulating the levels of malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), protein carbonyl content and mitochondria generated reactive oxygen species. In addition, it also controlled the enzyme activities of Na+-K+ ATPase, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR). Conclusions Pre-treatment with AA effectively prevented the cerebral I/R induced oxidative damage by virtue of its antioxidant potential. These results indicate that supplementation of AA may be beneficial in stroke prone population. © 2015 Institute of Pharmacology, Polish Academy of Sciences.

Rani K.U.,Sri Padmavati University
Procedia Computer Science | Year: 2016

Clustering of data simplifies the task of data analysis and results in better disease diagnosis. Well-existing K-Means clustering hard computes clusters. Due to which the data may be centered to a specific cluster having less concentration on the effect of the coupling of clusters. Soft Computing methods are widely used in medical field as it contains fuzzy natured data. A Soft Computing approach of clustering called Fuzzy C-Means (FCM) deals with coupling. FCM clustering soft computes the clusters to determine the clusters based on the probability of having memberships in each of the clusters. The probability function used, determines the extent of coupling among the clusters. In order to achieve the computational efficiency and binding of features genetic evaluation is introduced. Genetic-based features are identified having more cohesion based on the fitness function values and then the coupling of the clusters is done using K-Means clustering in one trial and FCM in another trial. Analysis of coupling and cohesion is performed on Wisconsin Breast Cancer Dataset. Nature of clusters formations are observed with respect to coupling and cohesion. © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.

Asha S.,Sri Padmavati University | Vidyavathi M.,Sri Padmavati University
Applied Biochemistry and Biotechnology | Year: 2010

Drug metabolism studies are essential and necessary during the evaluation of drugs. This review discusses the in vitro human liver models to estimate the drug metabolic fates in vivo. Different approaches are provided and emphasis is placed on the potential of human liver microsomes for drug metabolism and inhibition studies. The methodology for these studies using human liver microsomes, applications of human liver microsomes, and the drugs studied by human liver microsomes are listed. Human liver microsomes represent a critical experimental model for the evaluation of drug metabolites with a high probability of clinical success. © 2009 Humana Press.

Prasanthi G.,Sri Padmavati University | Prasad K.V.S.R.G.,Sri Padmavati University | Bharathi K.,Sri Padmavati University
European Journal of Medicinal Chemistry | Year: 2013

The present study is on the development of dialkyl 4-(benzo[d][1,3]dioxol- 6-yl)-1,4-dihydro-2,6-dimethyl-1-substituted pyridine-3,5-dicarboxylate derivatives as isosteric analogues of isradipine and nifedipine, by the replacement of benzofurazanyl and 2-nitrophenyl groups respectively with benzo [d][1,3]dioxo-6-yl group, as potential anticonvulsants. Fivfteen new derivatives (8a - 8o) were synthesized and tested for anticonvulsant activity using maximal electroshock and subcutaneous pentylenetetrazole induced seizure methods. Compound 8f possessing free NH group in 1,4-dihydropyridine ring, diethyl ester functionality at the positions 3 and 5 showed significant anticonvulsant and antioxidant activities. This was also supported by molecular properties prediction data. Selected compounds were evaluated for antinociceptive activity in capsaicin induced nociception assay at 10 mg/kg body weight, but displayed no significant activity at the tested dose. © 2013 Elsevier Masson SAS. All rights reserved.

Akondi K.B.,Sri Padmavati University | Lakshmi V.V.,Sri Padmavati University
OMICS A Journal of Integrative Biology | Year: 2013

Microorganisms constitute two out of the three domains of life on earth. They exhibit vast biodiversity and metabolic versatility. This enables the microorganisms to inhabit and thrive in even the most extreme environmental conditions, making them all pervading. The magnitude of biodiversity observed among microorganisms substantially supersedes that exhibited by the eukaryotes. These characteristics make the microbial world a very lucrative and inexhaustible resource for prospecting novel bioactive molecules. Despite their vast potential, over 99% of the microbial world still remains to be explored. The primary reason for this is that the culture-dependent methods used in the laboratories are grossly insufficient, as they support the growth of under 1% of the microorganisms found in nature. This limitation necessitated the development of techniques to circumvent culture dependency and gain access to the outstanding majority of the microorganisms. The development of culture-independent techniques has essentially reshaped the study of microbial diversity and community dynamics. Application of genomic and metagenomic approaches is contributing substantially towards characterization of the real microbial diversity. The amenability of these techniques to high throughput has opened the doors to explore the vast number of "uncultivable" microbial forms in substantially lesser time. The present article provides an update on the recent technological advances and emerging trends in exploring microbial community. © Copyright 2013, Mary Ann Liebert, Inc. 2013.

Yaidikar L.,Sri Padmavati University | Thakur S.,Sri Padmavati University
Molecular and Cellular Biochemistry | Year: 2015

Punicalagin (PG) is a hydrolysable tannin compound found in Punica granatum L. The purpose of the present work is to explore the neuroprotective mechanism of PG against ischemia–reperfusion (I/R) injury in rat model of middle cerebral artery occlusion (MCAO). Rats were randomly divided into sham, MCAO, and PG-treated groups. PG (15 and 30 mg/kg), the vehicle was administered orally for 7 days prior to MCAO. Rats were anesthetised with ketamine (100 mg/kg/im), xylazine (10 mg/kg/im) and subjected to 2 h occlusion and 22 h reperfusion. The effects of PG on behavioral deficit and infarct volume, the levels of glutamate and calcium as well as the levels of inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) were evaluated. Moreover, the expressions of caspase-3, Bcl-2, and Bax were detected by Western blotting. As compared with MCAO group, PG-treated rats showed dose-dependent reduction in infarct volume and substantial improvement in behavioral deficit. The levels of glutamate, calcium, TNF-α, IL-1β, and IL-6 were restored significantly. The Western blotting results revealed that the expression of Bcl-2 was up-regulated and that of caspase-3, Bax were down-regulated when exposed to PG. From our results, it can be concluded that PG showed an ameliorative effect against cerebral I/R injury in rats through its anti-inflammatory, antioxidant actions besides it inhibits excitotoxicity. It also suppresses apoptosis through regulating, Bcl-2, caspase-3, and Bax protein expressions, perhaps another mechanism by which PG employs its neuroprotective action. © 2015, Springer Science+Business Media New York.

Anitha T,Sri Padmavati University | Usha R,Sri Padmavati University
International Journal of Pharma and Bio Sciences | Year: 2012

Salinity stress is a major adverse factor that limits agricultural productivity and this is one of the major abiotic stresses faced by plants. Salinity affects plant growth, physiological activities and developmental processes. Soya bean is one of the proteinaceous commercial crops in India, where salt stress is the limiting factor. In the present work,six cultivars of beans (ADB-22, DSB-20, JS-93.05, JS-93.37, JS-335, and LSB-18) were tested under differing NaCl concentrations to assess their performance in salt conditions. The aim was to select salt tolerant bean cultivars. In order to investigate the effect of salt stress on plant height, fresh and dry weight, chlorophyll levels, total protein content, SOD, Catalase, Lipid peroxidase (LPX), Glutathione reductase (GR) and Ascorbate peroxidase (APX) of Soya plants of all the six cultivars subjected to salinity levels at varying concentrations of NaCl (control, 50, 100, 150, 200mM) and collected after 10days of NaCl treatment. The obtained results showed that higher levels of NaCl concentrations, reduced plant height, fresh weight, dry weight, chlorophyll levels and total protein content. Under stress conditions a decline in SOD and Catalase activity were observed in all six cultivars but the percentage of decrease was more significant in DSB-20. Meanwhile there was an increase in APX, LPX and GR activities in all the cultivars of soyabean. Among all the cultivars studied under salt conditions, changes were drastic and more in ADB-22, where as changes were less significant in JS-93.37 and DSB-20. Thus this paves a way to state that ADB-22 may be a salt susceptible variety while JS-93.37 and DSB-20may be salt tolerant varieties. The present findings indicate that salinity (NaCl) triggered an antioxidant response in Glycine max L.

Yaidikar L.,Sri Padmavati University | Byna B.,Sri Padmavati University | Thakur S.R.,Sri Padmavati University
Journal of Stroke and Cerebrovascular Diseases | Year: 2014

Background: Punicalagin (PG) is a hydrolyzable polyphenol in Punica granatum. It has been previously reported that it has a protective effect against hypoxia-induced ischemia brain injury. It is a potent antioxidant. The present study is aimed to evaluate the antioxidant potential of PG against focal cerebral ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion (MCAO). Methods: Rats were randomly divided into sham, MCAO, PG-treated groups. PG (15 and 30 mg/kg) vehicle was administered orally for 7 days before MCAO. Rats were anesthetized with ketamine (100 mg/kg), xylazine (10 mg/kg), and subjected to 2 hours occlusion, and 22 hours reperfusion.Neurologic deficit, brainwater content (BWC), histopathology changes, and oxidative stress markers were evaluated after 22 hours of reperfusion. In comparison with MCAO model group, treatment with PG significantly reduced the neurologic deficit scores and BWC. Results: PGattenuated neuronal damage occurred by downregulating the levels of malondialdehyde, sodium-potassiumadenosine triphosphatase activity, nitric oxide, protein carbonyl content, and mitochondria-generated reactive oxygen species and upregulating the superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, glutathione reductase activities. Conclusions: Taken together, these results suggested that supplementation of PG treatment effectively ameliorates the cerebral ischemia/reperfusion induced oxidative damage by virtue of its antioxidant potential.

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