Sri Padmavathi Mahila Visvavidyalayam Womens University

Tirupati, India

Sri Padmavathi Mahila Visvavidyalayam Womens University

Tirupati, India

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Sarala Devi T.,Sri Padmavathi Mahila Visvavidyalayam Womens University | Rajitha G.,Sri Padmavathi Mahila Visvavidyalayam Womens University | Bharathi K.,Sri Padmavathi Mahila Visvavidyalayam Womens University
Asian Journal of Chemistry | Year: 2010

A series of 4-substituted benzylidene-2-phenyl-1-substituted phenyl-1H-imidazol-5(4H)-one were synthesized by condensation of substituted oxazolones with p-amino benzoic acid and benzocaine. The chemical structures of synthesized compounds were confirmed by IR, 1H NMR, mass spectral and elemental analysis. The compounds were evaluated for antiinflammatory and antioxidant activities. Out of these series of compounds screened, the compounds 4, 5, 14 and 16 showed equipotent activity to the standard drug phenylbutazone. Compounds 8 and 17 showed good antioxidant activity.


Rajitha G.,Sri Padmavathi Mahila Visvavidyalayam Womens University | Prasad K.V.S.R.G.,Sri Padmavathi Mahila Visvavidyalayam Womens University | Bharathi K.,Sri Padmavathi Mahila Visvavidyalayam Womens University
Asian Journal of Chemistry | Year: 2011

A series of 3-amino-4-(substituted benzylidene)-1H-pyrazol-5(4H)-ones were synthesized by condensation of ethyl-2-cyano-3-(substituted) phenylacrylates with hydrazine hydrate. The chemical structures of synthesized compounds were confirmed by means of IR, 1H NMR, mass spectral and elemental analysis. All the compounds were screened for their antiinflammatory, analgesic and antioxidant activities. Out of these compounds, 4-hydroxy-3,5-dimethoxy (24) and 4-dimethylamino (17) derivatives showed good antiinflammatory activity. 4-dimethylamino (17) and 5-bromo-4-hydroxy-3-methoxy (23) derivatives showed moderate analgesic activity.

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