Sri Padmavathi Mahila Visvavidyalayam Womens University

Tirupati, India

Sri Padmavathi Mahila Visvavidyalayam Womens University

Tirupati, India
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Prasad K.V.S.R.G.,Sri Padmavathi Mahila VisvaVidyalayam womens University | Bharathi K.,Sri Padmavathi Mahila VisvaVidyalayam womens University | Haseena Banu B.,Sri Padmavathi Mahila VisvaVidyalayam womens University
International Journal of Pharmaceutical Sciences Review and Research | Year: 2011

Peptide synthesis includes a wide range of techniques and procedures that enable the preparation of molecules ranging from small peptides to large proteins. This review focuses on the coupling reagents and major advances that have had a great impact in the field of peptide synthesis. Coupling reagents have gained substantial popularity in peptide coupling reactions involving formation of azide, mixed anhydride and acid halide intermediates. Another significant development in the field of peptide coupling reactions is the discovery of the racemisation suppressants. Racemisation can occur at C-terminal amino acid residue in the course of a coupling reaction due to the ionization of the α-hydrogen and the formation of an oxazolone intermediate. A peptide coupling reagent with an appropriate racemisation suppressing agent assures suppression of the undesired racemisation and other side reactions.


Sowjanya C.,Sri Padmavathi Mahila Visvavidyalayam Womens University | Ramabharathi V.,Sri Padmavathi Mahila Visvavidyalayam Womens University | Kalpana Devi G.,Sri Padmavathi Mahila Visvavidyalayam Womens University | Rajitha G.,Sri Padmavathi Mahila Visvavidyalayam Womens University
Journal of Chemical and Pharmaceutical Research | Year: 2011

A series of 3-(5-phenyl-1,3,4-oxadiazole-2-yl)-2-(substituted styryl)-quinazoline-4(3H)-ones 3(ah) were synthesized by reacting 2-methyl-3-(5-phenyl-1,3,4-oxadiazole-2-yl)-quinazoline-4(3H)- one 2 and substituted benzaldehydes in glacial acetic acid. 2-methyl-3-(5-phenyl-1,3,4- oxadiazole-2-yl)-quinazoline-4(3H)one 2 was obtained by refluxing 2-methylbenzoxazin-4(3H)- one with the 2-amino-5-phenyl-1,3,4-oxadiazole 1. 2-Amino-5-phenyl-1,3,4-oxadiazole 1 was prepared by oxidative cyclization of benzaldehyde semicarbazone and bromine in the presence of glacial acetic acid. All the compounds were screened for antibacterial activity by using cup plate method. Out of these compounds unsubstituted styryl compounds showed significant activity.


Objectives: The objective of the present study was to enhance the solubility, dissolution and hence anti-inflammatory activity of poorly soluble drug indomethacin (IMN) by formulating into self emulsifying systems. Materials and Methods: Self emulsifying formulations were prepared using capmul MCM as oil, tween 80 as surfactant, transcutol P as cosurfactant. Fourier transform infrared spectroscopy and differential scanning calorimetry studies were conducted to know the interaction between drug and excipients. Pseudo ternary phase diagrams were constructed using surfactant and cosurfactant in 1:1 to 1:4 and 2:1 to 4:1 to know the efficient self emulsification region. The formulations were evaluated for their particle size, zeta potential, refractive index, viscosity and cloud point. In vitro dissolution studies were conducted in one part of pH 7.2 phosphate buffer and four parts of water. The pharmacokinetic parameters were analysed by Win Nonlin software. Results: The self emulsification was higher with the ratios 2:1, 3:1 and 1:2 of surfactant and co surfactant and the IMN formulations were prepared. The formulations were stable at different pH and dilutions. The globule size was in the range of 184.1 nm to 340.5 nm, as the ratio of oil, surfactant and cosurfactant mixture has varied effects on the size of globule. The negative charge on the globules of all formulations attributes their stability. The optimized formulation showed better release as compared to marketed product. The AUC of the optimised Self-Emulsifying Drug Delivery System was significantly higher than the marketed product. Conclusion: Thus, from the present research, self emulsifying systems of IMN provide a useful alternative to enhance dissolution and hence anti inflammatory activity. © Turk J Pharm Sci, Published by Galenos Publishing House.


Sarala Devi T.,Sri Padmavathi Mahila Visvavidyalayam Womens University | Rajitha G.,Sri Padmavathi Mahila Visvavidyalayam Womens University | Bharathi K.,Sri Padmavathi Mahila Visvavidyalayam Womens University
Asian Journal of Chemistry | Year: 2010

A series of 4-substituted benzylidene-2-phenyl-1-substituted phenyl-1H-imidazol-5(4H)-one were synthesized by condensation of substituted oxazolones with p-amino benzoic acid and benzocaine. The chemical structures of synthesized compounds were confirmed by IR, 1H NMR, mass spectral and elemental analysis. The compounds were evaluated for antiinflammatory and antioxidant activities. Out of these series of compounds screened, the compounds 4, 5, 14 and 16 showed equipotent activity to the standard drug phenylbutazone. Compounds 8 and 17 showed good antioxidant activity.


Rajitha G.,Sri Padmavathi Mahila Visvavidyalayam Womens University | Prasad K.V.S.R.G.,Sri Padmavathi Mahila Visvavidyalayam Womens University | Bharathi K.,Sri Padmavathi Mahila Visvavidyalayam Womens University
Asian Journal of Chemistry | Year: 2011

A series of 3-amino-4-(substituted benzylidene)-1H-pyrazol-5(4H)-ones were synthesized by condensation of ethyl-2-cyano-3-(substituted) phenylacrylates with hydrazine hydrate. The chemical structures of synthesized compounds were confirmed by means of IR, 1H NMR, mass spectral and elemental analysis. All the compounds were screened for their antiinflammatory, analgesic and antioxidant activities. Out of these compounds, 4-hydroxy-3,5-dimethoxy (24) and 4-dimethylamino (17) derivatives showed good antiinflammatory activity. 4-dimethylamino (17) and 5-bromo-4-hydroxy-3-methoxy (23) derivatives showed moderate analgesic activity.

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