Indira M.Y.,Sri Padmavathi Mahila University
Journal of Chemical and Pharmaceutical Sciences | Year: 2014
The objective of present work is to develop and evaluate a matrix system for Chronotherapeutic delivery of centrally acting opioid analgesic (Tramadol HCl) containing Gum kondagogu as carrier for the treatment of rheumatoid arthritis. If the formulation is administered at night time, symptoms that are sever in early morning hours can be treated. Core tablets of Tramadol HCl were prepared by using 30, 40, 50, 60 and 70% w/w of tablet of Gum kondagogu as carrier by wet granulation technique. These tablets were compression coated with Eudragit S100 to prevent drug release in stomach. All formulations were evaluated for hardness, friability, weight variation, drug content, in vitro and in-vivo studies. The Gum kondagogu was characterized by viscosity measurements and FTIR analysis. The coated (FC1 to FC5) and uncoated tablets (F1 to F5) were evaluated for in vitro release of Tramadol HCl after sequential exposure to pH 1.2, pH 7.4 and pH 6.8 respectively for 2hr, 3hr and 19hr in the absence as well as presence of rat caecal content. The selected formulation was subjected to in vivo targeting efficacy studies by Roentgenography technique. In vitro release studies indicated that the matrix tablets (F1 to F5) failed to control the drug release in the physiological environment of stomach and small intestine. On the other hand, compression coated formulations were able to protect the tablet cores from premature drug release. In the absence of rat caecal contents, compression coated FC4 and FC5 released 98.45±0.37% and 89.67±0.43% drug respectively at the end of 24hrs. When dissolution study was continued in pH 6.8 PBS containing 4% w/v of rat caecal contents, FC4 released about 99.18±0.29% drug at the end of 22hrs. FTIR studies confirmed that there was no interaction between the drug and the carrier. X-ray studies confirmed that the tablet successfully reached colon without getting disintegrated in upper gastro intestinal tract. Based on the results, selective delivery of Tramadol HCl to the colon could be achieved using 60% w/w (FC4) of Gum kondagogu matrix tablets compression coated with Eudragit S100. © 2014, SPB Pharma Society. All rights reserved.
Bharathi K.,Sri Padmavathi Mahila University |
Omprakash G.,PharmaZell R and D India Private Ltd
Asian Journal of Chemistry | Year: 2011
A series of 2,3-substituted-4-phenyl-1,3-oxazolidine derivatives were synthesized from DL-(±)-phenyl glycine. DL-(±)-Phenyl glycine was reduced to the corresponding alcohol, which was then condensed with different aldehydes to form Schiff bases, which are then educed and further condensed with different substituted aldehydes to give the oxazolidine derivatives. The synthesized compounds are characterized by 1H NMR, IR and mass spectral analysis. All the compounds were investigated for cardiac activity while all the compounds show significant activity.
Madhukar Reddy C.,AP Model School |
Deva Prasad Raju B.,Sri Venkateswara University |
John Sushma N.,Sri Padmavathi Mahila University |
Dhoble N.S.,Sevadal Mahila Mahavidhyalaya |
Dhoble S.J.,Rashtrasant Tukadoji Maharaj Nagpur University
Renewable and Sustainable Energy Reviews | Year: 2015
Trivalent rare earth ions show interesting optical properties and such properties have high technological applications of rare earth doped materials such as energy saving lighting devices, optical displays, optical fibers, amplifiers and lasers. Among these materials rare earth ions doped glasses are of great important to optoelectronics and are widely used in fiber amplifiers and solid state high power lasers for telecommunications and light emitting diodes. Near-infrared luminescence for high power lasers is a current requirement in modern fiber optic telecommunication network and emphasis has to put in recent advances of NIR emitting materials for amplifiers, fiber lasers and waveguides. We make an effort to satisfy the above needs by preparing the LCZSFB glasses doped with Sm3+, Dy3+, Eu3+, Tb3+ and Nd3+ rare earth ions. In this review, optical properties of LCZSFB glasses doped with Sm3+, Dy3+, Eu3+, Tb3+ and Nd3+ rare earth ions and the current status of their applications is given. © 2015 Elsevier Ltd.
Kotakadi V.S.,A.P.S. University |
Gaddam S.A.,A.P.S. University |
Gaddam S.A.,Sri Padmavathi Mahila University |
Saigopal D.V.R.,A.P.S. University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014
A tospo virus infecting sunflower in India was characterized by host range studies, the virus was purified and polyclonal anti serum was produced. The virus infecting sunflower reacted with homologous antiserum, and PBNV antiserum is DAC-ELISA, and failed to react with TSWV, INSV, IYSV and PSNV. The purified virus resolved as four polypepticles species of 331, 58, 52, 31 kD in SDS PAGE. In electro blot immuno assay, all four polypeptides reacted with homologous antiserum, and only nucleocapsid protein of 31kD reacted with recombinant nucleocapsid antibodies raised against PBNV and none of the polypeptides reacted with TSWV, INSV and IYSV. The RNA from purified virus resolved into three bands of L RNA of 9 Kb, M RNA of 5 Kb and S RNA of 3.5 Kb in agarose gel electrophoresis.
Reddy T.S.,R Y M Engineering College |
Reddy C.E.,Sri Padmavathi Mahila University
International Journal of Robotics and Automation | Year: 2011
Every tool is subjected to wear in machining. The wear of the tool is gradual and reach its limit of life which is identified when the tool no longer produce the parts to required quality. There are various types of wear a single point cutting tool may be subjected in turning. Of these, flank wear on the tool significantly affects surface roughness. The other types of tool wears are generally avoided by proper selection of tool material and cutting conditions. On-line tool wear compensations and surface roughness measurements gained significant importance in manufacturing systems to provide accurate machining. The Acoustic Emission (AE) analysis is one of the most promising techniques for on-line tool wear and surface roughness monitoring. The AE signals are very sensitive to changes in cutting process conditions. The gradual flank wear of the tool in turning causes changes in AE signal parameters. In the present work investigations are carried for turning operation on mild steel material using HSS tool. The AE signals are measured by highly sensitive piezoelectric element, the on-line signals are suitably amplified using a high gain pre-amplifier. The amplified signals then recorded on to a computer and then analysed using MAT LAB. A program is written to measure AE signal parameters like Ring down count (RDC), Signal Rise Time, and RMS voltage. The surface roughness is measured by roller ended linear variable probe, fitted and moved along with tool turret on a CNC lathe machine. The linear movements of probe are converted in the form of continuous signals and are displayed on-line in the computer. Flank wear is measured by Toolmaker's Microscope. The results thus plotted show a significant relation between Flank Wear and Surface Roughness with AE signal parameters. The conclusions are made for predicting tool wear and surface roughness by suggesting consistent values and ranges for on-line monitoring AE signal parameters.
Savithramma N.,Sri Venkateswara University |
Linga Rao M.,Sri Venkateswara University |
Rukmini K.,Sri Padmavathi Mahila University |
Suvarnalatha Devi P.,Sri Padmavathi Mahila University
International Journal of ChemTech Research | Year: 2011
Biologically synthesized silver nanoparticles (SNPs) are being widely using in the field of medicine. Extracellular biosynthesis of silver nanoparticles was carried out by using medicinal plant extracts for the reduction of aqueous silver ions in short period. The silver nanoparticles formation was confirmed by the colour change of plant extracts (SNPs) and further confirmed with the help of UV-Vis spectroscopy. These Phytosynthesized silver nanoparticles were tested for antibacterial and antifungal activities using disc diffusion method. The test cultures are Proteus, Pseudomonas, Klebsiella, Bacillus and E.coli species of bacteria and Aspergillus, Fusarium, Curvularia and Rhizopus species of fungal were used. The microbial property of silver nanoparticles was analyzed by measuring the inhibition zone. The silver nanoparticles synthesized from stem bark extracts of Boswellia and Shorea; and leaf extract of Svensonia. The SNPs synthesized from bark extracts of Boswellia ovalifoliolata and Shorea tumbuggaia showed toxic towards Klebsiella and Aspergillus; and Pseudomonas and Fusarium species respectively. Whereas the growth of Pseudomonas and Rhizopus species were inhibited maximum by the SNPs synthesized from leaf extract of Svensonia hyderobadensis, the results indicate that the silver nanoparticles may have an important advantage over conventional antibiotics.
Indira Muzib Y.,Sri Padmavathi Mahila University |
Chaitanya K.,Sri Padmavathi Mahila University
Research Journal of Pharmacy and Technology | Year: 2011
The objective of the study was to develop a oral controlled release drug delivery system of lamivudine using non effervescent approach with hydrocolloid gel forming agent HPMC (hydroxylpropyl methylcellulose) and sodium alginate. Alginate beads of lamivudine were prepared by ionotropic gelation method. The prepared alginate beads were subjected to evaluation for particle size, incorporation efficiency and in vitro drug release characteristics. Alginate beads were discrete spherical and free flowing with smooth surfaces and completely covered with polymer coat. The alginate beads produced were smooth and small in size with an average diameter of about 506.19±7.2μm to 537.31±8.6μm. The prepared floating alginate beads were exhibited prolonged drug release (~12 hrs) and remained buoyant for greater than 12hrs.The release kinetics showed that the release of drug from the beads followed zero order kinetics. Drug release was controlled by diffusion from the alginate beads that was slow and spreads over an extended period of time depending upon the drug polymer ratio. © RJPT All right reserved.
John Sushma N.,Sri Padmavathi Mahila University |
Mahitha B.,Sri Padmavathi Mahila University |
Sravanthi P.L.,Sri Padmavathi Mahila University |
Priyanka S.,Sri Padmavathi Mahila University |
Jayantha Rao K.,Sri Venkateswara University
International Journal of Pharma and Bio Sciences | Year: 2011
We have examined the effect of aluminum (Al) acetate on albino mice. Different doses of aluminum acetate (3.5 mg/kg body weight (b.w), intraperitoneal injection., single dose:3.5mg/kg b.w, double dose:3.5 mg/kg b.w, with 72 h interval on 1 st and 4 th day and multiple doses: 3.5 mg/kg b.w, with 72 h interval on 1 st, 4 th,7 th and 10 th day) resulted alterations in tissue histology of liver, kidney, intestine and testis. Our findings indicate that the pronounced pathological changes in multiple doses compared to double and single dose administered mice. We found that dose dependent exposure of aluminum acetate causes deleterious effects and make them less fit for better survival.
Bhanu Priya K.,Sri Padmavathi Mahila University |
Kotakadi V.S.,Sri Venkateswara University |
Josthna P.,Sri Padmavathi Mahila University
International Journal of Pharma and Bio Sciences | Year: 2013
Syzygium aromaticum is commonly known as clove, it is the dried bud of the tree. Cloves are of high medicinal value they are widely used in ayurveda, chinese medicine, western herbalism and also as a food ingredient. The present study was taken up to evaluate antimutagenic activity of ethyl acetate extract of clove with reference to the frequency of polychromatic erythrocytes (PCE) in the bone marrow of mice, administered intraperitoneally (i.p) using bone marrow micro nucleus test. Mice were given with ethyl acetate extract doses of 500,750 mg/kg/day intraperitoneal. In addition, Mitomycin C (MMC) given to the animals at the dose of 4mg/kg by single intraperitoneal injection. Smear specimens were prepared from bone marrows and stained with May-Grunwald's followed by Giemsa stain then the frequencies of micro nucleated PCEs and the ratio of total number of (PCE/NCE) were calculated. Ethyl acetate extract of Syzygium aromaticum (750mg/kg) showed significant antimutagenic activity.
PubMed | Sri Padmavathi Mahila University
Type: Journal Article | Journal: International journal of pharmaceutical investigation | Year: 2012
Glibenclamide is an oral hypoglycemic drug completely metabolized in the liver, the principal metabolite being very weakly active, buccal delivery may be useful for the treatment of diabetes more effectively. The aim of the present study was to design formulations and systematically evaluate in vitro and ex vivo performances of buccal films of glibenclamide so that the required therapeutic plasma concentrations can possibly be achieved more rapidly using the different grades of hydroxypropyl methyl cellulose (HPMC) as the base matrix.Mucoadhesive buccal films of glibenclamide were prepared by solvent casting technique using different grades of HPMC with different ratios. Prepared films were evaluated for weight, thickness, surface pH, swelling index (SI), folding endurance, drug content uniformity, in vitro release, and ex vivo permeation studies.The film thickness and weight were in the range of 0.213-0.4892mm and 22.25-39.83 mg, respectively. The films exhibited controlled release over more than 6 h. HPMC, HPMCK100, and HPMC3000 films exhibited satisfactory swelling. Surface pH of buccal films was found to be 6.4-6.8. SI observed to be highest for GF12 (275.3 12.17) and lowest for GF1 (173.5 5.65). The films exhibited controlled release over more than 6 h. HPMC exhibited satisfactory swelling, an optimum residence time, and promising drug release. The Higuchi plots were found to be linear with correlation coefficient values of 0.8933, 0.9138, and 0.9947 for GF4, GF8, and GF9, respectively.Among all the formulations, GF9 shows good controlled release results correlated with ex vivo permeation studies.