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Indira M.Y.,Sri Padmavathi Mahila University
Journal of Chemical and Pharmaceutical Sciences

The objective of present work is to develop and evaluate a matrix system for Chronotherapeutic delivery of centrally acting opioid analgesic (Tramadol HCl) containing Gum kondagogu as carrier for the treatment of rheumatoid arthritis. If the formulation is administered at night time, symptoms that are sever in early morning hours can be treated. Core tablets of Tramadol HCl were prepared by using 30, 40, 50, 60 and 70% w/w of tablet of Gum kondagogu as carrier by wet granulation technique. These tablets were compression coated with Eudragit S100 to prevent drug release in stomach. All formulations were evaluated for hardness, friability, weight variation, drug content, in vitro and in-vivo studies. The Gum kondagogu was characterized by viscosity measurements and FTIR analysis. The coated (FC1 to FC5) and uncoated tablets (F1 to F5) were evaluated for in vitro release of Tramadol HCl after sequential exposure to pH 1.2, pH 7.4 and pH 6.8 respectively for 2hr, 3hr and 19hr in the absence as well as presence of rat caecal content. The selected formulation was subjected to in vivo targeting efficacy studies by Roentgenography technique. In vitro release studies indicated that the matrix tablets (F1 to F5) failed to control the drug release in the physiological environment of stomach and small intestine. On the other hand, compression coated formulations were able to protect the tablet cores from premature drug release. In the absence of rat caecal contents, compression coated FC4 and FC5 released 98.45±0.37% and 89.67±0.43% drug respectively at the end of 24hrs. When dissolution study was continued in pH 6.8 PBS containing 4% w/v of rat caecal contents, FC4 released about 99.18±0.29% drug at the end of 22hrs. FTIR studies confirmed that there was no interaction between the drug and the carrier. X-ray studies confirmed that the tablet successfully reached colon without getting disintegrated in upper gastro intestinal tract. Based on the results, selective delivery of Tramadol HCl to the colon could be achieved using 60% w/w (FC4) of Gum kondagogu matrix tablets compression coated with Eudragit S100. © 2014, SPB Pharma Society. All rights reserved. Source

Reddy T.S.,R Y M Engineering College | Reddy C.E.,Sri Padmavathi Mahila University
International Journal of Robotics and Automation

Every tool is subjected to wear in machining. The wear of the tool is gradual and reach its limit of life which is identified when the tool no longer produce the parts to required quality. There are various types of wear a single point cutting tool may be subjected in turning. Of these, flank wear on the tool significantly affects surface roughness. The other types of tool wears are generally avoided by proper selection of tool material and cutting conditions. On-line tool wear compensations and surface roughness measurements gained significant importance in manufacturing systems to provide accurate machining. The Acoustic Emission (AE) analysis is one of the most promising techniques for on-line tool wear and surface roughness monitoring. The AE signals are very sensitive to changes in cutting process conditions. The gradual flank wear of the tool in turning causes changes in AE signal parameters. In the present work investigations are carried for turning operation on mild steel material using HSS tool. The AE signals are measured by highly sensitive piezoelectric element, the on-line signals are suitably amplified using a high gain pre-amplifier. The amplified signals then recorded on to a computer and then analysed using MAT LAB. A program is written to measure AE signal parameters like Ring down count (RDC), Signal Rise Time, and RMS voltage. The surface roughness is measured by roller ended linear variable probe, fitted and moved along with tool turret on a CNC lathe machine. The linear movements of probe are converted in the form of continuous signals and are displayed on-line in the computer. Flank wear is measured by Toolmaker's Microscope. The results thus plotted show a significant relation between Flank Wear and Surface Roughness with AE signal parameters. The conclusions are made for predicting tool wear and surface roughness by suggesting consistent values and ranges for on-line monitoring AE signal parameters. Source

Kotakadi V.S.,A.P.S. University | Gaddam S.A.,A.P.S. University | Gaddam S.A.,Sri Padmavathi Mahila University | Saigopal D.V.R.,A.P.S. University
Research Journal of Pharmaceutical, Biological and Chemical Sciences

A tospo virus infecting sunflower in India was characterized by host range studies, the virus was purified and polyclonal anti serum was produced. The virus infecting sunflower reacted with homologous antiserum, and PBNV antiserum is DAC-ELISA, and failed to react with TSWV, INSV, IYSV and PSNV. The purified virus resolved as four polypepticles species of 331, 58, 52, 31 kD in SDS PAGE. In electro blot immuno assay, all four polypeptides reacted with homologous antiserum, and only nucleocapsid protein of 31kD reacted with recombinant nucleocapsid antibodies raised against PBNV and none of the polypeptides reacted with TSWV, INSV and IYSV. The RNA from purified virus resolved into three bands of L RNA of 9 Kb, M RNA of 5 Kb and S RNA of 3.5 Kb in agarose gel electrophoresis. Source

Sasidhar R.L.C.,Chebrolu Hanumaiah Institute of Pharmaceutical science | Vidyadhara S.,Chebrolu Hanumaiah Institute of Pharmaceutical science | Nagaraju R.,Sri Padmavathi Mahila University
Asian Journal of Chemistry

In the present investigation controlled release formulations of losartan potassium were formulated using poly(ethylene oxides) as release rate controlling polymer. Different excipients like ethyl cellulose, di calcium phosphate and starch 1500 were used in the preparation of matrix tablets and evaluated for their influence on controlled drug release. The matrix tablets were prepared by direct compression process and evaluated for hardness, weight variation, friability, swelling index and for in vitro release of the drug. Biopharmaceutical evaluation of satisfactory formulations were also carried out and parameters like Cmax, tmax, AUC0-t and AUMC0-t were determined. The studies were conducted on Newzealand rabbits. All the physical characteristics evaluated for the tablets were found to be within the acceptable limits. Higher polymeric content of poly(ethylene oxide) in the matrix tablets decreased the release rate of drug. At lower polymeric level the rate and extent of drug release was elevated. On the other hand the excipients like dibasic calcium phosphate, starch 1500 and ethyl cellulose have significantly retarded the release rate of losartan potassium. In vivo pharmacokinetic study proves that the losartan potassium from test tablets show prolonged release and may be able to sustain the therapeutic effect which can be further proved by pharmacodynamic study. Source

Bharathi K.,Sri Padmavathi Mahila University | Omprakash G.,PharmaZell R and D India Private Ltd
Asian Journal of Chemistry

A series of 2,3-substituted-4-phenyl-1,3-oxazolidine derivatives were synthesized from DL-(±)-phenyl glycine. DL-(±)-Phenyl glycine was reduced to the corresponding alcohol, which was then condensed with different aldehydes to form Schiff bases, which are then educed and further condensed with different substituted aldehydes to give the oxazolidine derivatives. The synthesized compounds are characterized by 1H NMR, IR and mass spectral analysis. All the compounds were investigated for cardiac activity while all the compounds show significant activity. Source

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