Sri Padmavathi Mahila University

Tirupati, India

Sri Padmavathi Mahila University

Tirupati, India
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Vidyadhara S.,Chebrolu Hanumaiah Institute of Pharmaceutical science | Sasidhar R.L.C.,Chebrolu Hanumaiah Institute of Pharmaceutical science | Nagaraju R.,Sri Padmavathi Mahila University
Indian Journal of Pharmaceutical Sciences | Year: 2013

In the present investigation an attempt has been made to increase therapeutic efficacy, reduced frequency of administration and improved patient compliance by developing controlled release matrix tablets of verapamil hydrochloride. Verapamil hydrochloride was formulated as oral controlled release matrix tablets by using the polyethylene oxides (Polyox WSR 303). The aim of this study was to investigate the influence of polymer level and type of fillers namely lactose (soluble filler), swellable filler (starch 1500), microcrystalline cellulose and dibasic calcium phosphate (insoluble fillers) on the release rate and mechanism of release for verapamil hydrochloride from matrix tablets prepared by direct compression process. Higher polymeric content in the matrix decreased the release rate of drug. On the other hand, replacement of lactose with anhydrous dibasic calcium phosphate and microcrystalline cellulose has significantly retarded the release rate of verapamil hydrochloride. Biopharmaceutical evaluation of satisfactory formulations were also carried out on New Zealand rabbits and parameters such as maximum plasma concentration, time to reach peak plasma concentration, area under the plasma concentration time curve (0-t) and area under first moment curve (0-t) were determined. In vivo pharmacokinetic study proves that the verapamil hydrochloride from matrix tablets showed prolonged release and were be able to sustain the therapeutic effect up to 24 h.

Sasidhar R.L.C.,Chebrolu Hanumaiah Institute of Pharmaceutical science | Vidyadhara S.,Chebrolu Hanumaiah Institute of Pharmaceutical science | Deepti B.,P.A. College | Nagaraju R.,Sri Padmavathi Mahila University | Satish Raj K.,Chebrolu Hanumaiah Institute of Pharmaceutical science
Der Pharmacia Lettre | Year: 2014

Venlafaxine hydrochloride is used in the treatment of depression and anxiety disorders. The objective of the present study was to prepare the orodispersible tablets of venlafaxine hydrochloride by sublimation method. Camphor and menthol are used as subliming agents. Tablets are prepared by direct compression process with calcium silicate and sodium starch glycolate as super disintegrants and mannitol as bulking agent. The prepared tablets were evaluated for hardness, friability, in vitro dispersion time, weight uniformity, wetting time and for in vitro drug release. Further the tablets were characterized by Fourier Transform Infra Red Spectroscopy and by Differential Scanning Calorimetry. Sublimation of camphor from tablets resulted in superior tablets as compared with tablets prepared with menthol as sublimating agent. Among all the formulations the tablets prepared by sublimating camphor with sodium starch glycolate as super disintegrant showed faster disintegration and rapid drug release.

Indira Muzib Y.,Sri Padmavathi Mahila University | Kurri P.,Sri Padmavathi Mahila University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

Ambroxol hydrochloride was designed as a hydrophilic matrix sustained release tablet employing gum olibanum and the sustained release behavior of the fabricated tablets was investigated. Sustained release matrix tablets containing 75mg Ambroxol hydrochloride were formulated using natural polymer like gum olibanum in different drug: polymer ratios, such as F1(1:1), F2(1:1.5), F3(1:2) by wet granulation technique. Microcrystalline cellulose was used as diluent. All the lubricated formulations were compressed using 7mm flat faced punches. The formulation was optimized on the basis of acceptable tablet properties, in vitro drug release and similarity with marketed sample. The prepared granules were evaluated for angle of repose, bulk density, compressibility index, Hauser ratio and drug content. The resulting formulations showed optimum hardness, good weight uniformity, uniform thickness and low friability. The results of in vitro dissolution studies indicated that all the formulations exhibited good drug release pattern. The data was fitted to various kinetic models to know the mechanism of drug release. The optimized Ambroxol hydrochloride matrix tablets [F2] were packed in glass bottle and subjected to short term stability studies which were carried out at 45°C with 75% RH for 45 days revealed that no considerable differences in drug content, dissolution, T 50, and T 90 were observed. Present work indicates that utility of gum olibanum in the formulations of sustained release dosage forms.

Indira M.Y.,Sri Padmavathi Mahila University
Journal of Chemical and Pharmaceutical Sciences | Year: 2014

The objective of present work is to develop and evaluate a matrix system for Chronotherapeutic delivery of centrally acting opioid analgesic (Tramadol HCl) containing Gum kondagogu as carrier for the treatment of rheumatoid arthritis. If the formulation is administered at night time, symptoms that are sever in early morning hours can be treated. Core tablets of Tramadol HCl were prepared by using 30, 40, 50, 60 and 70% w/w of tablet of Gum kondagogu as carrier by wet granulation technique. These tablets were compression coated with Eudragit S100 to prevent drug release in stomach. All formulations were evaluated for hardness, friability, weight variation, drug content, in vitro and in-vivo studies. The Gum kondagogu was characterized by viscosity measurements and FTIR analysis. The coated (FC1 to FC5) and uncoated tablets (F1 to F5) were evaluated for in vitro release of Tramadol HCl after sequential exposure to pH 1.2, pH 7.4 and pH 6.8 respectively for 2hr, 3hr and 19hr in the absence as well as presence of rat caecal content. The selected formulation was subjected to in vivo targeting efficacy studies by Roentgenography technique. In vitro release studies indicated that the matrix tablets (F1 to F5) failed to control the drug release in the physiological environment of stomach and small intestine. On the other hand, compression coated formulations were able to protect the tablet cores from premature drug release. In the absence of rat caecal contents, compression coated FC4 and FC5 released 98.45±0.37% and 89.67±0.43% drug respectively at the end of 24hrs. When dissolution study was continued in pH 6.8 PBS containing 4% w/v of rat caecal contents, FC4 released about 99.18±0.29% drug at the end of 22hrs. FTIR studies confirmed that there was no interaction between the drug and the carrier. X-ray studies confirmed that the tablet successfully reached colon without getting disintegrated in upper gastro intestinal tract. Based on the results, selective delivery of Tramadol HCl to the colon could be achieved using 60% w/w (FC4) of Gum kondagogu matrix tablets compression coated with Eudragit S100. © 2014, SPB Pharma Society. All rights reserved.

Bharathi K.,Sri Padmavathi Mahila University | Omprakash G.,PharmaZell R and D India Private Ltd
Asian Journal of Chemistry | Year: 2011

A series of 2,3-substituted-4-phenyl-1,3-oxazolidine derivatives were synthesized from DL-(±)-phenyl glycine. DL-(±)-Phenyl glycine was reduced to the corresponding alcohol, which was then condensed with different aldehydes to form Schiff bases, which are then educed and further condensed with different substituted aldehydes to give the oxazolidine derivatives. The synthesized compounds are characterized by 1H NMR, IR and mass spectral analysis. All the compounds were investigated for cardiac activity while all the compounds show significant activity.

Madhukar Reddy C.,AP Model School | Deva Prasad Raju B.,Sri Venkateswara University | John Sushma N.,Sri Padmavathi Mahila University | Dhoble N.S.,Sevadal Mahila Mahavidhyalaya | Dhoble S.J.,Rashtrasant Tukadoji Maharaj Nagpur University
Renewable and Sustainable Energy Reviews | Year: 2015

Trivalent rare earth ions show interesting optical properties and such properties have high technological applications of rare earth doped materials such as energy saving lighting devices, optical displays, optical fibers, amplifiers and lasers. Among these materials rare earth ions doped glasses are of great important to optoelectronics and are widely used in fiber amplifiers and solid state high power lasers for telecommunications and light emitting diodes. Near-infrared luminescence for high power lasers is a current requirement in modern fiber optic telecommunication network and emphasis has to put in recent advances of NIR emitting materials for amplifiers, fiber lasers and waveguides. We make an effort to satisfy the above needs by preparing the LCZSFB glasses doped with Sm3+, Dy3+, Eu3+, Tb3+ and Nd3+ rare earth ions. In this review, optical properties of LCZSFB glasses doped with Sm3+, Dy3+, Eu3+, Tb3+ and Nd3+ rare earth ions and the current status of their applications is given. © 2015 Elsevier Ltd.

Reddy T.S.,R Y M Engineering College | Reddy C.E.,Sri Padmavathi Mahila University
International Journal of Robotics and Automation | Year: 2011

Every tool is subjected to wear in machining. The wear of the tool is gradual and reach its limit of life which is identified when the tool no longer produce the parts to required quality. There are various types of wear a single point cutting tool may be subjected in turning. Of these, flank wear on the tool significantly affects surface roughness. The other types of tool wears are generally avoided by proper selection of tool material and cutting conditions. On-line tool wear compensations and surface roughness measurements gained significant importance in manufacturing systems to provide accurate machining. The Acoustic Emission (AE) analysis is one of the most promising techniques for on-line tool wear and surface roughness monitoring. The AE signals are very sensitive to changes in cutting process conditions. The gradual flank wear of the tool in turning causes changes in AE signal parameters. In the present work investigations are carried for turning operation on mild steel material using HSS tool. The AE signals are measured by highly sensitive piezoelectric element, the on-line signals are suitably amplified using a high gain pre-amplifier. The amplified signals then recorded on to a computer and then analysed using MAT LAB. A program is written to measure AE signal parameters like Ring down count (RDC), Signal Rise Time, and RMS voltage. The surface roughness is measured by roller ended linear variable probe, fitted and moved along with tool turret on a CNC lathe machine. The linear movements of probe are converted in the form of continuous signals and are displayed on-line in the computer. Flank wear is measured by Toolmaker's Microscope. The results thus plotted show a significant relation between Flank Wear and Surface Roughness with AE signal parameters. The conclusions are made for predicting tool wear and surface roughness by suggesting consistent values and ranges for on-line monitoring AE signal parameters.

Savithramma N.,Sri Venkateswara University | Linga Rao M.,Sri Venkateswara University | Rukmini K.,Sri Padmavathi Mahila University | Suvarnalatha Devi P.,Sri Padmavathi Mahila University
International Journal of ChemTech Research | Year: 2011

Biologically synthesized silver nanoparticles (SNPs) are being widely using in the field of medicine. Extracellular biosynthesis of silver nanoparticles was carried out by using medicinal plant extracts for the reduction of aqueous silver ions in short period. The silver nanoparticles formation was confirmed by the colour change of plant extracts (SNPs) and further confirmed with the help of UV-Vis spectroscopy. These Phytosynthesized silver nanoparticles were tested for antibacterial and antifungal activities using disc diffusion method. The test cultures are Proteus, Pseudomonas, Klebsiella, Bacillus and E.coli species of bacteria and Aspergillus, Fusarium, Curvularia and Rhizopus species of fungal were used. The microbial property of silver nanoparticles was analyzed by measuring the inhibition zone. The silver nanoparticles synthesized from stem bark extracts of Boswellia and Shorea; and leaf extract of Svensonia. The SNPs synthesized from bark extracts of Boswellia ovalifoliolata and Shorea tumbuggaia showed toxic towards Klebsiella and Aspergillus; and Pseudomonas and Fusarium species respectively. Whereas the growth of Pseudomonas and Rhizopus species were inhibited maximum by the SNPs synthesized from leaf extract of Svensonia hyderobadensis, the results indicate that the silver nanoparticles may have an important advantage over conventional antibiotics.

John Sushma N.,Sri Padmavathi Mahila University | Mahitha B.,Sri Padmavathi Mahila University | Sravanthi P.L.,Sri Padmavathi Mahila University | Priyanka S.,Sri Padmavathi Mahila University | Jayantha Rao K.,Sri Venkateswara University
International Journal of Pharma and Bio Sciences | Year: 2011

We have examined the effect of aluminum (Al) acetate on albino mice. Different doses of aluminum acetate (3.5 mg/kg body weight (b.w), intraperitoneal injection., single dose:3.5mg/kg b.w, double dose:3.5 mg/kg b.w, with 72 h interval on 1 st and 4 th day and multiple doses: 3.5 mg/kg b.w, with 72 h interval on 1 st, 4 th,7 th and 10 th day) resulted alterations in tissue histology of liver, kidney, intestine and testis. Our findings indicate that the pronounced pathological changes in multiple doses compared to double and single dose administered mice. We found that dose dependent exposure of aluminum acetate causes deleterious effects and make them less fit for better survival.

Bhanu Priya K.,Sri Padmavathi Mahila University | Kotakadi V.S.,Sri Venkateswara University | Josthna P.,Sri Padmavathi Mahila University
International Journal of Pharma and Bio Sciences | Year: 2013

Syzygium aromaticum is commonly known as clove, it is the dried bud of the tree. Cloves are of high medicinal value they are widely used in ayurveda, chinese medicine, western herbalism and also as a food ingredient. The present study was taken up to evaluate antimutagenic activity of ethyl acetate extract of clove with reference to the frequency of polychromatic erythrocytes (PCE) in the bone marrow of mice, administered intraperitoneally (i.p) using bone marrow micro nucleus test. Mice were given with ethyl acetate extract doses of 500,750 mg/kg/day intraperitoneal. In addition, Mitomycin C (MMC) given to the animals at the dose of 4mg/kg by single intraperitoneal injection. Smear specimens were prepared from bone marrows and stained with May-Grunwald's followed by Giemsa stain then the frequencies of micro nucleated PCEs and the ratio of total number of (PCE/NCE) were calculated. Ethyl acetate extract of Syzygium aromaticum (750mg/kg) showed significant antimutagenic activity.

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