Sri Muthukumaran Medical College and research institute

Tamilnadu, India

Sri Muthukumaran Medical College and research institute

Tamilnadu, India
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Faridha Begum I.,SRM University | Mohankumar R.,SRM University | Jeevan M.,Sri Muthukumaran Medical College and Research Institute | Ramani K.,SRM University
Indian Journal of Microbiology | Year: 2016

The present investigation is focused on the study of chemical composition of a bioactive compound derived from a rumen isolate Paracoccus pantotrophus FMR19 using GC–MS and to find out the antibacterial activity of the extracted crude bioactive compounds against multidrug resistant organisms (MDROs) and other clinical pathogens. GC–MS analysis revealed that P. pantotrophus FMR19 produced eight major compounds that have been reported to exhibit antimicrobial property. The main components identified from hexane fraction are long chain alkanes, fatty alcohols, fatty acid methyl ester and aromatic hydrocarbons. These molecules are not only active against clinical pathogens such as Salmonella sp. and Proteus sp. and also effective against MDROs such as Metallo β lactamase and Pan drug resistant bacterial strains and Methicillin resistant Staphylococcus aureus. © 2016, Association of Microbiologists of India.


Rahul M.K.,Sri Muthukumaran Medical College and Research Institute | Krishnamoorthy,Meenakshi Medical College and Research Institute
Journal of Global Infectious Diseases | Year: 2012

Chikungunya, an alpha virus belonging to the family of Togaviridae is transmitted to humans by the bite of Aedes aegypti mosquito and presents with fever, headache, rash, and severe arthralgia. Chikungunya virus is not known to be neurotropic, but cases of meningoencephalitis have been reported during outbreaks. The clinical, laboratory and neuroimaging findings of a 56-year-old man who initially developed Chikungunya fever with arthralagia and later on lead to Chikungunya myeloradiculopathy, a relatively unknown and rare complication of the infection has been presented.


Nithyalakshmi J.,Sri Muthukumaran Medical College and research institute
International Journal of Pharma and Bio Sciences | Year: 2014

Urinary Tract Infection is a common medical complication of pregnancy. UTI is of great clinical concern in this group, as it has adverse maternal and obstetric outcomes. The changing pattern of antimicrobial resistance of uropathogens is a growing problem. Knowledge about the current trends of bacterial profile and their antibiogram pattern in pregnant women may help the clinician to choose the appropriate regime.The aims of this study were to assess bacterial profile that causes UTI among pregnant women and to determine the resistance patterns of urinary isolates in our region.Three hundred and three pregnant women with asymptomatic and symptomatic UTI were included in this study from March 2012 to march 2013. Samples were processed and isolates were identified as per the CLSI guidelines. Antibiotic susceptibility was done by kirby bauer disk diffusion method.The overall prevalence of UTI in pregnant women was 14.19%. The age range of the study group was 20 to 42 years. Screening for uropathogens by the gold standard culture technique revealed that 14.77% and 10.25% of the total midstream urine samples had significant bacteriuria in asymptomatic and symptomatic group. The predominant bacterial pathogens were E. coli (65.11%) followed by Klebsiella pneumonia (11.62%), Staphylococcus aureus (11.62%) and Proteus mirabilis (4.65%). The gram positive and gramnegative bacteria accounted for 18.6% and 81.39% respectively. The susceptibility pattern of gram negative bacteria showed that most of the isolates (>70% of the isolates) were sensitive to Norfloxacin, Ceftriaxone and Augmentin. Resistance to amoxicillin and cotrimoxazole was significant in all isolates. In this study the gram negative isolates showed a low degree of susceptibility to Gentamicin (22.85%) and Amikacin (25.71%). Among the gram positives, more than 75% of the isolates were sensitive to Ampicillin, Ciprofloxacin, Norfloxacin, Gentamicin, Amikacin , Ceftriaxone and Augmentin.Significant bacteriuria was observed both in symptomatic and asymptomatic pregnant women. Antimicrobial sensitivity pattern of isolated uropathogens showed a changing pattern,so we recommend periodic monitoring of resistance pattern and development of specific guidelines based on local susceptibility patterns, as this would prevent the spread and further development of resistant strains eventually.


Fathima H.,Sri Muthukumaran Medical College and Research Institute | Harish,Sri Muthukumaran Medical College and Research Institute
Journal of Natural Science, Biology and Medicine | Year: 2015

Objective: We analyzed the morphological changes and alkaline phosphatase (ALP) level in fibroblast, which is indicative of their functional ability when cultured in three different commercially available graft materials with osseoconductive property. Materials and Methods: Fibroblasts obtained from fifth passage were seeded within three different bone substitutes (bovine hydroxyapatite [HA] [Osseo-graft ® ], β-tricalciumphosphate [RTR ® ], bovine HA [Bio-oss ® ]) and incubated under standard cell culture conditions. 10 samples in each group were evaluated for cell morphology and alkaline phosphates activity using scanning electron microscopy and spectrophotometric analysis on the 7 th day of culture. Results: Fibroblast cultured with RTR ® showed changes in morphology and increase in ALP activity when compared to fibroblast cultured with Osseo-graft ® and Bio-oss ®. Conclusion: Alkaline phosphatase activity was observed in fibroblasts when cultured with three types of commercially available bone grafts. ALP activity was highest when cultured with β-tricalcium phosphate graft material indicating its better bone regenerating capacity of this graft material.


Thangarajah A.,Sri Muthukumaran Medical College and Research Institute | Parthasarathy R.,Sri Muthukumaran Medical College and Research Institute
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: With the increase in the hepatobiliary, pancreatic surgeries and liver transplantation, being aware of the anatomic variations of the celiac axis and the hepatic arteries is of paramount importance. Aim: To illustrate the normal anatomy and variants of the celiac axis and the hepatic arteries with multidetector computed tomographic (MDCT) angiography in South Indian population and determine the potential variations in the celiac axis anatomy and the hepatic arteries, thus assisting the hepatobiliary surgeon and the interventional radiologist in avoiding iatrogenic injury to the arteries. Materials and Methods: Two hundred patients undergoing abdominal CT angiography from July 2014 till July 2015 were retrospectively studied for hepatic arterial and celiac axis anatomical variation. The anatomic variations in our study were correlated with other studies. Results: The celiac axis (CA) and the hepatic artery (HA) variations were analysed as per criteria laid by Song et al., and Michel. Out of 15 possible CA variations, 5 types of celiac artery variations were seen in 14 patients. A normal CA was seen in 179(89.5%) patients of the 200 patients. In the remaining 7 patients, the CA anatomy was classified as ambiguous since there was separate origin of the right and left hepatic arteries from the CA with absent common hepatic artery (CHA). The CHA originated normally from the celiac axis in 94% of the cases. Variation of CHA origin was seen in 5 patients. Normal HA anatomy was seen in 114 (57%) patients. Variation in HA anatomy was seen in 86 (43%) patients. Origin of the right hepatic artery (RHA) from the hepatic artery proper was seen in 182 (91%) patients and replaced origin of RHA from the superior mesenteric artery (SMA) was seen in 18 (9%) of the cases. Accessory RHA was seen in 7(3.5%) patients. The left hepatic artery (LHA) originated from the hepatic artery proper in 186 (93%) patients and replaced origin of LHA from the left gastric artery (LGA) was found in 14 (7%) patients. Accessory left hepatic artery was found in 22(11%) cases. Double hepatic artery seen in 7(3.5%) patients. CHA replaced to LGA was seen in 1 patient (0.5%). CHA trifurcation was seen in 11 (5.5%) patients. CHA was replaced to SMA in 4 (2%) cases. Conclusion: Our study identified the normal anatomy and variations in celiac axis and hepatic arterial anatomy in South Indian population, which correlated well with studies in other populations. © 2015, Journal of Clinical and Diagnostic Research. All rights Reserved.


Fathima K.H.,Sri Muthukumaran Medical College and Research Institute | Harish V.S.,Sri Muthukumaran Medical College and Research Institute
Journal of Pharmacy and Bioallied Sciences | Year: 2015

Severe surgical techniques have been introduced to augment gingival tissue dimensions like the free gingival graft, free connective grafts, etc., However, both the techniques are associated with significant patient morbidity due to the secondary surgical site. In order to overcome these postsurgical complications, acellular dermal allografts have been used as a substitute for the palatal donor tissue yielding clinically comparable results. However, the cost and origin of the material raises concern regarding the frequent use of the material. As an improved alternative to above-mentioned graft material, the use of platelet-rich fibrin (PRF) and collagen matrices has been promoted in the recent past. The objective of this illustrative case report is to test the efficacy of collagen matrix, PRF to augment attached gingiva and to assess the esthetic outcome when compared to the standard treatment with free autogenous graft. © 2015 Journal of Pharmacy And Bioallied Sciences | Published by Wolters Kluwer - Medknow.


Gopinathan S.,Salem College | Janagond A.B.,Sri Muthukumaran Medical college and Research institute | Agatha D.,Madras Medical college | Thenmozhivalli P.R.,Villupuram Medical college
Journal of Clinical and Diagnostic Research | Year: 2013

Background and Aims: This study was done to detect the prevalence, risk factors for vaginal candidiasis in Chennai and to evaluate different methods for speciation of Candida isolates from vaginal candidiasis patients. This study was also aimed at detecting resistance patterns of Candida spp to common antifungals and at detecting mutant FUR1 genes in 5-Flucytosine (5 FC) resistant isolates. Materials and Methods: Two hundred clinically suspected vaginal candidiasis patients were screened for candidiasis and isolated Candida were speciated by standard morphological and biochemical tests (sugar fermentation and assimilation) and by using CHROM agar-Candida medium. Antifungal susceptibility was performed by disk diffusion method (CLSI M44-A) using fluconazole, itraconazole and 5FC disks. Five FC resistant isolates were subjected to PCR for detection of mutant FUR1 genes. Results: A total of 72 (36%) Candida spp. were obtained. Vaginal candidiasis was more prevalent in 31-40 years age group and among those with poor genital hygiene and who wore tight fitting synthetic/nylon underclothes. C.albicans (35), C.tropicalis (8), C.glabrata (21), C.krusei (4) were identified by both carbohydrate assimilation test and by using CHROM agar-Candida medium. C.kefyr (2) and C.parapsilosis (2) could not be identified using CHROM agar-Candida. Resistance to fluconazole, itraconazole and 5-flucytosine was seen in 19.44%, 23.61% and 41.66% of the isolates respectively. Mutant FUR1 gene was detected in all the Candida spp that were resistant to 5FC. Conclusion: C.albicans was the commonest species which caused vaginal candidiasis in Chennai. Though CHROM agar-candida medium is a useful differential isolation medium capable of early presumptive identification of Candida species, it could not identify C.kefyr and C.parapsilosis. Azole resistance was low in C. albicans but it was high in non-albicans Candida spp. Prevalence of primary resistance to 5-flucytosine was high in the strains studied and in all of them, it was mediated by mutant FUR1 gene.


PubMed | SRM University and Sri Muthukumaran Medical College and Research Institute
Type: Journal Article | Journal: Indian journal of microbiology | Year: 2016

The present investigation is focused on the study of chemical composition of a bioactive compound derived from a rumen isolate


PubMed | Sri Muthukumaran Medical College and Research Institute
Type: Journal Article | Journal: Journal of pharmacy & bioallied sciences | Year: 2015

Severe surgical techniques have been introduced to augment gingival tissue dimensions like the free gingival graft, free connective grafts, etc., However, both the techniques are associated with significant patient morbidity due to the secondary surgical site. In order to overcome these postsurgical complications, acellular dermal allografts have been used as a substitute for the palatal donor tissue yielding clinically comparable results. However, the cost and origin of the material raises concern regarding the frequent use of the material. As an improved alternative to above-mentioned graft material, the use of platelet-rich fibrin (PRF) and collagen matrices has been promoted in the recent past. The objective of this illustrative case report is to test the efficacy of collagen matrix, PRF to augment attached gingiva and to assess the esthetic outcome when compared to the standard treatment with free autogenous graft.


PubMed | Sri Muthukumaran Medical College and Research Institute
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

With the increase in the hepatobiliary, pancreatic surgeries and liver transplantation, being aware of the anatomic variations of the celiac axis and the hepatic arteries is of paramount importance.To illustrate the normal anatomy and variants of the celiac axis and the hepatic arteries with multidetector computed tomographic (MDCT) angiography in South Indian population and determine the potential variations in the celiac axis anatomy and the hepatic arteries, thus assisting the hepatobiliary surgeon and the interventional radiologist in avoiding iatrogenic injury to the arteries.Two hundred patients undergoing abdominal CT angiography from July 2014 till July 2015 were retrospectively studied for hepatic arterial and celiac axis anatomical variation. The anatomic variations in our study were correlated with other studies.The celiac axis (CA) and the hepatic artery (HA) variations were analysed as per criteria laid by Song et al., and Michel. Out of 15 possible CA variations, 5 types of celiac artery variations were seen in 14 patients. A normal CA was seen in 179(89.5%) patients of the 200 patients. In the remaining 7 patients, the CA anatomy was classified as ambiguous since there was separate origin of the right and left hepatic arteries from the CA with absent common hepatic artery (CHA). The CHA originated normally from the celiac axis in 94% of the cases. Variation of CHA origin was seen in 5 patients. Normal HA anatomy was seen in 114 (57%) patients. Variation in HA anatomy was seen in 86 (43%) patients. Origin of the right hepatic artery (RHA) from the hepatic artery proper was seen in 182 (91%) patients and replaced origin of RHA from the superior mesenteric artery (SMA) was seen in 18 (9%) of the cases. Accessory RHA was seen in 7(3.5%) patients. The left hepatic artery (LHA) originated from the hepatic artery proper in 186 (93%) patients and replaced origin of LHA from the left gastric artery (LGA) was found in 14 (7%) patients. Accessory left hepatic artery was found in 22(11%) cases. Double hepatic artery seen in 7(3.5%) patients. CHA replaced to LGA was seen in 1 patient (0.5%). CHA trifurcation was seen in 11 (5.5%) patients. CHA was replaced to SMA in 4 (2%) cases.Our study identified the normal anatomy and variations in celiac axis and hepatic arterial anatomy in South Indian population, which correlated well with studies in other populations.

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