Veluswami D.,Sri Manakula Vinayagar Medical College and HospitalPuducherry |
Ambigai Meena B.,Sree Lakshmi Narayana Institute of Medical SciencesPuducherry |
Latha S.,Sree Lakshmi Narayana Institute of Medical SciencesPuducherry |
Gayathri Fathima I.,Sree Lakshmi Narayana Institute of Medical SciencesPuducherry |
And 2 more authors.
Journal of Clinical and Diagnostic Research | Year: 2015
Introduction: Taste blindness to the phenylthiocarbamide (PTC) is an inherited trait that is shown to influence our food and dietary preferences which in turn influence our body weight. Obesity is a global epidemic issue known to be on rise among the developing countries. Relating taste perception to obesity, the present study was undertaken to assess the prevalence of phenylthiocarbamide (PTC) taste blindness among obese individuals. Materials and Methods: Three hundred and fifty individuals of age group 20-40 y were recruited from the local community for the present cross sectional study. Anthropometric measurements were taken and BMI was calculated. Subjects were classified as underweight, normal, overweight and obese based on their BMI. Normal, overweight and obese individuals were then asked to taste the commercially available PTC test papers and classified as non tasters and tasters of PTC. Results: Out of 350 individuals, mean age group of 30±6.02 y, based on their BMI they were divided into 4 groups, Group A-underweight (16%), Group B-normal (35%), Group C-overweight (28%) and Group D-obese (21%) individuals. In group B, 28% were non tasters of PTC and 65% were tasters. In group C, 82% were non tasters and 13% were tasters and in Group D, 81% were non tasters and 19% were tasters of PTC. The PTC non taster phenotype individuals showed higher BMI as compared with the tasters’ phenotype. Conclusion: Exploring the novel connections between taste perception and obesity would help us to gain a control over the global epidemic-Obesity, which is the crux factor for various other health problems. The study advocates the usage of PTC tasting as a reliable indicator of weight gain susceptibility. © 2015, Journal of Clinical and Diagnostic Research. All right reserved.
Kalaiselvan G.,Sri Manakula Vinayagar Medical College and HospitalPuducherry |
Dongre A.R.,Sri Manakula Vinayagar Medical College and HospitalPuducherry |
Murugan V.,Sri Manakula Vinayagar Medical College and HospitalPuducherry
Indian Journal of Tuberculosis | Year: 2014
Background: As per the Medical Council of India (MCI), the posting in the Chest and TB department is elective during internship. Hence, they lack hands on exposure to various components of RNTCP programme. This gap in treating TB patients by using RNTCP guidelines may be bridged by sensitizing the interns through early exposure of medical interns to training programmes. Objective: The workshop was conducted and evaluated, 1) To know learners’ immediate reaction and 2) To know its effects on their learning and practice. Methods: A series of training workshop on RNTCP guidelines was organized for Interns by the Core-committee of the State Task Force (STF), RNTCP and Department of Community Medicine, Sri Manakula Vinayagar Medical College and Hospital (SMVMCH), Puducherry, during January2012-November 2012. A Pre and Post test self-administrated questionnaire, immediate feedback and other open-ended feedback after six months was obtained from Interns to know its effect on their clinical practice. Results: The pre and post test mean scores were highly significant (p<0.001). In the analysis of feedback, the consensus score for all the responses was above 75%. As per the responses of the feedback from interns taken after six months, the three broad categories of common responses from the manual content analysis emerged were: 1) Effect of training in patient care, 2) Acquaintance of RNTCP Guidelines, 3) Future Plan of application of lessons learned. Conclusion: This training programme has been well received by the medical interns and has now been incorporated as a regular activity for the Interns posted in the Department of Community Medicine. © 2014, Tuberculosis Association of India. All rights reserved.
Selvaraj N.,Sri Manakula Vinayagar Medical College and HospitalPuducherry |
Adhimoolam M.,Sri Manakula Vinayagar Medical College and HospitalPuducherry |
Perumal D.K.,Sri Manakula Vinayagar Medical College and HospitalPuducherry |
Rajamohammed M.A.,Sri Manakula Vinayagar Medical College and HospitalPuducherry
Journal of Clinical and Diagnostic Research | Year: 2015
Background: The available conventional antiepileptics do not afford cure or prophylactic treatment and henceforth there is always a quest to explore new targets for management of convulsions. In this perspective, dihydropyridine calcium channel blockers have been investigated in various animal models of epilepsy. Lercanidipine, a newer dihydropyridine calcium antagonist, is a potential candidate with its favourable lipid profile and longer duration of action. Objective: (1) To evaluate the anticonvulsant effect of lercanidipine alone and in combination with standard drug in adult male Swiss albino mice. (2) To evaluate the muscle relaxant and spontaneous locomotor activity of lercanidipine in adult male Swiss albino mice. Materials and Methods: Adult male Swiss albino mice weighing 20-30g were used to study the anticonvulsant, muscle relaxant and spontaneous locomotor activity using electroconvulsometer, rotarod and actophotometer apparatus respectively. The mice were divided into six groups of six animals in each group. Group 1 and 2 served as control (vehicle treated) and standard group respectively. Standard drug used to evaluate anticonvulsant effect is phenytoin sodium 25 mg/kg I.P. whereas muscle relaxant activity and locomotor activity is diazepam 4 mg/kg I.P., Group 3 and 4 received lercanidipine 1 and 3 mg/kg I.P., respectively. Anticonvulsant models included group 5 and 6 and they were given combination of phenytoin sodium 12.5 mg/kg I.P., with lercanidipine 1 and 3 mg/kg i.p, respectively. Abolition or reduction of tonic hind limb extension was considered as index of anticonvulsant activity whereas the balancing time of the animals in rod was recorded to asses muscle relaxant activity. The locomotor activity was recorded for 5 minutes. The data were analysed with one-way Analysis of Variance followed by post-hoc ‘Dunnett t-test’. Results: Lercanidipine given alone in a dose of 1 and 3 mg/kg had significantly reduced the tonic hind limb extension. Combination of lercanidipine (3 mg/kg) and phenytoin had offered 100% protection. The results also revealed that the test drug didn’t impair the motor coordination and locomotor activity in mice. Conclusion: The present study had demonstrated that lercanidipine could be potential novel candidate for the treatment of convulsions. © 2015, Journal of Clinical and Diagnostic Research. All right reserved.