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Fernando M.S.,University of Colombo | De Silva W.R.M.,University of Colombo | De Silva K.M.N.,University of Colombo | De Silva K.M.N.,Sri Lanka Institute of Nanotechnology
International Journal of Nanoscience | Year: 2014

In this study a novel nano composite of hydroxyapatite nano particles impregnated activated carbon (C-HAp), which was synthesized in our own method, was used in iron adsorption studies. The study was conducted in order to investigate the potential of using C-HAp nanocomposite to be used in clinical detoxifications such as acute iron toxicity where the use of Activated carbon (GAC) is not very effective. Adsorption studies were conducted for synthetic solutions of Fe2+, Fe3+ and iron syrup using GAC, C-HAp and neat HAp as adsorbents. According to the results C-HAp nano composite showed improved properties than GAC in adsorbing Fe2+, Fe3+ and also Fe ions in iron syrup solutions. Thus the results of the in-vitro studies of iron adsorption studies indicated the potential of using C-HAp as an alternative to activated carbon in such clinical applications. © 2014 World Scientific Publishing Company.

Samindra K.M.S.,Institute of Chemistry Ceylon | Kottegoda N.,University of Sri Jayewardenepura | Kottegoda N.,Sri Lanka Institute of Nanotechnology
Nanotechnology Reviews | Year: 2014

This study focuses on the encapsulation of natural curcumin present in turmeric (Curcuma longa L.) into a layered double hydroxide (LDH), which demonstrates slow release properties with future potential in therapeutic applications such as slow release wound dressings. Turmeric has been used in traditional medicinal applications since ancient times. The main active substances in turmeric are curcumin together with two related compounds, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), which have been extensively studied as antibacterial compounds. However, these molecules are unstable and, therefore, demonstrate limited biological activity and practical applications. In this study, attempts were made to synthesize curcumin in-situ encapsulated layered LDHs in order to stabilize the curcumin molecules within the nanolayers of the LDHs. The curcumin intercalated LDHs were synthesized by a simple in-situ co-precipitation method. The release characteristics of curcumin from the nanocomposites were quantitatively monitored under different pH conditions using UV-Visible spectroscopic methods, and the results indicate that the nanocomposite has the future potential in slow release therapeutic applications.

Karunaratne D.N.,University of Peradeniya | Jafari M.,Massachusetts Institute of Technology | Ranatunga R.J.K.U.,University of Peradeniya | Siriwardhana A.,Sri Lanka Institute of Nanotechnology
Current Pharmaceutical Design | Year: 2015

This review is based on carriers of natural origin such as polysaccharides, proteins, and cell derived entities which have been used for delivery of siRNA. To realize the therapeutic potential of a delivery system, the role of the carrier is of utmost importance. Historical aspects of viral vectors, the first carriers of genes are briefly outlined. Chitosan, one of the extensively experimented carriers, alginates and other polysaccharides have shown success in siRNA delivery. Peptides of natural origin and mimics thereof have emerged as another versatile carrier. Exosomes and mini cells of cellular origin are the newest entrants to the area of siRNA delivery and probably the closest one can get to a natural carrier. In many of the carriers, modifications have provided better efficiency in delivery. The salient features of the carriers and their advantages and disadvantages are also reviewed © 2015 Bentham Science Publishers.

Wijesena R.N.,Sri Lanka Institute of Nanotechnology | Tissera N.,Sri Lanka Institute of Nanotechnology | Kannangara Y.Y.,Sri Lanka Institute of Nanotechnology | Lin Y.,CAS Changchun Institute of Applied Chemistry | And 2 more authors.
Carbohydrate Polymers | Year: 2015

A method of top down preparation of chitosan nanoparticles and nanofibers is proposed. Chitin nanofibrils (chitin NFs) were prepared using ultrasonic assisted method from crab shells with an average diameter of 5 nm and the length less than 3 μm as analyzed by atomic force microscopy and transmission electron microscopy. These chitin nanofibers were used as the precursor material for the preparation of chitosan nanoparticles and nanofibers. The degree of deacetylation of these prepared chitosan nanostructures were found to be approximately 98%. In addition these chitosan nanostructures showed amorphous crystallinity. Transmission electron microscopic studies revealed that chitosan nanoparticles were roughly spherical in nature and had diameters less than 300 nm. These larger particles formed through self-assembly of much smaller 25 nm particles as evidenced by the TEM imaging. The diameter and the length of the chitosan nanofibers were found to be less than 100 nm and 3 μm respectively. It is envisaged that due to the cavitation effect, the deacetylated chitin nanofibers were broken down to small pieces to form seed particles. These seed particles can then be self-assembled to form larger chitosan nanoparticles. © 2014 Elsevier Ltd. All rights reserved.

Butt H.,University of Cambridge | Dai Q.,University of Cambridge | Rajasekharan R.,University of Cambridge | Wilkinson T.D.,University of Cambridge | And 2 more authors.
Applied Physics Letters | Year: 2011

We report enhanced reflection displayed by arrays of silicon based inverted nanocones. Theoretical studies suggest that such arrays display enhanced reflection and photonic band gaps within the optical and near infrared regions. Measured results show three to four fold enhancement in reflection and agree well with calculations. Such arrays can be used to enhance infrared reflection in photovoltaic devices which mostly contribute towards heating. © 2011 American Institute of Physics.

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