Sri Lakshmi Narayana Institute of Medical science

Puducherry, India

Sri Lakshmi Narayana Institute of Medical science

Puducherry, India
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Basalingappa S.,Sri Lakshmi Narayana Institute of Medical science | Sharma A.,Sri Lakshmi Narayana Institute of Medical science | Amarnath S.,Sri Lakshmi Narayana Institute of Medical science
International Journal of Current Pharmaceutical Review and Research | Year: 2015

Therapeutic Drug Monitoring (TDM) is the process of measuring the concentration of a drug in blood and then correlating it clinically in order to optimize the therapy for the patient. It started in the 1960s and the last three decades have seen enormous spurt in the number of hospitals and laboratories routinely doing it in order to provide greater insights into factors that determine a patient's response to drug therapy. It is done mainly for drugs with narrow margin of safety, whose therapeutic effects cannot be quantified clinically. Suitable analytical tests like High Performance Liquid Chromatography (HPLC) and Immunoassays are available to detect drug or its metabolites and the results are then interpreted in the context of the condition of the patient. It serves as a useful tool to provide tailor made optimal drug therapy to the patient, thereby maximizing the efficacy and minimizing the side effects.

Arun Babu T.,Sri Lakshmi Narayana Institute of Medical science | Sharmila V.,Indira Gandhi Medical College and Research Institute
Pediatric Dermatology | Year: 2012

Miliaria crystallina (MC) is a self-limiting, superficial obstruction of the eccrine sweat ducts with subsequent extravasation of sweat, resulting in rapidly surfacing, tiny, clear, noninflammatory vesicles. The disease is seen frequently in hot, humid, tropical climates and in the neonatal period, but congenital occurrence is rare. We report a case of congenital MC in a baby born to a mother with chorioamnionitis. © 2011 Wiley Periodicals, Inc.

Babu T.A.,Sri Lakshmi Narayana Institute of Medical science | Sharmila V.,Sri Lakshmi Narayana Institute of Medical science
Indian Journal of Pharmacology | Year: 2011

A case of 7-day-old male neonate with cefotaxime-induced near-fatal anaphylaxis is being reported. Child was started on intravenous cefotaxime on day 3 of life in view of early-onset sepsis with pneumonia, following which there was clinical improvement. Child was then shifted out of intensive care to general ward for completion of antibiotic course. One day prior to the planned discharge, child suddenly developed poor sensorium, flaccidity, apnea, and cyanosis within seconds of receiving intravenous cefotaxime and was found to have bradypnea with bradycardia. Prompt resuscitation was carried out with artificial ventilation, adrenaline, and steroids. Spontaneous breathing reappeared and the clinical condition improved.

Venkatesh C.,Sri Lakshmi Narayana Institute of Medical science
Indian journal of dental research : official publication of Indian Society for Dental Research | Year: 2011

Teeth erupting at birth are referred to as natal teeth. It is a common and benign finding in the neonatal period. However, they may be associated with genetic syndromes like Ellis Van Creveld syndrome and Hallermann-Streiff syndrome. We report here a case of natal teeth in an infant with congenital hypothyroidism.

Renitha R.,Sri Lakshmi Narayana Institute of Medical science
Indian journal of public health | Year: 2012

Personal breastfeeding experiences of health care professionals play a major role in influencing their attitudes and expertise regarding counseling and managing breastfeeding issues in patients. This study was done with an objective of studying the current breastfeeding practices among health care professionals (HP) and their spouses and the factors influencing them. All children < 5 years of age, residing in hospital's residential quarters, were included. A detailed breastfeeding history demographic data were obtained following a semi-structured interview with mothers. Among 81 children included for analysis, in 73 children (90.1%), an initiation of breastfeeding was within 24 hours of birth and in 36 children (44.4%), it was within first hour of life. 43 children (58.1%) were exclusively breast fed for 6 months. Mean duration of EBF was 5.3 months and total duration of breastfeeding was 13.2 months. Gender of HP, gender of the child and socio-economic factors were not found to significantly affect breastfeeding practices among HP.

Kiran C.M.,Sri Lakshmi Narayana Institute of Medical science | Menon R.,Sri Lakshmi Narayana Institute of Medical science
Journal of Cytology | Year: 2013

Background: Pure neuritic leprosy (PNL) usually presents with neurological symptoms without skin involvement. Fine needle aspiration can play an important role in the management of PNL cases presenting as nerve abscesses. Aim: To assess the role of fine needle aspiration cytology (FNAC) in diagnosing and categorizing PNL cases presenting as nerve abscesses in the absence of neurological symptoms. Materials and Methods: Five patients with subcutaneous nerve related swellings without clinically evident neurological deficits were subjected to FNAC. As the cytological features were suggestive of nerve abscesses due to leprosy, Fite stain was performed in all cases. As none of the patients had any leprosy skin lesions, they were diagnosed as cases of PNL. Features like cellularity, caseous necrosis, presence or absence of lymphocytes, macrophages, epithelioid cells, granulomas, Langhans giant cells and nerve elements were analyzed with the bacteriological index, to categorize PNL according to the Ridley-Jopling classification. Results: Based on the cytological features and bacteriological indices, 3 cases were cytologically categorized into tuberculoid (TT)/borderline tuberculoid (BT) leprosy and the other two, as BT/borderline lepromatous (BL) and BL leprosy respectively in spite of having similar clinical presentation. Based on the cytological diagnoses, category-specific treatment could be instituted with clinical improvement. Conclusions: The simple and minimally invasive FNAC procedure allows diagnosis and a reasonably accurate categorization of PNL presenting as nerve abscess and therefore, highly useful in its clinical management.

Menon R.,Sri Lakshmi Narayana Institute of Medical science | Kiran C.M.,Sri Lakshmi Narayana Institute of Medical science
International Journal of Trichology | Year: 2012

Alopecia areata (AA) is one among the many causes of non-scarring alopecia in children. Family history has been noted in 10-20% of cases, but concomitant presentation in siblings is extremely rare. The patterns and associations of childhood AA are similar to adults; however, there are some differences which are being highlighted in this article.

Dorairajan G.,Sri Lakshmi Narayana Institute of Medical science
Journal of Obstetrics and Gynaecology Research | Year: 2010

Formaldehyde is an extensively used chemical; its ill effects have been of concern. Its nephrotoxic effects in laboratory animals and carcinogenic effects on humans are well established. We report of a pregnant woman with a normal ongoing pregnancy with a morphologically normal fetus. She was exposed to high doses of formaldehyde through inhalational route in the second trimester. Six weeks later she was found to have severe oligohydramnios with dysplastic fetal kidneys and fetal ascites. The various known causes for this problem reported in the literature are discussed. Based on the discussion the author has drawn a conclusion that the fate of the fetus reported can be attributed to transplacental nephrotoxic effect of formaldehyde. Previously two cases of malformations have been reported but this appears to be the first case of transplacental nephrotoxicty of formaldehyde. © 2010 The Authors.

More S.,Sri Lakshmi Narayana Institute of Medical science | Shivkumar V.B.,Mahatma Gandhi Institute | Gangane N.,Mahatma Gandhi Institute | Shende S.,Sri Lakshmi Narayana Institute of Medical science
Anemia | Year: 2013

Iron deficiency anemia is most common nutritional deficiency disorder in India and remains a formidable health challenge. Girls in the period of later school age and early adolescence are prone to develop iron deficiency. Iron deficiency leads to many non-hematological disturbances which include growth and development, depressed immune function in infants; reduces physical work capacity; decreases the cognitive function in both infants and adolescents. Present study was done to know the prevalence of iron deficiency in both the anemic and non anemic school going adolescent girls, to assess the effect of iron deficiency on cognitive functions in anemic iron deficient and non-anemic iron deficient school girls in a village school situated in central India. Methods. A secondary school having girl students in the age group of 12-15 years studying in sixth to ninth standard was selected. Serum ferritin concentration was estimated by ELISA. For assessing the cognitive function mathematics score, one multi-component test for memory, attention and verbal learning and Intelligent Quotient scores of the students were used. Results. Scholastic Performance, IQ and Scores of Mental balance, Attention & Concentration, Verbal Memory and Recognition were decreased in iron deficient girls, both anemic and non anemic as compared to the non iron deficient girls. © 2013 Sarika More et al.

Arun Babu T.,Sri Lakshmi Narayana Institute of Medical science
Indian journal of medical ethics | Year: 2013

The purpose of this study was to evaluate the awareness of the 'ethical code of conduct for medical practitioners' among medical undergraduate students. Tertiary care medical college and hospital. This study covered 172 medical students in a private medical school in Pondicherry, located in southern India. They were administered a questionnaire, containing ten scenarios, which was based on the 'medical code of ethics' as set out in the chapters on 'unethical acts' and 'misconduct' of the Indian Medical Council (Professional conduct, Etiquette and Ethics) Regulations, 2002. The students were given the option of responding with a 'yes,' 'no' or 'don't know.' Only 128 (74.4%) of the 172 medical undergraduates enrolled in the study returned the completed questionnaire. None of them answered all the questions correctly. The overall mean score was 6.13 out of 10, with an SD of 1.36. There were no significant differences between second-, third- or final-year students. There was no significant difference in the performance of boys and girls. Most of the students erred in scenarios related to decision-making and communication. There are major deficiencies in the understanding of medical ethics among medical undergraduates. Including medical ethics as a mandatory and separate subject in the first few years of under graduation can help students understand and follow ethical principles.

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