Sri Kaliswari College

Sivakasi, India

Sri Kaliswari College

Sivakasi, India
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Dhasarathan P.,Prathyush Institute of Technology and Management | Saravanan S.,Sri Kaliswari College | Perianayagasamy A.,Bharathiyar University
African Journal of Pharmacy and Pharmacology | Year: 2010

A major challenge for health care in 21st century is the increase in level of resistance to pathogens and effective vaccines to prevent the often life threatening infections are urgently required. Pathogen has been investigated for their potential use either as therapeutic or prophylactic vaccines, in order to identify new antigens of diagnostic and vaccine potential. The present investigation was done with five different type of antigens produced from single pathogen. It also identifies the immune complex and DNA antigen as most suitable for vaccine development against pathogens. Antigens may vary within the host during the course of infection or antigenic types of parasites in the population. Antigenic variation is an important mechanism used by pathogenic microorganism for escaping and neutralizing activities of the antibody. Immune complexes and DNA antigen serve as vaccines, and it can be used to develop multi antigen. Furthermore, it is also easy to produce in a large scale. Vaccination is still the best way for prevention of bacterial diseases. The conditions for the preparation of antigens of intact natural composition and conformation from Escherichia coli (whole cell and heat killed), was determined using Swiss albino mice (Balb/C) as experimental species. A novel approach for vaccine design and production is discussed. © 2010 Academic Journals.


Kathirvalavakumar T.,Vhnsn College | Subavathi S.J.,Sri Kaliswari College
International Conference on Pattern Recognition, Informatics and Medical Engineering, PRIME 2012 | Year: 2012

In this paper, a new adaptive learning rate algorithm to train a single hidden layer neural network is proposed. The adaptive learning rate is derived by differentiating linear and nonlinear errors and functional constraints weight decay term at hidden layer and penalty term at output layer. Since the adaptive learning rate calculation involves first order derivative of linear and nonlinear errors and second order derivatives of functional constraints, the proposed algorithm converges quickly. Simulation results show the advantages of proposed algorithm. © 2012 IEEE.


Mano Priya M.,Sri Kaliswari College | Karunai Selvi B.,Vvvanniaperumal College For Women | John Paul J.A.,Sri Kaliswari College
Digest Journal of Nanomaterials and Biostructures | Year: 2011

Development of reliable and eco-friendly processes for synthesis of metallic nanoparticles is an important step in the field of application of nanotechnology. In this study, we report the synthesis of silver nanoparticles using the leaf extracts of Euphorbia hirta and Nerium indicum. Synthesized particles are characterized by UV - Spectrophotometer, SEM, FTIR and X- ray diffraction analysis. The Debye-Scherrer equation was used to calculate particle sizes and the average size of the silver nanoparticles synthesized by E.hirta was 31nm and by N.indicum was 29nm. Further the synthesized silver nanoparticles were tested against common bacterial pathogens.


Boopala Bhagavan N.,Madurai Kamaraj University | Arunachalam S.,Sri Kaliswari College | Dhasarathan P.,Sri Kaliswari College | Kannan N.D.,Madurai Kamaraj University
Journal of Pharmacy Research | Year: 2013

Background: The objective of this study was to evaluate the anti inflammatory activity of Indigofera aspalathoides in Swiss albino mice. Methods: The anti inflammatory activity was evaluated by carrageenan induced paw edema model. Biochemical parameters such as Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT) and ESR counting were studied. High Performance Liquid Chromatography (HPLC) analysis was performed to identify the bioactive compounds present in I .aspalathoides. Results: The acute toxicity (LD50 value) of the Extract I. aspalathoides (EIA) was standardized as 250 mg/kg in orally treated mice. EIA found to have significant anti inflammatory activity in carrageenan induced paw edema compared to standard Indomethacin. It was evidenced by remarkable reduction in serum lysosomal enzymes and ESR as compared with control. HPLC chromatogram revealed the presence of five different bio active compounds in EIA. Conclusion: The result strongly suggested that I. aspalathoides has potent anti inflammatory property. © 2013, JPR Solutions; Published by Reed Elsevier India Pvt. Ltd.


Chordia M.A.,University of Madras | Kumari R.S.,University of Madras | Kannan R.R.,Sri Kaliswari College
Journal of Medicinal Plants Research | Year: 2010

Attempt was made to standardize the regeneration protocol. Medium was optimized for callusing, organogenesis and rooting of Vitex leucoxylon. Compact and greenish callus from internodal segments was achieved when stem segments were cultured on Murashige and Skoog (MS) medium fortified with 5.37 μM NAA + 2.22 μM BAP. In vitro regeneration of shoot buds was achieved from internodal callus cultured on MS medium supplemented with 13.30 μM BAP along with 5.37 μM NAA and/or 8.90 μM KN with 2.69 μM NAA. Regeneration and multiplication rate was high in MS medium containing 8.64 μM GA3 and 7.20 μM BAP. Elongated shoots were isolated and cultured on 1/2 strength MS medium supplemented with different concentrations of indole 3-butyric acid (IBA) for root induction. Higher degree of rooting was obtained on MS with 4.90 μM IBA. Rooted plantlets were hardened and successfully established using garden soil. This is the first report dealing with in vitro regeneration system for V. leucoxylon L. © 2010 Academic Journals.


Dhasarathan P.,Prathyusha Institute of Technology and Management | Gomathi R.,Sri Kaliswari College | Theriappan P.,Prathyusha Institute of Technology and Management | Paulsi S.,Bharathiyar University
Journal of Applied Sciences Research | Year: 2010

One of the most valuable gifts by the nature is fruit. In human nutrition, fruits are the cheapest source of natural nutritive foods that help in building resistance against diseases. In the present study, the fruits were selected on the basis of their ethnomedicinal use against infectious pathogens and autoimmune diseases. The ethanol extracts of Punica granatum L, Annona squamosa L and Cucumis melo have been investigated for their effect of cell mediated and humoral components of the immune system in mice. The test animals were divided in to three groups and three fruit extracts were injected into mice. The blood samples of fruits extracts administered mice were collected after 1st and 3rd weeks. The results suggest that the fruit extracts of Punica granatum, Annona Squamosa and Cucumis melo significantly stimulated both CMI and humoral immunity in mice compared to control animals. As evidenced by the enhancement of T cell, B cell count, Antibody titration, Delayed type hypersensitivity and IgG concentration. © 2010, INSInet Publication.


Sujatha M.,Bharathiyar University | Dhasarathan P.,Prathyusha Institute of Technology and Management | Karthick B.,Sri Kaliswari College
American Journal of Immunology | Year: 2010

Problem statement: Antibiotic susceptibility is still the best way for bacterial pathogen escape mechanism against immunity. Approach: In the present investigation, bacterial pathogens like Staphylococcus aureus, Escherichia coli, Aeromonas hydrophila, Klebsiella and Pseudomonas aeruginosa were used to screen antibiotic susceptibility and immunomodulatory potential. Results: All the test pathogens were sensitive to all the test antibiotics 11±2 mm) except penicillin. The conditions for the preparation of antigens of intact natural composition and conformation from pathogens (whole cell and heat killed), were determined using Swiss albino mice (Balb/C) as experimental species. Immunomodulatory potential of test pathogens were screened using animal model. Test pathogen decreases the body weight comparing that of normal mice, some notable changes were also noted in activity, growth, water consumption, feed consumption. Antibody titre level in animal serum decreased upto 50% in whole cell pathogen and heat killed pathogen treated animals. Conclusion: The five pathogens administered animals, decrement in B-lymphocyte was much pronounced in Pseudomonas aeruginosa followed by Escherichia coli, Staphylococcus aureus, Klebsiella sp., Aeromonas hydrophila in the 5 week. Pathogen treated mice showed an IgG suppressive effect. It is found to be suppressive to T cell production, so induction in cell mediated immunity has confirmed pathogenic potential of test pathogens. All these test pathogenic strains were remarkably suppressing immune system of pathogen exposed animals. © 2010 Science Publications.


John Paul J.A.,Sri Kaliswari College | Karmegam N.,Salem College | Daniel T.,Gandhigram Rural Institute
Bioresource Technology | Year: 2011

Municipal solid waste (MSW) was vermicomposted in combination with cowdung (CD) using Perionyx ceylanensis for 50. days. The decomposition rate of 55-78% was observed in different vermibed substrates, the highest being CD followed by 10:1 ratio of CD. +. MSW. The C/N ratio was reduced from 41.8 to 17.6 and 38.8 to 15.4 in MSW. +. CD (10:1) and CD, respectively. The difference in the final C/N ratio between MSW. +. CD (10:1) and CD vermicompost was not significant (p<0.05). The important nutrients, NPK showed significantly (p<0.05) higher contents in vermicomposts than worm-unworked composts. The degradation rate of cellulose and lignin was 37% and 12%, respectively, in 10:1 vermibed mix with P. ceylanensis. The bacterial, fungal and actinomycetes population in vermicompost was significantly higher than in the compost. The biomass, number and cocoons of P. ceylanensis collected after 50. days showed increase with the increase of CD incorporation in MSW. © 2011 Elsevier Ltd.


Sriramachandran P.,Physics Research Center | Viswanathan B.,Sri Kaliswari College | Shanmugavel R.,Physics Research Center
Solar Physics | Year: 2013

Aluminium monoxide (AlO) is widely known for its astrophysical significance. An analysis of the prominent lines of the (2,3;3,2;3,4;4,5;4,3;5,6;6,7) bands of the B2Σ+-X2Σ+ transition with those of sunspot umbral spectral lines suggests that the AlO molecule appears to be a non-negligible component of sunspot umbrae. Results of a recent (2008) rotational analysis were used to carry out the study. The effective rotational temperature determined for the above lines in the sunspot umbral spectrum is found to be of the order of 2900 K. The radiative-transition parameters that include Franck-Condon (FC) factors, r-centroids, electronic-transition moment, Einstein coefficient, absorption-band oscillator strength, and radiative lifetime have been estimated for the experimentally known vibrational levels using the Rydberg-Klein-Rees (RKR) potential. © 2013 Springer Science+Business Media Dordrecht.


Sriramachandran P.,Physics Research Center | Viswanathan B.,Sri Kaliswari college | Shanmugavel R.,Physics Research Center
International Journal of Thermodynamics | Year: 2014

On account of the high accuracy with which spectroscopic data are obtained, thermodynamic parameters estimated from these data are more reliable than those obtained by direct thermal measurements. Spectroscopic data of aluminum based diatomic gas molecules (AlO, AlH, AlD, AlF, AlC) and partition function theory have been used to evaluate the thermodynamical parameters in the temperature range 100 - 3000 0K. Equilibrium constants for astrophysically important chemical process have been calculated using partition function theory. It is noticed that for AlC the heat capacity decreases exponentially after the critical temperature 1200 0K.

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