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Rastogi N.,Lucknow Christian Post Graduate College | Kant P.,University of Lucknow | Sethi R.,University of Lucknow | Harrison D.A.,Lucknow Christian Post Graduate College | Shukla S.,Sri Jai Narain Post Graduate College
Journal of the Indian Chemical Society | Year: 2012

3-{4′-(Chlorobenzyloxy)-phenyl}-4-amino-5-mercapto-1,2,4-triazoies (1a-d) were prepared by treating 4-(chlorobenzyloxy)-benzoylhydrazines successively with alcoholic potassium hydroxide-carbon disulphide and hydrazine hydrate, which on reaction with hydrazine hydrate, carbon disulphide, benzoic acid, benzoin, phenacyl bromide, phenyl isothiocyanate, formic acid, chloroacetyl chloride, benzaldehyde and isatin gave condensed bridgehead heterocycles (triazolo-thiadiazoles and triazolo-thiadiazines). The structures of the compounds were established with the help of elemental analysis and spectral data (IR, PMR and Mass). Compounds were screened for their antimycotic potential against human pathogenic fungi. Source


Chantia A.,Sri Jai Narain Post Graduate College | Misra P.,Babasaheb Bhimrao Ambedkar University
Studies on Ethno-Medicine | Year: 2011

Human Immunodeficiency Virus (HIV) is endangering humanity. Many people at risk of or infected with the HIV are heavy drinkers. Both HIV infection and heavy alcohol use adversely affect the immune system and central nervous system (CNS) function. However, little research has addressed the effects of heavy alcohol use on the severity and progression of HIV disease, including the development of HIV associated CNS disease. Animal and in-vitro studies suggest that alcohol impairs various aspects of the immune system and increases the susceptibility to HIV infection, but may not accelerate progression of HIV disease. However, heavy alcohol use may interfere with the patient's adherence to antiretroviral treatment regimens. Neuropathological and neuropsychological studies have indicated that certain brain areas are affected by both HIV infection and chronic alcohol abuse. Magnetic resonance spectroscopy studies of both HIV positive and HIV negative people who were either heavy or light drinkers found that chronic alcohol abuse exacerbates some metabolic injury in the brains of HIV infected people, although this effect may be less pronounced in patients receiving effective antiretroviral therapy. Present study has been done on an endogamous group, Dhankut, living in Dhankuttypura of Bahraich district of Uttar Pradesh, India. The object of present paper is to see how alcohol impairs various aspects of the immune system and increases the susceptibility to HIV infection amongst this group. The paper also analyses the effects of heavy alcohol use on the severity and progression of HIV infection, including the development of HIV associated CNS disease with the help of various studies done on the subject. © Kamla-Raj 2011. Source


Rastogi N.,Lucknow Christian Post Graduate College | Kant P.,University of Lucknow | Sethi R.,University of Lucknow | Harrison D.A.,Lucknow Christian Post Graduate College | Shukla S.,Sri Jai Narain Post Graduate College
Indian Journal of Heterocyclic Chemistry | Year: 2011

A new series of bridgehead nitrogen containing heterocyclic compounds like thiazolo [3,2-b]-s-triazole, isomeric thiazolo [2,3-c]-s-triazole, thiazolo [3,2-b]-s-triazole-5(6H)-one, imidazolo [2,3-i)]-1,3,4-thiadiazol-5-one, 1,3,4-oxadiazolo [3,2-a]-5-triazine -5,7 (6H) dithione and 1,3,4-triazolo [3,2-b]-s-triazine-5,7 (6H)-dithione have been synthesized and screened for their antimycotic and antileishmanial potential against human pathogenic fungi and Leishmania donovani. Source


Tewari R.C.,Sri Jai Narain Post Graduate College | Maejima W.,Osaka City University
Journal of Geosciences | Year: 2010

The intracratonic Gondwana succession of Peninsular India represents about a 5.5 km thick sequence of strata ranging in age from Permo-Carboniferous to Early Cretaceous. It is dominantly clastic and characterized by glacial and glaciogenic sediments at the base followed by coal measures in the middle and red beds at the top. Besides minor marine ingression in the basal part (Talchir Formation), the rest of the Gondwana sequence is of fluvial origin. Integrated evidences from tectonic setting, lithofacies and sedimentary characters and longitudinal paleocurrents suggest that these basins superimpose reactivated Proterozoic intracratonic rifts. As sedimentation progressed through time, these basins expanded aerially and became wider. The Middle Triassic riftogenesis and Late Triassic intense transpression in eastern India Gondwana basins followed by Late Jurassic/Early Cretaceous rifting and dispersal terminated Gondwana sedimentation in Peninsular India. The Gondwana sequence of Peninsular India, therefore, largely represents sedimentary package sandwiched between Early Permian and Late Jurassic/Early Cretaceous rift episodes. The former rifting initiated sedimentation, whereas the latter is responsible for its cessation and present disposition. Source


Rastogi N.,Lucknow Christian Post Graduate College | Kant P.,University of Lucknow | Sethi R.,University of Lucknow | Shukla S.,Sri Jai Narain Post Graduate College | Harrison D.A.,Lucknow Christian Post Graduate College
Indian Journal of Heterocyclic Chemistry | Year: 2010

4-(Chlorobenzyloxy) anilines were incorporated into 5-nitro-1H-benzo [d] imidazole, 6-nitrobenzo [d] oxazol-2(3H)-one and 4-nitroisoindoline-1,3-dione in the presence of 40% aq formaldehyde to furnish a new series of 5-nitro-1-(4-chlorobenzyloxy)-anilinomethyl-1 H-benzo [d] imidazoles /6-nitro-3-(4-(chlorobenzyloxy)-anilinomethyl)-benzo [d] oxazol-2(3H)-ones and 4-nitro-2-(4-chlorobenzyloxy)-anilinomethyl) isoindoline-1,3-diones (11-25). The structures of the compounds were established by means of elemental analysis and spectral data (IR & PMR). Compounds were screened for their antileishmanial and antimicrobial potential. Source

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