Sri Indu Institute of Pharmacy

Sri Mādhopur, India

Sri Indu Institute of Pharmacy

Sri Mādhopur, India
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Hemamalini K.,University of Hyderabad | Sambasiva Rao A.,Sri Indu Institute of Pharmacy
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: To establish the pharmacological properties of the Sophora interrupta Solanum pubescens and Tabebuia rosea different plants with their phytochemical study the antiulcer activity. Method: The study was carried by using the cold stress induced gastric lesions in rats. Ethanomedical information leads to new drug discovery from the herbal medicine and shows potential results for the treatment of gastric ulcers. Results: Study has shown a reduction in gastric juice, total acidity and increase in the PH, for all the three plants but their efficacy differs for all the Sophora interrupta Solanum pubescens and Tabebuia rosea leaves. Conclusion: among all the three plants Tabebuia rosea showed significant antiulcer activity.

Aim: The objective of this work is to develop floating pulsatile microspheres of ivabradine Hydrochloride and statistical optimization using software based response surface methodology. Materials and Methods: The microspheres were prepared by nonaqueous solvent evaporation method in which three process variables were of utmost importance such as stirring speed, stirring time, and polymer concentration. The desired responses were % entrapment efficiency, % of buoyancy, and %DE at 20 min of microspheres. Optimization was done by fitting experimental data to the software program (Minitab). Obtained microspheres were subjected to different evaluation parameters which are essential in the development of the dosage form. Results and Discussion: The optimized batch of formulation showed satisfactory drug entrapment efficiency of 88.56 ± 1.12, % of buoyancy of 91.42 ± 1.09, and %DE at 20 min of 64.4 ± 0.36. Scanning electron microscopy analysis revealed that particles were spherical with smooth surface. Particles were free flowing and its average particle size 794 ± 1.43 μm. The developed optimized batch of microspheres maintained lag phase during floating in acidic medium (simulated gastric fluid) for 5 h followed by pulsatile release of ivabradine HCl within 30 min in phosphate buffer PH 7.4 (Simulated intestinal fluid). Fourier transform infrared spectroscopy and differential scanning calorimetry studies revealed that there was no interaction between ivabradine HCl and Eudragit S100. Conclusion: Ivabradine HCl floating pulsatile microspheres were successfully made using response surface methodology.

Naga Aparna T.,Sri Indu Institute of Pharmacy | Sambasiva Rao A.,Sri Indu Institute of Pharmacy
International Journal of Pharmaceutical Sciences Review and Research | Year: 2013

The desire of improved palatability in orally administered products has prompted the development of numerous formulations with improved performance and acceptability. Orally disintegrating tablets are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. The field has become a rapidly growing area in the pharmaceutical industry and gaining popularity due to ease of administration and better patient compliance especially for geriatric and paediatric patients. This type of property in dosage form can be attained by addition of different excipients, from which disintegrant is the key adjuvant. In recent years, several newer agents have been developed for fast disintegrating action known as super disintegrants. Diverse categories of super disintegrants such as synthetic, natural and co-processed blends etc. have been employed. The objective of the present article is to highlight the various kinds of traditional and emerging disintegrants along with their role in tablet disintegration. This review focuses on various synthetic disintegrants and super disintegrants, natural disintegrants from different plant sources, co-processed disintegrants and their efficiency.

Samba Shiva Rao A.,Sri Indu Institute Of Pharmacy
International Journal of Research in Pharmaceutical Sciences | Year: 2014

Ipomoea batata is commonly grown throughout India, and locally known as Sweet potato or Chilagada dumpa. In the present study, physicochemical property of sweet potato starch was comparatively with official potato and maize starch. Ipomoea batata starch is isolated from tubers and the yield is 13.5%. The granule shape is irregular and polygonal with the particle size diameter 10.5-26.3-40.83|im. The powders obtained were characterized for their particle size, particle size distribution. The organoleptic and physicochemical characterization such as viscosity, hydration capacity, swelling capacity, moisture sorption capacity, pH, flow rate and porosity, Carr's index and Hausner's ratio were evaluated. The total results were compared with the commercial maize and potato starch. The results suggest that the Ipomoea batata starch complies with the standards of maize and potato starch. The cost of production is less as compared to commercial starch as it is distributed throughout India. The powder characteristics are nearby similar to the official starches. Hydration and swelling capacity of sweet potato is approximately similar which makes this potential excipient in pharmaceutical formulation development. © JK Welfare & Pharmascope Foundation.

Macharla S.P.,Sri Indu Institute of Pharmacy | Goli V.,Venkateshwara Institute of Pharmaceutical science | Sattla S.R.,Center for Pharmaceutical science
Journal of Chemical and Pharmaceutical Research | Year: 2012

The different solvent extracts of Raphanus Sativus L. leaves (Family: Brassicaceae) were tested for antidiabetic activity using alloxan induced diabetic rats and compared with standard. The results expressed that aqueous extracts had shown significant protection and maximum reduction in blood glucose was observed in alloxan induced diabetic rats (p<0.001). The results of this comprehensive study reveal that R. sativus L leaves showed statistically significant Antidiabetic activity in comparison to the standard glibenclamide.

Kusuma R.,Bojjam Narasimhulu Pharmacy College for Women | Kusuma R.,JNTUH College of Engineering | Rao A.S.S.,Sri Indu Institute of Pharmacy
Asian Journal of Pharmaceutics | Year: 2015

Aim: The purpose of the present study was to develop and optimize the emulgel system for indomethacin (IND), using four types of gelling agents: Carbopol 934, HPMC K4M, xanthum gum, and pregelatinized Ipomoea batata starch (PGIBS), which are dispersed in purified water with constant stirring at a moderate speed, then the pH was adjusted to 6-6.5 using triethanolamine. Materials and Methods: The prepared emulgels were evaluated in terms of physical appearance, pH, spreadability, rheological study, viscosity, drug content determination, in vitro drug release, accelerated stability studies, and fitting of results into different kinetic equations was also carried out. Statistical Analysis Used: The Fourier transform infrared spectra of the IND and different polymers alone and in combination show the compatibility of the drug and excipients. Results: In vitro release study demonstrated diffusion controlled release of IND from formulation up to 8 h. The formulations showed higher R2 values for zero order plots indicating that drug release followed zero order kinetics a. The accelerated stability studies were performed according to ICH guidelines for 3 months, and the results were found to be stable in varying temperature. All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, pH value, and with higher drug release than conventional gel. Conclusion: The optimized formulations were found to be C4, H4, G4, and I4 containing a lower concentration of light castor oil and a higher concentration of emulsifiers. In the case of all evaluation parameters PGIBS and castor oilbased formulation, i.e., I4 showed better properties. So, as a general conclusion, it was suggested that the IND emulgel formulation prepared with PGIBS having the oil phase concentration in its low level and emulsifying agent concentration in its high level was the formula of choice. The results demonstrate that the release of the drug is dependent on the viscosity of the polymer used.

Samba Siva Rao A.,Sri Indu Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

Objective: The objective of the current work was to develop Ivabradine hydrochloride (HCl) floating pulsatile pellets containing drug loaded calcium alginate pellets coated with pH-dependent polymer Eudragit S100 oil dispersion. Methods: Fluidized bed coating technique was used to develop pellets. A 22factorial design was employed to study the effect of independent variables (inlet air temperature, spray rate), on dependent variables (% entrapment efficiency, % friability, and average particle size). Optimization was done by fitting experimental data to the software program (Minitab). Obtained pellets were subjected to different evaluation parameters which are critical in the development of the dosage form. An in vitro lag phase study was carried out for all batches in simulated gastric fluid (0.1N HCl) for 5 hrs and in vitro drug release study was carried out for optimized batch (B4) of two different sizes (10/12#, 12/16#) in simulated intestinal fluid (pH 7.4 phosphate buffer). Results: The optimized batch (B4) showed satisfactory % entrapment efficiency of 92.66±1.52; % friability of 0.57±0.03; and average particle size of 1424±16 (μm). All batches maintained lag phase for 5 hrs in 0.1N HCl. An optimized batch of two different sizes exhibited a burst release within 30 minutes in simulated intestinal fluid with no significant difference in release rate constant (*p>0.05) and followed first order kinetics. Conclusion: Thus, ivabradine HCl floating pulsatile pellets was successfully developed for treating angina pectoris which is an underlying cause of heart attack by fluidized bed coating technique employing factorial design. © 2016, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.

SirajuddinKhan M.,Sri Indu Institute of Pharmacy | Ravikumar V.,Sri Indu Institute of Pharmacy | Neelima K.,Sri Indu Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2011

The most dramatic, common and constant event of life is age-related modification of skin acts as the best external marker of aging. The skin protects against mechanical trauma, UV light and infection. In addition, the skin is concerned with thermoregulation, conservation and excretion of fluid, sensory perception and also has aesthetic role. In our day to day of our life the intrigrity of skin is compromised such as by a gunshot, fall, or surgical procedure; by an infectious disease; or by an underlying condition. It is therefore important to identify and evaluate available natural drugs as alternatives to currently used wound healing drugs which are not always free from adverse effects. A range of medicinal plants with wound healing properties is widely used by traditional healers. However, the effectiveness of many of these wound healing plants has not been scientifically evaluated. Ananas comosus commonly known as pineapple originated in the tropical regions of Brazil. It has been in cultivation since ancient times by various Indian tribes. It is now cultivated throughout the tropics. It is cultivated in Assam, west Bengal and along the coast of Kerela. The present study investigates the wound healing activity of the fruit of Ananas comosus.

Madhu C.,Sri Indu Institute of Pharmacy | Ramanjaneyulu M.,Sri Indu Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2013

In the present study, the anti-inflammatory and analgesic effect of the hydroalcoholic extract of coccinia grandis whole plant was investigated. The hydroalcoholic extracts of coccinia grandis whole plant were ingested orally (p.o.) in two different doses, 200 and 400 (mg/kg body weight). The anti-inflammatory effect of coccinia grandis was tested in: carrageenan-induced paw oedema in wistar albino rats and compared with the standard, diclofenac (10 mg/kg body weight). The analgesic effect of the hydroalcoholic effect of coccinia grandis was evaluated in Swiss albino mice by usingEddys hot plate method and compared with the standard, aspirin (25 mg/kg body weight). The results showed that coccinia grandis has significant reduction (p.0.01) in inflammation (200 mg/kg body weight) and (400 mg/kg body weight) as compared to the standard drug, diclofenac. In assessing analgesic effects, there is a significant (p<0.01) reduction in the paw licking for (400 mg/kg) and diclofenac (10 mg/kg) when compared to control. These results expressing that the extracts would possess analgesic and anti-inflammatory properties. All these effects and the changes in the behavioural activities could be suggested as contributory effects to the use of coccinia grandis whole plant in the management of inflammation and painful conditions.

Narasimha G.L.,Sri Indu Institute of Pharmacy | Jairam D.,Sri Indu Institute of Pharmacy | Krishna A.,Sri Indu Institute of Pharmacy | Qureshi M.R.,Sri Indu Institute of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2015

The present study was aimed at preparing a Floating drug delivery system for the model drug Losartan, and evaluating the various processing parameters including the buoyancy studies and in vitro drug release studies. Four formulations containing varying proportions of polymers like HPMC K4M and Ethyl cellulose and fixed amount of gas generating agent such as Sodium bi carbonate, material like bees wax were prepared. The tablets were prepared by melt granulation technique and the prepared tablets remained buoyant for more than 8hrs in the release medium. The proportions of the polymers showed significant difference in the release of the drug. All the formulations exhibited diffusion dominant drug release and were found to be stable. © RJPT All right reserved.

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