PubMed | Government of Punjab, Subharti Dental College and Sri Guru Ram Das Institute of Dental science and Research
Type: Journal Article | Journal: Indian journal of dentistry | Year: 2016
The purpose of the study was to determine the effect of border molding on the retention of the maxillary denture base.Two special trays, one with full extensions to the periphery and one 2 mm short from the borders were made on the cast obtained from the preliminary impression. Border molding was done on the tray which was short from borders. On both trays, the final impression was made with zinc oxide eugenol impression paste. Heat cure denture bases were fabricated on the prepared casts and retention was measured using specially designed instrument.Mean force with border molding (2765.0 g) was larger than mean force without border molding (1805.0 g) at P < 0.01 level. In terms of percentage, too, the mean improvement (59.4%) in force of dislodgement was statistically highly significant (i.e. P < 0.01).The results of the present study suggest that the dentures made with border molding will provide better retentive force than the dentures made without border molding.
PubMed | Sri Guru Ram Das Institute of Dental science and Research and Jamia Hamdard University
Type: Comparative Study | Journal: Drug development and industrial pharmacy | Year: 2016
The present work was aimed at developing an optimized oral nanostructured lipid carrier (NLC) formulation of poorly soluble atorvastatin Ca (AT Ca) and assessing its in vitro release, oral bioavailability and pharmacodynamic activity. In this study, chlorogenic acid, a novel excipient having synergistic cholesterol lowering activity was utilized and explored in NLC formulation development. The drug-loaded NLC formulations were prepared using a high pressure homogenization technique and optimized by the Box-Behnken statistical design using the Design-Expert software. The optimized NLC formulation was composed of oleic acid and stearic acid as lipid phase (0.9% w/v), poloxamer 188 as surfactant (1% w/v) and chlorogenic acid (0.05% w/v). The mean particle size, polydispersity index (PDI) and % drug entrapment efficiency of optimized NLC were 203.568.57nm, 0.270.028 and 83.665.69, respectively. In vitro release studies showed that the release of drug from optimized NLC formulations were markedly enhanced as compared to solid lipid nanoparticles (SLN) and drug suspension. The plasma concentration time profile of AT Ca in rats showed 3.08- and 4.89-fold increase in relative bioavailability of developed NLC with respect to marketed preparation (ATORVA tablet) and drug suspension, respectively. Pharmacodynamic study suggested highly significant (**p<0.01) reduction in the cholesterol and triglyceride values by NLC in comparison with ATORVA tablet. Therefore, the results of in vivo studies demonstrated promising prospects for successful oral delivery of AT Ca by means of its chlorogenic acid integrated NLC.
PubMed | Guru Nanak Institutions, Sri Guru Ram Das Institute of Dental science and Research and Government Medical College and Hospital
Type: Journal Article | Journal: Journal of Indian Society of Periodontology | Year: 2015
An association between oral conditions such as periodontal diseases and systemic conditions is noted. As such, periodontal disease is associated with an increased risk of systemic illnesses such as cardiovascular disease, diabetes, adverse pregnancy outcome, atherosclerosis, stroke and hospital acquired pneumonia. The concept of diagnosing and treating a potential patient to minimize the deleterious effects of this chronic infectious and inflammatory condition on systemic conditions represents both an unprecedented challenge and opportunity to our profession. Keeping this in view, the present survey was designed to evaluate the acquaintance, orientation and behavior of general medical practitioners; concerning the effects of periodontal disease on systemic health.A typed questionnaire carrying four sets of questions was distributed among general medical practitioners of seven different government and private medical colleges and hospitals. Questionnaire was developed to assess the acquaintance, orientation and behavior of general medical practitioners toward periodontal disease.Most of the respondents have knowledge regarding the signs and symptoms of periodontal disease and its association with cardiovascular disease. However, majority of them do not know about the potential effect of periodontal disease on other organ systems.General medical practitioners have inadequate knowledge regarding periodontal diseases. Hence, oral health related training should be an integral part of the medical curriculum.
Manchanda A.,Sri Guru Ram Das Institute of Dental science and Research |
Shetty D.-C.,Its Center For Dental Studies And Research
Medicina Oral, Patologia Oral y Cirugia Bucal | Year: 2012
Objective: To assess inter and intra observer variability in grading oral epithelial dysplasia (OED) using Smith and Pindborg grading system, WHO classification system and Brothwell DJ et al. classification system. Study design: In the study 45 histological tissues of dysplasia, 15 each of mild, moderate and severe dysplasia were coded and blindly graded by three observers in three grading systems. Further on the same observers graded 15 slides again of the previous 45 for analyzing the reproducibility in the three grading systems. The individual significance of various indicators of dysplasia among various grades of dysplasia was also assessed. Result: Inter observer agreement was significantly higher in Brothwell system as compared to WHO and Smith and Pindborg system. Intra observer agreement was significantly higher in Smith and Pindborg system, but the predictability and the probability index was distributed over a larger range in this system. Each indicator of dysplasia was also found to be statistically significant (P<0.05) for grading dysplasia. Conclusion: The present study puts forth the inherent intricacies in the grading of oral premalignant lesions. © Medicina Oral S. L.
PubMed | DAV C Dental College and Hospital, Sri Guru Ram Das Institute of Dental science and Research and Subharti Dental College and Hospital
Type: Journal Article | Journal: Journal of the Indian Society of Pedodontics and Preventive Dentistry | Year: 2016
The aim of the present study was to clinically evaluate and compare the efficacy and retention of various types of intracanal posts in the restoration of grossly decayed deciduous anterior teeth. The various posts used were polyethylene post, glass post, and composite post.A total number of 16 patients with 45 grossly decayed primary anterior teeth were selected. After biomechanical preparation and obturation, patients were randomly divided on the basis of posts to be used into three groups (Group I: Polyethylene post; Group II: Glass post, and Group III: Composite post). Then, space was created in the obturated canal and posts were placed, followed by core build up.After an interval of 12 months, 86.67% of the teeth exhibited complete retention of the post restored with polyethylene post (P > 0.005) and 93.3% of the teeth exhibited complete retention of the post that were restored with glass post (P > 0.005) whereas only 60% of the teeth exhibited complete retention of the post that were restored with composite post (P< 0.005). Only 20% of the teeth exhibited marginal discoloration in both Groups I and III and 13.33% in Group II and this was nonsignificant.Both glass post and polyethylene post proved to be effective. Glass post showed the maximum retention and marginal adaptation followed by polyethylene post. Thus, it appears to be of potential interest for use especially in clinical pediatric dentistry.
PubMed | National Dental College and Hospital and Sri Guru Ram Das Institute of Dental science and Research
Type: Journal Article | Journal: Indian journal of dentistry | Year: 2016
Forty years ago Marshal R. Urist discovered a substance in bone matrix that had inductive properties for the development of bone and cartilage, until date, at least 20 bone morphogenetic proteins (BMPs) have been identified, some of which have been shown in vitro to stimulate the process of stem cell differentiation into osteoblasts in human and animal models. The purpose of this paper is to give a brief overview of BMPs and to review critically the clinical data currently available on the use of BMPs in various periodontal applications. The literature on BMPs was reviewed. A comprehensive search was designed. The articles were independently screened for eligibility. Articles with authentic controls and proper randomization and pertaining specifically to their role in periodontal applications were included. The available literature was analyzed and compiled. The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus. Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject. On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.
Walia S.S.,Sri Guru Ram Das Institute of Dental science and Research |
Manchanda A.,Sri Guru Ram Das Institute of Dental science and Research |
Narang R.S.,Sri Guru Ram Das Institute of Dental science and Research |
Anup N.,Jaipur Dental College |
And 2 more authors.
Journal of Clinical and Diagnostic Research | Year: 2014
Objective: To assess bacterial contamination of cellular telephone of dental care personnel, and to determine factors contributing to their contamination. Materials and Methods: A descriptive, cross-sectional study was conducted, which included 300 people using a cellular telephone The study group (hundred in each group) comprised of dental health care personnel (DHCP), in - hospital personnel (IHP) and out- hospital personnel (OHP) of a dental college cum hospital. Swab was wiped along the front and all sides of cellular handset and it was incubated in glucose broth. The swab was subplated onto growth media plates made with half Mac Conkey's agar and half blood agar and allowed to incubate for 48 hours at 37°C. Isolates were tested for antimicrobial susceptibility. Result: The analysis of presence or absence of microorganisms in the DHCP, IHP and OHP group showed no pyogenic growth in 28%, 31% and 41% cases respectively, the distribution of which was not significant (p>.05). Among non potential pathogens, spore bearing gram positive bacilli were seen in 20 cases of DHCP group, 16 cases of IHP group and 17 cases of OHP group; the distribution of which was not significant (p>.05) Among potential pathogens, significant differences were observed in the distribution of growth of Enterobacter (p<.001), Pseudomonas species (p<.05), Acinetobacter bacteria (p<.05) and Methicillin-resistant Staphylococcus aureus (MRSA) bacteria (p<.001) between the participants of different groups. Conclusion: Results of this study showed that fomites such as cellular telephones can potentially act as "Trojan horses", thus causing hospital acquired infections in the dental setting.
Narang R.S.,Sri Guru Ram das Institute of Dental science and Research |
Manchanda A.S.,Sri Guru Ram das Institute of Dental science and Research |
Arora P.,Sri Guru Ram das Institute of Dental science and Research |
Randhawa K.,Sri Guru Ram das Institute of Dental science and Research
Annals of Diagnostic Pathology | Year: 2012
Odontogenic cysts commonly encountered in dental practice are the radicular cysts and dentigerous cysts. Apart from the developmental origin of dentigerous cysts, an inflammatory origin has also been suggested. It has been reported that inflammation progressing from the root apex of the deciduous tooth brings about development of the dentigerous cyst around the unerupted permanent tooth. The aim of the present article is to report 4 additional cases of dentigerous cyst believed to be of inflammatory origin and to highlight the diagnostic dilemma in segregating both the entities. The 4 cases were of patients with a mixed dentition with the pathology related to the deciduous tooth present. Radiographically, pericoronal radiolucency was seen attached at the cementoenamel junction of impacted tooth and in continuation with lamina dura of deciduous tooth. Microscopically, the cystic cavity was lined by reduced enamel epithelium like lining, which was hyperplastic to anastomosing in areas in few cases. This study proposes the predicament in accurately diagnosing such cases. © 2012 Elsevier Inc. All rights reserved.
Narang R.S.,Sri Guru Ram Das Institute of Dental science and Research
Oral health and dental management | Year: 2012
The aim of this study was to determine awareness of biomedical waste (BMW) management policies and practices among dental professionals and auxiliary staff in a dental hospital/clinics in Amritsar, India, to inform the development of future policies for effective implementation of BMW rules. The study involved 160 staff members at the Amritsar hospital/clinics (80 dentists and 80 auxiliary staff) to whom a questionnaire was distributed regarding policies, practices and awareness relating to BMW. The questionnaire was first piloted. Completed questionnaires were returned anonymously. The resulting data were statistically tested using the chi-square test for differences between the dentists and auxiliary staff. In respect of BMW management policies, there was a highly significant difference in the responses of the dentists, whose answers suggested far greater knowledge than that of the auxiliaries (P<0.001). Regarding BMW management practices, the dentists were significantly more aware (P<0.001) of the method of waste collection in the hospital and the disposal of various items into different colour-coded bags. As for employee education/awareness, there was a significant difference (P<0.05) between the dentists and the auxiliaries on the question regarding records of BMW maintained in the hospital and the other responses to questions on these topics had a highly significant (P<0.001) difference between the two groups in favour of the dentists. The results of this study have demonstrated a lack of awareness of most aspects of BMW management among dental auxiliary staff in the dental hospital/clinics in Amritsar and a lack of awareness of some aspects among dentists who work in the hospital/clinics. The results provide the hospital authorities with data upon which they can develop a strategy for improving BMW management.
PubMed | Sri Guru Ram Das Institute of Dental science and Research
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016
To overcome limitations of screw-retained prostheses, cement-retained prostheses have become the restoration of choice now a days. Selection of the cement hence becomes very critical to maintain retrievability of the prostheses.The purpose of this study was to assess and compare the retention of base metal crowns cemented to implant abutments with five different luting cements.Ten implant analogs were secured in five epoxy resin casts perpendicular to the plane of cast in right first molar and left first molar region and implant abutments were screwed. Total of 100 metal copings were fabricated and cemented. The cements used were zinc phosphate, resin modified glass ionomer cement, resin cement, non-eugenol acrylic based temporary implant cement & non-eugenol temporary resin cement implant cement. Samples were subjected to a pull-out test using an Instron universal testing machine at a crosshead speed of 0.5mm/min. The load required to de-cement each coping was recorded and mean values for each group calculated and put to statistical analysis.The results showed that resin cement has the highest retention value 581.075N followed by zinc phosphate luting cement 529.48N, resin modified glass ionomer cement 338.095 N, non-eugenol acrylic based temporary implant cement 249.045 N and non-eugenol temporary resin implant cement 140.49N.Within the limitations of study, it was concluded that non-eugenol acrylic based temporary implant cement and non-eugenol temporary resin implant cement allow for easy retrievability of the prosthesis in case of any failure in future. These are suitable for cement retained implant restorations. The results provide a possible preliminary ranking of luting agents based on their ability to retain an implant-supported prosthesis and facilitate easy retrieval.