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Khan S.,Jamia Hamdard University | Baboota S.,Jamia Hamdard University | Ali J.,Jamia Hamdard University | Narang R.S.,Sri Guru Ram Das Institute of Dental science and Research
Drug Development and Industrial Pharmacy | Year: 2016

The present work was aimed at developing an optimized oral nanostructured lipid carrier (NLC) formulation of poorly soluble atorvastatin Ca (AT Ca) and assessing its in vitro release, oral bioavailability and pharmacodynamic activity. In this study, chlorogenic acid, a novel excipient having synergistic cholesterol lowering activity was utilized and explored in NLC formulation development. The drug-loaded NLC formulations were prepared using a high pressure homogenization technique and optimized by the Box-Behnken statistical design using the Design-Expert software. The optimized NLC formulation was composed of oleic acid and stearic acid as lipid phase (0.9% w/v), poloxamer 188 as surfactant (1% w/v) and chlorogenic acid (0.05% w/v). The mean particle size, polydispersity index (PDI) and % drug entrapment efficiency of optimized NLC were 203.56 ± 8.57 nm, 0.27 ± 0.028 and 83.66 ± 5.69, respectively. In vitro release studies showed that the release of drug from optimized NLC formulations were markedly enhanced as compared to solid lipid nanoparticles (SLN) and drug suspension. The plasma concentration time profile of AT Ca in rats showed 3.08- and 4.89-fold increase in relative bioavailability of developed NLC with respect to marketed preparation (ATORVA® tablet) and drug suspension, respectively. Pharmacodynamic study suggested highly significant (∗∗p<0.01) reduction in the cholesterol and triglyceride values by NLC in comparison with ATORVA® tablet. Therefore, the results of in vivo studies demonstrated promising prospects for successful oral delivery of AT Ca by means of its chlorogenic acid integrated NLC. © 2015 Taylor & Francis. Source


Parhar S.,Swami Devi Dyal Hospital and Dental College | Preet Singh H.,Dasmesh Institute of Research and Dental science | Nayyar A.,Swami Devi Dyal Hospital and Dental College | Manchanda A.S.,Sri Guru Ram Das Institute of Dental science and Research
Journal of Clinical and Diagnostic Research | Year: 2014

Neurilemmoma (Schwannoma) is a benign tumour of neuroectodermal origin. It usually occurs as a asymptomatic, solitary, smooth-surfaced and slow growing lesion, emerging at any age, with as such, no gender prelidiction. Occurring as a common tumour in the head and neck region, its intraoral presentation is very rare. Here, we are reporting a rare case of intraoral schwannoma of the posterior palate which occurred in a 34-year-old female patient who had chief complaint of a painless, slow growing swelling on posterior palate. Source


Manchanda A.,Sri Guru Ram Das Institute of Dental science and Research | Shetty D.-C.,Its Center For Dental Studies And Research
Medicina Oral, Patologia Oral y Cirugia Bucal | Year: 2012

Objective: To assess inter and intra observer variability in grading oral epithelial dysplasia (OED) using Smith and Pindborg grading system, WHO classification system and Brothwell DJ et al. classification system. Study design: In the study 45 histological tissues of dysplasia, 15 each of mild, moderate and severe dysplasia were coded and blindly graded by three observers in three grading systems. Further on the same observers graded 15 slides again of the previous 45 for analyzing the reproducibility in the three grading systems. The individual significance of various indicators of dysplasia among various grades of dysplasia was also assessed. Result: Inter observer agreement was significantly higher in Brothwell system as compared to WHO and Smith and Pindborg system. Intra observer agreement was significantly higher in Smith and Pindborg system, but the predictability and the probability index was distributed over a larger range in this system. Each indicator of dysplasia was also found to be statistically significant (P<0.05) for grading dysplasia. Conclusion: The present study puts forth the inherent intricacies in the grading of oral premalignant lesions. © Medicina Oral S. L. Source


Arora P.C.,Sri Guru Ram Das Institute of Dental science and Research | Umarji H.R.,JKK Nataraja Dental College and Hospital | Arora A.,Sri Guru Ram Das Institute of Dental science and Research | Ramaswami E.,Dr DY Patil Dental College and Hospital
Imaging Science in Dentistry | Year: 2012

A case of hemifacial hyperplasia that presented with muscular, skeletal, and dental hyperplasia along with lipomatous infiltration was described. Advanced imaging was useful in identifying the lipomatous infiltration present in the lesion, which raises the possibility of lipomatosis having a diverse presentation in hemifacial hyperplasia. As there was a scarcity of related literature in the field of dentomaxillofacial radiology, this report would make us familiar with its computed tomographic and magnetic resonance image findings. © 2012 by Korean Academy of Oral and Maxillofacial Radiology. Source


Narang R.S.,Sri Guru Ram Das Institute of Dental science and Research | Sandhu S.V.,Genesis Research Institute | Padda S.,Genesis Research Institute | Sandhu J.,Genesis Research Institute | Manchanda A.S.,Sri Guru Ram Das Institute of Dental science and Research
Internet Journal of Pediatrics and Neonatology | Year: 2011

Apert's syndrome (Acrocephalo-syndactyly) is a rare congenital, autosomal dominant condition characterized by primary craniosynostosis, mid face malformations and symmetrical syndactyly of the hand and feet. Untreated craniosynostosis leads to inhibition of brain growth and an increase in intracranial and intraorbital pressure. Despite of tremendous advances which have been made in the prevention and treatment of developmental anomalies, they still remain a significant cause of morbidity worldwide. As such, it is incumbent on clinicians to learn as much as possible about this condition so as to improve their ability to handle and prevent them. We present a case of Apert's syndrome seen in a 10 year old boy. Because of the multiple alterations in patients with Apert syndrome, a multidisciplinary approach, including dentists and neurosurgeons, plastic surgeons, ophthalmologists and geneticists, is essential for a successful planning and treatment. The differences between Apert and Crouzon's syndrome are also highlighted. © internet Scientific Publications, LLC. Source

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