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Aswathappa J.,Sri Devaraj Urs Medical College | Garg S.,Sri Devaraj Urs Medical College | Kutty K.,Sri Devaraj Urs Medical College | Shankar V.,Sri Devaraj Urs Medical College
North American Journal of Medical Sciences | Year: 2013

Background: Obesity is a risk factor for type 2 diabetes mellitus. Insulin resistance is associated with visceral subcutaneous fat content. Neck circumference (NC) is a marker of upper body subcutaneous adipose tissue distribution. Aim: The aim of this study is to compare NC in diabetics and non-diabetics and to correlate NC with other anthropometric measures. Materials and Methods: A cross-sectional study was conducted in 350 type 2 diabetics and 350 non-diabetics of >30 years of age. Anthropometric parameters like body mass index (BMI), waist circumference (WC), hip circumference, and NC were measured. Independent t-test and Pearson's correlation were the tests of significance done to analyze quantitative data. Results: There was positive correlation of NC, BMI, and index of central obesity. The NC in diabetics was significantly higher than in non-diabetics (P < 0.001). NC >36 cm in diabetics and >37 cm in non-diabetics was the best cutoff value to determine subjects with central obesity. Conclusion: The findings indicated that NC may be used both in clinical practice and in epidemiologic studies as a straightforward and reliable index. It is an economical easy to use test with less consumption of time and correlates well with other standard anthropometric parameters.


Krishnappa S.,Sri Devaraj Urs Medical College | Naseeruddin K.,Sri Devaraj Urs Medical College
Indian Journal of Otology | Year: 2014

Background: Age related hearing loss is one of the most common chronic health conditions affecting the elderly people. With aging, risk of presbycusis and diabetes increases. Our study aims at evaluating auditory dysfunction in patients with diabetes mellitus aged above 50 years as compared to non-diabetic patient. We also tried to find the relation between duration of diabetes and severity of hearing loss and whether HbA1c and blood sugars levels affected the type and severity of hearing loss. Materials and Methods: A cross-sectional study on 106 patients with type 2 diabetes mellitus and 90 non-diabetic patients with age and sex matched (controls) was carried out during November 2011 to October 2013. All patients were evaluated for hearing loss by subjecting to pure tone audiometry and blood investigations like glycated hemoglobin, fasting and postprandial blood sugars and serum creatinine levels. Results: A prevalence of 73% hearing loss was seen in diabetics. The degree of hearing loss increased with age. There was bilateral progressive sensory neural hearing loss with right sloping curve in both diabetics as well as controls but with significantly (P < 0.001) higher loss in diabetics (at 4 KHz and 8 KHz). A significant relationship between duration of the diabetes, HbA1c and severity of hearing loss was observed. Conclusion: Diabetes mellitus was associated with higher hearing loss compared to presbycusis and hearing threshold was seen to affect all frequencies, but significantly the higher frequencies in diabetics. As duration of diabetes increased, the severity also increased. Poorer the HbA1c, more severe was the hearing loss. © 2014 Indian Journal of Otology.


Singh G.,Sri Devaraj Urs Medical College | Aneja S.P.S.,Sri Devaraj Urs Medical College
Indian Journal of Dermatology | Year: 2011

The chronic inflammatory nature of psoriasis is also thought to predispose patients to other diseases with an inflammatory component, the most notable being cardiovascular and metabolic (cardiometabolite) disorders. This concept is supported by studies showing that psoriasis is associated with cardiovascular risk factors like diabetes, obesity, hypertension, dyslipidemia, smoking and diseases including MI. Given the increased prevalence of cardiovascular co morbidities in patients, dermatologists treating psoriasis need to approach the disease as a potentially multisystem disorder and must alert these patients to the potentially negative effects of their disease.


Narasimha A.,Sri Devaraj Urs Medical College | Harendra Kumar M.L.,Sri Devaraj Urs Medical College
Indian Journal of Hematology and Blood Transfusion | Year: 2011

Neonates are easily prone for bacterial infection. Diagnosis of neonatal septicemia may be difficult as the early signs of sepsis may be subtle and different at different gestational ages. The present study was undertaken to assess the significance of the hematological scoring system (HSS) for early detection of neonatal sepsis. About 50 peripheral blood smears of all newborns collected were analysed for neonatal sepsis using the HSS of Rodwell et al. (J Pediatr 112:761-767, 1988). Analysis in our study found that an abnormal immature to total neutrophil ratio (I:T) followed by an abnormal immature to mature neutrophil ratio (I:M) were the most sensitive indicators in identifying infants with sepsis. The HSS is a simple, quick, cost effective tool which can be used as a screening test for early diagnosis of neonatal sepsis. © 2010 Indian Society of Haematology & Transfusion Medicine.


Harish S.,Sri Devaraj Urs Medical College | Bhuvana K.,Sri Devaraj Urs Medical College | Bengalorkar G.M.,Sri Devaraj Urs Medical College | Kumar T.N.,Sri Devaraj Urs Medical College
Journal of Anaesthesiology Clinical Pharmacology | Year: 2012

Flupirtine is neither an opioid nor a non steroidal anti-inflammatory drug (NSAID) producing its analgesic action through blockade of glutamate N-methyl-D-aspartate receptor. It is devoid of adverse effects of routinely used analgesic drugs, but is equally efficacious in reducing pain sensation. It has a distinctive mechanism of action, exerting a dual therapeutic effect with both analgesic and muscle relaxant properties that has utility in the treatment of pain, including that associated with muscle tension.


Paknikar S.S.,Sri Devaraj Urs Medical College | Narayana S.,Sri Devaraj Urs Medical College
North American Journal of Medical Sciences | Year: 2012

In order to deal with the rising problem of antibiotic resistance, newer antibacterials are being discovered and added to existing pool. Since the year 2000, however, only four new classes of antibacterials have been discovered. These include the oxazolidinones, glycolipopeptides, glycolipodepepsipeptide and pleuromutilins. Newer drugs were added to existing classes of antibiotics, such as streptogramins, quinolones, beta-lactam antibiotics, and macrolide-, tetracycline- and trimethoprim-related drugs. Most of the antibacterials are directed against resistant S. aureus infections, with very few against resistant gram-negative infections. The following article reviews the antibacterials approved by the FDA after the year 2000 as well as some of those in clinical trials. Data was obtained through a literature search via Pubmed and google as well as a detailed search of our library database.


Singh G.,Sri Devaraj Urs Medical College | Lavanya M.S.,Sri Devaraj Urs Medical College
International Journal of Trichology | Year: 2010

Alopecia Areata (AA) is a common non-scarring alopecia directed against the anagenic hair follicle. Various treatment modalities have been used for the treatment of severe AA. Topical immunotherapy is the best documented treatment so far for severe and refractory AA. Dinitrochlorobenzene (DNCB), squaric acid dibutylester (SADBE), and diphencyprone (DPCP) are the contact allergens used for this purpose. DNCB has been found to be mutagenic by the Ames test and is largely replaced by DPCP and SADBE. DPCP and SADBE are both known to be non-mutagenic compounds and have comparable efficacy results and relapse rates. SADBE requires special solvents and additives to maintain its potency and is more expensive than the rest. DPCP has a response rate varying from 60% in severe Alopecia Areata to 17% in patients with alopecia totalis or universalis, and shows about 88 to 100% high response rate in patients with patchy Alopecia Areata.


Jaiprakash H.,Sri Devaraj urs Medical College | Sarala N.,Sri Devaraj urs Medical College | Venkatarathnamma P.N.,Sri Devaraj urs Medical College | Kumar T.N.,Sri Devaraj urs Medical College
Food and Chemical Toxicology | Year: 2011

The global problem of acute poisoning has steadily increased over the past few years. It is an important cause of morbidity and mortality in developing countries. Better preventive and management strategies can be developed if the incidence and pattern of acute poisoning is known. The study aims at analyzing the pattern, cause and mortality rate of poisoning.The study was conducted in a rural area in South India. This retrospective study was conducted from January 2003-December 2003. The data was analysed using descriptive statistics.Out of the 225 cases 139 were males and 86 females. Poisoning was common in the age group of 21-30. years which was 84 cases and 11-20. years was 73 cases. The poisons consumed were as follows: Organophosphorous 135 cases, aluminum and zinc phosphide 50 cases, phenobarbitone 18 cases, benzodiazepines 7 cases, paracetamol 2 cases, miscellaneous 13 cases. 94% were suicides and 6% accidental. Mortality rate was 12.8%.Establishment of strict policies against the sale and availability of pesticides and over the counter drugs is an effective way to control organophosphorous and drug poisoning. © 2010 Elsevier Ltd.


Ashakiran S.,Sri Devaraj Urs Medical College | Sumati M.E.,Sri Devaraj Urs Medical College | Murthy N.K.,Sri Devaraj Urs Medical College
Clinical Biochemistry | Year: 2011

Objectives: Pre-analytical error decisively influences the total error and consequently the diagnostic accuracy. The following were the objectives for the study:. 1. To detect the percent of pre-analytical errors in clinical biochemistry laboratory 2. To categorize these pre-analytical errors 3.To formulate corrective measures to be taken to avoid such errors. Design and methods: Study period was for 3. months with documenting the frequency and type of pre-analytical errors occurring in the venous samples. Result: Average pre-analytical errors were 44.7% per day. Improper request, incorrect timing of sample, wrong tube collection and in-vitro hemolysis of samples amounted to the major proportion of errors. Conclusion: Pre-analytical errors occurring in each laboratory have to be checked. Such errors are not inevitable and can be avoided with a diligent application of quality control, continuing education and effective collection systems to ensure total quality patient care. © 2011 The Canadian Society of Clinical Chemists.


Patel P.K.,Sri Devaraj Urs Medical College
Indian Journal of Community Medicine | Year: 2012

Background: Lymphatic filariasis (LF) is endemic in 83 countries and territories, with more than a billion people at risk of infection. In view with the global elimination, mass drug administration (MDA) with single dose of diethylcarbamazine and albendazole tablets was carried out for the eligible population in Bagalkot and Gulbarga districts. Objective: Assess coverage of MDA against LF in Bagalkot and Gulbarga districts. Materials and Methods: In this cross-sectional coverage evaluation survey, one urban and three rural clusters were selected randomly in each district. The data were collected in a pretested performa, computed and analyzed using SPSS-10 to calculate frequencies and proportions. Results: A total of eight clusters in two districts resulted in a total study population of 1,228 individuals. The overall compliance rate in Bagalkot district was 78.6% and in Gulbarga district it was only 38.8%. The prime reason for noncompliance was fear of side effects and not received tablets. Conclusion: There is an urgent need for more effective drug delivery strategies to improve the compliance in both the districts.

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