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Keiner D.,SRH Zentralklinikum Suhl GmbH | Nusser-Rothermundt E.,Apotheke des Klinikums Stuttgart Katharinenhospital
Krankenhauspharmazie | Year: 2016

Audits/self-inspections as monitoring tools for the evaluation of an effectively implemented quality management system require additional resources for planning and conducting audits as well as follow-up actions. External audits in a pharmacy or hospital also require the presence of the pharmacy staff. The same applies to inspections conducted by the staff of occupational health & safety and hygiene departments. Implementation of clinical risk management §137 SGB V leads to an increasing number of inquiries relating to risk audits. As additional questions arise in that context the ADKA quality management committee has decided to address the relevant issues in a series of articles in the present journal.

Remmerbach T.W.,University of Leipzig | Remmerbach T.W.,Griffith University | Maurer K.,University of Leipzig | Janke S.,University of Leipzig | And 5 more authors.
Oral Oncology | Year: 2011

Oral squamous cell carcinomas (OSCCs) often present as advanced tumours requiring aggressive local and regional therapy and result in significant functional impairment. The objective is to develop pre-symptomatic screening detection of OSCC by a brush biopsy method which is less invasive than the conventional biopsy for histology. Given the molecular heterogeneity of oral cancer, it is unlikely that even a panel of tumour markers would provide accurate diagnosis. Therefore, approaches such as the matrix-assisted-laser- desorption/ionisation-time-of-flight-mass-spectrometry (MALDI-TOF-MS) allow several biomarkers or peptide profile patterns to be simultaneously assessed. Brush biopsies from 27 patients with histology-proven OSCCs plus 40 biopsies from 10 healthy controls were collected. MALDI-TOF-MS profiling was performed and additional statistical analysis of the data was used to classify the disease status according to the biological behaviour of the lesion. For classification a support vector machine algorithm was trained using spectra of brush biopsy samples to distinguish healthy control patients from patients with histology-proven OSCC. MALDI-TOF-MS was able to distinguish between healthy patients and OSCC patients with a sensitivity of 100% and specificity of 93%. In summary, MALDI-TOF-MS in combination with sophisticated bioinformatic methods can distinguish OSCC patients from non-cancer controls with excellent sensitivity and specificity. Further improvement and validation of this approach is necessary to determine its feasibility to assist the pre-symptomatic detection of head and neck cancer screening in routine daily practice. © 2011 Elsevier Ltd. All rights reserved.

Muther S.,Projektmanagement | Rodeck B.,Christliches Kinderhospital Osnabruck | Wurst C.,SRH Zentralklinikum Suhl GmbH | Nolting H.-D.,IGES Institute GmbH
Monatsschrift fur Kinderheilkunde | Year: 2014

Young people with special health care needs (YSHCN) play an increasingly important role in medical care. Transition from a pediatric healthcare setting into adult care is a critical stage. A number of adolescents may reappear in adult healthcare when potentially preventable complications have occurred. There are various groups of patients that may be transferred to the adult care system: young people with disorders also well-known in adulthood, adolescents with diseases unknown in adulthood and youths with disabilities who are treated in so-called social pediatric centers (sozialpädiatrische Zentren, SPZ). For the latter group, no adequate treatment structures are established in adult care. The establishment of medical centers for adults with intellectual and multiple disabilities (MZEB) is the declared goal of the current legislation The Berliner TransitionsProgramm (BTP, Berlin transition program) is a structured 2-year program supporting young people with various chronic diseases during the process of transition to adult care. The BTP comprises a professional case management and serves as a model for the establishment of a nationally standardized transition program covered by German statutory health insurances. The German Society for Pediatric and Adolescent Medicine (DGKJ), the German Society of Internal Medicine (DGIM) and the German Society of Neurology (DGN) have formed a working group to promote this process and are supported by the German Society of Transition Medicine (DGfTM). © 2014 Springer-Verlag.

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