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Maheswara Reddy L.,Sri Krishnadevaraya University | Janardhan Reddy K.,Gyeongju University | Janardhan Reddy K.,Sreevidyanikethan Engineering College Atonomous | Bhaskar Reddy L.,Sri Krishnadevaraya University | Raveendra Reddy P.,Sri Krishnadevaraya University
E-Journal of Chemistry | Year: 2012

A chromatographic method was established for the determination of lenalidomide and related substances in 10 mg and 5 mg capsules using Sunfire C-18(250×4.6 mm ID, 5 μm) HPCL column with 85:15 v/v ratio of mobile phases A (mixture of phosphoric acid buffer and 1-octane sulphonic acid sodium salt) and B(55: 45 v/v ratio of methanol and acetonitrile) at 40°C and 210 nm wave length. The degradation studies were performed using 0.1N HCl, 0.1 N NaOH, 1% v/v hydrogen peroxide, humidity, UV at 254 nm, Sun light, and heat to 60oC. No significant degradation of lenalidomide was observed. However, the slight degradation was observed in presence of NaOH. The developed HPLC method gave the peaks purity angle was less their threshold angle, indicating it to be suitable for stability studies. It was validated with respect to linearity, accuracy, precision, ruggedness, and robustness.

Reddy K.J.,Dongguk University | Reddy K.J.,Sreevidyanikethan Engineering College Atonomous | Duk L.K.,Dongguk University
E-Journal of Chemistry | Year: 2012

This study examined the effectinfluence of various factors on the extraction of Pd(II) to develop a new liquid-liquid extraction mechanism for the selective separation of palladium(II) from its acidic chloride solutions using 4-aroyl-3-phenyl-5-isoxazolones (HA), such as 3-phenyl-4-(4-fluorobenzoyl)-5- isoxazolone (HFBPI), 3-phenyl-4-benzoyl-5-isoxazolone (HPBI) and 3-phenyl-4-(4-toluoyl)-5-isoxazolone (HTPI). The extraction strength of Pd(II) with HA were in the followingorder: HFBPI > HPBI > HTPI, which is opposite to that observed withtheir pK avalues. HPBI was used to separatePd(II) from Pt(IV), Ni(II) and Rh(III) metal ions and calculated their separation factors (S.F.) were followed in the order: Pd/Ni (40±0.4) > Pd/Pt (25±0.2) > Pd/Rh (15±0.3 > Rh/Ni (2.7±0.3) > Pt/Ni ≈ Rh/Pt (1.7±0.2). The loading and striping of Pd(II) (1.12×10 -4 mol L -1) were also examinedusing 1.0×10 -3 mol L -1HPBI in CHCl 3 and 1.0 mol L-1HCl, respectively. The results demonstrated that the maximum (97.5%) extraction and desorption(89%) of metal required at least 3.0 cycles. The developed method was applied successfully tothe separation of palladium from synthetic water samples.

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