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Devarasetty K.,GVK Biosciences Pvt. Ltd. | Devarasetty K.,Jawaharlal Nehru Technological University Anantapur | Tharikoppula G.,GVK Biosciences Pvt. Ltd. | Tharikoppula G.,Jawaharlal Nehru Technological University Anantapur | And 5 more authors.
Synthetic Communications | Year: 2016

A series of novel 2-alkylamino and 2, 4-dialkyl amino 6-oxopyrimidin-1(6H)-yl) benzamide derivatives were prepared in good yields from a base-catalyzed ring opening of oxadiazolo[3,2-a]pyrimidin-5-one and evaluated for their antibacterial and cytotoxicity. Most of the compounds exhibited antibacterial activity. In particular, compounds 5b and 5k exhibited considerable antibiotic activity against Klebsiella pneumonia and Bacillus cereus. In addition, compounds 5g and 5i also inhibited the growth of two human tumor cell lines (A549 and H460) at micromolar concentrations. 2016 Copyright © Taylor & Francis Group, LLC Source

Vutukuru P.,Mediciti Institute of Medical science | Vutukuru S.S.,Sreenidhi Institute of Science and Technology Autonomous
Asian Journal of Microbiology, Biotechnology and Environmental Sciences | Year: 2015

Current aquaculture practices potentially lead to increased levels of antibiotic residues and antibiotic-resistant bacteria both in aquaculture products and their immediate environment. Research is warranted on the environmental and health impact of the use of antibiotics in aquaculture. In this study, the toxic impact of doxycycline on the glycogen and protein content of D. rerio exposed to 5, 10, 20 and 40 mg/L for 24 and 96 h was investigated. Loss of scales, hyper secretion of mucus, loss of balance, irregular swimming patterns were noticed in the fish exposed to 10 mg/L, 20 mg/L and 40 mg/L. Significant decline in the glycogen was observed in the gill and muscle tissues in 20 and 40 mg/L at 24 h while this decrease was observed even at 10 mg/L at 96 h. However, the decrease in glycogen of viscera exposed to all concentrations was insignificant at 24 and 96 h. After 24 h, the total protein content in gill decreased by 17.53%, 30.89%, 48.36% and 66.56%, and by 25.50%, 38.14%, 53.99% and 75.75% from control at 96 h, in 5, 10, 20 and 40 mg/L, respectively. Similar trends were also observed in muscle and viscera. Insignificant decrease was observed in protein content in gill, muscle and viscera of fish exposed to 5 mg/L at 24 h and 96 h. Zebra fish can be effectively used as model for understanding drug toxicity. The drug induced significant changes in glycogen and protein content of gills, muscle, viscera of the fish demonstrating a time concentration relationship. The occurrence of doxycycline at >10 mg/L in aquatic ecosystems is a matter of great concern in public health perspective via transmittance of antibiotic resistant genes. © 2015 Global Science Publications. Source

Rao K.R.,Dr. Reddys Laboratories Ltd | Raghunadh A.,Dr. Reddys Laboratories Ltd | Mekala R.,Dr. Reddys Laboratories Ltd | Meruva S.B.,Dr. Reddys Laboratories Ltd | And 6 more authors.
Tetrahedron Letters | Year: 2014

A dual reactant/catalyst role of glyoxylic acid in the reaction of isatoic anhydride with various amines afforded a novel, robust and rapid synthesis of 3-(un)substituted quinazolin-4(3H)-ones. This metal catalyst-free reaction proceeds via an unusual and unexpected cleavage of C-C bond. A shorter and common route to two alkaloids, that is, rutaecarpine and evodiamine is also accomplished. © 2014 Elsevier Ltd. All rights reserved. Source

Sanaboina C.,GVK Biosciences Private Ltd | Sanaboina C.,Sreenidhi Institute of Science and Technology Autonomous | Jana S.,GVK Biosciences Private Ltd | Chidara S.,GVK Biosciences Private Ltd | And 3 more authors.
Tetrahedron Letters | Year: 2012

Synthesis of indole alkaloid related compounds using Schiff base formation, intramolecular cyclization (or N-alkylation), and Pictet-Spengler reaction as a cascade one pot condensation has been reported. The cascade chemistry has been applied to the synthesis of (±)-harmicine as a key step. © 2012 Elsevier Ltd. All rights reserved. Source

Sajjalaguddam R.R.,Sreenidhi Institute of Science and Technology Autonomous | Paladugu A.,Sreenidhi Institute of Science and Technology Autonomous
Journal of Applied Pharmaceutical Science | Year: 2015

Flavonoids have aroused considerable interest because of their potential beneficial effect on human health. Quercetin is one of the most abundant natural flavonoids present in medicinal plants. In the present study, a comparative phytochemical analysis of bioactive compounds from leaf and leaf derived callus of Abutilon indicum L. was carried out. Thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) analysis of methanolic extract of Abutilon leaf revealed the presence of quercetin. To test the effect of precursor in enhancing flavonoid content, in vitro studies were conducted by supplementing phenylalanine to actively growing callus cultures of Abutilon. More than threefold increase in quercetin content was obtained in elicitor induced callus compared to control. © 2015 Ramgopal Rao Sajjalaguddam and Anitha Paladugu. Source

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