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Srinivasa Reddy P.,Sree Siddhartha Medical College
Indian Journal of Forensic Medicine and Toxicology | Year: 2012

A 23 year old male, complained of chest pain and breathlessness on getting up from bed in the early morning at 4.00 AM. On arrival at the casualty of Sri Siddhartha Medical College Hospital, Tumkur, he was declared brought dead to the hospital by the casualty medical officer at 6.15 AM on 8/7/09. Autopsy was conducted in the Department of Forensic Medicine, revealed no demonstrable changes in the myocardium except obstruction to the left coronary main trunk.

Hegde S.K.B.,Sree Siddhartha Medical College | Ramakrishna Goud B.,St Johns Medical College | Sulekha T.,St Johns Medical College
Indian Journal of Public Health Research and Development | Year: 2014

Background: Anthropometric measurements are integral to monitor the growth of the under five children of the Anganwadi. Under-nutrition, being one of the most common morbidities in the under fives, it was decided to assess the growth pattern of children attending 7 anganwadis in 6 villages situated in our field practice area. Objectives: To assess the growth pattern of Under-five children attending the Anganwadis in 6 villages in our field practice area. Materials: Study area-7 Anganwadis in 6 villages, under Sarjapura PHC area in Anekal taluk; Study period-July 2003 to July 2007; Study population-children in the age group of 2 to 5 years attending Anganwadi; Study design-longitudinal study; Instruments-A standard measuring tape, 'Salter and Harris' weighing scale; Method: Weight and height of each child was taken at monthly intervals. Quarterly anthropometric measurement of all children was considered for analysis. Inclusion criteria: Children between 2 to 5 years of age, who had at least 2 readings in our quarterly measurements in 1 year, were included in the study. Results: Out of the 403 children examined, 203 children (98 males and 105 females) fulfilled our inclusion criteria. The quarterly mean weights (in kgs) were calculated and 76.9% of these mean recordings were within normal limits. The quarterly mean heights (in cms) were calculated and it was found that all the mean heights were lower than 95% of the expected. Similarly, quarterly weights and heights for caste and gender were obtained and analysed. However, no significant difference was seen for these two categories. Conclusions: The mean heights of the children in this study were lower than the expected under the IAP classification; while that for weight, was within normal limits for most of the children. © 2014 Indian Journal of Public Health Research and Development. All rights reserved.

Arundhathi S.,Sree Siddhartha Medical College | Sunitha S.,Basaweshwara Medical College
International Journal of Pharma and Bio Sciences | Year: 2014

Diagnosis by direct immunofluorescence (DIF) requires skin biopsies with preserved immunoreactants for which biopsies are snap-frozen in liquid nitrogen or placed in Michel's fixative that facilitates transport. Retrospective study was conducted on 30 perilesional skin biopsies of immune- vesciculobullous lesions in Michel's medium to analyse its efficiency as transport medium. DIF was performed and samples were grouped according to the number of days they had been maintained in Michel's medium. DIF was positive in 28 cases, accounting for 93.33%. DIF was positive in 100%, 92.31% and 83.33% of biopsies even after 5, 10 and 15 days of preservation in Michel's medium, respectively. As the number of days in transport medium increased, the intensity of immunofluorescence decreased. There was no statistical significance (>0.05) between the intensity of immunofluorescence and the number of days the biopsies were in transport medium. Michel's medium is an efficient transport medium, when used within 15 days, in countries where DIF facilities are not available.

Annam V.,Sree Siddhartha Medical College | Suresh D.R.,Sree Siddhartha Medical College
Journal of Laryngology and Otology | Year: 2010

Background and objectives: Laryngeal and hypopharyngeal cancer is a multifactorial disease caused by various carcinogens such as tobacco, alcohol and viruses. Likewise, oxidative stress is known to cause aberrations in the cell membrane and DNA, leading to cancer. We conducted this prospective study in order to evaluate the level of oxidative stress in laryngeal and hypopharyngeal cancer patients. Methods: Fifty patients with laryngeal and hypopharyngeal cancer and 40 control subjects were selected. Serum malondialdehyde concentrations and ferric reducing antioxidant power were assessed, in order to evaluate oxidative stress. Results were analysed by Student's t-test.Results: Malondialdehyde levels were significantly higher and ferric reducing antioxidant power lower in the cancer patients, compared with the controls, indicating higher oxidative stress in the former. There was no statistically significant difference in malondialdehyde concentration or ferric reducing antioxidant power, comparing patients with versus without neck secondaries, and patients with early stage versus late stage tumours. Conclusion: Oxidative stress may have a role to play in the initiation of laryngeal and hypopharyngeal cancers, especially in patients with other risk factors such as tobacco and alcohol use. Copyright © JLO (1984) Limited 2009.

Arathi C.,Sree Siddhartha Medical College | Vijaya C.,Sree Siddhartha Medical College
Journal of Cytology | Year: 2010

The low incidence and the non-specific clinical symptoms led us to conclude that the diagnosis of a sebaceous carcinoma of the eyelid often occurs very late. Sebaceous carcinoma of the ocular adnexa is a malignant neoplasm which can exhibit aggressive local behavior, can have pagetoid spread and can metastasize to regional lymph nodes and distant organs. The neoplasm is known to masquerade as other benign and less malignant lesions, and has relatively high morbidity and mortality. Scrape cytology was done in a 70-year-old female with a tumor in left upper lid. Cytological smears were suggestive of sebaceous carcinoma. Subsequently, histopathology confirmed the diagnosis of sebaceous gland carcinoma. The article highlights the role of scrape cytology in early diagnosis and subsequent appropriate surgical management of eyelid sebaceous gland carcinoma, to prevent recurrence and metastasis.

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