Sree Lakshmi Narayana Institute of Medical science

Puducherry, India

Sree Lakshmi Narayana Institute of Medical science

Puducherry, India
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Rajkumar R.,Bharath University | Venkatesan V.,Sri Balaji Medical College and Hospitals | Thanigai S.,SRM University | Chidambaram R.,Sree Lakshmi Narayana Institute of Medical science
International Journal of Research in Pharmaceutical Sciences | Year: 2013

The present study is aimed at the effect of phenytoin induced differential regulation Crh gene in albino rat testis. The albino rats were divided into two groups, control and test.The test group was given 120mgs/kg /body weight of phenytoin orally and equal amount of normal saline was given for the control group. After 45 days with the rat under deep anaesthesia, the testis were removed from the scrotum and stored in liquid nitrogen. The stored spe-cimens of testis of control and tests group were subjected to cDNA microarray analysis. This study showed the differential expression of test group when compared with the control group. The expression patterns of several genes differentially regulated which can be confirmed by qRT PCR to verify the results of the microarray analysis. © JK Welfare & Pharmascope Foundation.


Rajkumar R.,Bharath University | Vathsala V.,Sri Balaji Medical College AndHospitals | Sriram T.,SRM University | Chidambaram R.,Sree Lakshmi Narayana Institute of Medical science
Journal of Chemical and Pharmaceutical Sciences | Year: 2014

Phenytoin alters brain cell sodium channels, which has the effect of limiting rapid firing of the brain cells Phenytoin may influence the secretion and functions of different hormones which may contribute to sexual dysfunction .Binding genes are involved in the regulation of gene expression by their molecular functions. They play many important roles like Basal transcription regulation, Differential enhancement of transcription, Development, Response to intercellular signals, Response to environment, Cell cycle control and Pathogenesis. The objective of the present study was to evaluate effect of phenytoin on the testicular binding genes of albino rat testis. The albino rats of test groups were treated with phenytoin for 45 consecutive days by oral gavage and control group was given equal amount of normal saline. After final day of exposure the testis were dissected out from both the groups and subjected for gene microarray analysis which revealed around 3373 genes were up regulated and 4430 genes were down regulated out of 44000 genes analysed further gene cluster analysis was performed to identify the specific binding genes. © 2014, SPB Pharma Society. All rights reserved.


Kembhavi R.S.,Sree Lakshmi Narayana Institute of Medical science | James B.,Sree Lakshmi Narayana Institute of Medical science
Journal of Clinical and Diagnostic Research | Year: 2016

Monteggia fracture constitutes about 5-10% of the forearm fractures. Monteggia fracture by definition is proximal ulnar fracture with disruption of proximal radioulnar joint. Bado classified Monteggia fracture dislocation into four types and Jupiter subclassified type II Bado’s fractures into four types. The associated injury in the form of distal radial fractures and distal humerus fractures are rare though many cases of distal radial physeal injuries have been reported in paediatric population. Hereby we report a rare association of type IIA Monteggia fracture dislocation with ipsilateral distal radius fracture in an adult patient. This case report also highlights on proper examination and full length radiographs of forearm to avoid missing injury at wrist in cases of elbow injuries. Management of such complex injuries included open reduction and internal fixation of olecronon fracture, distal radius fracture and radial head resection. Functional outcome at six months was good at wrist whereas at elbow, stiffness was a major concern with elbow range of movement from 40°‑110°. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved.


PubMed | Sree Lakshmi Narayana Institute of Medical science
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Monteggia fracture constitutes about 5-10% of the forearm fractures. Monteggia fracture by definition is proximal ulnar fracture with disruption of proximal radioulnar joint. Bado classified Monteggia fracture dislocation into four types and Jupiter subclassified type II Bados fractures into four types. The associated injury in the form of distal radial fractures and distal humerus fractures are rare though many cases of distal radial physeal injuries have been reported in paediatric population. Hereby we report a rare association of type IIA Monteggia fracture dislocation with ipsilateral distal radius fracture in an adult patient. This case report also highlights on proper examination and full length radiographs of forearm to avoid missing injury at wrist in cases of elbow injuries. Management of such complex injuries included open reduction and internal fixation of olecronon fracture, distal radius fracture and radial head resection. Functional outcome at six months was good at wrist whereas at elbow, stiffness was a major concern with elbow range of movement from 40-110.

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